Metabolic effects of resveratrol: Addressing the controversies

Cancer chemopreventive activity of resveratrol, a natural product derived from grapes

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AMPK: a nutrient and energy sensor that maintains energy homeostasis

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Resveratrol improves health and survival of mice on a high-calorie diet

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Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α

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Therapeutic potential of resveratrol: the in vivo evidence

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A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis

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Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

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Type 2 diabetes as an inflammatory disease

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Wine, alcohol, platelets, and the French paradox for coronary heart disease

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Anorexigenic and Orexigenic Hormone Modulation of Mammalian Target of Rapamycin Complex 1 Activity and the Regulation of Hypothalamic Agouti-Related Protein mRNA Expression

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AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

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Resveratrol Reduces the Proinflammatory Effects and Lipopolysaccharide- Induced Expression of HMGB1 and TLR4 in RAW264.7 Cells

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Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

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Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1

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Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase

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Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres

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Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

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The Effect of Retarded Growth Upon the Length of Life Span and Upon the Ultimate Body Size

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The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

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Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

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Sirtuin activators mimic caloric restriction and delay ageing in metazoans

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Requirement of NAD and <i>SIR2</i> for Life-Span Extension by Calorie Restriction in <i>Saccharomyces cerevisiae</i>

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Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

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SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function

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Pharmacology, physiology, and mechanisms of incretin hormone action.

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Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

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Sir2 mediates longevity in the fly through a pathway related to calorie restriction

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Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases

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Mammalian SIRT1 Represses Forkhead Transcription Factors

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Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

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The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

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The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

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Molecular inflammation: Underpinnings of aging and age-related diseases

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Biochemistry and Physiology of Cyclic Nucleotide Phosphodiesterases: Essential Components in Cyclic Nucleotide Signaling

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Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span

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Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study

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Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice

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ATM Activation by Oxidative Stress

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Mechanism of Human SIRT1 Activation by Resveratrol

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Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor

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SIRT1 Functionally Interacts with the Metabolic Regulator and Transcriptional Coactivator PGC-1α

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Inhibition of Silencing and Accelerated Aging by Nicotinamide, a Putative Negative Regulator of Yeast Sir2 and Human SIRT1

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Sirt1 protects against high-fat diet-induced metabolic damage

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Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle

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SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1

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Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

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Inhibition of human LDL oxidation by resveratrol

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SIRT1 Promotes Endothelium-Dependent Vascular Relaxation by Activating Endothelial Nitric Oxide Synthase

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PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation

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AMP‐activated protein kinase phosphorylation of endothelial NO synthase

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SIRT1 Modulation of the Acetylation Status, Cytosolic Localization, and Activity of LKB1

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Phase I Dose Escalation Pharmacokinetic Study in Healthy Volunteers of Resveratrol, a Potential Cancer Chemopreventive Agent

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Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt

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Resveratrol Prolongs Lifespan and Retards the Onset of Age-Related Markers in a Short-Lived Vertebrate

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SIRT1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase

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Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation

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Resveratrol Promotes Clearance of Alzheimer's Disease Amyloid-β Peptides

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Substrate-specific activation of sirtuins by resveratrol

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Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH

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Resveratrol stimulates AMP kinase activity in neurons

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SIRT1 transgenic mice show phenotypes resembling calorie restriction

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Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation

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Calorie restriction and aging: review of the literature and implications for studies in humans

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Repeat Dose Study of the Cancer Chemopreventive Agent Resveratrol in Healthy Volunteers: Safety, Pharmacokinetics, and Effect on the Insulin-like Growth Factor Axis

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Absorption of three wine-related polyphenols in three different matrices by healthy subjects

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Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients

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The effect of retarded growth upon the length of life span and upon the ultimate body size. 1935.

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Resveratrol, a Polyphenolic Phytoalexin Present in Red Wine, Enhances Expression and Activity of Endothelial Nitric Oxide Synthase

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Polyphenols Stimulate AMP-Activated Protein Kinase, Lower Lipids, and Inhibit Accelerated Atherosclerosis in Diabetic LDL Receptor–Deficient Mice

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AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-β Peptide Metabolism

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AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol

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SirT1 Gain of Function Increases Energy Efficiency and Prevents Diabetes in Mice

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Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila

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Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

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The Mammalian SIR2α Protein Has a Role in Embryogenesis and Gametogenesis

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Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans

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Small molecule SIRT1 activators for the treatment of aging and age-related diseases

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Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2

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Resveratrol: A multitargeted agent for age-associated chronic diseases

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Cardioprotective effect of resveratrol, a natural antioxidant derived from grapes

Hung, L. (2000) · Cardiovascular Research · doi:10.1016/s0008-6363(00)00102-4 · Cited by 542 · see citing works

FOXO4 Is Acetylated upon Peroxide Stress and Deacetylated by the Longevity Protein hSir2

van der Horst, A., Tertoolen, L. G. J., Smits, L. M. M., Frye, R. A., Medema, R. H., & Burgering, B. M. T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401138200 · Cited by 541 · see citing works

Resveratrol Acts as a Mixed Agonist/Antagonist for Estrogen Receptors α and β*

Bowers, J. L., Tyulmenkov, V. V., Jernigan, S. C., & Klinge, C. M. (2000) · Endocrinology · doi:10.1210/endo.141.10.7721 · Cited by 527 · see citing works

Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease

Karuppagounder, S. S., Pinto, J. T., Xu, H., Chen, H., Beal, M. F., & Gibson, G. E. (2008) · Neurochemistry International · doi:10.1016/j.neuint.2008.10.008 · Cited by 488 · see citing works

Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1α in skeletal muscle

Palacios, O. M., Carmona, J. J., Michan, S., Chen, K. Y., Manabe, Y., III, J. L. W., Goodyear, L. J., & Tong, Q. (2009) · Aging · doi:10.18632/aging.100075 · Cited by 487 · see citing works

Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus

Bhatt, J. K., Thomas, S., & Nanjan, M. J. (2012) · Nutrition Research · doi:10.1016/j.nutres.2012.06.003 · Cited by 475 · see citing works

Regulation of Hypoxia-Inducible Factor 2α Signaling by the Stress-Responsive Deacetylase Sirtuin 1

Dioum, E. M., Chen, R., Alexander, M. S., Zhang, Q., Hogg, R. T., Gerard, R. D., & Garcia, J. A. (2009) · Science · doi:10.1126/science.1169956 · Cited by 470 · see citing works

High-Dose Resveratrol Supplementation in Obese Men

Poulsen, M. M., Vestergaard, P. F., Clasen, B. F., Radko, Y., Christensen, L. P., Stødkilde-Jørgensen, H., Møller, N., Jessen, N., Pedersen, S. B., & Jørgensen, J. O. L. (2013) · Diabetes · doi:10.2337/db12-0975 · Cited by 455 · see citing works

Inhibition of mitochondrial proton F0F1‐ATPase/ATP synthase by polyphenolic phytochemicals

Zheng, J., & Ramirez, V. D. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703397 · Cited by 453 · see citing works

Resveratrol induces mitochondrial biogenesis in endothelial cells

Csiszár, A., Labinskyy, N., Pinto, J. T., Ballabh, P., Zhang, H., Losonczy, G., Pearson, K. J., de Cabo, R., Pacher, P., Zhang, C., et al. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00368.2009 · Cited by 450 · see citing works

