The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Gut Microbial Metabolites Fuel Host Antibody Responses
Open accessAbstract
Antibody production is a metabolically demanding process that is regulated by gut microbiota, but the microbial products supporting B cell responses remain incompletely identified. We report that short-chain fatty acids (SCFAs), produced by gut microbiota as fermentation products of dietary fiber, support host antibody responses. In B cells, SCFAs increase acetyl-CoA and regulate metabolic sensors to increase oxidative phosphorylation, glycolysis, and fatty acid synthesis, which produce energy and building blocks supporting antibody production. In parallel, SCFAs control gene expression to express molecules necessary for plasma B cell differentiation. Mice with low SCFA production due to reduced dietary fiber consumption or microbial insufficiency are defective in homeostatic and pathogen-specific antibody responses, resulting in greater pathogen susceptibility. However, SCFA or dietary fiber intake restores this immune deficiency. This B cell-helping function of SCFAs is detected from the intestines to systemic tissues and conserved among mouse and human B cells, highlighting its importance.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Since microbial metabolites can be utilized by T cells for their metabolic demand to enhance glycolysis and oxidative phosphorylation28,29”
From Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer (2021) · cites this paper as [28]
In the citing paper
“Intriguingly, they further found that SCFAs in parallel modulate the energy metabolism of B cells to promote production of antibodies (M. Kim et al., 2016).”
From Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System (2017) · cites this paper as M. Kim et al., 2016
In the citing paper
“Kim et al. shed further light on this observation and demonstrated that SCFAs support antibody responses by regulating gene expression through HDAC inhibition.”
From Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System (2017) · cites this paper as M. Kim et al., 2016
Citations
Cites
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., et al. (2013) · Nature · doi:10.1038/nature12721 · Cited by 5,549 · cited 6×
“A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript comparable to the C3 levels created by HFD (Figure S2A).”
BackgroundInfluentialThe Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic T reg Cell Homeostasis
Smith, P. M., Howitt, M. R., Panikov, N., Michaud, M., Gallini, C. A., Bohlooly-Y, M., Glickman, J. N., & Garrett, W. S. (2013) · Science · doi:10.1126/science.1241165 · Cited by 5,413 · cited 2×
“SCFAs increase colonic FoxP3+ Tregs (Furusawa et al., 2013; Smith et al., 2013).”
BackgroundRole of the microbiota in immunity and inflammation.
Belkaid, Y., & Hand, T. W. (2014) · Cell · doi:10.1016/j.cell.2014.03.011 · Cited by 5,385 · cited 1×
“A mounting body of evidence indicates that gut microbiota profoundly influences the host immune system (Alexander et al., 2014; Belkaid and Hand, 2014).”
BackgroundThe gut microbiota shapes intestinal immune responses during health and disease
Round, J. L., & Mazmanian, S. K. (2009) · Nature Reviews Immunology · doi:10.1038/nri2515 · Cited by 5,029 · cited 1×
“For example, germ-free mice are variably impaired in epithelial integrity, gut-associated lymphoid tissue development, innate and adaptive immunity, and immune tolerance (Round and Mazmanian, 2009).”
BackgroundMetabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
Arpaia, N., Campbell, C., Fan, X., Dikiy, S., van der Veeken, J., deRoos, P., Liu, H., Cross, J. R., Pfeffer, K., Coffer, P. J., et al. (2013) · Nature · doi:10.1038/nature12726 · Cited by 4,838 · cited 1×
“SCFAs support epithelial cell integrity, innate immune functions, and the generation of regulatory and effector T cells (Arpaia et al., 2013; Furusawa et al., 2013; Kim et al., 2013; Park et al., 2015; Sakata, 1987; Schauber et al., 2003).”
BackgroundFunctional interactions between the gut microbiota and host metabolism
Tremaroli, V., & Bäckhed, F. (2012) · Nature · doi:10.1038/nature11552 · Cited by 4,387 · cited 2×
“…and analyzed data and drafted the manuscript with MK. anuscript A uthor M anuscript Keywords Short chain fatty acids; antibody; B cells; metabolism INTRODUCTION Host and gut microbial flora functionally interact in the gut for mutual benefits (Brown et al., 2013; Tremaroli and Backhed, 2012).”
BackgroundMuramatsu, M., Kinoshita, K., Fagarasan, S., Yamada, S., Shinkai, Y., & Honjo, T. (2000) · Cell · doi:10.1016/s0092-8674(00)00078-7 · Cited by 3,475 · cited 1×
“These genes are linked to B cell differentiation and/or IgA and IgG production (Aldrich et al., 2003; Muramatsu et al., 2000; Turner et al., 1994).”
