Cited by 529Phagocytosis and Immune RegulationCell death mechanisms and regulationAutophagy in Disease and Therapy

The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.

Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury

Open access

Yurdagul, Arif, Subramanian, Manikandan, Wang, Xiaobo, Crown, Scott B., Ilkayeva, Olga R., Darville, Lancia, Kolluru, Gopi K., Rymond, Christina C., Gerlach, Brennan D., Zheng, Ze, Kuriakose, George, Kevil, Christopher G., Koomen, John M., Cleveland, John L., Muoio, Deborah M., Tabas, Ira·2020·Cell Metabolism

DOI 10.1016/j.cmet.2020.01.001PMC PMC7173557

Open this paper in CoChat — free account Open PDF

Abstract

Continual efferocytic clearance of apoptotic cells (ACs) by macrophages prevents necrosis and promotes injury resolution. How continual efferocytosis is promoted is not clear. Here, we show that the process is optimized by linking the metabolism of engulfed cargo from initial efferocytic events to subsequent rounds. We found that continual efferocytosis is enhanced by the metabolism of AC-derived arginine and ornithine to putrescine by macrophage arginase 1 (Arg1) and ornithine decarboxylase (ODC). Putrescine augments HuR-mediated stabilization of the mRNA encoding the GTP-exchange factor Dbl, which activates actin-regulating Rac1 to facilitate subsequent rounds of AC internalization. Inhibition of any step along this pathway after first-AC uptake suppresses second-AC internalization, whereas putrescine addition rescues this defect. Mice lacking myeloid Arg1 or ODC have defects in efferocytosis in vivo and in atherosclerosis regression, while treatment with putrescine promotes atherosclerosis resolution. Thus, macrophage metabolism of AC-derived metabolites allows for optimal continual efferocytosis and resolution of injury.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.cmet.2020.01.001

Cites

70 of 70 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Fiji: an open-source platform for biological-image analysis
Schindelin, J., Arganda-Carreras, I., Frise, E., Kaynig, V., Longair, M., Pietzsch, T., Preibisch, S., Rueden, C., Saalfeld, S., Schmid, B., et al. (2012) · Nature Methods · doi:10.1038/nmeth.2019 · Cited by 66,890
Macrophages in Tissue Repair, Regeneration, and Fibrosis
Wynn, T. A., & Vannella, K. M. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.015 · Cited by 4,481
Alternative Activation of Macrophages: An Immunologic Functional Perspective
Martinez, F. O., Helming, L., & Gordon, S. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132532 · Cited by 2,745
Conditional gene targeting in macrophages and granulocytes using LysMcre mice
Clausen, B. E., Burkhardt, C., Reith, W., Renkawitz, R., & Förster, I. (1999) · Transgenic Research · doi:10.1023/a:1008942828960 · Cited by 2,098
Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities
Bäck, M., Yurdagul, A., Tabas, I., Öörni, K., & Kovanen, P. T. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0169-2 · Cited by 1,341
Self-citation
Metabolism via Arginase or Nitric Oxide Synthase: Two Competing Arginine Pathways in Macrophages
Rath, M., ller, I. M. ⁄., Kropf, P., Closs, E. I., & Munder, M. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00532 · Cited by 1,332
HuR and mRNA stability
Brennan, C. M., & Steitz*, J. A. (2001) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000854 · Cited by 1,095
Phagocytosis of apoptotic cells in homeostasis
Arandjelovic, S., & Ravichandran, K. S. (2015) · Nature Immunology · doi:10.1038/ni.3253 · Cited by 959
Arginase-1–Expressing Macrophages Suppress Th2 Cytokine–Driven Inflammation and Fibrosis
Pesce, J. T., Ramalingam, T. R., Mentink-Kane, M. M., Wilson, M. S., El Kasmi, K. C., Smith, A. M., Thompson, R. W., Cheever, A. W., Murray, P. J., & Wynn, T. A. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000371 · Cited by 816
Apoptotic Cells Promote Their Own Clearance and Immune Tolerance through Activation of the Nuclear Receptor LXR
A-González, N., Bensinger, S. J., Hong, C., Beceiro, S., Bradley, M. N., Zelcer, N., Deniz, J. M., Ramírez, C. M., Díaz, M., Gallardo, G., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.06.018 · Cited by 703

