Provision of protein and energy in relation to measured requirements in intensive care patients

Allingstrup, Matilde Jo; Esmailzadeh, Negar; Wilkens Knudsen, Anne; Espersen, Kurt; Hartvig Jensen, Tom; Wiis, Jørgen; Perner, Anders; Kondrup, Jens

doi:10.1016/j.clnu.2011.12.006

Cited by 381Clinical Nutrition and GastroenterologySepsis Diagnosis and TreatmentMuscle metabolism and nutrition

Provision of protein and energy in relation to measured requirements in intensive care patients

Allingstrup, Matilde Jo, Esmailzadeh, Negar, Wilkens Knudsen, Anne, Espersen, Kurt, Hartvig Jensen, Tom, Wiis, Jørgen, Perner, Anders, Kondrup, Jens·2012·Clinical Nutrition

DOI 10.1016/j.clnu.2011.12.006

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Abstract

Background & aims Adequacy of nutritional support in intensive care patients is still a matter of investigation. This study aimed to relate mortality to provision, measured requirements and balances for energy and protein in ICU patients. Design Prospective observational cohort study of 113 ICU patients in a tertiary referral hospital. Results Death occurred earlier in the tertile of patients with the lowest provision of protein and amino acids. The results were confirmed in Cox regression analyses which showed a significantly decreased hazard ratio of death with increased protein provision, also when adjusted for baseline prognostic variables (APACHE II, SOFA scores and age). Provision of energy, measured resting energy expenditure or energy and nitrogen balance was not related to mortality. The possible cause-effect relationship is discussed after a more detailed analysis of the initial part of the admission. Conclusion In these severely ill ICU patients, a higher provision of protein and amino acids was associated with a lower mortality. This was not the case for provision of energy or measured resting energy expenditure or energy or nitrogen balances. The hypothesis that higher provision of protein improves outcome should be tested in a randomised trial.

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Weijs et al. studying 886 patients showed that ICU patients with 1.2 to 1.5 g/kg/d delivered protein had reduced 28-day mortality.
“Weijs et al. (162) studying 886 patients showed that ICU patients with 1.2 to 1.5 g/kg/d delivered protein had reduced 28-day mortality.”
From ESPEN guideline on clinical nutrition in the intensive care unit. (2019) · cites this paper as [162]

A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation
Charlson, M. E., Pompei, P., Ales, K. L., & MacKenzie, C. R. (1987) · Journal of Chronic Diseases · doi:10.1016/0021-9681(87)90171-8 · Cited by 49,742 · see citing works
The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: Guidelines for Reporting Observational Studies
von Elm, E., Altman, D. G., Egger, M., Pocock, S. J., Gøtzsche, P. C., Vandenbroucke, J. P., & Initiative, F. T. S. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040296 · Cited by 23,020 · see citing works
The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies.
von Elm, E., Altman, D. G., Egger, M., Pocock, S. J., Gøtzsche, P. C., & Vandenbroucke, J. P. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61602-x · Cited by 21,320 · see citing works
APACHE II
Knaus, W. A., Draper, E. A., Wagner, D. P., & Zimmerman, J. E. (1985) · Critical Care Medicine · doi:10.1097/00003246-198510000-00009 · Cited by 15,333 · see citing works
APACHE II-A Severity of Disease Classification System
Knaus, W. A., Draper, E. A., Wagner, D. P., & Zimmerman, J. E. (1986) · Critical Care Medicine · doi:10.1097/00003246-198608000-00028 · Cited by 13,379 · see citing works
Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis
Bone, R. C., BALK, R. A., Cerra, F. B., Dellinger, R. P., Fein, A. M., Knaus, W. A., Schein, R. M. H., & Sibbald, W. J. (1992) · CHEST Journal · doi:10.1378/chest.101.6.1644 · Cited by 13,192 · see citing works
Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome
(2000) · New England Journal of Medicine · doi:10.1056/nejm200005043421801 · Cited by 12,941 · see citing works
The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure: On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine (see contributors to the project in the appendix)
Vincent, J. L., Moreno, R., Takala, J., Willatts, S., De Mendonça, A., Bruining, H., Reinhart, C. K., Suter, P. M., & Thijs, L. G. (1996) · Intensive Care Medicine · doi:10.1007/bf01709751 · Cited by 11,674 · see citing works
The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies
von Elm, E., Altman, D. G., Egger, M., Pocock, S. J., Gøtzsche, P. C., & Vandenbroucke, J. P. (2007) · Preventive Medicine · doi:10.1016/j.ypmed.2007.08.012 · Cited by 2,698 · see citing works
Nutritional and metabolic assessment of the hospitalized patient
Blackburn, G. L., Bistrian, B. R., Maini, B. S., Schlamm, H. T., & Smith, M. F. (1977) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/014860717700100101 · Cited by 1,426 · see citing works
The relationship between nutritional intake and clinical outcomes in critically ill patients: results of an international multicenter observational study
Alberda, C., Gramlich, L., Jones, N., Jeejeebhoy, K., Day, A. G., Dhaliwal, R., & Heyland, D. K. (2009) · Intensive Care Medicine · doi:10.1007/s00134-009-1567-4 · Cited by 975 · see citing works
Best Practice Methods to Apply to Measurement of Resting Metabolic Rate in Adults: A Systematic Review
Compher, C., Frankenfield, D., Keim, N., & Roth-Yousey, L. (2006) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2006.02.009 · Cited by 923 · see citing works
Human Body Composition
Roche, A. F., Heymsfield, S. B., & Lohman, T. G. (2005) · Medical Entomology and Zoology · Cited by 743 · see citing works
Guidelines for evaluation of new fever in critically ill adult patients: 2008 update from the American College of Critical Care Medicine and the Infectious Diseases Society of America
O’Grady, N. P., Barie, P. S., Bartlett, J. G., Bleck, T. P., Carroll, K. C., Kalil, A. C., Linden, P., Maki, D. G., Nierman, D. M., Pasculle, W. A., et al. (2008) · Critical Care Medicine · doi:10.1097/ccm.0b013e318169eda9 · Cited by 593 · see citing works
The tight calorie control study (TICACOS): a prospective, randomized, controlled pilot study of nutritional support in critically ill patients
Singer, P., Anbar, R., Cohen, J., Shapiro, H., Shalita-Chesner, M., Lev, S., Grozovski, E., Theilla, M., Frishman, S., & Madar, Z. (2011) · Intensive Care Medicine · doi:10.1007/s00134-011-2146-z · Cited by 566 · see citing works
Human Body Composition: Growth, Aging, Nutrition, and Activity
Forbes, G. B. (1987) · Medical Entomology and Zoology · Cited by 461 · see citing works
Applied Nutrition in ICU Patients
Cerra, F. B., Benitez, M. R., Blackburn, G. L., Irwin, R. S., Jeejeebhoy, K. N., Katz, D. P., Pingleton, S. K., Pomposelli, J. J., Rombeau, J. L., Shronts, E. P., et al. (1997) · CHEST Journal · doi:10.1378/chest.111.3.769 · Cited by 458 · see citing works
Computerized energy balance and complications in critically ill patients: An observational study
DVIR, D., COHEN, J., & SINGER, P. (2006) · Clinical Nutrition · doi:10.1016/j.clnu.2005.10.010 · Cited by 429 · see citing works
Optimal Protein and Energy Nutrition Decreases Mortality in Mechanically Ventilated, Critically Ill Patients: A Prospective Observational Cohort Study
Weijs, P. J. M., Stapel, S. N., de Groot, S. D. W., Driessen, R. H., de Jong, E., Girbes, A. R. J., Strack van Schijndel, R. J. M., & Beishuizen, A. (2012) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607111415109 · Cited by 408 · see citing works
What Are the Essential Elements Needed for the Determination of Amino Acid Requirements in Humans?