BackgroundShort chain fatty acids in human large intestine, portal, hepatic and venous blood
Cummings, J. H., Pomare, E. W., Branch, W. J., Naylor, C. P., & Macfarlane, G. T. (1987) · Gut · doi:10.1136/gut.28.10.1221 · Cited by 3,119 · cited 3×
“The total luminal SCFA concentration in humans reaches ~130 mmol/Kg in the colon and ~15 mmol/Kg in the small intestine (SI) (Cummings et al., 1987).”
BackgroundInfluentialEnergy contributions of volatile fatty acids from the gastrointestinal tract in various species
Bergman, E. N. (1990) · Physiological Reviews · doi:10.1152/physrev.1990.70.2.567 · Cited by 2,750 · cited 12×
“Moreover, SCFAs enhanced the mitochondrial ATP production and maximal respiration rates in B cells (Figure 4C).”
BackgroundMethodInfluentialRegulation of short-chain fatty acid production
Macfarlane, S., & Macfarlane, G. T. (2003) · Proceedings of the Nutrition Society · doi:10.1079/pns2002207 · Cited by 1,939 · cited 1×
“Short chain fatty acid (SCFAs) are the major microbial metabolites of DF (Macfarlane and Macfarlane, 2003).”
Background
Flagged first, then by citations
Cited by
Sorted by citations
Gut microbiota-derived metabolites as key actors in inflammatory bowel disease
Lavelle, A., & Sokol, H. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0258-z · Cited by 2,015
Short-chain fatty acids: Linking diet, the microbiome and immunity
Mann, E. R., Lam, Y. K., & Uhlig, H. H. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-01014-8 · Cited by 1,595
SCFA: mechanisms and functional importance in the gut
Martin‐Gallausiaux, C., Marinelli, L., Blottière, H. M., Larraufie, P., & Lapaque, N. (2020) · Proceedings of The Nutrition Society · doi:10.1017/s0029665120006916 · Cited by 1,585
“Dietary fibres and SCFA enhance antibody response to bacteria by supporting B cell differentiation into plasma B cells via the increase of histone acetylation and of B cell metabolism((161,162)).”
BackgroundGut microbial metabolites as multi-kingdom intermediates
Krautkramer, K. A., Fan, J., & Bäckhed, F. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-020-0438-4 · Cited by 1,398
Metabolic Instruction of Immunity
Buck, M. D., Sowell, R., Kaech, S. M., & Pearce, E. L. (2017) · Cell · doi:10.1016/j.cell.2017.04.004 · Cited by 1,270
“…gut The metabolic relationship between commensals and immune cells in the gut is further illustrated by the finding that SCFAs derived from the fermentation of dietary fiber by gut microbiota promote B cell metabolism and boost antibody responses in both mouse and human B cells (Kim et al., 2016).”
Yang, W., Yu, T., Huang, X., Bilotta, A. J., Xu, L., Lu, Y., Sun, J., Pan, F., Zhou, J., Zhang, W., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18262-6 · Cited by 1,108
Microbes, Metabolites, and the Gut-Lung Axis
Dang, A. T., & Marsland, B. J. (2019) · Mucosal Immunology · doi:10.1038/s41385-019-0160-6 · Cited by 1,028
Postler, T. S., & Ghosh, S. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.05.008 · Cited by 876
“Arpaia et al., 2013; Brown et al., 2003; Chang et al., 2014; Donohoe et al., 2012; Kalina et al., 2002; Kim et al., 2016; Le Poul et al., 2003; Macia et al., 2015; Maslowski et al., 2009; Millard et al., 2002; Nilsson et al., 2003; Singh et al., 2010; Smith et al., 2013; Thangaraju et al., 2009a,…”
BackgroundLuu, M., Riester, Z., Baldrich, A., Reichardt, N., Yuille, S., Busetti, A., Klein, M., Wempe, A., Leister, H., Raifer, H., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24331-1 · Cited by 771
Trompette, A., Gollwitzer, E. S., Pattaroni, C., Lopez-Mejia, I. C., Riva, E., Pernot, J., Ubags, N., Fajas, L., Nicod, L. P., & Marsland, B. J. (2018) · Immunity · doi:10.1016/j.immuni.2018.04.022 · Cited by 678
“Acetyl-CoA produced during FAO can then fuel the OXPHOS and glycolytic pathways (Kim et al., 2016; Nsiah-Sefaa and McKenzie, 2016; van der Windt et al., 2012).”
