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Alternate-day fasting elicits larger changes in fat mass than time-restricted eating in adults without obesity - A randomized clinical trial

Derron, Nina, Güntner, Andreas T., Weber, Ines C., Braun, Julia, Koska, İlker Ö., Othman, Alaa, Mönch, Leonie, von Eckardstein, Arnold, Puhan, Milo A., Beuschlein, Felix, Hochuli, Michel, Zamboni, Nicola, Guggenberger, Roman, Gerber, Philipp A.·2025·Clinical Nutrition
DOI 10.1016/j.clnu.2025.08.033
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Abstract

Background & aims Intermittent fasting (IF) is a popular nutritional strategy for weight control and improved metabolic health, however it is unclear which type of intermittent fasting is most effective. This randomized trial directly compared short-term alternate-day fasting (ADF) and time-restricted eating (TRE) with controls in adults with overweight or a high normal weight. The aim was to compare the effects of ADF and TRE versus controls regarding whole-body fat mass loss, weight control and cardiometabolic health. Methods In this 4-week, parallel-arm, randomized clinical trial (February 2021-May 2022), participants aged 18-40 years with a body mass index between 23 and 30 kg/m 2 were assigned to ADF (alternating fasting and ad libitum eating days), to TRE (eating only between 12:00-20:00), or control (no change in eating times). The primary outcome was change in total fat volume (assessed by whole-body magnetic resonance imaging). Secondary outcomes were subcutaneous and visceral fat mass, body weight, resting metabolic rate, biochemical markers, energy intake, activity energy expenditure and health-related quality of life. Results Seventy-six participants (mean [standard deviation (SD)] age, 29.6 [5.6] years; body mass index, 25.8 [2.2] kg/m 2 ; 34 [44 %] female) were randomized to ADF (n = 26), TRE (n = 26), or control (n = 24). Seventy-five participants completed the trial (25 in ADF, 26 in TRE, 24 in control). ADF led to a greater reduction in total fat volume than…

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Metadata

Authors
Derron, N., Güntner, A. T., Weber, I. C., Braun, J., Koska, İ. Ö., Othman, A., Mönch, L., von Eckardstein, A., Puhan, M. A., Beuschlein, F., Hochuli, M., Zamboni, N., Guggenberger, R., & Gerber, P. A.
ORCID
Derron, Nina
Venue
Clinical Nutrition
Publisher
Elsevier BV
Published
2025-10
Volume
53
Pages
212-221
ISSN
0261-5614
DOI
10.1016/j.clnu.2025.08.033
Cited by
12
References
13
Language
en
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