The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Adiponectin Stimulates AMP-Activated Protein Kinase in the Hypothalamus and Increases Food Intake
Open accessAbstract
Adiponectin has been shown to stimulate fatty acid oxidation and enhance insulin sensitivity through the activation of AMP-activated protein kinase (AMPK) in the peripheral tissues. The effects of adiponectin in the central nervous system, however, are still poorly understood. Here, we show that adiponectin enhances AMPK activity in the arcuate hypothalamus (ARH) via its receptor AdipoR1 to stimulate food intake; this stimulation of food intake by adiponectin was attenuated by dominant-negative AMPK expression in the ARH. Moreover, adiponectin also decreased energy expenditure. Adiponectin-deficient mice showed decreased AMPK phosphorylation in the ARH, decreased food intake, and increased energy expenditure, exhibiting resistance to high-fat-diet-induced obesity. Serum and cerebrospinal fluid levels of adiponectin and expression of AdipoR1 in the ARH were increased during fasting and decreased after refeeding. We conclude that adiponectin stimulates food intake and decreases energy expenditure during fasting through its effects in the central nervous system.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In the brain, adiponectin activates AMPK signaling in hypothalamic ARC, resulting in an increase in food intake and a reduction in energy expenditure, suggesting that in the hypothalamus adiponectin promotes feeding and inhibits the anorexigenic effects of leptin 55, 56.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [56]
In the citing paper
“In contrast to leptin, adiponectin levels increase in low glucose and low insulin conditions, at least in the cerebrospinal fluid (CSF) 55, 56.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [56]
In the citing paper
“In pathological conditions of obesity, the reduction in CSF levels of adiponectin that is accompanied by feeding is lost, thus maintaining a “high food intake behavior” even in conditions that are not of energy scarcity (high energy conditions) 56.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [56]
Citations
Cites
The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859
Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine · doi:10.1038/90984 · Cited by 4,915
Self-citationYamauchi, T., Kamon, J., Minokoshi, Y., Ito, Y., Waki, H., Uchida, S., Yamashita, S., Noda, M., Kita, S., Ueki, K., et al. (2002) · Nature Medicine · doi:10.1038/nm788 · Cited by 4,238
Self-citationmouse brain in stereotaxic coordinates
Franklin, K. B. J., & Paxinos, G. (1997) · Cited by 3,258
A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes
Scherer, P. E., Williams, S. P., Fogliano, M., Baldini, G., & Lodish, H. F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.45.26746 · Cited by 3,238
Cloning of adiponectin receptors that mediate antidiabetic metabolic effects
Yamauchi, T., Kamon, J., Ito, Y., Tsuchida, A., Yokomizo, T., Kita, S., Sugiyama, T., Miyagishi, M., Hara, K., Tsunoda, M., et al. (2003) · Nature · doi:10.1038/nature01705 · Cited by 3,176
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
Kadowaki, T. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29126 · Cited by 2,824
Self-citationThe adipocyte-secreted protein Acrp30 enhances hepatic insulin action
Berg, A. H., Combs, T. P., Du, X., Brownlee, M., & Scherer, P. E. (2001) · Nature Medicine · doi:10.1038/90992 · Cited by 2,526
Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
Minokoshi, Y., Kim, Y.-B., Peroni, O. D., Fryer, L. G. D., Müller, C., Carling, D., & Kahn, B. B. (2002) · Nature · doi:10.1038/415339a · Cited by 2,053
Self-citationFruebis, J., Tsao, T., Javorschi, S., Ebbets-Reed, D., Erickson, M., Yen, F. T., Bihain, B. E., & Lodish, H. F. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.2005 · Cited by 2,007
AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
Minokoshi, Y., Alquier, T., Furukawa, N., Kim, Y.-B., Lee, A., Xue, B., Mu, J., Foufelle, F., Ferré, P., Birnbaum, M. J., et al. (2004) · Nature · doi:10.1038/nature02440 · Cited by 1,637
Self-citationYamauchi, T., Nio, Y., Maki, T., Kobayashi, M., Takazawa, T., Iwabu, M., Okada-Iwabu, M., Kawamoto, S., Kubota, N., Kubota, T., et al. (2007) · Nature Medicine · doi:10.1038/nm1557 · Cited by 1,396
Self-citationPPARγ Mediates High-Fat Diet–Induced Adipocyte Hypertrophy and Insulin Resistance
Kubota, N., Terauchi, Y., Miki, H., Tamemoto, H., Yamauchi, T., Komeda, K., Satoh, S., Nakano, R., Ishii, C., 杉山, 拓., et al. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80210-5 · Cited by 1,351
Self-citationObesity-associated improvements in metabolic profile through expansion of adipose tissue
Kim, J.-Y., van de Wall, E., Laplante, M., Azzara, A., Trujillo, M. E., Hofmann, S. M., Schraw, T., Durand, J. L., Li, H., Li, G., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31021 · Cited by 1,310 · cited 1×
“Scherer’s group (Kim et al., 2007) has generated adiponectin-transgenic ob/ob mice that show serum adiponectin levels 3- to 4-fold higher than ob/ob mice.”