BackgroundYang, W., & Cong, Y. (2021) · Cellular and Molecular Immunology · doi:10.1038/s41423-021-00661-4 · Cited by 715
Gut-Microbiota-Derived Metabolites Maintain Gut and Systemic Immune Homeostasis
Wang, J., Zhu, N., Su, L., Gao, Y., & Yang, R. (2023) · Cells · doi:10.3390/cells12050793 · Cited by 649
Gut microbiota-derived short-chain fatty acids and their role in human health and disease
Mukhopadhya, I., & Louis, P. (2025) · Nature Reviews Microbiology · doi:10.1038/s41579-025-01183-w · Cited by 628
“SCFAs have been shown to amplify antibody production by modulating gene expression, leading to a differentiation of B cells into specific plasma cells 91 .”
Luu, M., Pautz, S., Kohl, V., Singh, R., Romero, R., Lucas, S., Hofmann, J., Raifer, H., Vachharajani, N., Carrascosa, L. C., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08711-2 · Cited by 508
Functions of Gut Microbiota Metabolites, Current Status and Future Perspectives
Liu, J., Tan, Y., Cheng, H., Zhang, D., Feng, W., & Peng, C. (2022) · Aging and disease · doi:10.14336/ad.2022.0104 · Cited by 529
“production of cecal sIgA and thus modulate the composition of gut microbiota [77].”
BackgroundInfluentialGill, P. A., van Zelm, M. C., Muir, J. G., & Gibson, P. R. (2018) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14689 · Cited by 520
“leading to, increased glucose uptake, glycolytic activity and terminal differentiation into antibody-secreting plasma cells.(153) Such observa-”
BackgroundWu, W. H., Sun, M., Chen, F., Cao, A., Liu, H., Zhao, Y., Huang, X., Xiao, Y., Yao, S., Zhao, Q., et al. (2016) · Mucosal Immunology · doi:10.1038/mi.2016.114 · Cited by 510
“A recent report further demonstrated that SCFA promote intestinal IgA responses.(24) However, the mechanisms by which SCFA regulate intestinal IgA responses are still unknown.”
BackgroundResultGut microbiota influence immunotherapy responses: mechanisms and therapeutic strategies
(2022) · doi:10.1186/s13045-022-01273-9 · Cited by 495
“Finally, SCFAs provide energy for B-cell differentiation into plasma cells, antibody production, and overall changes in cell metabolism [95].”
BackgroundZeng, H., Umar, S., Rust, B., Lazarova, D., & Bordonaro, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20051214 · Cited by 480
“Furthermore, with strong HDAC inhibitory effects, butyrate not only increases B-cell production of antibodies but also promotes B-cell differentiation into plasma B-cells [125].”
BackgroundInfluentialChambers, E. S., Byrne, C. S., Morrison, D. J., Murphy, K. G., Preston, T., Tedford, C., Garcia-Perez, I., Fountana, S., Serrano-Contreras, J. I., Holmes, E., et al. (2019) · Gut · doi:10.1136/gutjnl-2019-318424 · Cited by 443
“24 To the best of our knowledge, this is the first evidence in vivo in humans that selectively increasing colonic propionate delivery increases circulating IgG levels and it would be of future interest to determine if this effect of IPE on adaptive immunity can decrease susceptibility to pathogen…”
BackgroundMontero, C. G., Fraile‐Μartinez, O., Gomez-Lahoz, A. M., Pekarek, L., Castellanos, A. J., Noguerales-Fraguas, F., Coca, S., Guijarro, L. G., García‐Honduvilla, N., Asúnsolo, Á., et al. (2021) · Nutrients · doi:10.3390/nu13020699 · Cited by 487
Dietary fiber and SCFAs in the regulation of mucosal immunity
Tan, J. K., Macia, L., & Mackay, C. R. (2022) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2022.11.007 · Cited by 439
Role of the gut microbiota in type 2 diabetes and related diseases
Yang, G., Wei, J., Liu, P., Zhang, Q., Tian, Y., Hou, G., Meng, L., Xin, Y., & Jiang, X. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154712 · Cited by 418
Regulation of short-chain fatty acids in the immune system
Liu, X., Shao, J.-H., Liao, Y.-T., Wang, L., Yuan, J., Dong, P.-J., Liu, Z., He, D., Li, C., & Zhang, X. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1186892 · Cited by 464
Diet, Microbiota and Gut-Lung Connection
Anand, S., & Mande, S. S. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02147 · Cited by 423
“Multiple roles of SCFAs in energy and metabolism support activation/differentiation of B cells as well as production of antibodies (IgM/IgA; Supplementary Figure S1; Kim, 2016; Kim et al., 2016).”
BackgroundKim, C. H. (2023) · Cellular & Molecular Immunology · doi:10.1038/s41423-023-00987-1 · Cited by 420
“Thus, SCFAs and prebiotics appear to selectively increase the activity of regulatory lymphocytes, such as Tregs and Bregs, over in fl ammatory effector cells, such as Th17 cells and autoantibody-producing B cells.”