Fürst, P., & Stehle, P. (2004) · Journal of Nutrition · doi:10.1093/jn/134.6.1558s · Cited by 200 · see citing works
Indirect calorimetry in mechanically ventilated patients. A systematic comparison of three instruments
Sundström, M., Tjäder, I., Rooyackers, O., & Wernerman, J. (2012) · Clinical Nutrition · doi:10.1016/j.clnu.2012.06.004 · Cited by 106 · see citing works
Nutrition and clinical outcome in intensive care patients
Thibault, R., & Pichard, C. (2010) · Current opinion in clinical nutrition and metabolic care · doi:10.1097/mco.0b013e32833574b9 · Cited by 92 · see citing works
Monitoring Energy Metabolism with Indirect Calorimetry: Instruments, Interpretation, and Clinical Application
Holdy, K. E. (2004) · Nutrition in Clinical Practice · doi:10.1177/0115426504019005447 · Cited by 84 · see citing works
ERRATUM
(2008) · Critical Care Medicine · doi:10.1097/ccm.0b013e31817e81d0 · Cited by 77 · see citing works
Inadequate energy delivery during early critical illness correlates with increased risk of mortality in patients who survive at least seven days: A retrospective study
Tsai, J., Chang, W., Sheu, C., Wu, Y., Sheu, Y.-H., Liu, P., Ker, C., & Huang, M. (2010) · Clinical Nutrition · doi:10.1016/j.clnu.2010.09.003 · Cited by 68 · see citing works
PP132-MON INDIRECT CALORIMETRY IN MECHANICALLY VENTILATED PATIENTS: A SYSTEMATIC COMPARISON OF THREE INSTRUMENTS
Sundström, M., Tjäder, I., Rooyackers, O., & Wernerman, J. (2011) · Clinical Nutrition Supplements · doi:10.1016/s1744-1161(11)70422-7 · Cited by 2 · see citing works
The Tight Calorie Control Study (TICACOS)
Singer, P., Anbar, R., Cohen, J., Shapiro, H., Shalita-Chesner, M., Lev, S., Grozovski, E., Theilla, M., Frishman, S., & Madar, Z. (2012) · Survey of Anesthesiology · doi:10.1097/01.sa.0000412380.85365.93 · Cited by 1 · see citing works

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Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically Ill Patient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.)
McClave, S. A., Taylor, B. E., Martindale, R. G., Warren, M. M., Johnson, D. R., Braunschweig, C., McCarthy, M. S., Davanos, E., Rice, T. W., Cresci, G. A., et al. (2016) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607115621863 · Cited by 3,982 · see citing works
ESPEN guideline on clinical nutrition in the intensive care unit.
Singer, P., Blaser, A. R., Berger, M. M., Alhazzani, W., Calder, P. C., Casaer, M. P., Hiesmayr, M., Mayer, K., Montejo, J. C., Pichard, C., et al. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2018.08.037 · Cited by 2,904 · see citing works
Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically Ill Patient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.)
Taylor, B. E., McClave, S. A., Martindale, R. G., Warren, M. M., Johnson, D. R., Braunschweig, C., McCarthy, M. S., Davanos, E., Rice, T. W., Cresci, G. A., et al. (2016) · Critical Care Medicine · doi:10.1097/ccm.0000000000001525 · Cited by 1,476 · see citing works
Metabolic and nutritional support of critically ill patients: consensus and controversies
Preiser, J.-C., van Zanten, A. R., Berger, M. M., Biolo, G., Casaer, M. P., Doig, G. S., Griffiths, R. D., Heyland, D. K., Hiesmayr, M., Iapichino, G., et al. (2015) · Critical Care · doi:10.1186/s13054-015-0737-8 · Cited by 416 · see citing works
Early high protein intake is associated with low mortality and energy overfeeding with high mortality in non-septic mechanically ventilated critically ill patients
Weijs, P. J., Looijaard, W. G., Beishuizen, A., Girbes, A. R., & Oudemans-van Straaten, H. M. (2014) · Critical Care · doi:10.1186/s13054-014-0701-z · Cited by 358 · see citing works
Early goal-directed nutrition versus standard of care in adult intensive care patients: the single-centre, randomised, outcome assessor-blinded EAT-ICU trial
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Casaer, M. P., & Van den Berghe, G. (2014) · New England Journal of Medicine · doi:10.1056/nejmra1304623 · Cited by 335 · see citing works
Clinical Outcomes Related to Protein Delivery in a Critically Ill Population: A Multicenter, Multinational Observation Study
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ACG Clinical Guideline: Nutrition Therapy in the Adult Hospitalized Patient
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The Canadian Critical Care Nutrition Guidelines in 2013: An Update on Current Recommendations and Implementation Strategies
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High-Protein Enteral Nutrition Enriched With Immune-Modulating Nutrients vs Standard High-Protein Enteral Nutrition and Nosocomial Infections in the ICU: A Randomized Clinical Trial