Sir2-Independent Life Span Extension by Calorie Restriction in Yeast

Kaeberlein, M., Kirkland, K. T., Fields, S., & Kennedy, B. K. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020296 · Cited by 441 · see citing works

Pharmacokinetic and safety profile oftrans‐resveratrol in a rising multiple‐dose study in healthy volunteers

Almeida, L., Vaz‐da‐Silva, M., Falcão, A. C., Soares, E., Costa, R., Loureiro, A. I., Fernandes‐Lopes, C., Rocha, J., Nunes, T., Wright, L. C., et al. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200800177 · Cited by 427 · see citing works

Resveratrol Mitigates Lipopolysaccharide- and Aβ-Mediated Microglial Inflammation by Inhibiting the TLR4/NF-Κb/STAT Signaling cascade

Capiralla, H., Vingtdeux, V., Zhao, H., Sankowski, R., Al‐Abed, Y., Davies, P., & Marambaud, P. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07594.x · Cited by 426 · see citing works

Long-term resveratrol administration reduces metabolic disturbances and lowers blood pressure in obese Zucker rats

Rivera, L., Morón, R., Zarzuelo, A., & Galisteo, M. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.11.027 · Cited by 391 · see citing works

Are sirtuins viable targets for improving healthspan and lifespan?

Baur, J. A., Ungvari, Z. I., Minor, R. K., Couteur, D. G. L., & de Cabo, R. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3738 · Cited by 389 · see citing works

Resveratrol Supplementation Does Not Improve Metabolic Function in Nonobese Women with Normal Glucose Tolerance

Yoshino, J., Conte, C., Fontana, L., Mittendorfer, B., Imai, S., Schechtman, K. B., Gu, C. C., Kunz, I., Fanelli, F. R., Patterson, B. W., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.09.015 · Cited by 381 · see citing works

Mechanism of inhibition of bovine F 1 -ATPase by resveratrol and related polyphenols

Gledhill, J. R., Montgomery, M. G., Leslie, A. G. W., & Walker, J. E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706290104 · Cited by 379 · see citing works

Cardioprotection by resveratrol: A human clinical trial in patients with stable coronary artery disease

Magyar, K., Halmosi, R., Pálfi, A., Fehér, G., Czopf, L., Fulop, A., Battyány, I., Sümegi, B., Tóth, K., & Szabados, E. (2012) · Clinical Hemorheology and Microcirculation · doi:10.3233/ch-2011-1424 · Cited by 364 · see citing works

Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure

Tanno, M., Kuno, A., Yano, T., Miura, T., Hisahara, S., Ishikawa, S., Shimamoto, K., & Horio, Y. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.090266 · Cited by 358 · see citing works

LKB1/STRAD Promotes Axon Initiation During Neuronal Polarization

Shelly, M., Cancedda, L., Heilshorn, S. C., Sumbre, G., & Poo, M. (2007) · Cell · doi:10.1016/j.cell.2007.04.012 · Cited by 354 · see citing works

Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells

Ungvari, Z. I., Labinskyy, N., Mukhopadhyay, P., Pinto, J. T., Bagi, Z. A., Ballabh, P., Zhang, C., Pacher, P., & Csiszár, A. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00375.2009 · Cited by 343 · see citing works

NAD+-Dependent Activation of Sirt1 Corrects the Phenotype in a Mouse Model of Mitochondrial Disease

Cerutti, R., Pirinen, E., Lamperti, C., Marchet, S., Sauve, A. A., Li, W., Leoni, V., Schon, E. A., Dantzer, F., Auwerx, J., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.04.001 · Cited by 343 · see citing works

Resveratrol Modulates Drug- and Carcinogen-Metabolizing Enzymes in a Healthy Volunteer Study

Chow, H. ‐. S., Garland, L. L., Hsu, C., Vining, D. R., Chew, W. M., Miller, J. A., Perloff, M., Crowell, J. A., & Alberts, D. S. (2010) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-09-0155 · Cited by 333 · see citing works

The cAMP/PKA Pathway Rapidly Activates SIRT1 to Promote Fatty Acid Oxidation Independently of Changes in NAD+

Gerhart‐Hines, Z., Dominy, J. E., Blättler, S. M., Jedrychowski, M. P., Banks, A. S., Lim, J.-H., Chim, H., Gygi, S. P., & Puigserver, P. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.12.005 · Cited by 323 · see citing works

Transgenic expression and activation of PGC-1α protect dopaminergic neurons in the MPTP mouse model of Parkinson’s disease

Mudó, G., Mäkelä, J., Liberto, V. D., Tselykh, T. V., Olivieri, M., Piepponen, P., Eriksson, O., Mälkiä, A., Bonomo, A., Kairisalo, M., et al. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0850-z · Cited by 315 · see citing works

SRT1720 improves survival and healthspan of obese mice

Minor, R. K., Baur, J. A., Gomes, A. P., Ward, T. M., Csiszár, A., Mercken, E. M., Abdelmohsen, K., Shin, Y., Cantó, C., Scheibye‐Knudsen, M., et al. (2011) · Scientific Reports · doi:10.1038/srep00070 · Cited by 297 · see citing works

Resveratrol Does Not Benefit Patients With Nonalcoholic Fatty Liver Disease

Chachay, V., Macdonald, G. A., Martin, J. H., Whitehead, J. P., O'Moore‐Sullivan, T. M., Lee, P., Franklin, M. E., Klein, K., Taylor, P. J., Ferguson, M. L., et al. (2014) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2014.02.024 · Cited by 291 · see citing works

Resveratrol reduces endothelial oxidative stress by modulating the gene expression of superoxide dismutase 1 (SOD1), glutathione peroxidase 1 (GPx1) and NADPH oxidase subunit (Nox4).

Spanier, G., Xu, H., Xia, N., Tobias, S., Deng, S., Wojnowski, L., Förstermann, U., & Li, H. (2009) · PubMed · Cited by 288 · see citing works

A Molecular Mechanism for Direct Sirtuin Activation by Resveratrol

Gertz, M., Nguyen, G. T. T., Fischer, F. F., Suenkel, B., Schlicker, C., Fränzel, B., Tomaschewski, J., Aladini, F., Becker, C., Wolters, D. A., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049761 · Cited by 286 · see citing works

Urinary and Plasma Levels of Resveratrol and Quercetin in Humans, Mice, and Rats after Ingestion of Pure Compounds and Grape Juice

Meng, X., Maliakal, P. P., Lu, H., Lee, M., & Yang, C. S. (2004) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf030582e · Cited by 281 · see citing works

Pilot study of resveratrol in older adults with impaired glucose tolerance

Crandall, J. P., Oram, V., Trandafirescu, G., Reid, M., Kishore, P., Hawkins, M., Cohen, H. W., & Barzilai, N. (2012) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glr235 · Cited by 281 · see citing works

PKA phosphorylates and inactivates AMPKα to promote efficient lipolysis

Djouder, N., Tuerk, R. D., Suter, M., Chiabotti, P. S., Thali, R. F., Scholz, R., Vaahtomeri, K., Auchli, Y., Rechsteiner, H., Brunisholz, R., et al. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.339 · Cited by 277 · see citing works

Effects of stilbenes on arachidonate metabolism in leukocytes

Kimura, Y., Hiromichi, O., & Arichi, S. (1985) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(85)90167-5 · Cited by 273 · see citing works

Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO

Wang, Y., & Tissenbaum, H. A. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.09.005 · Cited by 263 · see citing works

One-Year Consumption of a Grape Nutraceutical Containing Resveratrol Improves the Inflammatory and Fibrinolytic Status of Patients in Primary Prevention of Cardiovascular Disease

Tomé‐Carneiro, J., Gonzálvez, M., Larrosa, M., Yáñez-Gascón, M. J., García‐Almagro, F. J., Ruiz‐Ros, J. A., García‐Conesa, M., Tomás-Barberán, F. A., & Espı́n, J. C. (2012) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2012.03.030 · Cited by 260 · see citing works

Effects of resveratrol on the rat brain respiratory chain.

