Cited by 91Gut microbiota and healthEvolution and Genetic DynamicsNutrition, Genetics, and Disease

Diet leaves a genetic signature in a keystone member of the gut microbiota

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Dapa, Tanja, Ramiro, Ricardo Serotte, Pedro, Miguel Filipe, Gordo, Isabel, Xavier, Karina Bivar·2022·Cell Host & Microbe

Abstract

Switching from a low-fat and high-fiber diet to a Western-style high-fat and high-sugar diet causes microbiota imbalances that underlay many pathological conditions (i.e., dysbiosis). Although the effects of dietary changes on microbiota composition and functions are well documented, their impact in gut bacterial evolution remains unexplored. We followed the emergence of mutations in Bacteroides thetaiotaomicron, a prevalent fiber-degrading microbiota member, upon colonization of the murine gut under different dietary regimens. B. thetaiotaomicron evolved rapidly in the gut and Western-style diet selected for mutations that promote degradation of mucin-derived glycans. Periodic dietary changes caused fluctuations in the frequency of such mutations and were associated with metabolic shifts, resulting in the maintenance of higher intraspecies genetic diversity compared to constant dietary regimens. These results show that dietary changes leave a genetic signature in microbiome members and suggest that B. thetaiotaomicron genetic diversity could be a biomarker for dietary differences among individuals.

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Crossref · 10.1016/j.chom.2022.01.002

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  • Consumption of a western-style diet drives the emergence of mutations in Bacteroides thetaiotaomicron that promote degradation of mucin O-glycans in the mouse gut.

    “Consumption of a western-style diet also drives the emergence of mutations in Bacteroides thetaiotaomicron, an anaerobe specialized in fermenting complex polysaccharides. These mutations promote the degradation of mucin O-glycans in the mouse gut.”

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Authors
Dapa, T., Ramiro, R. S., Pedro, M. F., Gordo, I., & Xavier, K. B.
Affiliations
Instituto Gulbenkian de Ciência (PT)
Corresponding author
Xavier, Karina Bivar
Venue
Cell Host & Microbe
Publisher
Elsevier BV
Published
2022-02
Volume
30
Issue
2
Pages
183-199.e10
ISSN
1931-3128 (ISSN-L)
OpenAlex
W4220756682
Cited by
91
References
108
Citations by year
2026: 11 · 2025: 23 · 2024: 22 · 2023: 24 · 2022: 11
FWCI
6.53
Type
journal article
Language
en
Open access
Locations
  • Cell Host & Microbe (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
Keywords
Bacteroides thetaiotaomicron, Western diet, high-fat high-sugar diet, fiber-degrading bacteria, intraspecies genetic diversity, dysbiosis, dietary change, intestinal colonization, metabolic switch
MeSH terms
Gastrointestinal Microbiome, Bacteroides thetaiotaomicron, Animals, Diet, Dietary Fiber, Humans, Mice, Diet, High-Fat, Dysbiosis

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