A randomized controlled trial on the efficacy of resistant dextrin, as functional food, in women with type 2 diabetes: targeting the hypothalamic-pituitary-adrenal axis and immune system
Abstract
Objective The aim of this trial was to determine the efficacy of a resistant dextrin on immune-mediated inflammation and hypothalamic-pituitary-adrenal axis in women with type 2 diabetes mellitus (T2DM).Methods Females (n = 55) with T2DM were randomly allocated into intervention group (n = 30) and control group (n = 25), in which they received 10 g/d of Nutriose®06 (a resistant dextrin) or maltodextrin for 8 weeks, respectively. Fasting blood samples were taken to measure immune system related parameters like white blood cell count, CD4, CD8, interferon-γ (IFNγ), interleukins (IL12, IL4, IL10), cortisol, tryptophan (TRP), ACTH (Adrenocorticotropic hormone), Kynurenine (KYN) and plasma lipopolysaccharide (LPS) at the beginning and end of trial. Mental health was assessed using general health questionnaire (GHQ) and depression, anxiety and stress scale (DASS).Results Resistant dextrin caused a significant decrease in levels of cortisol, KYN, KYN/TRP ratio, IFNγ, IL12, IFNγ/IL10 ratio, LPS, and a significant increase in the monocyte, GHQ, DASS, CD8, IL10, IL4 in the intervention group as compared with baseline. A significant decrease in the level of LPS (-6.20 EU/mL, -17.8%), IFNγ (-0.6 pg/ml, -26.8%), cortisol (-2.6 μg/dl, -20.9%), IFNγ/IL10 ratio (0.01, 10%), GHQ (-5.1, -12.5%), DASS (-10.4, -38.4%), KYN/TRP ratio (6.8, 29.1%), and a significant increase in levels of CD8 (6.4%, 6.1%) and IL10 (2.6 pg/ml, 21.6%) in the intervention group as compared with the control group (P < 0.05). No significant changes were observed in white blood cell count, CD4, CD4/CD8 ratio, ACTH, KYN, TRP, IL4 and IL12 in the intervention group as compared with the control group (P > 0.05).Conclusion Supplementation of Nutriose®06 may have beneficial effects on mental health and the immune system response in women with T2DM.
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Similar results were reported in a randomized controlled trial of resistant dextrin in a sample of women with type-2 diabetes mellitus.
“Similar results were reported in a randomized controlled trial of resistant dextrin in a sample of women with type-2 diabetes mellitus (401).”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [401]
Cites
Diagnosis and Classification of Diabetes Mellitus
American Diabetes Association (2010) · Diabetes Care · doi:10.2337/dc11-s062 · Cited by 14,019 · see citing works
A scaled version of the General Health Questionnaire
Goldberg, D. P., & Hillier, V. F. (1979) · Psychological Medicine · doi:10.1017/s0033291700021644 · Cited by 5,494 · see citing works
Diagnosis and classification of diabetes mellitus
American Diabetes Association (2010) · Diabetes Care · doi:10.2337/dc10-s062 · Cited by 5,491 · see citing works
Everard, A., Belzer, C., Geurts, L., Ouwerkerk, J. P., Druart, C., Bindels, L. B., Guiot, Y., Derrien, M., Muccioli, G. G., Delzenne, N. M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219451110 · Cited by 4,511 · see citing works
Sokol, H., Pigneur, B., Watterlot, L., Lakhdari, O., Bermúdez-Humarán, L. G., Gratadoux, J.-J., Blugeon, S., Bridonneau, C., Furet, J.-P., Corthier, G., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804812105 · Cited by 4,413 · see citing works
Bravo, J. A., Forsythe, P., Chew, M. V., Escaravage, E., Savignac, H. M., Dinan, T. G., Bienenstock, J., & Cryan, J. F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102999108 · Cited by 3,888 · see citing works
Cytokines sing the blues: inflammation and the pathogenesis of depression
Raison, C. L., Capuron, L., & Miller, A. H. (2006) · Trends in Immunology · doi:10.1016/j.it.2005.11.006 · Cited by 3,009 · see citing works
Crawford, J. R., & Henry, J. D. (2004) · British Journal of Clinical Psychology · doi:10.1348/0144665031752934 · Cited by 2,957 · see citing works
Clinical Trials: A Practical Approach.