Zini, R., Morin, C., Bertelli, A., Bertelli, A., & Tillement, J. P. (1999) · PubMed · Cited by 252 · see citing works

Effect of resveratrol on mitochondrial function: Implications in parkin-associated familiar Parkinson's disease

Ferretta, A., Gaballo, A., Tanzarella, P., Piccoli, C., Capitanio, N., Nico, B., Annese, T., Paola, M. D., Dell’Aquila, C., Mari, M. D., et al. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.02.010 · Cited by 244 · see citing works

Grape Resveratrol Increases Serum Adiponectin and Downregulates Inflammatory Genes in Peripheral Blood Mononuclear Cells: A Triple-Blind, Placebo-Controlled, One-Year Clinical Trial in Patients with Stable Coronary Artery Disease

Tomé‐Carneiro, J., Gonzálvez, M., Larrosa, M., Yáñez-Gascón, M. J., García‐Almagro, F. J., Ruiz‐Ros, J. A., Tomás-Barberán, F. A., García‐Conesa, M., & Espı́n, J. C. (2012) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-012-6427-8 · Cited by 241 · see citing works

Resveratrol Improves Adipose Insulin Signaling and Reduces the Inflammatory Response in Adipose Tissue of Rhesus Monkeys on High-Fat, High-Sugar Diet

Jiménez, Y., Mattison, J. A., Pearson, K. J., Martín‐Montalvo, A., Palacios, H. H., Sossong, A. M., Ward, T. M., Younts, C. M., Lewis, K. N., Allard, J. S., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.09.004 · Cited by 240 · see citing works

Resveratrol is a Peroxidase-mediated Inactivator of COX-1 but Not COX-2

Szewczuk, L. M., Forti, L., Stivala, L. A., & Penning, T. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m314302200 · Cited by 240 · see citing works

Resveratrol increases vascular oxidative stress resistance

Ungvari, Z. I., Orosz, Z. Z., Rivera, A., Labinskyy, N., Xiangmin, Z., Olson, S. C., Podlutsky, A. J., & Csiszár, A. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01258.2006 · Cited by 239 · see citing works

Resveratrol stimulates glucose transport in C2C12 myotubes by activating AMP-activated protein kinase

Park, C.-E., Kim, M., Lee, J. H., Min, B.-I., Bae, H., Choe, W., Kim, S. S., & Ha, J. (2007) · Experimental & Molecular Medicine · doi:10.1038/emm.2007.25 · Cited by 239 · see citing works

An Antiinflammatory and Reactive Oxygen Species Suppressive Effects of an Extract of Polygonum Cuspidatum Containing Resveratrol

Ghanim, H., Sia, C. L., Abuaysheh, S., Korzeniewski, K., Patnaik, P., Marumganti, A., Chaudhuri, A., & Dandona, P. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0482 · Cited by 237 · see citing works

Resveratrol Prevents the Prohypertrophic Effects of Oxidative Stress on LKB1

Dolinsky, V. W., Chan, A. Y. M., Frayne, I. R., Light, P. E., Rosiers, C. D., & Dyck, J. R. B. (2009) · Circulation · doi:10.1161/circulationaha.108.787440 · Cited by 232 · see citing works

Evaluation of Resveratrol, Green Tea Extract, Curcumin, Oxaloacetic Acid, and Medium-Chain Triglyceride Oil on Life Span of Genetically Heterogeneous Mice

Strong, R., Miller, R. A., Astle, C. M., Baur, J. A., de Cabo, R., Fernandez, E., Guo, W., Javors, M. A., Kirkland, J. L., Nelson, J. F., et al. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls070 · Cited by 232 · see citing works

Effects of Resveratrol and SIRT1 on PGC-1α Activity and Mitochondrial Biogenesis: A Reevaluation

Higashida, K., Kim, S. H., Jung, S. R., Asaka, M., Holloszy, J. O., & Han, D.-H. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001603 · Cited by 228 · see citing works

Inhibition by red wine extract, resveratrol, of cytokine release by alveolar macrophages in COPD

Culpitt, S. V. (2003) · Thorax · doi:10.1136/thorax.58.11.942 · Cited by 227 · see citing works

SIRT1, a Longevity Gene, Downregulates Angiotensin II Type 1 Receptor Expression in Vascular Smooth Muscle Cells

Miyazaki, R., Ichiki, T., Hashimoto, T., Inanaga, K., Imayama, I., Sadoshima, J., & Sunagawa, K. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.166991 · Cited by 214 · see citing works

SIRT1 Activation by Small Molecules

Dai, H., Kustigian, L. M., Carney, D. P., Case, A. W., Considine, T., Hubbard, B. P., Perni, R. B., Riera, T. V., Szczepankiewicz, B. G., Vlasuk, G. P., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.133892 · Cited by 211 · see citing works

Resveratrol Improves Endothelial Function

Zhang, H., Zhang, J., Ungvari, Z. I., & Zhang, C. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.187146 · Cited by 211 · see citing works

Resveratrol Prevents Monocrotaline-Induced Pulmonary Hypertension in Rats

Csiszár, A., Labinskyy, N., Olson, S. C., Pinto, J. T., Gupte, S. A., WU, J. M., Hu, F., Ballabh, P., Podlutsky, A. J., Losonczy, G., et al. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.133397 · Cited by 210 · see citing works

Resveratrol prevents hypertension and cardiac hypertrophy in hypertensive rats and mice

Dolinsky, V. W., Chakrabarti, S., Pereira, T. J., Oka, T., Levasseur, J. L., Beker, D. L., Zordoky, B. N. M., Morton, J. S., Nagendran, J., Lopaschuk, G. D., et al. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.05.018 · Cited by 206 · see citing works

Resveratrol Prevents High Fat/Sucrose Diet-Induced Central Arterial Wall Inflammation and Stiffening in Nonhuman Primates

Mattison, J. A., Wang, M., Bernier, M., Zhang, J., Park, S. S., Maudsley, S. R., An, S. S., Santhanam, L., Martin, B., Faulkner, S., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.04.018 · Cited by 206 · see citing works

Dysregulation of mitochondrial biogenesis in vascular endothelial and smooth muscle cells of aged rats

Ungvari, Z. I., Labinskyy, N., Gupte, S. A., Chander, P. N., Edwards, J. G., & Csiszár, A. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00012.2008 · Cited by 202 · see citing works

Resveratrol treatment rescues neurovascular coupling in aged mice: role of improved cerebromicrovascular endothelial function and downregulation of NADPH oxidase

Tóth, P., Tarantini, S., Tucsek, Z., Ashpole, N. M., Sosnowska, D., Gautam, T., Ballabh, P., Koller, Á., Sonntag, W. E., Csiszár, A., et al. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00744.2013 · Cited by 197 · see citing works