BackgroundDisruption of Adiponectin Causes Insulin Resistance and Neointimal Formation
Kubota, N., Terauchi, Y., Yamauchi, T., Kubota, T., Moroi, M., Matsui, J., Eto, K., Yamashita, T., Kamon, J., Satoh, H., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200251200 · Cited by 1,213
Self-citationThe AMP-activated protein kinase pathway – new players upstream and downstream
Hardie, D. G. (2004) · Journal of Cell Science · doi:10.1242/jcs.01540 · Cited by 1,163
Disruption of adiponectin causes insulin resistance and neointimal formation
Froguel, P. (2002) · HAL · Cited by 1,126
Scherer, P. E. (2006) · Diabetes · doi:10.2337/db06-0263 · Cited by 1,092
Structure-Function Studies of the Adipocyte-secreted Hormone Acrp30/Adiponectin
Pajvani, U. B., Du, X., Combs, T. P., Berg, A. H., Rajala, M. W., Schulthess, T., Engel, J., Brownlee, M., & Scherer, P. E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207198200 · Cited by 1,090
Diabetes, Obesity, and the Brain
Schwartz, M. W., & Porte, D. (2005) · Science · doi:10.1126/science.1104344 · Cited by 841
Adiponectin acts in the brain to decrease body weight
Qi, Y., Takahashi, N., Hileman, S. M., Patel, H. R., Berg, A. H., Pajvani, U. B., Scherer, P. E., & Ahima, R. S. (2004) · Nature Medicine · doi:10.1038/nm1029 · Cited by 809
AMP-activated Protein Kinase Plays a Role in the Control of Food Intake
Andersson-Hall, U. K., Filipsson, K., Abbott, C. R., Woods, A., Smith, K. L., Bloom, S. R., Carling, D., & Small, C. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c300557200 · Cited by 777
Nawrocki, A. R., Rajala, M. W., Tomás, E., Pajvani, U. B., Saha, A. K., Trumbauer, M. E., Pang, Z., Chen, A. S., Ruderman, N. B., Chen, H., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505311200 · Cited by 655
AMPK, the metabolic syndrome and cancer
Luo, Z., Saha, A. K., Xiang, X., & Ruderman, N. B. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2004.12.011 · Cited by 426
Xue, B., & Kahn, B. B. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.113217 · Cited by 338
Kubota, N., Terauchi, Y., Kubota, T., Kumagai, H., Itoh, S., Satoh, H., Yano, W., Ogata, H., Tokuyama, K., Takamoto, I., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m505649200 · Cited by 331
Self-citationKos, K., Harte, A. L., da Silva, N. F., Tonchev, A. B., Chaldakov, G., James, S. G., Snead, D. R. J., Hoggart, B., O’Hare, J. P., McTernan, P. G., et al. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1841 · Cited by 237
Kondo, T., Vicent, D., Suzuma, K., Yanagisawa, M., King, G. L., Holzenberger, M., & Kahn, C. R. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17455 · Cited by 228
Self-citationAdiponectin complexes in human cerebrospinal fluid: distinct complex distribution from serum
Kusminski, C. M., McTernan, P. G., Schraw, T., Kos, K., O’Hare, J. P., Ahima, R. S., Kumar, S., & Scherer, P. E. (2007) · Diabetologia · doi:10.1007/s00125-006-0577-9 · Cited by 225
Spranger, J., Verma, S., Göhring, I., Bobbert, T., Seifert, J., Sindler, A. L., Pfeiffer, A. F. H., Hileman, S. M., Tschöp, M. H., & Banks, W. A. (2006) · Diabetes · doi:10.2337/diabetes.55.01.06.db05-1077 · Cited by 220
AMP-activated protein kinase: balancing the scales
Carling, D. (2004) · Biochimie · doi:10.1016/j.biochi.2004.10.017 · Cited by 202
Kondo, T., Vicent, D., Suzuma, K., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200317455 · Cited by 190
Self-citationZloković, B. V., Jovanovic, S. S., Miao, W., Samara, S., Verma, S. P., & Farrell, C. L. (2000) · Endocrinology · doi:10.1210/endo.141.4.7435 · Cited by 176
Selective purification and characterization of adiponectin multimer species from human plasma