Hill, I. D., & Pocock, S. (1984) · Biometrics · doi:10.2307/2531186 · Cited by 2,918 · see citing works
Cani, P. D., Possemiers, S., Van de Wiele, T., Guiot, Y., Everard, A., Rottier, O., Geurts, L., Naslain, D., Neyrinck, A., Lambert, D. M., et al. (2009) · Gut · doi:10.1136/gut.2008.165886 · Cited by 2,518 · see citing works
Neufeld, K. M., Kang, N., Bienenstock, J., & Foster, J. A. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01620.x · Cited by 1,392 · see citing works
Differential Adaptation of Human Gut Microbiota to Bariatric Surgery–Induced Weight Loss
Furet, J.-P., Kong, L.-C., Tap, J., Poitou, C., Basdevant, A., Bouillot, J.-L., Mariat, D., Corthier, G., Doré, J., Henegar, C., et al. (2010) · Diabetes · doi:10.2337/db10-0253 · Cited by 1,173 · see citing works
Clinical trials: A practical approach
Daly, M. J. (1984) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(84)90515-7 · Cited by 1,057 · see citing works
Desbonnet, L., Garrett, L., Clarke, G., Bienenstock, J., & Dinan, T. G. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2008.03.009 · Cited by 952 · see citing works
Dewulf, E. M., Cani, P. D., Claus, S. P., Fuentes, S., Puylaert, P. G., Neyrinck, A. M., Bindels, L. B., de Vos, W. M., Gibson, G. R., Thissen, J.-P., et al. (2013) · Gut · doi:10.1136/gutjnl-2012-303304 · Cited by 825 · see citing works
Probiotics, prebiotics, and synbiotics: impact on the gut immune system and allergic reactions
Gourbeyre, P., Denery-Papini, S., & Bodinier, M. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.1109753 · Cited by 396 · see citing works
Yarandi, S., Peterson, D. A., Treisman, G. J., Moran, T. H., & Pasricha, P. J. (2016) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm15146 · Cited by 294 · see citing works
Savignac, H. M., Couch, Y., Stratford, M., Bannerman, D. M., Tzortzis, G., Anthony, D. C., & Burnet, P. W. J. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.10.007 · Cited by 223 · see citing works
Dehghan, P., Pourghassem Gargari, B., & Asghari Jafar-abadi, M. (2014) · Nutrition · doi:10.1016/j.nut.2013.09.005 · Cited by 207 · see citing works
Self-citationPlace, R. F., Noonan, E. J., & Giardina, C. A. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.04.030 · Cited by 189 · see citing works
Liew, S. C., Dasgupta, E., Wong, S. F., Lee, N., Safdar, N., & Jamil, A. (2012) · Nutrition Journal · doi:10.1186/1475-2891-11-1 · Cited by 178 · see citing works
Dehghan, P., Gargari, B. P., Jafarabadi, M. A., & Aliasgharzadeh, A. (2013) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2013.836738 · Cited by 175 · see citing works
Klatt, N. R., Canary, L., Sun, X., Vinton, C. L., Funderburg, N., Morcock, D. R., Quiñones, M., Deming, C., Perkins, M. R., Hazuda, D. J., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66227 · Cited by 171 · see citing works
Lancaster, G., Halson, S., Khan, Q., Drysdale, P., Wallace, F., Jeukendrup, A., Drayson, M., & Gleeson, M. (2026) · Exercise Immunology Review · doi:10.22029/eir.2004.1608 · Cited by 159 · see citing works
Aliasgharzadeh, A., Dehghan, P., Gargari, B. P., & Jafarabadi, M. A. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114514003675 · Cited by 150 · see citing works
Cost-of-Illness Analysis of Type 2 Diabetes Mellitus in Iran
Javanbakht, M., Baradaran, H. R., Mashayekhi, A., Haghdoost, A. A., Khamseh, M. E., Kharazmi, E., & Sadeghi, A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026864 · Cited by 135 · see citing works