Resveratrol as a calorie restriction mimetic: therapeutic implications

Chung, J. H., Manganiello, V., & Dyck, J. R. B. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2012.07.004 · Cited by 192 · see citing works

Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes

Viswanathan, M., & Guarente, L. (2011) · Nature · doi:10.1038/nature10440 · Cited by 191 · see citing works

Resveratrol Reverses Endothelial Nitric-Oxide Synthase Uncoupling in Apolipoprotein E Knockout Mice

Xia, N., Daiber, A., Habermeier, A., Closs, E. I., Thum, T., Spanier, G., Lü, Q., Oelze, M. W., Torzewski, M., Lackner, K. J., et al. (2010) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.168724 · Cited by 183 · see citing works

Alterations in regulation of energy homeostasis in cyclic nucleotide phosphodiesterase 3B–null mice

Choi, Y. H., Park, S., Hockman, S. C., Zmuda‐Trzebiatowska, E., Svennelid, F., Haluzı́k, M., Gavrilova, O., Ahmad, F., Pepin, L., Napolitano, M., et al. (2006) · Journal of Clinical Investigation · doi:10.1172/jci24867 · Cited by 181 · see citing works

Anti-inflammatory Effect of Resveratrol and Polydatin by In Vitro IL-17 Modulation

Lanzilli, G., Cottarelli, A., Nicotera, G., Guida, S., Ravagnan, G., & Fuggetta, M. P. (2011) · Inflammation · doi:10.1007/s10753-011-9310-z · Cited by 178 · see citing works

SIRT1 activation confers neuroprotection in experimental optic neuritis.

Shindler, K., Ventura, E. S., Rex, T. S., Elliott, P., & Rostami, A. (2007) · Investigative Ophthalmology and Visual Science · doi:10.1167/iovs.07-0131 · Cited by 176 · see citing works

Resveratrol Prevents the Development of Pathological Cardiac Hypertrophy and Contractile Dysfunction in the SHR Without Lowering Blood Pressure

Thandapilly, S. J., Wojciechowski, P. W., Behbahani, J., Louis, X. L., Yu, L., Juric, D., Kopilas, M. A., Anderson, H. D., & Netticadan, T. (2009) · American Journal of Hypertension · doi:10.1038/ajh.2009.228 · Cited by 172 · see citing works

Resveratrol Levels and All-Cause Mortality in Older Community-Dwelling Adults

Semba, R. D., Ferrucci, L., Bartali, B., Urpí-Sardà, M., Zamora‐Ros, R., Sun, K., Cherubini, A., Bandinelli, S., & Andrés‐Lacueva, C. (2014) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2014.1582 · Cited by 168 · see citing works

Calorie restriction and resveratrol in cardiovascular health and disease

Dolinsky, V. W., & Dyck, J. R. B. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.06.010 · Cited by 168 · see citing works

Resveratrol Increases Glucose Induced GLP-1 Secretion in Mice: A Mechanism which Contributes to the Glycemic Control

Dao, T.-M. A., Waget, A., Klopp, P., Sérino, M., Vachoux, C., Pechère, L., Drucker, D. J., Champion, S., Barthélemy, S., Barra, Y., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020700 · Cited by 163 · see citing works

Concurrent regulation of AMP-activated protein kinase and SIRT1 in mammalian cells

Suchankova, G., Nelson, L. E., Gerhart-Hines, Z., Kelly, M., Gauthier, M.-S., Saha, A. K., Ido, Y., Puigserver, P., & Ruderman, N. B. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.11.130 · Cited by 162 · see citing works

Resveratrol stimulates nitric oxide production by increasing estrogen receptor αa‐Src‐caveolin‐1 interaction and phosphorylation in human umbilical vein endothelial cells

Klinge, C. M., Wickramasinghe, N. S. M. D., Ivanova, M. M., & Dougherty, S. M. (2008) · The FASEB Journal · doi:10.1096/fj.07-103366 · Cited by 162 · see citing works

Resveratrol and life extension

Agarwal, B., & Baur, J. A. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05850.x · Cited by 158 · see citing works

Role of SIRT1 and FOXO factors in eNOS transcriptional activation by resveratrol

Xia, N., Strand, S., Schlufter, F., Siuda, D., Reifenberg, G., Kleinert, H., Förstermann, U., & Li, H. (2013) · Nitric Oxide · doi:10.1016/j.niox.2013.04.001 · Cited by 157 · see citing works

Chronic administration of resveratrol prevents biochemical cardiovascular changes in fructose-fed rats

Miatello, R. M., VAZQUEZ, M., Renna, N. F., Cruzado, M., Zumino, A. Z. P., & Risler, N. (2005) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2004.12.012 · Cited by 152 · see citing works

Resveratrol Induces Apoptosis in Chemoresistant Cancer Cells via Modulation of AMPK Signaling Pathway

Hwang, J., KWAK, D. W., Sun, L., Kim, H. M., KIM, Y. M., & Park, O. J. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1397.047 · Cited by 151 · see citing works

Activation of AMP-Activated Protein Kinase by Interleukin-6 in Rat Skeletal Muscle

Kelly, M., Gauthier, M., Saha, A. K., & Ruderman, N. B. (2009) · Diabetes · doi:10.2337/db08-1293 · Cited by 144 · see citing works

The effects of 30-days resveratrol supplementation on adipose tissue morphology and gene expression patterns in obese men

Konings, E., Timmers, S., Boekschoten, M. V., Goossens, G. H., Jocken, J. W., Afman, L. A., Müller, M., Schrauwen, P., Mariman, E. C., & Blaak, E. E. (2014) · International Journal of Obesity · doi:10.1038/ijo.2013.155 · Cited by 143 · see citing works

Resveratrol Induces a Mitochondrial Complex I-dependent Increase in NADH Oxidation Responsible for Sirtuin Activation in Liver Cells

Desquiret‐Dumas, V., Guéguen, N., Leman, G., Baron, S., Nivet‐Antoine, V., Chupin, S., Chevrollier, A., Vessières, E., Ayer, A., Ferré, M., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.466490 · Cited by 141 · see citing works

Regulation of AMP-activated protein kinase by cAMP in adipocytes: Roles for phosphodiesterases, protein kinase B, protein kinase A, Epac and lipolysis

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Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network

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Resveratrol Prevents β-Cell Dedifferentiation in Nonhuman Primates Given a High-Fat/High-Sugar Diet

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Proatherogenic Abnormalities of Lipid Metabolism in SirT1 Transgenic Mice Are Mediated through Creb Deacetylation

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Modified resveratrol Longevinex improves endothelial function in adults with metabolic syndrome receiving standard treatment

Fujitaka, K., Otani, H., Jo, F., Jo, H., Nomura, E., Iwasaki, M., Nishikawa, M., Iwasaka, T., & Das, D. K. (2011) · Nutrition Research · doi:10.1016/j.nutres.2011.09.028 · Cited by 123 · see citing works

Sirtuins as Novel Targets for Alzheimer's Disease and Other Neurodegenerative Disorders: Experimental and Genetic Evidence

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Role of Deleted in Breast Cancer 1 (DBC1) Protein in SIRT1 Deacetylase Activation Induced by Protein Kinase A and AMP-activated Protein Kinase

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Sirt1 activation by resveratrol is substrate sequence-selective

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The lifespan extension effects of resveratrol are conserved in the honey bee and may be driven by a mechanism related to caloric restriction