Hada, Y., Yamauchi, T., Waki, H., Tsuchida, A., Hara, K., Yago, H., Miyazaki, O., Ebinuma, H., & Kadowaki, T. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.03.004 · Cited by 155
Self-citationKarpichev, I. V., Cornivelli, L., & Small, G. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202045200 · Cited by 88
Kim, M., & Lee, K. (2005) · Journal of Molecular Medicine · doi:10.1007/s00109-005-0659-z · Cited by 71
Ueta, Y., Levy, A., Chowdrey, H., & Lightman, S. (1995) · Journal of neuroendocrinology · doi:10.1111/j.1365-2826.1995.tb00783.x · Cited by 32
Self-citationTriglycerides and toggling the tummy
Kahn, C. R. (2000) · Nature Genetics · doi:10.1038/75610 · Cited by 31
Flagged first, then by citations
Cited by
Sorted by citations
AMPK: a nutrient and energy sensor that maintains energy homeostasis
Hardie, D. G., Ross, F. A., & Hawley, S. A. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3311 · Cited by 4,602
What we talk about when we talk about fat
Rosen, E. D., & Spiegelman, B. M. (2014) · Cell · doi:10.1016/j.cell.2013.12.012 · Cited by 2,373
Steinberg, G. R., & Kemp, B. E. (2009) · Physiological Reviews · doi:10.1152/physrev.00011.2008 · Cited by 1,672
Adipose tissue as an endocrine organ
Galić, S., Oakhill, J. S., & Steinberg, G. R. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.08.018 · Cited by 1,654
AMPK and PPARδ Agonists Are Exercise Mimetics
Narkar, V. A., Downes, M., Yu, R. T., Embler, E., Wang, Y.-X., Banayo, E., Mihaylova, M. M., Nelson, M. C., Zou, Y., Juguilon, H., et al. (2008) · Cell · doi:10.1016/j.cell.2008.06.051 · Cited by 1,222
Metadata
- Authors
- Kubota, N., Yano, W., Kubota, T., Yamauchi, T., Itoh, S., Kumagai, H., Kozono, H., Takamoto, I., Okamoto, S., Shiuchi, T., Suzuki, R., Satoh, H., Tsuchida, A., Moroi, M., Sugi, K., Noda, T., Ebinuma, H., Ueta, Y., Kondo, T., Araki, E., Ezaki, O., Nagai, R., Tobe, K., Terauchi, Y., Ueki, K., Minokoshi, Y., & Kadowaki, T.
- Affiliations
- Japan Science and Technology Agency (JP)
- The University of Tokyo (JP)
- Toho University (JP)
- National Institute for Physiological Sciences (JP)
- Tohoku University (JP)
- University of Occupational and Environmental Health Japan (JP)
- Kumamoto University (JP)
- Yokohama City University (JP)
- Corresponding author
- Kadowaki, Takashi
- ORCID
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2007-07
- Volume
- 6
- Issue
- 1
- Pages
- 55-68
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2128485668
- Cited by
- 844
- References
- 37
- Citations by year
- 2026: 24 · 2025: 26 · 2024: 26 · 2023: 46 · 2022: 36 · 2021: 54 · 2020: 37 · 2019: 36 · 2018: 42 · 2017: 34 · 2016: 59 · 2015: 31 · 2014: 56 · 2013: 54 · 2012: 53
- FWCI
- 22.05
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Ministry of Health and Welfare
- Juvenile Diabetes Research Foundation International (1-2003-746)
- Daiichi Sankyo Foundation of Life Science
- Astellas Foundation for Research on Metabolic Disorders
- Kanae Foundation for the Promotion of Medical Science
- Japan Society for the Promotion of Science (10NP0201)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- adiponectin, AMPK, arcuate nucleus, hypothalamus, dietary intake, energy expenditure, AdipoR1, fasting, refeeding, high-fat diet-induced obesity, central nervous system
- MeSH terms
- Adenoviridae, Animals, Arcuate Nucleus of Hypothalamus, Eating, Energy Metabolism, Female, Hypothalamus, Immunoenzyme Techniques, Male, Mice, Inbred C57BL, Multienzyme Complexes, Phosphorylation, Receptors, Cell Surface, RNA Probes, Protein Serine-Threonine Kinases, In Situ Hybridization, Mice, Knockout, Leptin, Mice, Adiponectin, Adipose Tissue, White, Receptors, Leptin, Receptors, Adiponectin, AMP-Activated Protein Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