Fusunyan, R. D., Quinn, J. J., Fujimoto, M., MacDermott, R. P., & Sanderson, I. R. (1999) · Molecular Medicine · doi:10.1007/bf03402075 · Cited by 117 · see citing works
Long-term gastrointestinal tolerance of NUTRIOSE®FB in healthy men
Pasman, W. J., Wils, D., Saniez, M.-H., & Kardinaal, A. F. M. (2006) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602418 · Cited by 102 · see citing works
González-Hernández, L. A., Jave‐Suárez, L. F., Fafutis‐Morris, M., Montes-Salcedo, K. E., Valle-Gutiérrez, L. G., Campos-Loza, A. E., Gómez, L. F. E., & Andrade-Villanueva, J. F. (2012) · Nutrition Journal · doi:10.1186/1475-2891-11-90 · Cited by 93 · see citing works
Karimi, P., Farhangi, M. A., Sarmadi, B., Gargari, B. P., Javid, A. Z., Pouraghaei, M., & Dehghan, P. (2015) · Annals of Nutrition and Metabolism · doi:10.1159/000441683 · Cited by 93 · see citing works
Aliasgharzadeh, A., Khalili, M., Mirtaheri, E., Gargari, B. P., Tavakoli, F., Farhangi, M. A., Babaei, H., & Dehghan, P. (2015) · Advanced Pharmaceutical Bulletin · doi:10.15171/apb.2015.069 · Cited by 84 · see citing works
Lefranc‐Millot, C., Guérin‐Deremaux, L., Wils, D., Neut, C., Miller, L. E., & Saniez, M.-H. (2012) · Journal of International Medical Research · doi:10.1177/147323001204000122 · Cited by 81 · see citing works
Dehghan, P., Farhangi, M. A., Tavakoli, F., Aliasgarzadeh, A., & Akbari, A. M. (2015) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2015.12.010 · Cited by 79 · see citing works
Is there any place for resistant starch, as alimentary prebiotic, for patients with type 2 diabetes?
Gargari, B. P., Namazi, N., Khalili, M., Sarmadi, B., Jafarabadi, M. A., & Dehghan, P. (2015) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2015.09.005 · Cited by 78 · see citing works
Palizgir, M., Bakhtiari, M., & Esteghamati, A. (2013) · Iranian Red Crescent Medical Journal · doi:10.5812/ircmj.12107 · Cited by 61 · see citing works
Neuropeptides, Microbiota, and Behavior
Holzer, P. D. (2016) · International review of neurobiology · doi:10.1016/bs.irn.2016.08.005 · Cited by 57 · see citing works
Guérin‐Deremaux, L., Li, S., Pochat, M., Wils, D., Mubasher, M., Reifer, C. J., & Miller, L. E. (2011) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2011.569492 · Cited by 53 · see citing works
The Metabolic Syndrome - A Global Challenge for Prevention
Schwarz, P. E. H., Reimann, M., Li, J., Bergmann, A., Licinio, J., Wong, M., & Bornstein, S. (2007) · Hormone and Metabolic Research · doi:10.1055/s-2007-990312 · Cited by 50 · see citing works
Mizutani, H., Ishihara, Y., Izawa, A., Fujihara, Y., Kobayashi, S., Gotou, H., Okabe, E., Takeda, H., Ozawa, Y., Kamiya, Y., et al. (2013) · Journal of Periodontal Research · doi:10.1111/jre.12065 · Cited by 42 · see citing works
Pouillart, P., Dépeint, F., Nour, A. M. A., Deremaux, L., Vincent, O., Mazière, J., Madec, J.-Y., Chatelain, D., Younes, H., Wils, D., et al. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21130 · Cited by 36 · see citing works
An, L., Yang, J., Yin, H., Xue, R., Wang, Q., Sun, Y. C., Zhang, Y., & Yang, M. (2016) · Phytotherapy Research · doi:10.1002/ptr.5698 · Cited by 22 · see citing works
Mirghani, H. O., & Elbadawi, A. (2016) · Journal of Taibah University Medical Sciences · doi:10.1016/j.jtumed.2016.05.009 · Cited by 17 · see citing works
Samal, L., Chaturvedi, V. B., Saxena, S., & Pattanaik, A. K. (2012) · Animal Nutrition and Feed Technology · Cited by 12 · see citing works
Immunomodulatory Activity of Type-4 Resistant Starch in the Mesenteric Lymph Nodes of Rats