BackgroundInfluentialSelf-citationGut microbiota as the key controllers of 'healthy' aging of elderly people
Ragonnaud, E., & Biragyn, A. (2021) · Immunity & Ageing · doi:10.1186/s12979-020-00213-w · Cited by 383
“By supporting differentiation of antibody-producing B cells, SCFAs increase both intestinal IgA and systemic IgG responses to combat pathogens [90].”
BackgroundControl of lymphocyte functions by gut microbiota-derived short-chain fatty acids
Kim, C. H. (2021) · Cellular & Molecular Immunology · doi:10.1038/s41423-020-00625-0 · Cited by 404
“SCFAs enhance the effect of the activation signals from B cell receptor and cytokine receptors when triggered by IL-5, IL-6, and IL-10.(45) While DF and SCFAs increase the production of IgG and IgA, they suppress IgE production.”
BackgroundInfluentialSelf-citationGonçalves, P., Araújo, J. R., & Santo, J. P. D. (2018) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izx029 · Cited by 404
The Immunomodulatory Functions of Butyrate
Siddiqui, M. T., & Cresci, G. A. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s300989 · Cited by 381
“also induce antibody response by stimulating intestinal mucosal IgA responses and systemic IgG responses.(105)”
BackgroundImmune regulation by microbiome metabolites
Kim, C. H. (2018) · Immunology · doi:10.1111/imm.12930 · Cited by 375
Self-citationSanchez, H. N., Moroney, J. B., Gan, H., Shen, T., Im, J. L., Li, T., Taylor, J. R., Zan, H., & Casali, P. (2020) · Nature Communications · doi:10.1038/s41467-019-13603-6 · Cited by 369
Regulation of the Germinal Center Response
Stebegg, M., Kumar, S. D., Silva-Cayetano, A., Fonseca, V. R., Linterman, M. A., & Graca, L. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02469 · Cited by 349
“Microbial ATP controls Tfh cell differentiation (153) and short-chain fatty acids, a diverse group of bacterial metabolites, were shown to boost plasma cell differentiation and intestinal antibody production in PPs (162, 163).”
BackgroundPartners in Leaky Gut Syndrome: Intestinal Dysbiosis and Autoimmunity
Kinashi, Y., & Hase, K. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.673708 · Cited by 373
“” Commensal microbiota-derived metabolites have substantial impacts on host physiological functions through metabolic reprograming (64), epigenetic modifications (65), and the activation of specific receptors like G protein-coupled receptors (GPRs) and aryl hydrocarbon receptor (AhR).”
Backgroundvan der Beek, C. M., Dejong, C. H. C., Troost, F. J., Masclee, A., & Lenaerts, K. (2016) · Nutrition Reviews · doi:10.1093/nutrit/nuw067 · Cited by 356
Regulation of the effector function of CD8+ T cells by gut microbiota-derived metabolite butyrate
Luu, M., Weigand, K., Wedi, F., Breidenbend, C., Leister, H., Pautz, S., Adhikary, T., & Visekruna, A. (2018) · Scientific Reports · doi:10.1038/s41598-018-32860-x · Cited by 344
Rethinking mucosal antibody responses: IgM, IgG and IgD join IgA
Chen, K., Magri, G., Grasset, E. K., & Cerutti, A. (2020) · Nature reviews. Immunology · doi:10.1038/s41577-019-0261-1 · Cited by 346
Connecting the immune system, systemic chronic inflammation and the gut microbiome: the role of sex
Rizzetto, L., Fava, F., Tuohy, K. M., & Selmi, C. (2018) · Journal of Autoimmunity · doi:10.1016/j.jaut.2018.05.008 · Cited by 331
Epigenetic regulation by gut microbiota
Woo, V., & Alenghat, T. (2022) · Gut Microbes · doi:10.1080/19490976.2021.2022407 · Cited by 338
“Microbiota-derived SCFAs also supported intestinal B cell differentiation and antibody production by inhibiting HDAC activity leading to increased histone acetylation (H3K9Ac) and gene expression of multiple genes associated with B cell function.(93) Similar effects were observed in human and mouse B cells treated spe…”
BackgroundNey, L.-M., Wipplinger, M., Grossmann, M., Engert, N., Wegner, V. D., & Mosig, A. S. (2023) · Open Biology · doi:10.1098/rsob.230014 · Cited by 367
The Gut Microbiota at the Service of Immunometabolism
Michaudel, C., & Sokol, H. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.09.004 · Cited by 323
Gut Microbiota, Immune System, and Bone
D’Amelio, P., & Sassi, F. (2018) · Calcified Tissue International · doi:10.1007/s00223-017-0331-y · Cited by 315
“A recent study by Kim and colleagues suggests that GM may also affect B cells antibody production through SCFAs inhibition of HDAC and modulation of gene expression [49]; however, further studies are needed to clarify the”
BackgroundMining the microbiota for microbial and metabolite-based immunotherapies
Skelly, A. N., Sato, Y., Kearney, S., & Honda, K. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-019-0144-5 · Cited by 306
Bridging intestinal immunity and gut microbiota by metabolites
Wang, G., Huang, S., Wang, Y., Cai, S., Yu, H., Liu, H., Zeng, X., Zhang, G., & Qiao, S. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03190-6 · Cited by 305
“One study revealed that SCFAs are able to regulate B-cell gene expression via HDAC inhibition to promote antibody secretion, similar to the effect of SCFAs on other cells [157].”
