Genetically dictated change in host mucus carbohydrate landscape exerts a diet-dependent effect on the gut microbiota
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Significance: Our data demonstrate that differences in host genotype that affect the carbohydrate landscape of the distal gut interact with diet to alter the composition and function of resident microbes in a diet-dependent manner.
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Differences in host genotype that affect the carbohydrate landscape of the distal gut interact with diet to alter the composition and function of resident microbes in a diet-dependent manner.
“differences in host genotype, which affect the carbohydrate landscape of the distal gut, interact with diet to alter the composition and function of resident microbes in a diet-dependent manner.103”
From The gut microbiota and host health: a new clinical frontier (2016) · cites this paper as [103]
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The gut microbiome in cardio-metabolic health
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The gut microbiota and inflammatory bowel disease
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Compartmentalizing intestinal epithelial cell toll-like receptors for immune surveillance
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The microbiome: Composition and locations
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Spatially distinct physiology of Bacteroides fragilis within the proximal colon of gnotobiotic mice
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Diet leaves a genetic signature in a keystone member of the gut microbiota
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Metabolic ecology of microbiomes: Nutrient competition, host benefits, and community engineering
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The mouse gut microbiome revisited: From complex diversity to model ecosystems
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- Authors
- Kashyap, P. C., Marcobal, A., Ursell, L. K., Smits, S. A., Sonnenburg, E. D., Costello, E. K., Higginbottom, S. K., Domino, S. E., Holmes, S. P., Relman, D. A., Knight, R., Gordon, J. I., & Sonnenburg, J. L.
- Affiliations
- Mayo Clinic (US)
- Stanford Medicine (US)
- Howard Hughes Medical Institute (US)
- University of Michigan (US)
- Stanford University (US)
- VA Palo Alto Health Care System (US)
- Washington University in St. Louis (US)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2013-09-23
- Volume
- 110
- Issue
- 42
- Pages
- 17059-17064
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3800993
- OpenAlex
- W1989848555
- Cited by
- 285
- References
- 43
- Citations by year
- 2026: 8 · 2025: 13 · 2024: 14 · 2023: 37 · 2022: 23 · 2021: 26 · 2020: 20 · 2019: 15 · 2018: 18 · 2017: 19 · 2016: 26 · 2015: 27 · 2014: 36 · 2013: 2
- FWCI
- 13.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Science Foundation
- Howard Hughes Medical Institute
- Crohn's and Colitis Foundation of America
- Crohn's and Colitis Foundation
- National Institutes of Health (DGE-114747, DP1OD000964)
- National Institute of General Medical Sciences (R01GM086884, GM86884, T32GM008759, T32GM142607)
- National Institute of Diabetes and Digestive and Kidney Diseases (R37DK030292, DK-30292, DK085025, P30DK084567, R01DK030292, R01DK085025)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- gut microbiota, fucosyltransferase, Bacteroides thetaiotaomicron, host-microbe interactions, fecal metabolites
- MeSH terms
- Galactoside 2-alpha-L-fucosyltransferase, Animals, Bacteroides, Dietary Carbohydrates, Fucosyltransferases, Glucans, Humans, Intestinal Mucosa, Mice, Knockout, Mice, Microbiota
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