The DOI matches its Crossref record; 117 of the 117 references it cites were found in a registry or an index.
Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice
Open accessAbstract
Calorie restriction (CR) is the most robust non-genetic intervention to delay aging. However, there are a number of emerging experimental variables that alter CR responses. We investigated the role of sex, strain, and level of CR on health and survival in mice. CR did not always correlate with lifespan extension, although it consistently improved health across strains and sexes. Transcriptional and metabolomics changes driven by CR in liver indicated anaplerotic filling of the Krebs cycle together with fatty acid fueling of mitochondria. CR prevented age-associated decline in the liver proteostasis network while increasing mitochondrial number, preserving mitochondrial ultrastructure and function with age. Abrogation of mitochondrial function negated life-prolonging effects of CR in yeast and worms. Our data illustrate the complexity of CR in the context of aging, with a clear separation of outcomes related to health and survival, highlighting complexities of translation of CR into human interventions.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“However, dietary restriction regimens do not extend lifespan in all mouse strains, supporting the contention that they must be adapted to the genetic makeup of each individual 151 .”
From Hallmarks of aging: An expanding universe (2023) · cites this paper as [151]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.
Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., & Yoshimori, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5720 · Cited by 6,605 · cited 1×
“Analysis of steady-state levels of LC3-II, the most commonly used marker to measure autophagic compartments (Kabeya et al., 2000), revealed that 40% CR significantly increased levels of LC3-II in B6 mice when compared to 20% CR (Figures 5E and 5F).”
BackgroundCui, C., Cui, J., Jin, F., Cui, Y., Li, R., Jiang, X., Tian, Y., Wang, R. C., Jiang, P., & Gao, J. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479571 · Cited by 5,214
Flegal, K. M., Kit, B. K., Orpana, H., & Graubard, B. I. (2013) · JAMA · doi:10.1001/jama.2012.113905 · Cited by 3,998 · cited 1×
“Indeed, recent work has shown in humans that slight overweight is associated with the lowest level of all-cause mortality (Flegal et al., 2013; Grabowski and Ellis, 2001).”
Autophagy regulates lipid metabolism
Singh, R., Kaushik, S., Wang, Y., Xiang, Y., Novak, I., Komatsu, M., Tanaka, K., Cuervo, A. M., & Czaja, M. J. (2009) · Nature · doi:10.1038/nature07976 · Cited by 3,975 · cited 3×
“Interestingly, all CR livers displayed a significant increase in lipid droplets withmorphological signatures of lipophagy (Singh et al., 2009), which was rarely observed in the AL groups (Figures S4H and S4M).”
BackgroundInfluentialSelf-citationSuppression of basal autophagy in neural cells causes neurodegenerative disease in mice
Hara, T., Nakamura, K., Matsui, M., Yamamoto, A., Nakahara, Y., Suzuki-Migishima, R., Yokoyama, M., Mishima, K., Saito, I., Okano, H., et al. (2006) · Nature · doi:10.1038/nature04724 · Cited by 3,882 · cited 1×
“Ubiquitinated proteins are amenable to degradation via macroautophagy, and blockage of this pathway leads to intracellular accumulation of K48- and K63-positive aggregates (Hara et al., 2006; Olzmann and Chin, 2008; Tan et al., 2008).”
BackgroundRapamycin fed late in life extends lifespan in genetically heterogeneous mice
Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766 · cited 1×
“Not surprisingly, most of these interventions have strain-, diet-, and sex-specific effects on health and survival in mice (Anisimov et al., 2008; Harrison et al., 2009, 2014; Martin-Montalvo et al., 2013; Miller et al., 2011, 2014; Pearson et al., 2008a; Strong et al., 2008, 2013).”
BackgroundFission and selective fusion govern mitochondrial segregation and elimination by autophagy
Twig, G., Elorza, A., Molina, A. J. A., Mohamed, H., Wikstrom, J. D., Walzer, G., Stiles, L., Haigh, S. E., Katz, S., Las, G., et al. (2008) · The EMBO Journal · doi:10.1038/sj.emboj.7601963 · Cited by 3,082 · cited 1×
“Whereas all CR groups showed reducedmitochondria circularity, suggestive of reducedmitophagy, only some of them displayed enhanced lipophagy (Gomes et al., 2011; Twig et al., 2008).”
BackgroundCaloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys
Colman, R. J., Anderson, R. M., Johnson, S. C., Kastman, E. K., Kosmatka, K. J., Beasley, T. M., Allison, D. B., Cruzen, C., Simmons, H. A., Kemnitz, J. W., et al. (2009) · Science · doi:10.1126/science.1173635 · Cited by 2,277 · cited 3×
“This uncoupling of lifespan/health span benefits by CR has been reported in earlier studies in mice and non-human primates (Colman et al., 2009; Mattison et al., 2012; Rikke and Johnson, 2007; Turturro and Hart, 1991).”
ResultThe Effect of Retarded Growth Upon the Length of Life Span and Upon the Ultimate Body Size
McCay, C. M., Crowell, M. F., & Maynard, L. A. (1935) · The Journal of Nutrition · doi:10.1093/jn/10.1.63 · Cited by 2,264 · cited 2×
“, 1917) and then McCay and colleagues reported the lifespan effects of calorie-restricted diet in rats (McCay et al., 1935).”
BackgroundDuring autophagy mitochondria elongate, are spared from degradation and sustain cell viability
Gomes, L. C., Benedetto, G. D., & Scorrano, L. (2011) · Nature Cell Biology · doi:10.1038/ncb2220 · Cited by 1,735 · cited 3×
“It has been shown that mitochondrial shape is closely related to mitophagy in such a way that elongated mitochondria are preserved from mitophagy (Gomes et al., 2011).”
Background
Flagged first, then by citations
Research works printed but not linked: 1
- Moreschi, 1909, Beziehungen zwischen ernährung und tumorwachstum, Zeitschrift f Immunitätsforschung Originale, 2, 651
Cited by
Sorted by citations
Items 401–452 of 452
Hahn, O., Drews, L. F., Nguyen, A., Tatsuta, T., Gkioni, L., Hendrich, O., Zhang, Q., Langer, T., Pletcher, S. D., Wakelam, M. J. O., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/730853 · Cited by 1
Dutta, S., Heintz, C., Pérez-Matos, M. C., Mutlu, A. S., Piper, M. E., Mistry, M., Sharma, A., Smith, H. J., Howell, P. R., Sehgal, R., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.11.01.466772 · Cited by 1
Editorial: Nutrition and metabolic aging
Wahl, D., & Clayton, Z. S. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1191958 · Cited by 1
“Perhaps the most robust nutritional intervention to reduce age-associated disease and increase healthspan in pre-clinical models is calorie restriction (CR) (2), a reduction in total caloric intake by 10–50% without malnutrition (3).”
BackgroundEditorial: Special issue cellular aging
Zwerschke, W. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.111065
Dietary Protein and Muscle in Aging People
Cesari, M., & Marzetti, E. (2018) · MDPI eBooks · doi:10.3390/books978-3-03897-458-1
Nutritional Aspect of Sex-Dependent Difference in Heart Disease
Shah, A. K., Kim, A., & Adase, C. (2020) · Springer eBooks · doi:10.1007/978-3-030-58677-5_12
Glucose supplementation impacts lifespan and immunity in Drosophila melanogaster
Galenza, A. (2020) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3-vcpw-fj52
Diet effects on mouse meiotic recombination: a warning for recombination studiesPreprint
Belmonte-Tebar, A., Perez, E. S. M., Nam‐Cha, S. H., Soler, A. J., Singh, N. D., & de la Casa‐Esperón, E. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.12.443881
Weiss, L. M. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733689125.793562572
Cuervo, A. M., & Kaushik, S. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733512731.793549142
Spurious intragenic transcription is a hallmark of mammalian cellular senescence and tissue agingPreprint
Sen, P., Donahue, G., Li, C., Lan, Y., Egervári, G., Robertson, N., Shah, P. P., Kerkhoven, E., Schultz, D., Adams, P. D., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.20.492816
Na, E., Jeon, Y., Kim, H.-J., Kim, H., Lee, K., & Kim, H. J. (2022) · Research Square · doi:10.21203/rs.3.rs-1675650/v1
Aging principles and interventional perspectives
Sikora, E. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90581-7.00002-5
Nodweddu effaith signalu ghrelin-GHS-R ar awtoffagi niwronaidd
Roberts, L. D. (2022) · Cronfa (Swansea University) · doi:10.23889/suthesis.62285
Regulation of fetal brain development in short versus long lived mice
Islam, M. (2022) · MOspace Institutional Repository (University of Missouri) · doi:10.32469/10355/94012
Sexual Dysfunctions, Gender Dysphoria, and Paraphilic Disorders