van Zanten, A. R. H., Sztark, F., Kaisers, U. X., Zielmann, S., Felbinger, T. W., Sablotzki, A. R., De Waele, J. J., Timsit, J.-F., Honing, M. L. H., Keh, D., et al. (2014) · JAMA · doi:10.1001/jama.2014.7698 · Cited by 279 · see citing works
Greater protein and energy intake may be associated with improved mortality in higher risk critically ill patients: a multicenter, multinational observational study
Compher, C., Chittams, J., Sammarco, T., Nicolo, M., & Heyland, D. K. (2017) · Critical Care Medicine · doi:10.1097/ccm.0000000000002083 · Cited by 264 · see citing works
Protein Requirements in the Critically Ill: A Randomized Controlled Trial Using Parenteral Nutrition
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Older Adults in the Cardiac Intensive Care Unit: Factoring Geriatric Syndromes in the Management, Prognosis, and Process of Care: A Scientific Statement From the American Heart Association
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Enhanced Protein-Energy Provision via the Enteral Route Feeding Protocol in Critically Ill Patients
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Clinical Nutrition in Critical Care Medicine – Guideline of the German Society for Nutritional Medicine (DGEM)
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The effect of higher versus lower protein delivery in critically ill patients: a systematic review and meta-analysis of randomized controlled trials
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Peev, M. P., Yeh, D. D., Quraishi, S. A., Osler, P. M., Chang, Y., Gillis, E., Albano, C. E., Darak, S., & Velmahos, G. C. (2014) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607114526887 · Cited by 127 · see citing works
Untitled work
Singer (2009) · doi:10.1016/j.clnu.2013.12.004 · Cited by 118 · see citing works
Self-citation
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“[15] There is also a recent observational study that concludes that higher provision of protein and amino acids correlates with decreased mortality in critically ill patients, even after adjusting for baseline prognostic variables as the Acute Physiology and Chronic Health Evaluation (APACHE) and the Sequential Organ…”
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Stoppe, C., Wendt, S., Mehta, N. M., Compher, C. W., Preiser, J., Heyland, D. K., & Kristof, A. S. (2020) · Critical Care · doi:10.1186/s13054-020-03208-7 · Cited by 71 · see citing works
Nutrition and Exercise in Critical Illness Trial (NEXIS Trial): a protocol of a multicentred, randomised controlled trial of combined cycle ergometry and amino acid supplementation commenced early during critical illness
Heyland, D. K., Day, A. G., Clarke, G., Hough, C. L., Files, D. C., Mourtzakis, M., Deutz, N. E. P., Needham, D. M., & Stapleton, R. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-027893 · Cited by 71 · see citing works
Specialized nutritional support interventions in critically ill patients on renal replacement therapy
Fiaccadori, E., Regolisti, G., & Maggiore, U. (2012) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32835c20b0 · Cited by 70 · see citing works
Effect of initial calorie intake via enteral nutrition in critical illness: a meta-analysis of randomised controlled trials
Tian, F., Wang, X., Gao, X., Wan, X., Wu, C., Zhang, L., Li, N., & Li, J. (2015) · Critical Care · doi:10.1186/s13054-015-0902-0 · Cited by 69 · see citing works
Calorie delivery and clinical outcomes in the critically ill: a systematic review and meta-analysis
Parikh, H. G., Miller, A., Chapman, M., Moran, J. L., & Peake, S. L. (2016) · Critical Care and Resuscitation · doi:10.1016/s1441-2772(23)00927-4 · Cited by 69 · see citing works
Comparisons between intragastric and small intestinal delivery of enteral nutrition in the critically ill: a systematic review and meta-analysis
Adam, M. D., Dhaliwal, R., Andrew, G. D., Ridley, E. J., Andrew, R. D., & Daren, K. H. (2013) · Critical Care · doi:10.1186/cc12800 · Cited by 68 · see citing works
Optimizing energy and protein balance in the ICU
Weijs, P. J. M., & Wischmeyer, P. E. (2013) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32835bdf7e · Cited by 67 · see citing works
Energy, Protein, Carbohydrate, and Lipid Intakes and Their Effects on Morbidity and Mortality in Critically Ill Adult Patients: A Systematic Review
Patkova, A. R., Joskova, V., Havel, E., Kovařík, M., Kuchařová, M., Zadák, Z., & Hronek, M. (2017) · Advances in Nutrition · doi:10.3945/an.117.015172 · Cited by 67 · see citing works
Protein Delivery in the Intensive Care Unit: Optimal or Suboptimal?