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Chronic Resveratrol Enhances Endothelium-Dependent Relaxation but Does Not Alter eNOS Levels in Aorta of Spontaneously Hypertensive Rats

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dSir2 in the Adult Fat Body, but Not in Muscles, Regulates Life Span in a Diet-Dependent Manner

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The effect of resveratrol on lifespan depends on both gender and dietary nutrient composition in Drosophila melanogaster

Wang, C., Wheeler, C. T., Alberico, T., Sun, X., Seeberger, J., Laslo, M., Spangler, E. L., Kern, B., de Cabo, R., & Zou, S. (2011) · AGE · doi:10.1007/s11357-011-9332-3 · Cited by 112 · see citing works

Resveratrol attenuates oxLDL-stimulated NADPH oxidase activity and protects endothelial cells from oxidative functional damages

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Cilostazol suppresses β‐amyloid production by activating a disintegrin and metalloproteinase 10 via the upregulation of SIRT1‐coupled retinoic acid receptor‐β

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Effect of the Phosphodiesterase 4 Inhibitor Roflumilast on Glucose Metabolism in Patients with Treatment-Naive, Newly Diagnosed Type 2 Diabetes Mellitus

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Is Resveratrol an Estrogen Agonist in Growing Rats?**This work was supported by NIH Grant AA-11140 and the Mayo Foundation.

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Resveratrol prevents the development of abdominal aortic aneurysm through attenuation of inflammation, oxidative stress, and neovascularization

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Resveratrol improves insulin signaling in a tissue-specific manner under insulin-resistant conditions only: in vitro and in vivo experiments in rodents

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PKA/AMPK signaling in relation to adiponectin’s antiproliferative effect on multiple myeloma cells

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Protective Effect Of Resveratrol On Oxidative Damage In Male And Female Stroke‐Prone Spontaneously Hypertensive Rats

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Constitutive SIRT1 overexpression impairs mitochondria and reduces cardiac function in mice

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Resveratrol in primary and secondary prevention of cardiovascular disease: a dietary and clinical perspective

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Effects of trans-resveratrol on hypertension-induced cardiac hypertrophy using the partially nephrectomized rat model

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Resveratrol up-regulates hepatic uncoupling protein 2 and prevents development of nonalcoholic fatty liver disease in rats fed a high-fat diet

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Adrenergic Regulation of AMP-activated Protein Kinase in Brown Adipose Tissue in Vivo

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Resveratrol Improves Cardiovascular Function in DOCA-Salt Hypertensive Rats

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Resveratrol Suppresses Constitutive Activation of AKT via Generation of ROS and Induces Apoptosis in Diffuse Large B Cell Lymphoma Cell Lines

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Resveratrol has antiinflammatory and antifibrotic effects in the peptidoglycan-polysaccharide rat model of Crohnʼs disease

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Resveratrol improves cardiovascular function and reduces oxidative organ damage in the renal, cardiovascular and cerebral tissues of two-kidney, one-clip hypertensive rats

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The Red Wine Antioxidant Resveratrol Prevents Cardiomyocyte Injury Following Ischemia-Reperfusion Via Multiple Sites and Mechanisms

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Reduced Adiposity and High-Fat Diet-Induced Adipose Inflammation in Mice Deficient for Phosphodiesterase 4B

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Effects of resveratrol on longevity, cognitive ability and aging-related histological markers in the annual fish Nothobranchius guentheri

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Red wine and equivalent oral pharmacological doses of resveratrol delay vascular aging but do not extend life span in rats

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Resveratrol inhibits interleukin-6 production in cortical mixed glial cells under hypoxia/hypoglycemia followed by reoxygenation

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Resveratrol suppresses interferon-γ-induced biochemical pathways in human peripheral blood mononuclear cells in vitro

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Resveratrol and aspirin eliminate tetraploid cells for anticancer chemoprevention

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Resveratrol supplementation improves white adipose tissue function in a depot-specific manner in Zucker diabetic fatty rats

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Life-long caloric restriction elicits pronounced protection of the aged myocardium: A role for AMPK

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The role of the PDE4D cAMP phosphodiesterase in the regulation of glucagon‐like peptide‐1 release

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Effects of Chronic Calorie Restriction or Dietary Resveratrol Supplementation on Insulin Sensitivity Markers in a Primate, Microcebus murinus

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C-terminal Phosphorylation of LKB1 Is Not Required for Regulation of AMP-activated Protein Kinase, BRSK1, BRSK2, or Cell Cycle Arrest

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Resveratrol prevents norepinephrine induced hypertrophy in adult rat cardiomyocytes, by activating NO-AMPK pathway

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Resveratrol prevents hyperglycemia-induced endothelial dysfunction via activation of adenosine monophosphate-activated protein kinase

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Effects of trans‐resveratrol on hypertension‐induced cardiac hypertrophy using the partially nephrectomized rat model

Liu, Z., Song, Y., Zhang, X., Liu, Z., Zhang, W., Mao, W., Wang, W., Cui, W., Zhang, X., Jia, X., et al. (2005) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2005.04299.x · Cited by 55 · see citing works

Idebenone and Resveratrol Extend Lifespan and Improve Motor Function of HtrA2 Knockout Mice

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Calorie restriction does not elicit a robust extension of replicative lifespan in Saccharomyces cerevisiae

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Resveratrol (RV): A pharmacological review and call for further research

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Resveratrol and Its Effects on the Vascular System

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Pitfalls of the MTT assay: Direct and off-target effects of inhibitors can result in over/underestimation of cell viability

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An Overview of Herbal Products and Secondary Metabolites Used for Management of Type Two Diabetes

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Therapeutic Versatility of Resveratrol Derivatives

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Dietary strategies implicated in the prevention and treatment of metabolic syndrome

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Resveratrol Induces Brain Resilience Against Alzheimer Neurodegeneration Through Proteostasis Enhancement

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Pterostilbene‐induced changes in gut microbiota composition in relation to obesity

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PGC-1α affects skeletal muscle and adipose tissue development by regulating mitochondrial biogenesis

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No Beneficial Effects of Resveratrol on the Metabolic Syndrome: A Randomized Placebo-Controlled Clinical Trial

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Dietary resveratrol supplementation inhibits heat stress-induced high-activated innate immunity and inflammatory response in spleen of yellow-feather broilers

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Resveratrol in Treating Diabetes and Its Cardiovascular Complications: A Review of Its Mechanisms of Action

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Resveratrol in Cancer Patients: From Bench to Bedside

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Antidiabetic Effects of Resveratrol: The Way Forward in Its Clinical Utility

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Antioxidants reveal an inverted U‐shaped dose‐response relationship between reactive oxygen species levels and the rate of aging in Caenorhabditis elegans

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Epigenetic regulation of energy metabolism in obesity

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Dietary Polyphenols and Mitochondrial Function: Role in Health and Disease

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Resveratrol distinctively modulates the inflammatory profiles of immune and endothelial cells

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Resveratrol exhibits an effect on attenuating retina inflammatory condition and damage of diabetic retinopathy via PON1

Chen, Y., Meng, J., Li, H., Hong Kui, W. E. I., Bi, F., Liu, S., Tang, K., Guo, H., & Liu, W. (2018) · Experimental Eye Research · doi:10.1016/j.exer.2018.11.023 · Cited by 86 · see citing works

P53 coordinates decidual sestrin 2/AMPK/mTORC1 signaling to govern parturition timing

