Cited by 897Gut microbiota and healthT-cell and B-cell ImmunologyMicrobial Metabolites in Food Biotechnology

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Gut Microbial Metabolites Fuel Host Antibody Responses

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Kim, Myunghoo, Qie, Yaqing, Park, Jeongho, Kim, Chang H.·2016·Cell Host & Microbe

DOI 10.1016/j.chom.2016.07.001PMC PMC4982788

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Abstract

Antibody production is a metabolically demanding process that is regulated by gut microbiota, but the microbial products supporting B cell responses remain incompletely identified. We report that short-chain fatty acids (SCFAs), produced by gut microbiota as fermentation products of dietary fiber, support host antibody responses. In B cells, SCFAs increase acetyl-CoA and regulate metabolic sensors to increase oxidative phosphorylation, glycolysis, and fatty acid synthesis, which produce energy and building blocks supporting antibody production. In parallel, SCFAs control gene expression to express molecules necessary for plasma B cell differentiation. Mice with low SCFA production due to reduced dietary fiber consumption or microbial insufficiency are defective in homeostatic and pathogen-specific antibody responses, resulting in greater pathogen susceptibility. However, SCFA or dietary fiber intake restores this immune deficiency. This B cell-helping function of SCFAs is detected from the intestines to systemic tissues and conserved among mouse and human B cells, highlighting its importance.

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“A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript comparable to the C3 levels created by HFD (Figure S2A).”
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“SCFAs increase colonic FoxP3+ Tregs (Furusawa et al., 2013; Smith et al., 2013).”
Background
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Belkaid, Y., & Hand, T. W. (2014) · Cell · doi:10.1016/j.cell.2014.03.011 · Cited by 5,385 · cited 1×
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Round, J. L., & Mazmanian, S. K. (2009) · Nature Reviews Immunology · doi:10.1038/nri2515 · Cited by 5,029 · cited 1×
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Background
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Arpaia, N., Campbell, C., Fan, X., Dikiy, S., van der Veeken, J., deRoos, P., Liu, H., Cross, J. R., Pfeffer, K., Coffer, P. J., et al. (2013) · Nature · doi:10.1038/nature12726 · Cited by 4,838 · cited 1×
“SCFAs support epithelial cell integrity, innate immune functions, and the generation of regulatory and effector T cells (Arpaia et al., 2013; Furusawa et al., 2013; Kim et al., 2013; Park et al., 2015; Sakata, 1987; Schauber et al., 2003).”
Background
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Tremaroli, V., & Bäckhed, F. (2012) · Nature · doi:10.1038/nature11552 · Cited by 4,387 · cited 2×
“…and analyzed data and drafted the manuscript with MK. anuscript A uthor M anuscript Keywords Short chain fatty acids; antibody; B cells; metabolism INTRODUCTION Host and gut microbial flora functionally interact in the gut for mutual benefits (Brown et al., 2013; Tremaroli and Backhed, 2012).”
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Cummings, J. H., Pomare, E. W., Branch, W. J., Naylor, C. P., & Macfarlane, G. T. (1987) · Gut · doi:10.1136/gut.28.10.1221 · Cited by 3,119 · cited 3×
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Bergman, E. N. (1990) · Physiological Reviews · doi:10.1152/physrev.1990.70.2.567 · Cited by 2,750 · cited 12×
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“Short chain fatty acid (SCFAs) are the major microbial metabolites of DF (Macfarlane and Macfarlane, 2003).”