Heyland, D. K., Weijs, P. J. M., Coss‐Bu, J. A., Taylor, B. E., Kristof, A. S., O’Keefe, G. E., & Martindale, R. G. (2017) · Nutrition in Clinical Practice · doi:10.1177/0884533617691245 · Cited by 65 · see citing works
Initial nutritional management during noninvasive ventilation and outcomes: a retrospective cohort study
for the OUTCOMEREA study group, Terzi, N., Darmon, M., Reignier, J., Ruckly, S., Garrouste-Orgeas, M., Lautrette, A., Azoulay, É., Mourvillier, B., Argaud, L., et al. (2017) · Critical Care · doi:10.1186/s13054-017-1867-y · Cited by 64 · see citing works
Chronic Critical Illness: Application of What We Know
Rosenthal, M. D., Kamel, A. Y., Rosenthal, C. M., Brakenridge, S. C., Croft, C. A., & Moore, F. A. (2018) · Nutrition in Clinical Practice · doi:10.1002/ncp.10024 · Cited by 64 · see citing works
The Effect of Higher Protein Dosing in Critically Ill Patients: A Multicenter Registry‐Based Randomized Trial: The EFFORT Trial
Heyland, D. K., Patel, J. J., Bear, D. E., Sacks, G. S., Nixdorf, H., Dolan, J., Aloupis, M., Licastro, K., Jovanović, V., Rice, T. W., et al. (2018) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.1449 · Cited by 63 · see citing works
Nutrition artificielle en réanimation
Lefrant, J. Y., Hurel, D., Cano, N., Ichaï, C., Preiser, J., & Tamion, F. (2014) · Annales Françaises d Anesthésie et de Réanimation · doi:10.1016/j.annfar.2014.01.008 · Cited by 62 · see citing works
Protein-energy nutrition in the ICU is the power couple: A hypothesis forming analysis
Oshima, T., Deutz, N. E. P., Doig, G. S., Wischmeyer, P. E., & Pichard, C. (2015) · Clinical Nutrition · doi:10.1016/j.clnu.2015.10.016 · Cited by 58 · see citing works
Use of a High‐Protein Enteral Nutrition Formula to Increase Protein Delivery to Critically Ill Patients: A Randomized, Blinded, Parallel‐Group, Feasibility Trial
Chapple, L. S., Summers, M. J., Bellomo, R., Chapman, M. J., Davies, A. R., Ferrie, S., Finnis, M., Hurford, S., Lange, K. M., Little, L., et al. (2020) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.2059 · Cited by 58 · see citing works
Early high protein intake and mortality in critically ill ICU patients with low skeletal muscle area and -density
Looijaard, W. G. P. M., Dekker, I. M., Beishuizen, A., Girbes, A. R. J., Straaten, H. M. O., & Weijs, P. J. M. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2019.09.007 · Cited by 57 · see citing works
Why critically ill patients are protein deprived.
Hoffer, L., & Bistrian, B. (2013) · JPEN - Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607113478192 · Cited by 27 · see citing works
Ultrasound assessment of rectus femoris and anterior tibialis muscles in young trauma patients
Annetta, M. G., Pittiruti, M., Silvestri, D., Grieco, D. L., Maccaglia, A., la Torre, M. F., Magarelli, N., Mercurio, G., Caricato, A., & Antonelli, M. M. (2017) · Annals of Intensive Care · doi:10.1186/s13613-017-0326-x · Cited by 56 · see citing works
Effect of Critical Illness on Triglyceride Absorption
Ali Abdelhamid, Y., Cousins, C. E., Sim, J. A., Bellon, M. S., Nguyen, N. Q., Horowitz, M., Chapman, M. J., & Deane, A. M. (2015) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607114540214 · Cited by 55 · see citing works
The Effect of IV Amino Acid Supplementation on Mortality in ICU Patients May Be Dependent on Kidney Function: Post Hoc Subgroup Analyses of a Multicenter Randomized Trial
Ran, Z., Allingstrup, M. J., Perner, A., & Doig, G. S. (2018) · Critical Care Medicine · doi:10.1097/ccm.0000000000003221 · Cited by 54 · see citing works
Self-citation
Enteral Nutrition in the Critically Ill: Myths and Misconceptions
Marik, P. (2014) · Critical Care Medicine · doi:10.1097/ccm.0000000000000051 · Cited by 54 · see citing works
The evolution of nutrition in critical care: how much, how soon?