Gnanapragasam, S., Scott, F., & Bhugra, D. K. (2023) · Springer eBooks · doi:10.1007/978-3-031-15401-0_22
Extended lifespan in female Drosophila melanogaster through late-life caloric restrictionPreprint
Li, M., Macro, J., Huggins, B., Meadows, K., Mishra, D., Martin, D., & Rogina, B. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.13.548896
Experimental precision medicine: Mouse models to test precision medicine
Ashbrook, D. G. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-824010-6.00057-5
Sex dimorphism in the aged metabolic phenotype of smoothelin-like 1 (SMTNL1) deficient micePreprint
Murali, M., Alabi, N., Chelikani, P. K., & MacDonald, J. A. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.19.558520
Sex-specific resilience of neocortex to food restrictionPreprint
Padamsey, Z., Katsanevaki, D., Maeso, P. A., Rizzi, M., Osterweil, E. K., & Rochefort, N. L. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.06.561185
eLife Assessment: Sex-specific resilience of neocortex to food restriction
Bathellier, B. (2023) · eLife · doi:10.7554/elife.93052.1.sa3
Sex-specific resilience of neocortex to food restrictionPreprint
Padamsey, Z., Katsanevaki, D., Maeso, P. A., Rizzi, M., Osterweil, E. K., & Rochefort, N. L. (2023) · eLife · doi:10.7554/elife.93052.1
Lopez-Guadamillas, E. (2024) · Springer eBooks · doi:10.1007/978-3-031-47620-4_6
Science and Sex: A Bold Agenda for Women’s Health
Johnson, P. A. (2024) · NAM Perspectives · doi:10.31478/202401a
Sex differences in brain aging
Goyal, M. S., Gordon, B. A., & Resnick, S. M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-12-820480-1.00090-5
Gong, H., Zhang, M., Han, Y., Zhang, Y., Pang, J., Zhao, Y., Chen, B., Wu, W., Qi, R., & Zhang, T. (2021) · Figshare · doi:10.6084/m9.figshare.14252227
Sex-specific resilience of neocortex to food restrictionPreprint
Padamsey, Z., Katsanevaki, D., Maeso, P. A., Rizzi, M., Osterweil, E. K., & Rochefort, N. L. (2024) · eLife · doi:10.7554/elife.93052.2
Neuromuscular Signal Transmission
Myers, C. (2024) · Springer eBooks · doi:10.1007/978-3-031-47065-3_5
Sinigaglia, G., Zanini, G., Selleri, V., & Pinti, M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15260-3.00022-3
Wu, P., Vandemeulebroucke, L., Guiritan, K. R. A., & Braeckman, B. P. (2025) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaf129
Pappert, F. A., Newrzella, N., & Roth, O. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.30.662305
“Such sex-specific responses are conserved across taxa: in mice, for instance, males tend to preserve muscle and bone by mobilizing fat stores, while females resist fat loss and instead catabolize lean mass, often alongside reproductive suppression (71,72).”
Standardizing caloric restriction for preclinical cancer research
Jacoby, J. L., Aparicio, A. C., François, N., Thapar, M., Burke, S. E., Xu, S., DeAngelis, T., Shastri, A. A., Tran, P. T., & Simone, N. L. (2025) · BioTechniques · doi:10.1080/07366205.2025.2577029
Pappert, F. A., Newrzella, N., & Roth, O. (2026) · BMC Biology · doi:10.1186/s12915-026-02509-7
“Such sex-specific responses are conserved across taxa: in mice, for instance, males tend to preserve muscle and bone by mobilizing fat stores, while females resist fat loss and instead catabolize lean mass, often alongside reproductive suppression [63, 64].”
Moore, M. N. (2026) · Journal of the Marine Biological Association of the United Kingdom · doi:10.1017/s0025315426101180
“Autophagy is a cellular waste removal and recycling process that is activated in response to various types of metabolic stress and including nutrient deprivation, as well as exposure to toxic metals and xenobiotics causing generation of ROS, growth factor depletion, and hypoxia (Cuervo, 2004, 2008; Moore, 2004; Yen an…”
InfluentialGenetic regulation of fasting-induced longevity effects
Luciano, A., Robinson, L. L., Schott, W. H., West, A. P., Korstanje, R., & Churchill, G. A. (2026) · Genetics · doi:10.1093/genetics/iyag045
“…that genetic background modulates dietary effects on lifespan (Rikke et al. 2003; Yuan et al. 2009; Liao et al. 2010; Rikke et al. 2010; Yuan et al. 2012; Mitchell et al. 2016; Yuan et al. 2020; Mulvey et al. 2021; Roy et al. 2021; Unnikrishnan et al. 2021; Wright et al. 2022; Zhang et al. 2022).”