BackgroundLynn, D. J., Benson, S. C., Lynn, M. A., & Pulendran, B. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00554-7 · Cited by 311
The impacts of natural polysaccharides on intestinal microbiota and immune responses – a review
Tang, C., Ding, R., Sun, J. G., Liu, J., Kan, J., & Jin, C. (2019) · Food & Function · doi:10.1039/c8fo01946k · Cited by 284
Chen, Y., Cui, W., Xiao, L., & Yang, H. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.761981 · Cited by 293
“SCFAs activate and release IL-18 through inflammasomes to maintain the integrity of the intestinal epithelium (38).”
BackgroundUnhealthy gut, unhealthy brain: The role of the intestinal microbiota in neurodegenerative diseases
Spielman, L. J., Gibson, D. L., & Klegeris, A. (2018) · Neurochemistry International · doi:10.1016/j.neuint.2018.08.005 · Cited by 266
“3-fold increase in cluster of differentiation (CD)20/CD38 B cells following stimulation with either acetate, propionate or butyrate (Kim et al., 2016).”
The nutrition‐gut microbiome‐physiology axis and allergic diseases
McKenzie, C. I., Tan, J., Macia, L., & Mackay, C. R. (2017) · Immunological Reviews · doi:10.1111/imr.12556 · Cited by 281
Adaptive immune education by gut microbiota antigens
Zhao, Q. S., & Elson, C. O. (2018) · Immunology · doi:10.1111/imm.12896 · Cited by 288
Gut microbiota influence in type 2 diabetes mellitus (T2DM)
Cunningham, A., Stephens, J. W., & Harris, D. A. (2021) · Gut Pathogens · doi:10.1186/s13099-021-00446-0 · Cited by 286
Gut Microbiota Features in Young Children With Autism Spectrum Disorders
Coretti, L., Paparo, L., Riccio, M. P., Amato, F., Cuomo, M., Natale, A., Borrelli, L., Corrado, G., De Caro, C., Comegna, M., et al. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.03146 · Cited by 266
“With positive effects on brain functions and behavior of low doses of butyrate (<500 mg/kg) and stress-like response elicited by high doses of butyrate (>1,000 mg/kg) (Gagliano et al., 2014; Takuma et al., 2014; Kratsman et al., 2016).”
BackgroundGut microbiota in COVID-19: key microbial changes, potential mechanisms and clinical applications
Zhang, F., Lau, R. I., Liu, Q., Su, Q., Chan, F. K. L., & Ng, S. C. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-022-00698-4 · Cited by 282
Gut-Brain Psychology: Rethinking Psychology From the Microbiota–Gut–Brain Axis
Liang, S., Wu, X., & Jin, F. (2018) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2018.00033 · Cited by 279
Zhang, Z., Tang, H., Chen, P., Xie, H., & Tao, Y. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0074-5 · Cited by 263
Nutrients Mediate Intestinal Bacteria–Mucosal Immune Crosstalk
Ma, N., Guo, P., Zhang, J., He, T., Kim, S. W., Zhang, G., & Ma, X. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00005 · Cited by 252
Dietary Fibers from Fruits and Vegetables and Their Health Benefits via Modulation of Gut Microbiota
Cui, J., Lian, Y., Zhao, C., Du, H., Han, Y., Gao, W. Y., Xiao, H., & Zheng, J. (2019) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12489 · Cited by 255
The maintenance of memory plasma cells
Khodadadi, L., Cheng, Q., Radbruch, A., & Hiepe, F. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00721 · Cited by 232
“The metabolism of short-chain fatty acids (SCFAs) produced by gut microbiota are involved in plasma cell differentiation and promote antigen-specific host antibody responses (137).”