Wischmeyer, P. E. (2013) · Critical Care · doi:10.1186/cc11505 · Cited by 53 · see citing works
International observational study of nutritional support in mechanically ventilated patients following burn injury
Czapran, A., Headdon, W., Deane, A. M., Lange, K. M., Chapman, M. J., & Heyland, D. K. (2014) · Burns · doi:10.1016/j.burns.2014.09.013 · Cited by 52 · see citing works
Nutrition Therapy in Critically Ill Patients Following Cardiac Surgery: Defining and Improving Practice
Rahman, A., Agarwala, R., Martin, C. M., Nagpal, D., Teitelbaum, M., & Heyland, D. K. (2016) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607116661839 · Cited by 52 · see citing works
Protein Turnover and Metabolism in the Elderly Intensive Care Unit Patient
Phillips, S. M., Dickerson, R. N., Moore, F. A., Paddon‐Jones, D., & Weijs, P. J. M. (2017) · Nutrition in Clinical Practice · doi:10.1177/0884533616686719 · Cited by 52 · see citing works
Protein delivery and clinical outcomes in the critically ill: a systematic review and meta-analysis
Davies, M. L., Chapple, L. S., Chapman, M. J., Moran, J. L., & Peake, S. (2017) · Critical Care and Resuscitation · doi:10.1016/s1441-2772(23)00783-4 · Cited by 52 · see citing works
When should we add parenteral to enteral nutrition?
Vincent, J., & Preiser, J. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61893-5 · Cited by 51 · see citing works
Timing of (supplemental) parenteral nutrition in critically ill patients: a systematic review
Bost, R. B., Tjan, D., & van Zanten, A. V. (2014) · Annals of Intensive Care · doi:10.1186/s13613-014-0031-y · Cited by 54 · see citing works
Prospective observational cohort study of reached protein and energy targets in general wards during the post-intensive care period: The PROSPECT-I study
Slingerland-Boot, R., van der Heijden, I., Schouten, N., Driessen, L., Meijer, S., Mensink, M., & van Zanten, A. R. H. (2022) · Clinical Nutrition · doi:10.1016/j.clnu.2022.07.031 · Cited by 47 · see citing works
The Japanese Critical Care Nutrition Guideline 2024
Nakamura, K., Yamamoto, R., Higashibeppu, N., Yoshida, M., Tatsumi, H., Shimizu, Y., Izumino, H., Oshima, T., Hatakeyama, J., Ouchi, A., et al. (2025) · Journal of Intensive Care · doi:10.1186/s40560-025-00785-z · Cited by 50 · see citing works
Fundamental determinants of protein requirements in the ICU
Weijs, P. J. M. (2014) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0000000000000029 · Cited by 47 · see citing works
Relationship of energy and protein adequacy with 60-day mortality in mechanically ventilated critically ill patients: A prospective observational study
Lee, Z., Airini, I. N., & Yusof, B. N. M. (2017) · Clinical Nutrition · doi:10.1016/j.clnu.2017.05.013 · Cited by 47 · see citing works
Nutrition in the critically ill patient
Koekkoek, K. W. A. C., & van Zanten, A. R. H. (2017) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0000000000000441 · Cited by 45 · see citing works
Association of PROtein and CAloric Intake and Clinical Outcomes in Adult SEPTic and Non‐Septic ICU Patients on Prolonged Mechanical Ventilation: The PROCASEPT Retrospective Study
de Koning, M.-S. L. Y., Koekkoek, W. A. C., Kars, J. C. N., & van Zanten, A. R. H. (2019) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.1663 · Cited by 45 · see citing works
High protein intake during the early phase of critical illness: Yes or no?
Preiser, J.-C. (2018) · Critical Care · doi:10.1186/s13054-018-2196-5 · Cited by 44 · see citing works
The influence of protein provision in the early phase of intensive care on clinical outcomes for critically ill patients on mechanical ventilation.