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Grier, A., McDavid, A., Wang, B., Qiu, X., Java, J., Bandyopadhyay, S., Yang, H., Holden‐Wiltse, J., Kessler, H. A., Gill, A. L., et al. (2018) · Microbiome · doi:10.1186/s40168-018-0566-5 · Cited by 94
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Background
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Nie, P., Li, Z., Wang, Y., Zhang, Y., Zhao, M., Luo, J., Du, S., Deng, Z., Chen, J., Wang, Y., et al. (2019) · Medicinal Research Reviews · doi:10.1002/med.21584 · Cited by 94
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Background
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Tang, C., Sun, J., Liu, J., Jin, C., Wu, X., Zhang, X., Chen, H., Gou, Y., Kan, J., Qian, C.-L., et al. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.11.187 · Cited by 81
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Background
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“SCFAs modulate gut microbiota-mediated IgA immune response SCFAs are important for maintaining the intestinal barrier and promoting immune homeostasis (16).”
BackgroundInfluential
The Anti-colitis Effect of Schisandra chinensis Polysaccharide Is Associated With the Regulation of the Composition and Metabolism of Gut Microbiota
Su, L., Mao, C., Wang, X., Li, L., Tong, H., Mao, J., Ji, D., Lu, T., Hao, M., Huang, Z., et al. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.519479 · Cited by 87
“In addition, butyric acid, as a histone deacetylase inhibitor, enhances the intestinal mucosal immune response in the proliferation and differentiation of T and B lymphocytes (Park et al., 2015; Kim et al., 2016), which may be related to butyric acid driving the differentiation and function of macrophages, increasing…”
Background
Modulation of microbially derived short-chain fatty acids on intestinal homeostasis, metabolism, and neuropsychiatric disorder
Xiao, S., Jiang, S., Qian, D., & Duan, J. (2019) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-019-10312-4 · Cited by 89
Utilizing the Gastrointestinal Microbiota to Modulate Cattle Health through the Microbiome-Gut-Organ Axes
Welch, C. B., Ryman, V. E., Pringle, T. D., & Lourenco, J. M. (2022) · Microorganisms · doi:10.3390/microorganisms10071391 · Cited by 90
“Additionally, SCFA increase IgA production by enhancing plasma B cells metabolism to ensure the intestines are protected from inflammation [169,170].”
Background
The microbiome in cancer
Lin, A., Xiong, M., Jiang, A., Huang, L., Wong, H. Z. H., Feng, S., Zhang, C., Yu, H., Chen, L., Chi, H., et al. (2025) · iMeta · doi:10.1002/imt2.70070 · Cited by 99
Penile Anaerobic Dysbiosis as a Risk Factor for HIV Infection
Liu, C. M., Prodger, J. L., Tobian, A. A. R., Abraham, A. G., Kigozi, G., Hungate, B. A., Aziz, M., Nalugoda, F. K., Sariya, S., Serwadda, D. M., et al. (2017) · mBio · doi:10.1128/mbio.00996-17 · Cited by 86
Metabolic control of B cell immune responses
Jellusova, J. (2019) · Current Opinion in Immunology · doi:10.1016/j.coi.2019.11.002 · Cited by 83
Short-Chain Fatty Acids: A Soldier Fighting Against Inflammation and Protecting From Tumorigenesis in People With Diabetes
Yang, Q., Ouyang, J., Sun, F., & Yang, J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.590685 · Cited by 87
“Kim et al. also revealed that by promoting activation and differentiation of B cells to plasma B cells, SCFAs accelerated the production of most antibodies types, including IgG and IgA (86) (4).”
Background
Short-chain fatty acid butyrate induces IL-10-producing B cells by regulating circadian-clock-related genes to ameliorate Sjögren's syndrome
Kim, D. S., Woo, J. S., Min, H.-K., Choi, J., Moon, J. H., Park, M.-J., Kwok, S., Park, S., & Cho, M. (2021) · Journal of Autoimmunity · doi:10.1016/j.jaut.2021.102611 · Cited by 83
Dietary Resistant Potato Starch Alters Intestinal Microbial Communities and Their Metabolites, and Markers of Immune Regulation and Barrier Function in Swine
Trachsel, J., Briggs, C., Gabler, N. K., Allen, H. K., & Loving, C. L. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01381 · Cited by 87
“SCFAs benefit mucosal barrier function by stimulating increased secretion of mucus, antimicrobial peptides (14), and IgA (7), therefore preventing the translocation of intestinal bacteria that would elicit an immune response.”