Cambraia, A., Schleh, M. W., Cartailler, J. P., Cutler, M., dos Santos, C., Many, G. M., Kim, H., Kim, Y., Nakayasu, E. S., Mogilenko, D. A., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.15.705935
Marin-Jerez, E., Rueda‐Carrasco, J., Melendez-Rodriguez, F., Partido-Borge, P., Tapia, E., Leibowitz, B. D., & Parras, A. (2026) · Research Square · doi:10.21203/rs.3.rs-9682683/v1
Rusu, P. M., Aung, O. H., Chan, A. Y., Wu, Y., Cleofe, M. A. S., Trewin, A. J., Giri, S., Foollee, A., flores, S., Lemus, M. B., et al. (2026) · Journal of sport and health science/Journal of Sport and Health Science · doi:10.1016/j.jshs.2026.101132
“48,49 Nonetheless, it is already established that DPD inconsistently induces energy expenditure and reduces body weight and in male mice across various strains, 10,11 yet whether the effects on movement economy differ according to body weight changes between strains remains unknown.”
Sex differences in response to longevity interventions
Hajdarovic, K. H., Riddle, N. C., & Webb, A. E. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103123 · Cited by 1
The Elucidation of Hydrogen Sulfide Signalling Through Persulfidation
Kouroussis, E. (2019) · theses.fr (ABES) · doi:10.70675/7d7beb54z2f84z43cdz8a1fz2342abbe3731
山原, 康., 久米, 真., 古家, 大., 山原, 真., 武田, 尚., 大澤, 紀., 金崎, 雅., 前川, 聡., 荒木, 信., Yoshida, S., et al. (2018) · Institutional Repositories DataBase (IRDB)
Wang, H., Hao, J., & Cartee, G. D. (2026) · The Journals of Gerontology Series A · doi:10.1093/gerona/glag144
Pfabe, J. U., Cambraia, A., Dadi, P. K., Cutler, M., dos Santos, C., Acree, C., Habashy, A., Perkins, G. A., Ellisman, M. H., Jacobson, D. A., et al. (2026) · Cell Calcium · doi:10.1016/j.ceca.2026.103161 · Cited by 1
Cryptic transcription in aging
Wu, D., Nguyen, B. P., Zholdybayeva, E., & Liu, J. (2026) · iScience · doi:10.1016/j.isci.2026.116915
Burke, S. J., Galvin, D. M., Nolan, Y. M., Schellekens, H., & Henry, R. J. (2026) · Neurotrauma Reports · doi:10.1177/2689288x261456994
“247 It is likely that sex, diet composition, and also genetic background are important considerations when employing and interpreting dietary restriction feeding regimens.”
Zhao, Y., Zhang, J., Liu, C., Wang, C., Shao, X., Xu, X., & Wang, C. (2026) · Comparative Biochemistry and Physiology Part D Genomics and Proteomics · doi:10.1016/j.cbd.2026.101972
Whitehead, N. N., Schwartz, N. E., Jiang, C., Read, H. M., Holt, N. C., & Garland, T. (2026) · Behavior Genetics · doi:10.1007/s10519-026-10277-x
“Under ad libitum feeding, as in the present study, sex differences in lifespan sometimes occur, but they vary by strain and with conditions (Mitchell et al. 2016; Cheng et al. 2019; e.g., see Baumann et al. 2019; Yuan et al. 2020; Garratt et al. 2020, 2021; Félix et al. 2025 ).”
Sex-specific effects of automated feeding on lifespan and reproduction in Nothobranchius furzeri
Dolfi, L., Kothmayer, M., Ebner, E. E., Löhnert, R., & Pusch, O. (2026) · Frontiers in Aging · doi:10.3389/fragi.2026.1869084
“These findings deviate from existing literature on killifish, where an ad libitum diet showed no impact on female lifespan (McKay et al., 2022), and in mice (Mitchell et al., 2016; Liao et al., 2010), where only or primarily male lifespan was affected by diet.”