(2017) · PubMed · doi:10.6133/apjcn.032016.01 · Cited by 43 · see citing works
Measuring nutrition‐related outcomes in a cohort of multi‐trauma patients following intensive care unit discharge
Wittholz, K., Fetterplace, K., Clode, M., George, E. S., MacIsaac, C., Judson, R., Presneill, J., & Deane, A. M. (2019) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.12719 · Cited by 43 · see citing works
Energy and Protein in Critically Ill Patients with AKI: A Prospective, Multicenter Observational Study Using Indirect Calorimetry and Protein Catabolic Rate
Sabatino, A., Theilla, M., Hellerman, M., Singer, P., Maggiore, U., Barbagallo, M., Regolisti, G., & Fiaccadori, E. (2017) · Nutrients · doi:10.3390/nu9080802 · Cited by 42 · see citing works
Optimized calorie and high protein intake versus recommended caloric-protein intake in critically ill patients: a prospective, randomized, controlled phase II clinical trial
de Azevedo, J. R. A., Lima, H. C. M., Montenegro, W. S., Souza, S. C. D. C., Nogueira, I. R. O. M., Silva, M. M., & Muniz, N. D. A. (2019) · Revista Brasileira de Terapia Intensiva · doi:10.5935/0103-507x.20190025 · Cited by 42 · see citing works
The clinical relevance and mechanism of skeletal muscle wasting
Duan, K., Gao, X., & Zhu, D. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.07.029 · Cited by 42 · see citing works
Controversies Surrounding Critical Care Nutrition: An Appraisal of Permissive Underfeeding, Protein, and Outcomes
Patel, J. J., Martindale, R. G., & McClave, S. A. (2017) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607117721908 · Cited by 41 · see citing works
Should We Prescribe More Protein to Critically Ill Patients?
Heyland, D. K., Stapleton, R., & Compher, C. W. (2018) · Nutrients · doi:10.3390/nu10040462 · Cited by 40 · see citing works
Association of protein intake with the outcomes of critically ill patients: a post hoc analysis of the PermiT trial
Arabi, Y. M., Al‐Dorzi, H. M., Mehta, S., Tamim, H., Haddad, S. H., Jones, G., McIntyre, L., Solaiman, O., Sakkijha, M. H., Sadat, M., et al. (2018) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqy189 · Cited by 40 · see citing works
Supplemental Parenteral Nutrition Is the Key to Prevent Energy Deficits in Critically Ill Patients
Oshima, T., Heidegger, C., & Pichard, C. (2016) · Nutrition in Clinical Practice · doi:10.1177/0884533616651754 · Cited by 40 · see citing works
Chronic Critical Illness and PICS Nutritional Strategies
Rosenthal, M. D., Vanzant, E. L., & Moore, F. A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10112294 · Cited by 42 · see citing works
Safety and efficacy of volume-based feeding in critically ill, mechanically ventilated adults using the ‘Protein & Energy Requirements Fed for Every Critically ill patient every Time’ (PERFECT) protocol: a before-and-after study
Brierley-Hobson, S., Clarke, G., & O’Keeffe, V. (2019) · Critical Care · doi:10.1186/s13054-019-2388-7 · Cited by 38 · see citing works
Relationship between Nutrition Intake and 28-Day Mortality Using Modified NUTRIC Score in Patients with Sepsis
Jeong, D. H., Hong, S., Lim, C., Koh, Y., Seo, J., Kim, Y., Min, J.-Y., & Huh, J. W. (2019) · Nutrients · doi:10.3390/nu11081906 · Cited by 38 · see citing works
Systematic Review With Meta‐Analysis of Patient‐Centered Outcomes, Comparing International Guideline–Recommended Enteral Protein Delivery With Usual Care
Fetterplace, K., Gill, B. M. T., Chapple, L. S., Presneill, J., MacIsaac, C., & Deane, A. M. (2019) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.1725 · Cited by 38 · see citing works
Nutrition in the ICU: new trends versus old-fashioned standard enteral feeding?