BackgroundInfluential
Puerarin Rebuilding the Mucus Layer and Regulating Mucin-Utilizing Bacteria to Relieve Ulcerative Colitis
Wu, Y., Li, Y., Ruan, Z., Li, J. J., Zhang, L., Lu, H., & Xu, Z. Z. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c04119 · Cited by 85
The emerging role of microbiota-derived short-chain fatty acids in immunometabolism
Jasim, S. A., Opulencia, M. J. C., Ramírez‐Coronel, A. A., Abdelbasset, W. K., Abed, M. H., Markov, A. A., Al‐Awsi, G. R. L., Shamsiev, J. A., Hammid, A. T., Shalaby, M. N., et al. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108983 · Cited by 90
Regulation of CD4+ and CD8+ T Cell Biology by Short-Chain Fatty Acids and Its Relevance for Autoimmune Pathology
Schiweck, C., Thanarajah, S. E., Aichholzer, M., Matura, S., Reif, A., Vrieze, E., Weigert, A., & Visekruna, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158272 · Cited by 80
“Next to strong effects on epithelial and dendritic cells, macrophages and neutrophils, SCFAs have a strong IgA inducing effect [4,5] and promote Treg differentiation and responses [6,7,21,22].”
Background
Epigenetic effects of short-chain fatty acids from the large intestine on host cells
Stein, R. A., & Riber, L. (2023) · microLife · doi:10.1093/femsml/uqad032 · Cited by 85
Immunomodulatory role of gut microbial metabolites: mechanistic insights and therapeutic frontiers
Zeng, L., Qian, Y., Cui, X., Zhao, J., Ning, Z., Cha, J., Wang, K., Ge, C., Jia, J., Dou, T., et al. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1675065 · Cited by 102
Host-microbiota interactions and adaptive immunity
McCoy, K. D., Ronchi, F., & Geuking, M. B. (2017) · Immunological Reviews · doi:10.1111/imr.12575 · Cited by 77
The antibody/microbiota interface in health and disease
Sterlin, D., Fadlallah, J., Slack, E. M. C., & Gorochov, G. (2019) · Mucosal Immunology · doi:10.1038/s41385-019-0192-y · Cited by 77
Immunomodulatory Properties of Probiotics and Their Derived Bioactive Compounds
Thoda, C., & Touraki, M. (2023) · Applied Sciences · doi:10.3390/app13084726 · Cited by 91
“SCFAs employ multiple mechanisms in order to boost B cell differentiation into plasma cells and antibody production, including epigenetic regulation of specific genes such as Aicda, Xbp1, and Irf4, production of IL-6, and activation of Tfh cells [160,161].”
BackgroundInfluential
Communication Between the Microbiota and Mammalian Immunity
Ost, K. S., & Round, J. L. (2018) · Annual Review of Microbiology · doi:10.1146/annurev-micro-090817-062307 · Cited by 75
“SCFAs also serve as a source of energy for intestinal epithelial cells and influence barrier function (93, 94).”
Background
Core Fucosylation of Maternal Milk N-Glycan Evokes B Cell Activation by Selectively Promoting the l -Fucose Metabolism of GutBifidobacteriumspp. andLactobacillusspp
Li, M., Bai, Y., Zhou, J., Huang, W., Yan, J., Tao, J., Fan, Q., Liu, Y., Mei, D., Yan, Q., et al. (2019) · mBio · doi:10.1128/mbio.00128-19 · Cited by 73
“In the newborn, short-chain fatty acids (SCFAs) are produced through the bacterial fermentation of glycans that are present in breast milk and SCFAs increase both mitochondrial energy production and glycolysis, which promote B cell differentiation and antibody (Ab) production (11).”