BackgroundHost- and Microbiota-Derived Extracellular Vesicles, Immune Function, and Disease Development
Macia, L., Nanan, R. K. H., Hosseini‐Beheshti, E., & Grau, G. E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms21010107 · Cited by 241
“While initially they were only considered as bacterial waste products, it is now established that SCFAs play a key role in the differentiation and function of most immune cells including anti-inflammatory regulatory T cells (Treg) [84,85], CD8+ T cells [86], macrophages [87,88], tolerogenic CD103+ dendritic cells [79,…”
BackgroundAcetate differentially regulates IgA reactivity to commensal bacteria
Takeuchi, T., Miyauchi, E., Kanaya, T., Kato, T., Nakanishi, Y., Watanabe, T., Kitami, T., Taida, T., Sasaki, T., Negishi, H., et al. (2021) · Nature · doi:10.1038/s41586-021-03727-5 · Cited by 232
Gut microbiome in type 1 diabetes: A comprehensive review
Zheng, P., Li, Z., & Zhou, Z. (2018) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3043 · Cited by 244
“Recently, Kim and colleagues demonstrated that SCFAs regulated the energy metabolism of B cells in the gut, and promoted B cells differentiating into plasma cells and memory B cells through BCR‐ activating antigens, resulting in more IgG and IgA production.(80,81) Meanwhile, IgA can coat a substantial amount of gut mi…”
BackgroundDeehan, E. C., Duar, R. M., Armet, A. M., Pérez-Muñoz, M. E., Jin, M., & Walter, J. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.bad-0019-2017 · Cited by 240
Yang, C., Mogno, I., Contijoch, E. J., Borgerding, J. N., Aggarwala, V., Li, Z., Siu, S., Grasset, E. K., Helmus, D. S., Dubinsky, M. C., et al. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.01.016 · Cited by 221
“ovatus (Kim et al., 2016), GF mice were administered heat-killed B.”
MethodBarrow, F., Khan, S., Fredrickson, G., Wang, H., Dietsche, K., Parthiban, P., Robert, S., Kaiser, T., Winer, S., Herman, A., et al. (2021) · Hepatology · doi:10.1002/hep.31755 · Cited by 210
Russo, E., Giudici, F., Fiorindi, C., Ficari, F., Scaringi, S., & Amedei, A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02754 · Cited by 204
“Plasma B cell differentiation could be promoted also by SCFAs, as they could modulate the gene expression that is necessary for antibody generation in a SCFAs receptor-independent manner (83).”
BackgroundThe regulation of gut mucosal IgA B-cell responses: recent developments
Lycke, N. Y., & Bemark, M. (2017) · Mucosal Immunology · doi:10.1038/mi.2017.62 · Cited by 210
“Interestingly, even microbial production of shortchain fatty acids from dietary fiber can stimulate broadly reactive SIgA antibodies in the gut.(155) IgA antibodies reactive to commensal bacteria are found in gut secretions, but not in serum, and it was, therefore, proposed that some SIgA antibodies are involved in co…”
BackgroundParticipation of Short-Chain Fatty Acids and Their Receptors in Gut Inflammation and Colon Cancer
Carretta, M. D., Quiroga, J., López‐Muñoz, R., Hidalgo, M. A., & Burgos, R. A. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.662739 · Cited by 209
“In this regard, research demonstrated that SCFAs promote intestinal IgA responses (Kim et al., 2016), and this role has been attributed in part to the FFAR2 receptor (Wu et al.”
BackgroundDeciphering the Chemical Lexicon of Host–Gut Microbiota Interactions
Nicolas, G. R., & Chang, P. V. (2019) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2019.04.006 · Cited by 195
“Alternatively, SCFAs were found to mediate proinflammatory effects by up-regulating B cell metabolism, which increases the systemic production of IgG and IgA to regulate both homeostatic and pathogen-specific immune responses [12].”
BackgroundPark, J., Wang, Q., Wu, Q., Mao‐Draayer, Y., & Kim, C. H. (2019) · Scientific Reports · doi:10.1038/s41598-019-45311-y · Cited by 199
Self-citationMagri, G., Comerma, L., Pybus, M., Sintes, J., Lligé, D., Segura-Garzón, D., Bascones, S., Yeste, A., Grasset, E. K., Gutzeit, C., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.06.013 · Cited by 196
“By degrading dietary polysaccharides into shortchain fatty acids with immunoregulatory and SIgA-inducing functions (Arpaia et al., 2013; Kim et al., 2016), these commensals may enhance protection against obesity and infection (Biddle et al.”
BackgroundDietary cellulose prevents gut inflammation by modulating lipid metabolism and gut microbiota
Kim, Y., Hwang, S. W., Kim, S., Lee, Y., Kim, T., Lee, S.-H., Kim, S. J., Yoo, H. J., Kim, E. N., & Kweon, M. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1730149 · Cited by 197
“SCFAs can modulate the homeostasis of regulatory T (Treg) cells, plasma B cell differentiation, and antibody production.(11,12) Previous studies found that butyrate plays an important role in mammalian physiology, including serving as an energy source for gut epithelia and Treg generation.”