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Effects of resveratrol on drug- and carcinogen-metabolizing enzymes, implications for cancer prevention

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Perspectives and controversies regarding the use of natural products for the treatment of lung cancer

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Mitochondrial dysfunction precedes depression of AMPK / AKT signaling in insulin resistance induced by high glucose in primary cortical neurons

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Effect of resveratrol on growth performance, rectal temperature and serum parameters of yellow‐feather broilers under heat stress

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Caloric restriction and exercise “mimetics”: ready for prime time

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The Role of Resveratrol Administration in Human Obesity

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Sirtuin 1 regulates pulmonary artery smooth muscle cell proliferation

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Efficacy of an orlistat‐resveratrol combination for weight loss in subjects with obesity: A randomized controlled trial

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Quercetin enhances motility in aged and heat-stressed Caenorhabditis elegans nematodes by modulating both HSF-1 activity, and insulin-like and p38-MAPK signalling

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Synergistic Hypolipidemic Effects and Mechanisms of Phytochemicals: A Review

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Mitochondrial Dynamics Is Linked to Longevity and Protects from End-Organ Injury: The Emerging Role of Sirtuin 3

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Glucoregulatory Relevance of Small Intestinal Nutrient Sensing in Physiology, Bariatric Surgery, and Pharmacology

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Combination treatment with quercetin and resveratrol attenuates high fat diet‑induced obesity and associated inflammation in rats via the AMPKα1/SIRT1 signaling pathway

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Effects of exercise training and resveratrol on vascular health in aging

Gliemann, L., Nyberg, M., & Hellsten, Y. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.03.037 · Cited by 53 · see citing works

Acquired Resilience: An Evolved System of Tissue Protection in Mammals

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Role of Resveratrol on Indoxyl Sulfate-Induced Endothelial Hyperpermeability via Aryl Hydrocarbon Receptor (AHR)/Src-Dependent Pathway

Assefa, E. G., Yan, Q., Gezahegn, S. B., Salissou, M. T. M., He, S., Wu, N., Zuo, X., & Ying, C. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/5847040 · Cited by 49 · see citing works

Multiple drug treatments that increase cAMP signaling restore long-term memory and aberrant signaling in fragile X syndrome models

Choi, C. H., Schoenfeld, B. P., Bell, A. J., Hinchey, J., Rosenfelt, C., Gertner, M. J., Campbell, S. R., Emerson, D., Hinchey, P., Kollaros, M., et al. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00136 · Cited by 46 · see citing works

Inositol and antioxidant supplementation: Safety and efficacy in pregnancy

Formoso, G., BALDASSARRE, M. P. A., Ginestra, F., Carlucci, M. A., Bucci, I., & Consoli, A. (2019) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3154 · Cited by 46 · see citing works

Promoting healthspan and lifespan with caloric restriction in primates

Pifferi, F., Terrien, J., Perret, M., Epelbaum, J., Blanc, S., Picq, J., Dhénain, M., & Aujard, F. (2019) · Communications Biology · doi:10.1038/s42003-019-0348-z · Cited by 44 · see citing works

The application of resveratrol to mesenchymal stromal cell-based regenerative medicine

Hu, C., & Lan-juan, L. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1412-9 · Cited by 43 · see citing works

Ataxia telangiectasia syndrome: moonlighting ATM

Zaki‐Dizaji, M., Akrami, S. M., Abolhassani, H., Rezaei, N., & Aghamohammadi, A. (2017) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2017.1392856 · Cited by 41 · see citing works

Resveratrol and its Related Polyphenols Contribute to the Maintenance of Genome Stability

Matsuno, Y., Atsumi, Y., Alauddin, M., Rana, M. M., Fujimori, H., Hyodo, M., Shimizu, A., Ikuta, T., Tani, H., Torigoe, H., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-62292-5 · Cited by 42 · see citing works

The Role of Resveratrol in Human Male Fertility

Mongioì, L. M., Perelli, S., Condorelli, R. A., Barbagallo, F., Crafa, A., Cannarella, R., Vignera, S. L., & Calogero, A. E. (2021) · Molecules · doi:10.3390/molecules26092495 · Cited by 42 · see citing works

Maximizing Longevity and Healthspan: Multiple Approaches All Converging on Autophagy

Bareja, A., Lee, D. E., & White, J. P. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00183 · Cited by 41 · see citing works

Resveratrol for patients with chronic obstructive pulmonary disease

Beijers, R. J. H. C. G., Gosker, H. R., & Schols, A. M. W. J. (2017) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000444 · Cited by 41 · see citing works

Mitochondrial Genetic Disorders: Cell Signaling and Pharmacological Therapies

Djouadi, F., & Bastin, J. (2019) · Cells · doi:10.3390/cells8040289 · Cited by 36 · see citing works

Immobilized Lipase Based on Hollow Mesoporous Silicon Spheres for Efficient Enzymatic Synthesis of Resveratrol Ester Derivatives

Xu, L., Yang, T., Wang, J., Huang, F., & Zheng, M. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c07501 · Cited by 31 · see citing works

Resveratrol and Myopathy

Bastin, J., & Djouadi, F. (2016) · Nutrients · doi:10.3390/nu8050254 · Cited by 30 · see citing works

Increased expression of tripartite motif (TRIM) like 2 promotes tumoral growth in human oral cancer

Hayashi, F., Kasamatsu, A., Endo‐Sakamoto, Y., Eizuka, K., Hiroshima, K., Kita, A., Saito, T., Koike, K., Tanzawa, H., & Uzawa, K. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.12.060 · Cited by 30 · see citing works

Resveratrol and Diabetic Cardiomyopathy: Focusing on the Protective Signaling Mechanisms

Song, Y., Zhong, C., & Wu, W. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/7051845 · Cited by 30 · see citing works

Resveratrol alleviates heat stress-induced impairment of intestinal morphology, barrier integrity and inflammation in yellow-feather broilers

He, S., Chen, L., He, Y., Chen, F., Ma, Y., Xiao, D., & He, J. (2020) · Animal Production Science · doi:10.1071/an19218 · Cited by 30 · see citing works

Protective Effects of Resveratrol and Apigenin Dietary Supplementation on Serum Antioxidative Parameters and mRNAs Expression in the Small Intestines of Diquat-Challenged Pullets

Zhou, N., Tian, Y., Liu, W., Tu, B., Xu, W., Gu, T., Zou, K., & Lizhi, L. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.850769 · Cited by 29 · see citing works

Multi-effects of Resveratrol on stem cell characteristics: Effective dose, time, cell culture conditions and cell type-specific responses of stem cells to Resveratrol

Safaeinejad, Z., Kazeminasab, F., Kiani‐Esfahani, A., Ghaedi, K., & Nasr‐Esfahani, M. H. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.06.037 · Cited by 28 · see citing works

Resveratrol supplementation at old age reverts changes associated with aging in inflammatory, oxidative and apoptotic markers in rat heart

Torregrosa‐Muñumer, R., Vara, E., Fernández-Tresguerres, J. Á., & Gredilla, R. (2021) · European Journal of Nutrition · doi:10.1007/s00394-020-02457-0 · Cited by 28 · see citing works

Resveratrol supplementation and plasma adipokines concentrations? A systematic review and meta-analysis of randomized controlled trials

Sartang, M. M., Mazloom, Z., Sohrabi, Z., Sherafatmanesh, S., & Barati‐Boldaji, R. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.01.012 · Cited by 26 · see citing works