Complementary fish models for brain ageing: insights from killifish and zebrafish
Leggieri, A., & Bähler, J. (2026) · Essays in Biochemistry · doi:10.1042/ebc20260052
Chaperone-mediated autophagy in physiological homeostasis, disease and ageing
Kaushik, S., & Cuervo, A. M. (2026) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-026-01023-6
Metadata
- Authors
- Mitchell, S. J., Madrigal-Matute, J., Scheibye-Knudsen, M., Fang, E., Aon, M., González-Reyes, J. A., Cortassa, S., Kaushik, S., Gonzalez-Freire, M., Patel, B., Wahl, D., Ali, A., Calvo-Rubio, M., Burón, M. I., Guiterrez, V., Ward, T. M., Palacios, H. H., Cai, H., Frederick, D. W., Hine, C., Broeskamp, F., Habering, L., Dawson, J., Beasley, T. M., Wan, J., Ikeno, Y., Hubbard, G., Becker, K. G., Zhang, Y., Bohr, V. A., Longo, D. L., Navas, P., Ferrucci, L., Sinclair, D. A., Cohen, P., Egan, J. M., Mitchell, J. R., Baur, J. A., Allison, D. B., Anson, R. M., Villalba, J. M., Madeo, F., Cuervo, A. M., Pearson, K. J., Ingram, D. K., Bernier, M., & de Cabo, R.
- Affiliations
- National Institutes of Health (US)
- University of Córdoba (ES)
- Albert Einstein College of Medicine (US)
- University of Pennsylvania (US)
- Harvard University (US)
- University of Graz (AT)
- University of Alabama (US)
- University of Southern California (US)
- The University of Texas at San Antonio Health Science Center (US)
- Pennington Biomedical Research Center (US)
- ORCID
- Mitchell, Sarah J.
- Fang, Evandro
- Aon, Miguel
- González-Reyes, José A.
- Cortassa, Sonia
- Kaushik, Susmita
- Wahl, Devin
- Burón, María I.
- Palacios, Hector H.
- Cai, Huan
- Hine, Christopher
- Broeskamp, Filomena
- Dawson, John
- Beasley, T. Mark
- Wan, Junxiang
- Ikeno, Yuji
- Becker, Kevin G.
- Zhang, Yongqing
- Bohr, Vilhelm A.
- Ferrucci, Luigi
- Sinclair, David A.
- Cohen, Pinchas
- Egan, Josephine M.
- Mitchell, James R.
- Baur, Joseph A.
- Allison, David B.
- Anson, R. Michael
- Villalba, José M.
- Madeo, Frank
- Pearson, Kevin J.
- Ingram, Donald K.
- Bernier, Michel
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2016-06
- Volume
- 23
- Issue
- 6
- Pages
- 1093-1112
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC4911707
- OpenAlex
- W2421296032
- Cited by
- 451
- References
- 117
- Citations by year
- 2026: 28 · 2025: 37 · 2024: 45 · 2023: 51 · 2022: 56 · 2021: 57 · 2020: 44 · 2019: 38 · 2018: 50 · 2017: 37 · 2016: 8
- FWCI
- 23.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Deposito Digital UFV (Francisco de Vitoria University) (submittedVersion, cc-by-nc-nd)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Repository of Digital Objects for Teaching Research and Culture (University of Valencia) (submittedVersion, other-oa)
- Funders
- American Diabetes Association (1-15-MI-03)
- Austrian Science Fund (P 24381, P 27893, I1000, P29203)
- Bundesministerium für Wissenschaft, Forschung und Wirtschaft
- National Institutes of Health (AG031782, AG038072)
- National Institute on Aging (AG-04-3483, P01AG034906, R01AG043483, P01AG031782, AG031782, P30AG038072, AG038072, P30AG013319, ZIAAG000368)
- National Institute of General Medical Sciences (R01GM090311)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK041296, P30DK020541, R01DK098656, P30DK079626)
- National Institute of Environmental Health Sciences (R01ES020812, P30ES013508)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Keywords
- caloric restriction, aging, sex differences, mouse strains, lifespan extension, healthspan, mitochondrial function, fatty acid metabolism, mitochondrial ultrastructure, metabolomics, gene expression changes
- MeSH terms
- Aging, Animals, Autophagy, Energy Intake, Female, Gene Expression Regulation, Glucose, Homeostasis, Hydrogen Sulfide, Islets of Langerhans, Liver, Longevity, Male, Mice, Inbred Strains, Mitochondria, Phenotype, Sex Characteristics, Biomarkers, Cluster Analysis, Gene Expression Profiling, Ubiquitin, Caloric Restriction, Proteasome Endopeptidase Complex, Mice, Metabolomics, Metabolome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