BackgroundElshahed, M. S., Miron, A., Aprotosoaie, A. C., & Farag, M. A. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.117388 · Cited by 199
“They increased the expression of Xbp1 and Aicda genes and cellular metabolism in mouse and human B cells to aid and support the antibody production (Kim, Qie, Park, & Chang, 2016).”
BackgroundRegionalized Development and Maintenance of the Intestinal Adaptive Immune Landscape
Agace, W. W., & McCoy, K. D. (2017) · Immunity · doi:10.1016/j.immuni.2017.04.004 · Cited by 194
Short‐chain fatty acids: Bacterial messengers modulating the immunometabolism of T cells
Luu, M., & Visekruna, A. (2019) · European Journal of Immunology · doi:10.1002/eji.201848009 · Cited by 187
Wang, B., Zhang, L., Wang, Y., Dai, T., Qin, Z., Zhou, F., & Zhang, L. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00986-0 · Cited by 187
“expression and supported optimal homeostatic and pathogenspecific antibody responses.(159) SCFAs have these effects on the B cells in the gut and systemic tissues.”
BackgroundRoles of the intestinal microbiota in pathogen protection
Úbeda, C., Djuković, A., & Isaac, S. (2017) · Clinical & Translational Immunology · doi:10.1038/cti.2017.2 · Cited by 186
Antibiotic-Induced Disruption of Gut Microbiota Alters Local Metabolomes and Immune Responses
Sun, L., Zhang, X., Zhang, Y., Zheng, K., Xiang, Q., Chen, N., Chen, Z., Zhang, N., Zhu, J., & He, Q. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00099 · Cited by 186
Critical role of the gut microbiota in immune responses and cancer immunotherapy
Li, Z., Xiong, W., Zhu, L. W., Wang, J., Zeng, Z., Kołat, D., Li, X., Zhou, D., Xu, X., & Zhao, L.-Y. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01541-w · Cited by 197
“In addition, SCFAs increase acetyl-CoA levels to modulate energy metabolism in B cells to support antibody production [112].”
BackgroundLi, L., Wang, Y., Zhu, L., Liu, Z., Ye, C., & Qin, S. (2020) · Scientific Reports · doi:10.1038/s41598-020-58048-w · Cited by 177
The Role of the Gut Microbiota in the Pathogenesis of Diabetes
Bielka, W., Przezak, A., & Pawlik, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23010480 · Cited by 189
“These molecules can be considered as indicators of IR and predictors of diabetes mellitus development, because the serum metabolomes of patients suffering from IR or T2D contain an increased amount of BCAAs [38,39].”
BackgroundInfluentialGut microbiota composition is associated with SARS-CoV-2 vaccine immunogenicity and adverse events
Ng, S. C., Peng, Y., Zhang, L., Mok, C. K. P., Zhao, S., Li, A., Ching, J. Y. L., Liu, Y., Yan, S., Chan, D. L. S., et al. (2022) · Gut · doi:10.1136/gutjnl-2021-326563 · Cited by 186
Metabolic adaptations of tissue-resident immune cells
Caputa, G., Castoldi, Â., & Pearce, E. J. (2019) · Nature Immunology · doi:10.1038/s41590-019-0407-0 · Cited by 179
Depletion of microbiome-derived molecules in the host using Clostridium genetics
Guo, C., Allen, B. M., Hiam-Galvez, K. J., Dodd, D., Treuren, W. V., Higginbottom, S. K., Nagashima, K., Fischer, C. R., Sonnenburg, J. L., Spitzer, M. H., et al. (2019) · Science · doi:10.1126/science.aav1282 · Cited by 179
Microbiota or short-chain fatty acids: which regulates diabetes?
Kim, C. H. (2017) · Cellular and Molecular Immunology · doi:10.1038/cmi.2017.57 · Cited by 172
Self-citationPathogens, microbiome and the host: emergence of the ecological Koch's postulates
Vonaesch, P., Anderson, M. C., & Sansonetti, P. J. (2018) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuy003 · Cited by 177
Microbiota–Gut–Brain Axis and Epilepsy: A Review on Mechanisms and Potential Therapeutics
Ding, M., Lang, Y., Shu, H., Shao, J., & Cui, L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.742449 · Cited by 177
Perinatal and Early-Life Nutrition, Epigenetics, and Allergy
Acevedo, N., Alhamwe, B. A., Caraballo, L. R., Ding, M., Ferrante, A., Garn, H., Garssen, J., Hii, C. S. T., Irvine, J., Llinás-Caballero, K., et al. (2021) · Nutrients · doi:10.3390/nu13030724 · Cited by 183
Obianwuna, U. E., Chang, X., Oleforuh-Okoleh, V. U., Onu, P. N., Zhang, H., Qiu, K., & Wu, S. (2024) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-024-01101-9 · Cited by 213
“Microbes such as Succiniclasticum and Akkermansia are involved in immunoglobulin secretion, which supports immune function [93].”