Song, Y., Bae, C.-H., Woo, D.-H., Kim, Y., & Park, T. (2010) · Journal of Medicinal Food · doi:10.1089/jmf.2009.1170 · Cited by 5 · see citing works
The burden of the complications of diabetes mellitus
Hidayat, A. (2016) · Universa Medicina · doi:10.18051/univmed.2016.v35.65-67 · Cited by 3 · see citing works
Flagged first, then by citations
2 of the 47 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286 · see citing works
Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health
Berding, K., Vlckova, K., Marx, W., Schellekens, H., Stanton, C., Clarke, G., Jacka, F., Dinan, T. G., & Cryan, J. F. (2021) · Advances in Nutrition · doi:10.1093/advances/nmaa181 · Cited by 451 · see citing works
Gut Microbiota Dysbiosis: Pathogenesis, Diseases, Prevention, and Therapy
Shen, Y., Fan, N., Ma, S., Cheng, X., Yang, X., & Wang, G. (2025) · MedComm · doi:10.1002/mco2.70168 · Cited by 364 · see citing works
Regulation of Gut Microbiota and Metabolic Endotoxemia with Dietary Factors
Fuke, N., Nagata, N., Suganuma, H., & Ota, T. (2019) · Nutrients · doi:10.3390/nu11102277 · Cited by 269 · see citing works
Treatment strategies against diabetes: Success so far and challenges ahead.
Khursheed, R., Singh, S. K., Wadhwa, S., Kapoor, B., Gulati, M., Kumar, R., Ramanunny, A. K., Awasthi, A., & Dua, K. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.172625 · Cited by 239 · see citing works
Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia
Connell, E., Le Gall, G., Pontifex, M. G., Sami, S., Cryan, J. F., Clarke, G., Müller, M., & Vauzour, D. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00548-6 · Cited by 208 · see citing works
Dehghan, P., Farhangi, M. A., Nikniaz, L., Nikniaz, Z., & Jafarabadi, M. A. (2020) · Obesity Reviews · doi:10.1111/obr.12993 · Cited by 162 · see citing works
Gutted! Unraveling the Role of the Microbiome in Major Depressive Disorder
Bastiaanssen, T. F. S., Cussotto, S., Claesson, M. J., Clarke, G., Dinan, T. G., & Cryan, J. F. (2020) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000243 · Cited by 159 · see citing works
Effects of regulating intestinal microbiota on anxiety symptoms: A systematic review
Yang, B., Wei, J., Ju, P., & Chen, J. (2019) · General Psychiatry · doi:10.1136/gpsych-2019-100056 · Cited by 111 · see citing works
“11 Azpiroz et al(30) 2017 Intake of scFOS was well tolerated and the number of adverse events was similar in the scFOS (18) and placebo (21) groups† Colonic lavage prior to the rectal sensitivity test (1), antibiotic treatment (1)”
BackgroundVaghef‐Mehrabany, E., Maleki, V., Behrooz, M., Ranjbar, F., & Ebrahimi‐Mameghani, M. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2019.06.004 · Cited by 95 · see citing works
Filippis, A. D., Ullah, H., Baldi, A., Dacrema, M., Esposito, C., Garzarella, E. U., Santarcangelo, C., Tantipongpiradet, A., & Daglia, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144929 · Cited by 85 · see citing works
Freijy, T. M., Cribb, L., Oliver, G., Metri, N., Opie, R., Jacka, F. N., Hawrelak, J. A., Rucklidge, J. J., Ng, C. H., & Sarris, J. J. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1097278 · Cited by 81 · see citing works
Purton, T., Staskova, L., Lane, M. M., Dawson, S. L., West, M. L., Firth, J., Clarke, G. A., Cryan, J. F., Berk, M., O'Neil, A. E., et al. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.12.026 · Cited by 74 · see citing works
Włodarczyk, M., & Śliżewska, K. (2021) · Nutrients · doi:10.3390/nu13113808 · Cited by 73 · see citing works