Influential
Parenteral Nutrition-Associated Liver Disease: The Role of the Gut Microbiota
Cahová, M., Brátová, M., & Wohl, P. (2017) · Nutrients · doi:10.3390/nu9090987 · Cited by 74
“In healthy humans, the lactate produced by the gut microbiota is not accumulated in faeces but it is readily absorbed by intestinal cells or converted to other metabolites, particularly the short-chain fatty acids (SCFA) [29,30].”
BackgroundInfluential
The Role of the Microbiome in Food Allergy: A Review
Nance, C. L., Deniskin, R., Diaz, V. C., Paul, M., Anvari, S., & Anagnostou, A. (2020) · Children · doi:10.3390/children7060050 · Cited by 75
“SCFAs increase intracellular concentrations of acetyl-CoA and enhance oxidative phosphorylation, glycolysis and fatty acid synthesis [58].”
Background
Temporal microbiota changes of high-protein diet intake in a rat model
Mu, C., Yang, Y., Luo, Z., & Zhu, W. (2017) · Anaerobe · doi:10.1016/j.anaerobe.2017.06.003 · Cited by 67
Unraveling the diversity and functions of tissue-resident plasma cells
Tellier, J., Tarasova, I., Nie, J., Smillie, C. S., Fedele, P. L., Cao, W. H. J., Groom, J. R., Belz, G. T., Bhattacharya, D., Smyth, G. K., et al. (2024) · Nature Immunology · doi:10.1038/s41590-023-01712-w · Cited by 65
“…modulate the differentiation and maintenance of ASCs, including cytokine milieu, presence of T cell help, affinity of the B cell receptor (BCR) for its antigen, stimulation by Toll-like receptor ligands, the relative oxygen tension 10 and the presence of bacterial and dietary metabolites 11 .”
Dietary Corn Bran Altered the Diversity of Microbial Communities and Cytokine Production in Weaned Pigs
Liu, P., Zhao, J., Wang, W., Guo, P., Lu, W., Wang, C., Liu, L., Johnston, L. J., Zhao, Y., Wu, X., et al. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02090 · Cited by 70
The Potential Roles of Probiotics, Resistant Starch, and Resistant Proteins in Ameliorating Inflammation during Aging (Inflammaging)
Warman, D. J., Jia, H., & Kato, H. (2022) · Nutrients · doi:10.3390/nu14040747 · Cited by 80
“SCFAs (overall) Stimulating immune system [50] Providing energy for and supporting the growth of beneficial bacteria [8] Increasing both intestinal immunoglobulin A (IgA) and systemic immunoglobulin G (IgG) responses to prevent pathogens growth [51] Acetate Supporting the growth of probiotics [52]”
Background
Modulation of the Tumor Microenvironment by Microbiota-Derived Short-Chain Fatty Acids: Impact in Colorectal Cancer Therapy
Gomes, S., Rodrigues, A., Pazienza, V., & Preto, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065069 · Cited by 77
“revealed that SCFAs effectively increase cellular metabolism in B cells, which provides energy and building blocks to support B cell activation, differentiation, and antibody production [64].”
Background
Gut microbiota in dementia. Critical review of novel findings and their potential application
Łuc, M., Misiak, B., Pawłowski, M., Stańczykiewicz, B., Zabłocka, A., Szcześniak, D. M., Pałęga, A., & Rymaszewska, J. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110039 · Cited by 69
Nutrient sensing, signal transduction and immune responses
Walls, J. F., Sinclair, L. V., & Finlay, D. K. (2016) · Seminars in Immunology · doi:10.1016/j.smim.2016.09.001 · Cited by 69
“Microbiome derived SCFA are also important fuels for B cell responses; SCFA fuel energy producing pathways in B cells and boost antibody responses [94].”