Disruption of maternal gut microbiota during gestation alters offspring microbiota and immunity
Nyangahu, D. D., Lennard, K. S., Brown, B. P., Darby, M., Wendoh, J. M., Havyarimana, E., Smith, P., Butcher, J., Stintzi, A., Mulder, N., et al. (2018) · Microbiome · doi:10.1186/s40168-018-0511-7 · Cited by 173
“immunoglobulin levels [33], these could be explored as po-”
BackgroundThe Impact of the Microbiome on Immunity to Vaccination in Humans
de Jong, S. E., Olin, A., & Pulendran, B. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.06.014 · Cited by 160
Visekruna, A., & Luu, M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.703218 · Cited by 170
Zou, F., Qiu, Y., Huang, Y., Zou, H., Xiao, C., Niu, Q., Luo, A., & Sun, J. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03880-9 · Cited by 162
Effects of short chain fatty acids on metabolic and inflammatory processes in human health
Campos-Perez, W. Y., & Martínez‐López, E. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2021.158900 · Cited by 157
Gut Microbiota Modulation on Intestinal Mucosal Adaptive Immunity
Wang, L., Zhu, L., & Qin, S. (2019) · Journal of Immunology Research · doi:10.1155/2019/4735040 · Cited by 157
“SCFAs can promote IgA production through regulating the metabolism and gene expression in B cells independent of T cells [92, 93].”
BackgroundHow the microbiome challenges our concept of self
Rees, T., Bosch, T. C. G., & Douglas, A. E. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2005358 · Cited by 152
Effects of Fish n-3 PUFAs on Intestinal Microbiota and Immune System
Parolini, C. (2019) · Marine Drugs · doi:10.3390/md17060374 · Cited by 158
“In addition, as above described several evidences support the role of both the microbiota and the n-3 PUFAs in regulating inflammation and the immune system [45,52,74].”
BackgroundMa, N., Zhang, J., Reiter, R. J., & Ma, X. (2019) · Medicinal Research Reviews · doi:10.1002/med.21628 · Cited by 155
Nutritional regulation of microbiota-derived metabolites: Implications for immunity and inflammation
Arifuzzaman, M., Collins, N., Guo, C., & Artis, D. (2024) · Immunity · doi:10.1016/j.immuni.2023.12.009 · Cited by 159
Xu, Z., Takizawa, F., Casadei, E., Shibasaki, Y., Ding, Y., Sauters, T. J. C., Yu, Y., Salinas, I., & Sunyer, J. O. (2020) · Science Immunology · doi:10.1126/sciimmunol.aay3254 · Cited by 154
Emerging concepts in intestinal immune control of obesity-related metabolic disease
Khan, S. M., Luck, H., Winer, S., & Winer, D. A. (2021) · Nature Communications · doi:10.1038/s41467-021-22727-7 · Cited by 161
Metadata
- Authors
- Kim, M., Qie, Y., Park, J., & Kim, C. H.
- Affiliations
- Purdue University West Lafayette (US)
- Corresponding author
- Kim, Chang H.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2016-08
- Volume
- 20
- Issue
- 2
- Pages
- 202-214
- ISSN
- 1931-3128 (ISSN-L)
- PMC
- PMC4982788
- OpenAlex
- W2491805933
- Cited by
- 893
- References
- 59
- Citations by year
- 2026: 92 · 2025: 129 · 2024: 110 · 2023: 110 · 2022: 107 · 2021: 106 · 2020: 90 · 2019: 61 · 2018: 47 · 2017: 32 · 2016: 8
- FWCI
- 25.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Host & Microbe (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Seoul National University Open Repository (Seoul National University) (submittedVersion)
- Funders
- National Multiple Sclerosis Society
- Purdue University Center for Cancer Research
- National Institutes of Health
- National Cancer Institute (P30CA023168)
- National Institute of Allergy and Infectious Diseases (R01AI121302, R01AI080769, R01AI074745)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK076616)
- National Center for Research Resources (S10RR028293)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Keywords
- short-chain fatty acids, gut microbiota, antibody production, B cells, dietary fiber, acetyl-CoA, oxidative phosphorylation, glycolysis, fatty acid synthesis, plasma cell differentiation, immunodeficiency, microbial metabolites
- MeSH terms
- Gastrointestinal Microbiome, Animals, Antibody Formation, B-Lymphocytes, Cell Differentiation, Dietary Fiber, Fatty Acids, Volatile, Fermentation, Gene Expression Regulation, Mice, Inbred C57BL, Gastrointestinal Tract, Metabolic Networks and Pathways
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