Two methoxy derivatives of resveratrol, 3,3′,4,5′-tetramethoxy-trans-stilbene and 3,4′,5-trimethoxy-trans-stilbene, suppress lipopolysaccharide-induced inflammation through inactivation of MAPK and NF-κB pathways in RAW 264.7 cells

Zhou, C., Zhang, X., Ruan, C., & Wai, S.-C.-A. (2021) · Chinese Medicine · doi:10.1186/s13020-021-00480-9 · Cited by 23 · see citing works

The Resveratrol Rice DJ526 Callus Significantly Increases the Lifespan of Drosophila (Resveratrol Rice DJ526 Callus for Longevity)

Khan, M., Park, S., Kim, H., Lee, K.-J., Kim, D. H., Baek, S.-H., & Hong, S. (2019) · Nutrients · doi:10.3390/nu11050983 · Cited by 25 · see citing works

Sirtuins as Modifiers of Huntington's Disease (HD) Pathology

Neo, S. H., & Tang, B. L. (2017) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2017.11.013 · Cited by 24 · see citing works

Obesity and Male Reproduction: Do Sirtuins Play a Role?

Barbagallo, F., Vignera, S. L., Cannarella, R., Mongioì, L., Garofalo, V., Leanza, C., Marino, M., Calogero, A., & Condorelli, R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020973 · Cited by 24 · see citing works

Resveratrol regulates neuronal glucose uptake and insulin sensitivity via P21-activated kinase 2 (PAK2)

Varshney, P., & Dey, C. S. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.02.070 · Cited by 24 · see citing works

Resveratrol Attenuates High Glucose‐Induced Vascular Endothelial Cell Injury by Activating the E2F3 Pathway

Ding, X., Yao, W., Zhu, J., Mu, K., Zhang, J., & Zhang, J. (2020) · BioMed Research International · doi:10.1155/2020/6173618 · Cited by 24 · see citing works

Resveratrol targeting tau proteins, amyloid‐beta aggregations, and their adverse effects: An updated review

Ashrafizadeh, M., Zarrabi, A., Najafi, M., Samarghandian, S., Mohammadinejad, R., & Ahn, K. S. (2020) · Phytotherapy Research · doi:10.1002/ptr.6732 · Cited by 24 · see citing works

Effects and safety of resveratrol supplementation in older adults: A comprehensive systematic review

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Natural Products as Tools for Defining How Cellular Metabolism Influences Cellular Immune and Inflammatory Function during Chronic Infection

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Sweet Mitochondria: A Shortcut to Alzheimer’s Disease

Moreira, P. I. (2018) · Journal of Alzheimer’s Disease · doi:10.3233/jad-170931 · Cited by 20 · see citing works

Effect of Simvastatin, Coenzyme Q10, Resveratrol, Acetylcysteine and Acetylcarnitine on Mitochondrial Respiration

Fišar, Z., Hroudová, J., Singh, N., Kopřivová, A., & Maceckova, D. (2016) · Folia Biologica · doi:10.14712/fb2016062020053 · Cited by 18 · see citing works

Resveratrol suppresses the reprogramming of macrophages into an endotoxin-tolerant state through the activation of AMP-activated protein kinase

Quan, H. Y., Yin, M., Kim, J., Jang, E.-A., Yang, S.-H., Bae, H., & Jeong, S. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.173993 · Cited by 16 · see citing works

No effect of resveratrol on fatty acid oxidation or exercise capacity in patients with fatty acid oxidation disorders: A randomized clinical cross‐over trial

Storgaard, J. H., Løkken, N., Madsen, K. L., Voermans, N. C., Laforêt, P., Nadaj‐Pakleza, A., Tard, C., van Hall, G., Vissing, J., & Ørngreen, M. C. (2022) · Journal of Inherited Metabolic Disease · doi:10.1002/jimd.12479 · Cited by 15 · see citing works

Resveratrol inhibited LPS induced transcription of immune genes and secretion of eicosanoids in Atlantic salmon (Salmo salar), comparing mono-, co- and a novel triple cell culture model of head kidney leukocytes, liver cells and visceral adipocyte tissue

Holen, E., Araujo, P. W., Xie, S., Søfteland, L., & Espe, M. (2019) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2019.108560 · Cited by 15 · see citing works

Effect and mechanism of resveratrol against polycystic ovary syndrome: a review

Chang, H., Shi, B., Wang, Y., Lu, F., Guan, M., & Wu, X. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1529231 · Cited by 14 · see citing works

3,4′,5-Trimethoxy-trans-stilbene Alleviates Endothelial Dysfunction in Diabetic and Obese Mice via Activation of the AMPK/SIRT1/eNOS Pathway

Zhou, C., Tan, Y., Xu, B., Wang, Y., & Cheang, W. S. (2022) · Antioxidants · doi:10.3390/antiox11071286 · Cited by 14 · see citing works

Effects of resveratrol on the anthropometric indices and inflammatory markers: an umbrella meta-analysis

Molani‐Gol, R., & Rafraf, M. (2024) · European Journal of Nutrition · doi:10.1007/s00394-024-03335-9 · Cited by 13 · see citing works

Dietary Phytonutrients in the Prevention of Diabetes-related Complications

Jha, P., Kumari, S., Jobby, R., Desai, N., & Ali, A. (2019) · Current Diabetes Reviews · doi:10.2174/1573399815666190906151319 · Cited by 12 · see citing works

Oxysterols from a Marine Sponge Inflatella sp. and Their Action in 6-Hydroxydopamine-Induced Cell Model of Parkinson’s Disease

Kolesnikova, S. A., Lyakhova, E. G., Kalinovsky, A. I., Popov, R. S., Yurchenko, E. A., & Stonik, V. A. (2018) · Marine Drugs · doi:10.3390/md16110458 · Cited by 12 · see citing works

Sirtuin activation as a therapeutic approach against inborn errors of metabolism

Bleeker, J. C., & Houtkooper, R. H. (2016) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-016-9939-8 · Cited by 11 · see citing works

Natural products as therapeutics for malignant melanoma: preclinical evidence and mechanism

Gao, H., Huang, J., Zhang, D., Li, S., Long, S., & Qin, Y. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1641838 · Cited by 9 · see citing works

Tortuous Paths of Insulin Signaling and Mitochondria in Alzheimer’s Disease

Carvalho, C., Cardoso, S., Correia, S. C., & Moreira, P. I. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-3540-2_9 · Cited by 9 · see citing works

Highlighting the Protective or Degenerative Role of AMPK Activators in Dementia Experimental Models

Nikbakhtzadeh, M., Shaerzadeh, F., & Ashabi, G. (2021) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527320666210526160214 · Cited by 9 · see citing works

Anti-diabetic activity of fused PPARγ-SIRT1 ligands with limited body-weight gain by mimicking calorie restriction and decreasing SGK1 expression

Pirat, C., Dacquet, C., Leclerc, V., Hennuyer, N., Beucher-Gaudin, M., Zanirato, G., Géant, A., Staels, B., Ktorza, A., Farce, A., et al. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.06.006 · Cited by 9 · see citing works

The Effects of Resveratrol and Apigenin on Jejunal Oxidative Injury in Ducks and on Immortalized Duck Intestinal Epithelial Cells Exposed to H2O2