Koekkoek, K. W. A. C., & van Zanten, A. R. H. (2018) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0000000000000571 · Cited by 38 · see citing works
Metabolism of Proteins and Amino Acids in Critical Illness: From Physiological Alterations to Relevant Clinical Practice
Hsu, C.-C., Sun, C.-Y., Tsai, C., Chen, M.-Y., Wang, S., Hsu, J., Yeh, C., & Yeh, T. (2021) · Journal of Multidisciplinary Healthcare · doi:10.2147/jmdh.s306350 · Cited by 37 · see citing works
The Biological Value of Protein
Moore, D. R., & Soeters, P. B. (2015) · Nestlé Nutrition Institute Workshop series · doi:10.1159/000382000 · Cited by 37 · see citing works
A supplemental intravenous amino acid infusion sustains a positive protein balance for 24 hours in critically ill patients
Rehal, M. S., Liebau, F., Tjäder, I., Norberg, Å., Rooyackers, O., & Wernerman, J. (2017) · Critical Care · doi:10.1186/s13054-017-1892-x · Cited by 35 · see citing works
Current perspective for tube feeding in the elderly: from identifying malnutrition to providing of enteral nutrition
Mundi, M. S., Patel, J. J., McClave, S. A., & Hurt, R. T. (2018) · Clinical Interventions in Aging · doi:10.2147/cia.s134919 · Cited by 35 · see citing works

F-124 : Free Paper Presentation ; Optimal Protein Provision in Mechanical Ventilated Patients in the ICU
Song, J. H., Lee, H., Kim, S. Y., Chung, K. S., Kim, E. Y., Jung, J. Y., Kang, Y. A., Park, M. S., Kim, Y. S., Kim, S. K., et al. (2013) · 대한결핵및호흡기학회 추계학술발표초록집
Adequacy of prescribed caloric and protein intake and reduction of mortality in critically ill patients with body mass indices <30 kg/m2
Tsai, J., Chang, W., Sheu, C., Wu, Y., Chen, M.-A., Hsu, Y.-H., Lee, C.-Y., Chang, C.-I., Wang, T., & Huang, M. (2021) · Nutrition · doi:10.1016/j.nut.2021.111529 · Cited by 5 · see citing works
Relationship of energy and protein adequacy with 60-day mortality in mechanically ventilated critically ill patients: A prospective observational study
Lee, Z., Airini, I. N., & Yusof, B. N. M. (2017) · Clinical Nutrition · doi:10.1016/j.clnu.2017.05.013 · Cited by 47 · see citing works
The relationship between nutritional intake and clinical outcomes in critically ill patients: results of an international multicenter observational study
Alberda, C., Gramlich, L., Jones, N., Jeejeebhoy, K., Day, A. G., Dhaliwal, R., & Heyland, D. K. (2009) · Intensive Care Medicine · doi:10.1007/s00134-009-1567-4 · Cited by 975 · see citing works
The influence of protein provision in the early phase of intensive care on clinical outcomes for critically ill patients on mechanical ventilation.
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Authors: Allingstrup, M. J., Esmailzadeh, N., Wilkens Knudsen, A., Espersen, K., Hartvig Jensen, T., Wiis, J., Perner, A., & Kondrup, J.
Affiliations: Copenhagen University Hospital (DK)
University of Copenhagen (DK)
Corresponding author: Allingstrup, Matilde Jo
ORCID: Perner, Anders
Venue: Clinical Nutrition
Publisher: Elsevier BV
Published: 2012-08
Volume: 31
Issue: 4
Pages: 462-468
ISSN: 0261-5614 (ISSN-L)
DOI: 10.1016/j.clnu.2011.12.006
OpenAlex: W2054596359
Cited by: 381
References: 27
Citations by year: 2026: 9 · 2025: 13 · 2024: 24 · 2023: 19 · 2022: 23 · 2021: 33 · 2020: 37 · 2019: 41 · 2018: 31 · 2017: 42 · 2016: 23 · 2015: 28 · 2014: 30 · 2013: 23 · 2012: 3
FWCI: 16.51
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Clinical Nutrition (publishedVersion)
PubMed (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Keywords: amino acids, energy supply, intensive care unit patients, nutritional support, mortality, resting energy expenditure, nitrogen balance, energy balance, critically ill patients
MeSH terms: Adult, Aged, Energy Intake, Critical Care, Dietary Proteins, Humans, Intensive Care Units, Length of Stay, Middle Aged, Nutritional Requirements, Prospective Studies, Proportional Hazards Models, Treatment Outcome, Hospital Mortality, Nutritional Support, APACHE, Tertiary Care Centers

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Provision of protein and energy in relation to measured requirements in intensive care patients

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