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Cited by 844Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Adiponectin Stimulates AMP-Activated Protein Kinase in the Hypothalamus and Increases Food Intake

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Kubota, Naoto, Yano, Wataru, Kubota, Tetsuya, Yamauchi, Toshimasa, Itoh, Shinsuke, Kumagai, Hiroki, Kozono, Hideki, Takamoto, Iseki, Okamoto, Shiki, Shiuchi, Tetsuya, Suzuki, Ryo, Satoh, Hidemi, Tsuchida, Atsushi, Moroi, Masao, Sugi, Kaoru, Noda, Tetsuo, Ebinuma, Hiroyuki, Ueta, Yoichi, Kondo, Tatsuya, Araki, Eiichi, Ezaki, Osamu, Nagai, Ryozo, Tobe, Kazuyuki, Terauchi, Yasuo, Ueki, Kohjiro, Minokoshi, Yasuhiko, Kadowaki, Takashi·2007·Cell Metabolism
DOI 10.1016/j.cmet.2007.06.003
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Abstract

Adiponectin has been shown to stimulate fatty acid oxidation and enhance insulin sensitivity through the activation of AMP-activated protein kinase (AMPK) in the peripheral tissues. The effects of adiponectin in the central nervous system, however, are still poorly understood. Here, we show that adiponectin enhances AMPK activity in the arcuate hypothalamus (ARH) via its receptor AdipoR1 to stimulate food intake; this stimulation of food intake by adiponectin was attenuated by dominant-negative AMPK expression in the ARH. Moreover, adiponectin also decreased energy expenditure. Adiponectin-deficient mice showed decreased AMPK phosphorylation in the ARH, decreased food intake, and increased energy expenditure, exhibiting resistance to high-fat-diet-induced obesity. Serum and cerebrospinal fluid levels of adiponectin and expression of AdipoR1 in the ARH were increased during fasting and decreased after refeeding. We conclude that adiponectin stimulates food intake and decreases energy expenditure during fasting through its effects in the central nervous system.

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Metadata

Authors
Kubota, N., Yano, W., Kubota, T., Yamauchi, T., Itoh, S., Kumagai, H., Kozono, H., Takamoto, I., Okamoto, S., Shiuchi, T., Suzuki, R., Satoh, H., Tsuchida, A., Moroi, M., Sugi, K., Noda, T., Ebinuma, H., Ueta, Y., Kondo, T., Araki, E., Ezaki, O., Nagai, R., Tobe, K., Terauchi, Y., Ueki, K., Minokoshi, Y., & Kadowaki, T.
Affiliations
  • Japan Science and Technology Agency (JP)
  • The University of Tokyo (JP)
  • Toho University (JP)
  • National Institute for Physiological Sciences (JP)
  • Tohoku University (JP)
  • University of Occupational and Environmental Health Japan (JP)
  • Kumamoto University (JP)
  • Yokohama City University (JP)
Corresponding author
Kadowaki, Takashi
ORCID
Venue
Cell Metabolism
Publisher
Elsevier BV
Published
2007-07
Volume
6
Issue
1
Pages
55-68
ISSN
1550-4131 (ISSN-L)
DOI
10.1016/j.cmet.2007.06.003
OpenAlex
W2128485668
Cited by
844
References
37
Citations by year
2026: 24 · 2025: 26 · 2024: 26 · 2023: 46 · 2022: 36 · 2021: 54 · 2020: 37 · 2019: 36 · 2018: 42 · 2017: 34 · 2016: 59 · 2015: 31 · 2014: 56 · 2013: 54 · 2012: 53
FWCI
22.05
Type
journal article
Language
en
Open access
Licence
Locations
  • Cell Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Ministry of Education, Culture, Sports, Science and Technology
  • Ministry of Health and Welfare
  • Juvenile Diabetes Research Foundation International (1-2003-746)
  • Daiichi Sankyo Foundation of Life Science
  • Astellas Foundation for Research on Metabolic Disorders
  • Kanae Foundation for the Promotion of Medical Science
  • Japan Society for the Promotion of Science (10NP0201)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords
adiponectin, AMPK, arcuate nucleus, hypothalamus, dietary intake, energy expenditure, AdipoR1, fasting, refeeding, high-fat diet-induced obesity, central nervous system
MeSH terms
Adenoviridae, Animals, Arcuate Nucleus of Hypothalamus, Eating, Energy Metabolism, Female, Hypothalamus, Immunoenzyme Techniques, Male, Mice, Inbred C57BL, Multienzyme Complexes, Phosphorylation, Receptors, Cell Surface, RNA Probes, Protein Serine-Threonine Kinases, In Situ Hybridization, Mice, Knockout, Leptin, Mice, Adiponectin, Adipose Tissue, White, Receptors, Leptin, Receptors, Adiponectin, AMP-Activated Protein Kinases

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