The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Diacylglycerol Activation of Protein Kinase Cε and Hepatic Insulin Resistance
Open accessAbstract
Nonalcoholic fatty liver disease (NAFLD) is now the most frequent chronic liver disease in Western Societies, affecting one in four adults in the USA and is strongly associated with hepatic insulin resistance, a major risk factor in the pathogenesis of type 2 diabetes. Although the cellular mechanisms underlying this relationship are unknown, hepatic accumulation of diacylglycerol (DAG) in both animals and humans has been linked to hepatic insulin resistance. In this Perspective, we discuss the role of DAG activation of protein kinase Cε as the mechanism responsible for NAFLD-associated hepatic insulin resistance seen in obesity, type 2 diabetes and lipodystrophy.
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Cites
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Angulo, P. (2002) · New England Journal of Medicine · doi:10.1056/nejmra011775 · Cited by 5,228
Inflammation and insulin resistance
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Self-citationImpaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes
Petersen, K. F., Dufour, S., Befroy, D., Garcia, R., & Shulman, G. I. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031314 · Cited by 2,193
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Self-citationMechanism of hepatic insulin resistance in non-alcoholic fatty liver disease
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Self-citationGriffin, M. E., Marcucci, M. J., Cline, G. W., Bell, K., Barucci, N., Lee, D., Goodyear, L. J., Kraegen, E. W., White, M. F., & Shulman, G. I. (1999) · Diabetes · doi:10.2337/diabetes.48.6.1270 · Cited by 1,267
Self-citationLeptin-Replacement Therapy for Lipodystrophy
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Roles of diacylglycerols and ceramides in hepatic insulin resistance
Petersen, M. C., & Shulman, G. I. (2017) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2017.04.004 · Cited by 373
Self-citationScherer, P. E. (2016) · Diabetes · doi:10.2337/db16-0339 · Cited by 133
Somm, E., Montandon, S. A., Loizides-Mangold, U., Gaïa, N., Lazarevic, V., De Vito, C., Perroud, E., Bochaton-Piallat, M.-L., Dibner, C., Schrenzel, J., et al. (2021) · Translational Research · doi:10.1016/j.trsl.2020.07.008 · Cited by 118
Self-citationCimini, F. A., Barchetta, I., Carotti, S., Bertoccini, L., Baroni, M. G., Vespasiani-Gentilucci, U., Cavallo, M.-G., & Morini, S. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i19.3407 · Cited by 101
Lipid-mediated muscle insulin resistance: different fat, different pathways?
Ritter, O., Jelenik, T., & Roden, M. (2015) · Journal of Molecular Medicine · doi:10.1007/s00109-015-1310-2 · Cited by 74
Myeloid FoxO1 depletion attenuates hepatic inflammation and prevents nonalcoholic steatohepatitis
Lee, S., Usman, T. O., Yamauchi, J., Chhetri, G., Wang, X., Coudriet, G. M., Zhu, C., Gao, J., McConnell, R., Krantz, K., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci154333 · Cited by 64
Dalhaimer, P. (2019) · Cells · doi:10.3390/cells8090974 · Cited by 52
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Metadata
- Authors
- Jornayvaz, F. R., & Shulman, G. I.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2012-05
- Volume
- 15
- Issue
- 5
- Pages
- 574-584
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2087410169
- Cited by
- 317
- References
- 35
- FWCI
- 23.70
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