Zhou, N., Cao, Y., Luo, Y., Wang, L., Li, R., Di, H.-S., Gu, T., Cao, Y., Zeng, T., Zhu, J., et al. (2024) · Antioxidants · doi:10.3390/antiox13050611 · Cited by 8 · see citing works

L-NAME-induced Preeclampsia: correction of functional disorders of the hemostasis system with Resveratrol and Nicorandil

Stupakova, E. G., Lazareva, G. A., Gureev, V. V., Dolzhikova, I. N., Zhilinkova, L. A., & Gureeva, A. V. (2019) · Research Results in Pharmacology · doi:10.3897/rrpharmacology.5.35316 · Cited by 8 · see citing works

Caloric Restriction Mimetics as Priming Agents of Mesenchymal Stem Cells Secretome to Enhance Regenerative Responses to Parkinson’s Disease

Carneiro-Pereira, B., Ferreira-Antunes, F., Campos, J., Salgado, A. J., & Sampaio‐Marques, B. (2025) · Molecules · doi:10.3390/molecules30112260 · Cited by 6 · see citing works

Cardioprotective Effects of Resveratrol in the Mediterranean Diet: A Short Narrative Review

Capurso, C. A., Bellanti, F., Buglio, A. L., & Vendemiale, G. (2023) · Dietetics · doi:10.3390/dietetics2020014 · Cited by 6 · see citing works

High-throughput screening identifies cell cycle-associated signaling cascades that regulate a multienzyme glucosome assembly in human cells

Schmitt, D. L., Dranchak, P. K., Parajuli, P., Blivis, D., Voss, T. C., Kohnhorst, C. L., Kyoung, M., Inglese, J., & An, S. (2023) · PLoS ONE · doi:10.1371/journal.pone.0289707 · Cited by 6 · see citing works

Tetrahydropyrrolization of Resveratrol and Other Stilbenes Improves Inhibitory Effects on DNA Oxidation

Bao, L.-L., & Liu, Z. (2016) · ChemMedChem · doi:10.1002/cmdc.201600205 · Cited by 6 · see citing works

Impact of Diquat on the Intestinal Health and the Composition and Function of the Gut Microbiome

He, J., Tang, Q., Liu, Y., Wang, L., & Chai, Y. (2025) · Antioxidants · doi:10.3390/antiox14060721 · Cited by 5 · see citing works

Resveratrol reverses Palmitic Acid-induced cow neutrophils apoptosis through shifting glucose metabolism into lipid metabolism via Cav-1/ CPT 1-mediated FAO enhancement

Li, Y., Zhang, Y., Deng, Q., Mao, J., Jia, Z., Tang, M., Zhang, Y., Zhao, J., Chen, J., Wang, Y., et al. (2023) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2023.106363 · Cited by 5 · see citing works

Resveratrol (3,4ʹ,5-trihydroxy-trans-stilbene) or caffeic acid phenethyl ester supplementation prevents premature ovarian insufficiency due to chemotherapy

Erşahin, S. S. (2020) · Archives of Medical Science · doi:10.5114/aoms.2020.100668 · Cited by 3 · see citing works

2,4-Dinitrophenol is toxic on a low caloric diet but extends lifespan of Drosophila melanogaster on nutrient-rich diets without an impact on metabolism

Strilbytska, O. M., Semaniuk, U. V., Yurkevych, I. S., Berezovskyi, V., Glovyak, A., Gospodaryov, D. V., Bayliak, M. M., & Lushchak, O. V. (2024) · Biogerontology · doi:10.1007/s10522-024-10169-9 · Cited by 2 · see citing works

Better neuroprotective profile of caffeic acid phenyl ester over resveratrol in non-traumatic ischemia-reperfusion injury of the spinal cord

Aslan, E., Boyacı, M. G., Güzel, H., & Pektaş, M. B. (2021) · British Journal of Neurosurgery · doi:10.1080/02688697.2021.1999391 · Cited by 2 · see citing works

Phytochemicals from medicinal plants as alternative therapeutics for metabolic syndrome: A review of randomized controlled trials

Rad, M. S., Jamialahmadi, T., Kesharwani, P., & Sahebkar, A. (2025) · South African Journal of Botany · doi:10.1016/j.sajb.2025.08.017 · Cited by 2 · see citing works

Effects of Resveratrol on Cognitive Functions

Hühn, S., & Witte, A. V. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805376-8.00024-1 · Cited by 2 · see citing works

Chronic liquid fructose supplementation does not cause liver tumorigenesis but elicits clear sex differences in the metabolic response in Sprague–Dawley rats

Roglans, N., Baena, M., Sangüesa, G., Velázquez, A. M., Griñán‐Ferré, C., Pallàs, M., Sánchez, R. M., Alegret, M., & Laguna, J. C. (2021) · Food & Nutrition Research · doi:10.29219/fnr.v65.7670 · Cited by 2 · see citing works

Nuts

Capurso, A., Crepaldi, G., & Capurso, C. A. (2018) · Practical issues in geriatrics · doi:10.1007/978-3-319-78084-9_11 · Cited by 2 · see citing works

Hibernating Squirrels

Berkowitz, D. E., Steenbergen, C., & O'Rourke, B. P. (2016) · Anesthesiology · doi:10.1097/aln.0000000000001114 · Cited by 2 · see citing works

4′-Methoxyresveratrol Improves Hepatic Insulin Resistance Induced by a High-Fat-Diet via Anti-Oxidative-Stress Activity

Zhang, Z., Zhang, X., Yang, L., Nie, Q., & Song, G. (2025) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s535103 · Cited by 1 · see citing works

Novel therapeutic strategies targeting mitochondrial quality control for metabolic dysfunction-associated steatotic liver disease

Zuo, H., Chen, J., Jiao, Y., Ma, X., Li, X., Xiao, Y., He, J., Jia, Z., & Shi, A. (2026) · Frontiers in Physiology · doi:10.3389/fphys.2026.1803228 · Cited by 1 · see citing works

Resveratrol Causes Gender-dependent and Bardoxolone Methyl-like Effects in Patients with IgA Nephropathy: Pilot Study

Brasnyó, P., & Kovács, T. (2016) · Journal of Nutrition & Food Sciences · doi:10.4172/2155-9600.1000442 · Cited by 1 · see citing works

BIOLOGICAL EFFECTS AND PROPERTIES OF EUKARYOTIC SIRTUINS

Stupchuk, M. S., & Voznesenskaja, T. Y. (2017) · Fìzìologìčnij žurnal · doi:10.15407/fz63.04.105 · Cited by 1 · see citing works

Prevention of Murine Atherosclerosis with Bempedoic Acid

Samsoondar, J. P. (2016) · Scholarship@Western (Western University)

Resveratrol and obesity: can resveratrol relieve metabolic disturbances?

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Metabolic effects of resveratrol: experimental and human clinical aspects

Poulsen, M. M. (2013)

Resveratrol in metabolic health: an overview of the current evidence and perspectives

Poulsen, M. M., Jørgensen, J. O. L., Jessen, N., Richelsen, B., & Pedersen, S. B. (2013) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12141 · Cited by 95 · see citing works

Therapeutic potential of resveratrol in obesity and type 2 diabetes: new avenues for health benefits?

Timmers, S., Hesselink, M. K. C., & Schrauwen, P. (2013) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12185 · Cited by 93 · see citing works

Progress in the Preclinical and Clinical Study of Resveratrol for Vascular Metabolic Disease

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