Dietary fibre and the gut–brain axis: microbiota-dependent and independent mechanisms of action
Torre, D. L., Verbeke, K., & Dalile, B. (2021) · Gut Microbiome · doi:10.1017/gmb.2021.3 · Cited by 68 · see citing works
Kazemi, A., Noorbala, A. A., Azam, K., & Djafarian, K. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.11.041 · Cited by 67 · see citing works
Farhangi, M. A., Dehghan, P., & Namazi, N. (2019) · European Journal of Nutrition · doi:10.1007/s00394-019-02140-z · Cited by 61 · see citing works
Vaghef‐Mehrabany, E., Ranjbar, F., Jafarabadi, M. A., Hosseinpour-Arjmand, S., & Ebrahimi‐Mameghani, M. (2019) · Nutritional Neuroscience · doi:10.1080/1028415x.2019.1630985 · Cited by 55 · see citing works
Gao, J., Yang, T., Song, B., Ma, X., Ma, Y., Lin, X., & Wang, H. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115395 · Cited by 55 · see citing works
Patrignani, F., Siroli, L., Parolin, C., Serrazanetti, D. I., Vitali, B., & Lanciotti, R. (2019) · PLOS ONE · doi:10.1371/journal.pone.0208906 · Cited by 51 · see citing works
Aslam, H., Lotfaliany, M., So, D., Berding, K., Berk, M., Rocks, T., Hockey, M., Jacka, F. N., Marx, W., Cryan, J. F., et al. (2023) · Nutrition Reviews · doi:10.1093/nutrit/nuad143 · Cited by 53 · see citing works
Vaghef‐Mehrabany, E., Harouni, R., Behrooz, M., Ranjbar, F., Jafarabadi, M. A., & Ebrahimi‐Mameghani, M. (2022) · British Journal Of Nutrition · doi:10.1017/s000711452200232x · Cited by 45 · see citing works
Ayakdaş, G., & Ağagündüz, D. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e19888 · Cited by 46 · see citing works
Increasing dietary fiber intake for type 2 diabetes mellitus management: A systematic review
Nitzke, D. L. D. S., Czermainski, J. G. E. S., Rosa, C. B., Coghetto, C. C., Fernandes, S. A., & Carteri, R. B. (2024) · World Journal of Diabetes · doi:10.4239/wjd.v15.i5.1001 · Cited by 51 · see citing works
Xu, B., Fu, J., Qiao, Y., Cao, J., Deehan, E. C., Li, Z., Jin, M., Wang, X., & Wang, Y. (2020) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqaa435 · Cited by 37 · see citing works
Farhangi, M. A., Dehghan, P., Musazadeh, V., Kavyani, M., & Maleki, P. (2022) · Journal of Functional Foods · doi:10.1016/j.jff.2022.105074 · Cited by 37 · see citing works
Williams, L. M., Stoodley, I. L., Berthon, B. S., & Wood, L. G. (2021) · Advances in Nutrition · doi:10.1093/advances/nmab114 · Cited by 34 · see citing works
Saleh‐Ghadimi, S., Dehghan, P., Sarmadi, B., & Maleki, P. (2022) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.11876 · Cited by 34 · see citing works
Kavyani, M., Saleh‐Ghadimi, S., Dehghan, P., Farhangi, M. A., & Khoshbaten, M. (2021) · Food & Function · doi:10.1039/d1fo00448d · Cited by 33 · see citing works
Fajriyah, N., Firmanti, T. A., Mufidah, A., & Septiana, N. T. (2019) · Jurnal NERS · doi:10.20473/jn.v14i3.16979 · Cited by 32 · see citing works
The microbiota–gut–brain axis: A novel nutritional therapeutic target for growth retardation
Qi, M., Tan, B., Wang, J., Liao, S., Deng, Y., Ji, P., Song, T., Zha, A., & Yin, Y. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1879004 · Cited by 26 · see citing works
Sajedi, D., Shabani, R., & Elmieh, A. (2021) · Cytokine · doi:10.1016/j.cyto.2021.155590 · Cited by 29 · see citing works
Li, F. R., Muhmood, A., Akhter, M., Gao, X., Jie, S., Du, Z., Wei, Y., Zhang, T., & Wei, Y. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.126970 · Cited by 26 · see citing works