Background
Microbiome-immune interactions in tuberculosis
Mori, G., Morrison, M., & Blumenthal, A. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1009377 · Cited by 80
The role of microbiota in respiratory health and diseases, particularly in tuberculosis
Shah, T., Shah, Z., Baloch, Z., & Cui, X. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112108 · Cited by 73
Regulation of Gut Microbiota on Immune Reconstitution in Patients With Acquired Immunodeficiency Syndrome
Geng, S.-T., Zhang, Z., Wang, Y.-X., Lu, D., Yu, J., Zhang, J., Kuang, Y., & Wang, K. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.594820 · Cited by 63
“Although there is still a contradiction regarding whether the development of ILCs requires the participation of gut microbiota (Kiss et al., 2011; Hill et al., 2012), gut microbiological signals certainly affect the maturation and acquisition of normal ILC function (Sawa et al., 2010).”
Background
Shaping functional gut microbiota using dietary bioactives to reduce colon cancer risk
Seidel, D., Azcárate-Peril, M. A., Chapkin, R. S., & Turner, N. D. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.06.009 · Cited by 64
Effects of dietary poly-β-hydroxybutyrate (PHB) on microbiota composition and the mTOR signaling pathway in the intestines of litopenaeus vannamei
Duan, Y., Zhang, Y., Dong, H., Wang, Y., & Zhang, J. (2017) · The Journal of Microbiology · doi:10.1007/s12275-017-7273-y · Cited by 65
“Since mTOR activation increases glycolytic activity in general, the increased glycolysis in SCFAtreated B-cells is consistent with observed increases in mTOR activity (Kim et al., 2016).”
Role of IgA in the early-life establishment of the gut microbiota and immunity: Implications for constructing a healthy start
Guo, J., Ren, C., Han, X., Huang, W., You, Y., & Zhan, J. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1908101 · Cited by 64
“Dietary fiber-derived short-chain fatty acids can enhance IgA generation in mice by promoting energy production and mRNA expression of genes related to B cell differentiation.(132) Similarly, 26 weeks of oligosaccharide supplementation in infants from birth resulted in a significant increase in fecal SIgA independent…”
Background
A guide to germ‐free and gnotobiotic mouse technology to study health and disease
Jans, M., & Vereecke, L. (2024) · FEBS Journal · doi:10.1111/febs.17124 · Cited by 67
“Mice experiencing microbial insufﬁciency exhibit deﬁcien-cies in both homeostatic and pathogen-speciﬁc antibody responses, highlighting the far-reaching impact of microbiota on immune function [101].”
Gut microbiota-derived fatty acid and sterol metabolites: biotransformation and immunomodulatory functions
Zhang, H., Xie, Y., Cao, F., & Song, X. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2382336 · Cited by 71
“115 SCFAs may also indirectly promote antibody production by regulating DC function.”
Background
Targeting gut microbiota as a therapeutic target in T2DM: A review of multi-target interactions of probiotics, prebiotics, postbiotics, and synbiotics with the intestinal barrier
Chen, K., Wang, H., Yang, X., Tang, C., Hu, G., & Gao, Z. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107483 · Cited by 71
Microbiota Metabolite Short-Chain Fatty Acids Facilitate Mucosal Adjuvant Activity of Cholera Toxin through GPR43
Yang, W., Xiao, Y., Huang, X., Chen, F., Sun, M., Bilotta, A. J., Xu, L., Lu, Y., Yao, S., Zhao, Q., et al. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1801068 · Cited by 62
“Recently, SCFAs have been shown to promote intestinal immune responses (12, 13).”
BackgroundResult
A Comprehensive Evaluation of the Impact of Bovine Milk Containing Different Beta-Casein Profiles on Gut Health of Ageing Mice
Guantario, B., Giribaldi, M., Devirgiliis, C., Finamore, A., Colombino, E., Capucchio, M. T., Evangelista, R., Motta, V., Zinno, P., Cirrincione, S., et al. (2020) · Nutrients · doi:10.3390/nu12072147 · Cited by 62
“High levels of luminal SCFAs, besides the shaping of lymphocyte populations, have also been reported to increase the levels of systemic blood IgGs [43], thus exerting a significant role in regulating both mucosal and systemic antibody responses.”
