Cited by 68Microbial Metabolites in Food BiotechnologyAdipokines, Inflammation, and Metabolic DiseasesFood composition and properties

A randomized controlled trial on the efficacy of resistant dextrin, as functional food, in women with type 2 diabetes: targeting the hypothalamic-pituitary-adrenal axis and immune system

Farhangi, Mahdieh Abbasalizad, Javid, Ahmad Zare, Sarmadi, Bahareh, Karimi, Poran, Dehghan, Parvin·2018·Clinical Nutrition

Abstract

Objective The aim of this trial was to determine the efficacy of a resistant dextrin on immune-mediated inflammation and hypothalamic-pituitary-adrenal axis in women with type 2 diabetes mellitus (T2DM).Methods Females (n = 55) with T2DM were randomly allocated into intervention group (n = 30) and control group (n = 25), in which they received 10 g/d of Nutriose®06 (a resistant dextrin) or maltodextrin for 8 weeks, respectively. Fasting blood samples were taken to measure immune system related parameters like white blood cell count, CD4, CD8, interferon-γ (IFNγ), interleukins (IL12, IL4, IL10), cortisol, tryptophan (TRP), ACTH (Adrenocorticotropic hormone), Kynurenine (KYN) and plasma lipopolysaccharide (LPS) at the beginning and end of trial. Mental health was assessed using general health questionnaire (GHQ) and depression, anxiety and stress scale (DASS).Results Resistant dextrin caused a significant decrease in levels of cortisol, KYN, KYN/TRP ratio, IFNγ, IL12, IFNγ/IL10 ratio, LPS, and a significant increase in the monocyte, GHQ, DASS, CD8, IL10, IL4 in the intervention group as compared with baseline. A significant decrease in the level of LPS (-6.20 EU/mL, -17.8%), IFNγ (-0.6 pg/ml, -26.8%), cortisol (-2.6 μg/dl, -20.9%), IFNγ/IL10 ratio (0.01, 10%), GHQ (-5.1, -12.5%), DASS (-10.4, -38.4%), KYN/TRP ratio (6.8, 29.1%), and a significant increase in levels of CD8 (6.4%, 6.1%) and IL10 (2.6 pg/ml, 21.6%) in the intervention group as compared with the control group (P < 0.05). No significant changes were observed in white blood cell count, CD4, CD4/CD8 ratio, ACTH, KYN, TRP, IL4 and IL12 in the intervention group as compared with the control group (P > 0.05).Conclusion Supplementation of Nutriose®06 may have beneficial effects on mental health and the immune system response in women with T2DM.

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Crossref · 10.1016/j.clnu.2017.06.005

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  • Similar results were reported in a randomized controlled trial of resistant dextrin in a sample of women with type-2 diabetes mellitus.

    “Similar results were reported in a randomized controlled trial of resistant dextrin in a sample of women with type-2 diabetes mellitus (401).”

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Authors
Farhangi, M. A., Javid, A. Z., Sarmadi, B., Karimi, P., & Dehghan, P.
Affiliations
  • Tabriz University of Medical Sciences (IR)
  • Ahvaz Jundishapur University of Medical Sciences (IR)
  • Universiti Putra Malaysia (MY)
Corresponding author
Dehghan, Parvin
Venue
Clinical Nutrition
Publisher
Elsevier BV
Published
2018-08
Volume
37
Issue
4
Pages
1216-1223
ISSN
0261-5614 (ISSN-L)
OpenAlex
W2624390528
Cited by
68
References
47
Citations by year
2026: 5 · 2025: 7 · 2024: 7 · 2023: 8 · 2022: 10 · 2021: 10 · 2020: 8 · 2019: 12 · 2018: 1
FWCI
4.77
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Funders
Tabriz University of Medical Sciences
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
Keywords
resistant dextrin, type 2 diabetes, functional foods, hypothalamic-pituitary-adrenal axis, immune-mediated inflammation, kynurenine pathway, cortisol, lipopolysaccharide, interferon-gamma, interleukins, mental health, depression, anxiety, stress, women, maltodextrin, CD8+ T cells, tryptophan
MeSH terms
Adult, Aged, Depression, Dextrins, Diabetes Mellitus, Type 2, Female, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Middle Aged, Pituitary-Adrenal System, Cytokines, Functional Food, Prebiotics

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