Wang, K., Cheng, Z., Qiao, D., Xie, F., Zhao, S., & Zhang, B. (2024) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2024.2330711 · Cited by 26 · see citing works
Hu, Q., Lu, Y., Hu, F., He, S., Xu, X., Niu, Y., Zhang, H., Li, X., & Su, Q. (2020) · International Journal of Medical Sciences · doi:10.7150/ijms.45723 · Cited by 22 · see citing works
Thirion, F., Silva, K. D., Oñate, F. P., Alvarez, A., Thabuis, C., Pons, N., Berland, M., Chatelier, E. L., Galleron, N., Levenez, F., et al. (2022) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202101091 · Cited by 22 · see citing works
Paul, P., Kaul, R., Abdellatif, B., Arabi, M., Upadhyay, R., Saliba, R., Sebah, M., & Châari, A. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.906243 · Cited by 22 · see citing works
Ghorbani, Z., Shoaibinobarian, N., Noormohammadi, M., Taylor, K. S. M., Kazemi, A., Bonyad, A., Khoshdooz, S., Löber, U., & Forslund, S. K. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107780 · Cited by 21 · see citing works
Wang, S., Zhang, S., Huang, S., Wu, Z., Pang, J., Wu, Y., Wang, J., & Han, D. (2020) · BioMed Research International · doi:10.1155/2020/7694734 · Cited by 21 · see citing works
Perreau, C., Thabuis, C., Verstrepen, L., Ghyselinck, J., & Marzorati, M. (2023) · Nutrients · doi:10.3390/nu15194229 · Cited by 19 · see citing works
“Two clinical studies reported increased serum levels of anti-inflammatory cytokines (IL-4 and IL-10) and decreased levels of TNF-α, IFNγ, IL-12, and IL-6 in females with type 2 diabetes who received 8 weeks of daily NUTRIOSE® supplementation (10 g/day) versus baseline levels [21,22].”
BackgroundDong, Y., Wang, P., Yang, X., Chen, M., & Li, J. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1027413 · Cited by 17 · see citing works
Kong, H., Yu, L., Li, C., Ban, X., Gu, Z., & Li, Z. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c04978 · Cited by 16 · see citing works
Zhou, X., Zheng, W., Kong, W., Zhang, J., Liao, Y., Min, J., & Zeng, T. (2025) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaf340 · Cited by 14 · see citing works
Rajab, E., Keogh, M. B., Laiva, A. L., Hannan, F. A., Fateel, M., Abdulwahab, F., Madhoob, F. A., AlHamer, B., Ghazzal, S., Dawaishan, A. A., et al. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104757 · Cited by 14 · see citing works
Nejati, M., Dehghan, P., Hashempour‐Baltork, F., Alizadeh, A. M., Farshi, P., & Khosravi‐Darani, K. (2021) · International Journal of Preventive Medicine · doi:10.4103/ijpvm.ijpvm_493_20 · Cited by 12 · see citing works
Lamíquiz-Moneo, I., Pérez‐Calahorra, S., Gracia‐Rubio, I., Cebollada, A., Bea, A. M., Fumanal, A. J., Ferrer‐Mairal, A., Prieto-Martín, A., Sanz-Fernández, M. L., Cenarro, A., et al. (2022) · Nutrients · doi:10.3390/nu14051046 · Cited by 10 · see citing works
Vajdi, M., Khorvash, F., & Askari, G. (2024) · Food & Function · doi:10.1039/d4fo02796e · Cited by 9 · see citing works
Xu, B., Cao, J., Fu, J., Li, Z., Jin, M., Wang, X., & Wang, Y. (2021) · Nutrition Reviews · doi:10.1093/nutrit/nuab018 · Cited by 8 · see citing works
Chen, X., Hou, Y., Liao, A., Pan, L., Yang, S., Liu, Y., Wang, J. J., Xue, Y., Zhang, M., Zhu, Z., et al. (2024) · Biomolecules · doi:10.3390/biom14020186 · Cited by 8 · see citing works
“RD, a soluble dietary fiber, exhibits diverse nutritional functions, including the potential to improve obesity, type 2 diabetes, sleep disorders in obese patients, non-alcoholic fatty liver disease, and polycystic ovary syndrome [30–34].”