BackgroundInfluential
Microbiota Modulating Nutritional Approaches to Countering the Effects of Viral Respiratory Infections Including SARS-CoV-2 through Promoting Metabolic and Immune Fitness with Probiotics and Plant Bioactives.
Shinde, T., Hansbro, P. M., Sohal, S. S., Dingle, P., Eri, R., & Stanley, R. (2020) · Microorganisms · doi:10.3390/microorganisms8060921 · Cited by 61
“Furthermore, SCFAs also accelerate cellular metabolism and regulate gene expression to promote plasma B cell differentiation in antibody-producing cells [54].”
Background
Supplying the trip to antibody production—nutrients, signaling, and the programming of cellular metabolism in the mature B lineage
Boothby, M. R., Brookens, S. K., Raybuck, A. L., & Cho, S. H. (2021) · Cellular and Molecular Immunology · doi:10.1038/s41423-021-00782-w · Cited by 60
“Recent work provides evidence that such processes can modulate the qualities of antibody responses via B cellintrinsic effects on fates of activated B cells [223, 224].”
Background
Dietary Patterns and Gut Microbiota: The Crucial Actors in Inflammatory Bowel Disease
He, P., Yu, L., Tian, F., Zhang, H., Chen, W., & Zhai, Q. (2022) · Advances in Nutrition · doi:10.1093/advances/nmac029 · Cited by 65
The Impact of Gut Microbiota-Derived Metabolites on the Tumor Immune Microenvironment
Luu, M., Schütz, B., Lauth, M., & Visekruna, A. (2023) · Cancers · doi:10.3390/cancers15051588 · Cited by 65
“Bacterial SCFAs, such as acetate (C2), propionate (C3), butyrate (C4) and valerate (C5), are potent signaling molecules that promote the induction of mucosal protective IgA responses and the epithelial barrier function [76,77].”
Background
Metabolism Characteristics of Th17 and Regulatory T Cells in Autoimmune Diseases
Qin, Y., Gao, C., & Luo, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.828191 · Cited by 68

Authors: Kim, M., Qie, Y., Park, J., & Kim, C. H.
Affiliations: Purdue University West Lafayette (US)
Corresponding author: Kim, Chang H.
ORCID: Kim, Myunghoo
Park, Jeongho
Kim, Chang H.
Venue: Cell Host & Microbe
Publisher: Elsevier BV
Published: 2016-08
Volume: 20
Issue: 2
Pages: 202-214
ISSN: 1931-3128 (ISSN-L)
DOI: 10.1016/j.chom.2016.07.001
PMC: PMC4982788
OpenAlex: W2491805933
Cited by: 893
References: 59
Citations by year: 2026: 92 · 2025: 129 · 2024: 110 · 2023: 110 · 2022: 107 · 2021: 106 · 2020: 90 · 2019: 61 · 2018: 47 · 2017: 32 · 2016: 8
FWCI: 25.63
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 374 d)
Locations: Cell Host & Microbe (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Seoul National University Open Repository (Seoul National University) (submittedVersion)
Funders: National Multiple Sclerosis Society
Purdue University Center for Cancer Research
National Institutes of Health
National Cancer Institute (P30CA023168)
National Institute of Allergy and Infectious Diseases (R01AI121302, R01AI080769, R01AI074745)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK076616)
National Center for Research Resources (S10RR028293)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Keywords: short-chain fatty acids, gut microbiota, antibody production, B cells, dietary fiber, acetyl-CoA, oxidative phosphorylation, glycolysis, fatty acid synthesis, plasma cell differentiation, immunodeficiency, microbial metabolites
MeSH terms: Gastrointestinal Microbiome, Animals, Antibody Formation, B-Lymphocytes, Cell Differentiation, Dietary Fiber, Fatty Acids, Volatile, Fermentation, Gene Expression Regulation, Mice, Inbred C57BL, Gastrointestinal Tract, Metabolic Networks and Pathways

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Gut Microbial Metabolites Fuel Host Antibody Responses

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