Cited by 352Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic DiseasesLipid metabolism and biosynthesis

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The Adipose Tissue Microenvironment Regulates Depot-Specific Adipogenesis in Obesity

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Jeffery, Elise, Wing, Allison, Holtrup, Brandon, Sebo, Zachary, Kaplan, Jennifer L., Saavedra-Peña, Rocio, Church, Christopher D., Colman, Laura, Berry, Ryan, Rodeheffer, Matthew S.·2016·Cell Metabolism

DOI 10.1016/j.cmet.2016.05.012PMC PMC4945385

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Abstract

The sexually dimorphic distribution of adipose tissue influences the development of obesity-associated pathologies. The accumulation of visceral white adipose tissue (VWAT) that occurs in males is detrimental to metabolic health, while accumulation of subcutaneous adipose tissue (SWAT) seen in females may be protective. Here, we show that adipocyte hyperplasia contributes directly to the differential fat distribution between the sexes. In male mice, high-fat diet (HFD) induces adipogenesis specifically in VWAT, while in females HFD induces adipogenesis in both VWAT and SWAT in a sex hormone-dependent manner. We also show that the activation of adipocyte precursors (APs), which drives adipocyte hyperplasia in obesity, is regulated by the adipose depot microenvironment and not by cell-intrinsic mechanisms. These findings indicate that APs are plastic cells, which respond to both local and systemic signals that influence their differentiation potential independent of depot origin. Therefore, depot-specific AP niches coordinate adipose tissue growth and distribution.

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Authors: Jeffery, E., Wing, A., Holtrup, B., Sebo, Z., Kaplan, J. L., Saavedra-Peña, R., Church, C. D., Colman, L., Berry, R., & Rodeheffer, M. S.
Affiliations: Yale University (US)
Corresponding author: Rodeheffer, Matthew S.
ORCID: Wing, Allison
Holtrup, Brandon
Sebo, Zachary
Rodeheffer, Matthew S.
Venue: Cell Metabolism
Publisher: Elsevier BV
Published: 2016-07
Volume: 24
Issue: 1
Pages: 142-150
ISSN: 1550-4131 (ISSN-L)
DOI: 10.1016/j.cmet.2016.05.012
PMC: PMC4945385
OpenAlex: W2428513306
Semantic Scholar: 14d4836b147602658442b978ed95166249fdc6b9
Cited by: 352
References: 47
Citations by year: 2026: 21 · 2025: 36 · 2024: 44 · 2023: 27 · 2022: 36 · 2021: 38 · 2020: 38 · 2019: 36 · 2018: 33 · 2017: 37 · 2016: 6
FWCI: 30.06
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 376 d)
Locations: Cell Metabolism (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Yale University
National Institutes of Health (UL1TR001863)
National Institute of General Medical Sciences (T32GM007223)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK090489, R56DK090489, P30DK045735)
National Center for Advancing Translational Sciences
Topics: Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords: adipose tissue microenvironment, adipogenesis, obesity, sex differences, visceral white adipose tissue, subcutaneous white adipose tissue, adipocyte hyperplasia, adipocyte precursors, high-fat diet, sex hormones, adipose depots, body fat distribution
MeSH terms: Adipose Tissue, Animals, Female, Hyperplasia, Male, Obesity, Organ Size, Sex Characteristics, Adipocytes, Adipogenesis, Mice, Adipose Tissue, White, Diet, High-Fat

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The Adipose Tissue Microenvironment Regulates Depot-Specific Adipogenesis in Obesity

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