BackgroundKhademi, F., Tutunchi, H., Vaghef‐Mehrabany, E., & Ebrahimi‐Mameghani, M. (2024) · BMC Research Notes · doi:10.1186/s13104-024-06963-w · Cited by 7 · see citing works
“…resistant dextrin for 8 weeks in women with type 2 diabetes led to a significant decrease in serum levels of Kyn, Kyn/Trp ratio as well as interferon gamma (IFNγ), Interleukin (IL)-12, IFNγ/ IL-10 ratio, and lipopolysaccharide (LPS) and a significant increase in serum levels of IL-10 and IL-4 [17].”
BackgroundMethodInfluentialDimeji, I. Y., & Ayodeji, A. S. (2025) · ASPET Discovery · doi:10.1016/j.aspetd.2025.100010 · Cited by 7 · see citing works
Nourishing the gut microbiota: The potential of prebiotics in microbiota-gut-brain axis research
Dalile, B., Verbeke, K., Oudenhove, L. V., & Vervliet, B. (2019) · Behavioral and Brain Sciences · doi:10.1017/s0140525x18002856 · Cited by 6 · see citing works
Rudiansyah, M., Salman, D. A., Doshi, H., Renuka Jyothi, S., Shit, D., Sharma, S., & Nouri, M. (2025) · BMC Nutrition · doi:10.1186/s40795-025-01080-8 · Cited by 4 · see citing works
“Further investigation into the effects of RD on glycemic control could contribute to the development of complementary dietary interventions aimed at improving diabetes management [27].”
Maghsoumi‐Norouzabad, L., Karimi, A. B., Majd, S. A., Hosseini, L., & Shahi, F. (2025) · Europe PMC (PubMed Central) · doi:10.30476/ijms.2024.102363.3525 · Cited by 4 · see citing works
Human T-cell activation with Toxoplasma gondii antigens loaded in maltodextrin nanoparticles
García-López, L., Zamora-Vélez, A., Vargas-Montes, M., Sánchez‐Arcila, J. C., Fasquelle, F., Betbeder, D., & Gómez‐Marín, J. E. (2024) · Life Science Alliance · doi:10.26508/lsa.202302486 · Cited by 3 · see citing works
Impact of the Gut Microbiome on Behavior and Emotions
Rivera‐Íñiguez, I., Román, S., Ojeda‐Granados, C., & Arturo, P. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815249-2.00040-3 · Cited by 3 · see citing works
Schneider, A. E., Zeiler, M. D., Kopp, K., Wagner, G., & Karwautz, A. F. K. (2023) · Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie · doi:10.1024/1422-4917/a000930 · Cited by 3 · see citing works
Xu, M., Li, S., Zou, Y., Yan, J., Li, L., Liu, Y., Chen, S., Zhang, S., Li, Y., Chen, X., et al. (2024) · Food Reviews International · doi:10.1080/87559129.2024.2326572 · Cited by 3 · see citing works
“[48] RD supplementation demonstrated improvements in immune system function, inflammatory/anti-inflammatory biomarkers, and psychological well-being in patients with type II diabetes, leading to decreased insulin sensitivity.”
Chen, S., Zhang, L., Zong, A., Gan, Z., Zhang, X., Du, F., liu, H., & Xu, T. (2026) · Nutrition Journal · doi:10.1186/s12937-026-01292-z · Cited by 2 · see citing works
“RD was also reported to reduce circulation lipopolysaccharide in T2DM, a potent activator of inflammation from mostly gram-negative bacteria inhabiting in the gut [12, 32, 51].”
Krüger, K., van der Veen, H., Beigy, M., O’Donovan, S. D., van Riel, N. A. W., Remie, L. B., Aarts, E., Steegenga, W. T., Smeets, P. A. M., van Trijp, M. P. H., et al. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1738622 · Cited by 2 · see citing works
Effect of Pre/Probiotic Supplementation on Metabolic Endotoxemia
Bansal, S., & Bansal, N. (2022) · Springer eBooks · doi:10.1007/978-981-16-8444-9_3 · Cited by 1 · see citing works
Weltens, N., Dalile, B., & Oudenhove, L. V. (2019) · Encyclopedia of Gastroenterology · doi:10.1016/b978-0-12-801238-3.66130-5
Developing Novel Personalized Foods
(2023) · Royal Society of Chemistry eBooks · doi:10.1039/bk9781839162428-00383
Mirzababaei, A., Mahmoodi, M. S., Abaj, F., Ebrahimi, S., Samadi, M., Khalili, P., Mohamadi, A., Zarrinvafa, Z., & Mirzaei, K. (2025) · Nutrire · doi:10.1186/s41110-025-00390-y
Morrissey, P. I., Clarke, E. D., Loh, X. T., Collins, C. E., Burrows, T. L., & Stanford, J. (2026) · Diabetes Obesity and Metabolism · doi:10.1111/dom.70444
“All except one 33 found no significant differences in dietary intakes between groups at baseline or post-intervention indicating efficacy of the supplement used.”
Wang, J., Ma, F. Y., Wang, P.-F., Hung, C.-H., Wu, K.-T., Liao, L. A., Guo, J.-Y., & Hou, C. (2026) · Nutrients · doi:10.3390/nu18121851
“Similar findings have also been reported in previous studies, in which resistant starch supplementation improved depression, anxiety, and stress in some populations [42–44].”
Yoshida, K., Matsubara, T., Morita, S., Sakata, Y., Sonoki, H., & Miyaji, K. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1909212
“In contrast, intake of RD reduces blood kynurenine levels in patients with type 2 diabetes (43).”
- Authors
- Farhangi, M. A., Javid, A. Z., Sarmadi, B., Karimi, P., & Dehghan, P.
- Affiliations
- Tabriz University of Medical Sciences (IR)
- Ahvaz Jundishapur University of Medical Sciences (IR)
- Universiti Putra Malaysia (MY)
- Corresponding author
- Dehghan, Parvin
- Venue
- Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2018-08
- Volume
- 37
- Issue
- 4
- Pages
- 1216-1223
- ISSN
- 0261-5614 (ISSN-L)
- OpenAlex
- W2624390528
- Cited by
- 68
- References
- 47
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 7 · 2023: 8 · 2022: 10 · 2021: 10 · 2020: 8 · 2019: 12 · 2018: 1
- FWCI
- 4.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Tabriz University of Medical Sciences
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
- Keywords
- resistant dextrin, type 2 diabetes, functional foods, hypothalamic-pituitary-adrenal axis, immune-mediated inflammation, kynurenine pathway, cortisol, lipopolysaccharide, interferon-gamma, interleukins, mental health, depression, anxiety, stress, women, maltodextrin, CD8+ T cells, tryptophan
- MeSH terms
- Adult, Aged, Depression, Dextrins, Diabetes Mellitus, Type 2, Female, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Middle Aged, Pituitary-Adrenal System, Cytokines, Functional Food, Prebiotics
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