Flagged first, then by citations

Show all 70 references

Sorted by citations

Items 101–200 of 529

Enhancement of efferocytosis through biased FPR2 signaling attenuates intestinal inflammation
Wu, M., Ge, Y., Wang, E., Liao, Q., Ren, Z., Yu, Y., Zhu, G., Liu, C., Zhang, M., Su, H., et al. (2023) · EMBO Molecular Medicine · doi:10.15252/emmm.202317815 · Cited by 42
Biomaterials that passively and actively target macrophages promote the regeneration of injured tissues
Zhuang, P., Wu, Y., Chen, Y., Zhang, Y., Leboucher, C., Rosenholm, J. M., & Zhang, H. (2024) · Biomedical Technology · doi:10.1016/j.bmt.2024.09.005 · Cited by 46
Metabolic Consequences of Efferocytosis and Its Impact on Atherosclerosis
Yurdagul, A. (2021) · Immunometabolism · doi:10.20900/immunometab20210017 · Cited by 41
Self-citation
Rapid unleashing of macrophage efferocytic capacity via transcriptional pause release
Tufan, T., Cömertpay, G., Villani, A., Nelson, G. M., Terekhova, M., Kelley, S. M., Zakharov, P. N., Ellison, R. M., Shpynov, O., Raymond, M. H., et al. (2024) · Nature · doi:10.1038/s41586-024-07172-y · Cited by 41
An update on ox-LDL-inducing vascular smooth muscle cell-derived foam cells in atherosclerosis
Guo, J., & Du, L. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1481505 · Cited by 44
The interplay between nonalcoholic fatty liver disease and atherosclerotic cardiovascular disease
Finney, A. C., Das, S., Kumar, D., McKinney, M. P., Cai, B., Yurdagul, A., & Rom, O. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1116861 · Cited by 40
Self-citation
Dead cell and debris clearance in the atherosclerotic plaque: Mechanisms and therapeutic opportunities to promote inflammation resolution
Dhawan, U. K., Singhal, A., & Subramanian, M. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105699 · Cited by 41
Self-citation
Hepatocyte SGK1 activated by hepatic ischemia-reperfusion promotes the recurrence of liver metastasis via IL-6/STAT3
Li, X., Wang, Z., Jiao, C., Zhang, Y., Xia, N. L., Yu, W., Chen, X., Wikana, L. P., Liu, Y., Sun, L., et al. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-03977-z · Cited by 43
MSCs mediate long-term efficacy in a Crohn’s disease model by sustained anti-inflammatory macrophage programming via efferocytosis
Dave, M., Dev, A., Somoza, R. A., Zhao, N., Viswanath, S. E., Mina, P. R., Chirra, P. V., Obmann, V. C., Mahabeleshwar, G. H., Menghini, P., et al. (2024) · npj Regenerative Medicine · doi:10.1038/s41536-024-00347-1 · Cited by 44
Myeloid Trem2 ameliorates the progression of metabolic dysfunction-associated steatotic liver disease by regulating macrophage pyroptosis and inflammation resolution
Yu, W., Zhang, Y., Sun, L., Huang, W., Li, X., Xia, N. L., Chen, X., Wikana, L. P., Xiao, Y., Chen, M., et al. (2024) · Metabolism · doi:10.1016/j.metabol.2024.155911 · Cited by 43
Macrophage LRP1 (Low-Density Lipoprotein Receptor-Related Protein 1) Is Required for the Effect of CD47 Blockade on Efferocytosis and Atherogenesis—Brief Report
Mueller, P. A., Kojima, Y., Huynh, K. T., Maldonado, R. A., Ye, J., Tavori, H., Pamir, N., Leeper, N. J., & Fazio, S. (2021) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.121.316854 · Cited by 40
Therapeutic induction of energy metabolism reduces neural tissue damage and increases microglia activation in severe spinal cord injury
Dolci, S., Mannino, L., Bottani, E., Campanelli, A., Chio, M. D., Zorzin, S., D’Arrigo, G., Amenta, A., Segala, A., Paglia, G., et al. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106149 · Cited by 39
Lighting up arginine metabolism reveals its functional diversity in physiology and pathology
Li, R., Li, Y., Jiang, K., Zhang, L., Li, T., Zhao, A., Zhang, Z., Xia, Y., Ge, K., Chen, Y., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.09.011 · Cited by 41
Efferocytosis in multisystem diseases (Review)
Zhang, Y., Wang, Y., Ding, J., & Liu, P. (2021) · Molecular Medicine Reports · doi:10.3892/mmr.2021.12529 · Cited by 38
New insight into arginine and tryptophan metabolism in macrophage activation during tuberculosis
Zhang, K., Mishra, A., & Jagannath, C. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1363938 · Cited by 40
Dys-regulated phosphatidylserine externalization as a cell intrinsic immune escape mechanism in cancer
Pulica, R., Aquib, A., Varsanyi, C., Gadiyar, V., Wang, Z., Frederick, T., Calianese, D. C., Patel, B., de Dios, K. V., Poalasin, V., et al. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02090-6 · Cited by 41
Metabolic adaptations of cells at the vascular-immune interface during atherosclerosis
Bonacina, F., Dalt, L. D., Catapano, A. L., & Norata, G. D. (2020) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2020.100918 · Cited by 37
Adipose Tissue Immunometabolism and Apoptotic Cell Clearance
Rőszer, T. (2021) · Cells · doi:10.3390/cells10092288 · Cited by 41
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease
Zhang, J., Ding, W. B., Zhao, M., Liu, J., Xu, Y., Wan, J., & Wang, M. (2022) · British Journal of Pharmacology · doi:10.1111/bph.15939 · Cited by 38
Loss of selenoprotein W in murine macrophages alters the hierarchy of selenoprotein expression, redox tone, and mitochondrial functions during inflammation
Misra, S., Lee, T.-J., Sebastian, A., McGuigan, J., Liao, C., Koo, I., Patterson, A. D., Rossi, R. M., Hall, M. A., Albert, I. U., et al. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102571 · Cited by 36
Protocatechuic acid boosts continual efferocytosis in macrophages by derepressing KLF4 to transcriptionally activate MerTK
Li, Q., Liu, X., Du, Y., Zhang, X., Xiang, P., Chen, G., Ling, W., & Wang, D. (2023) · Science Signaling · doi:10.1126/scisignal.abn1372 · Cited by 36
RETRACTED: Endogenous H2S targets mitochondria to promote continual phagocytosis of erythrocytes by microglia after intracerebral hemorrhage
Yan, X., He, M., Huang, H., Wang, Q., Hu, Y., Wang, X., Jin, M., Wang, Y., Xia, Y., Li, Y., et al. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102442 · Cited by 37
Self-citation
Retracted
Harnessing metabolism of hepatic macrophages to aid liver regeneration
Liu, R., Scimeca, M., Sun, Q., Melino, G., Mauriello, A., Shao, C., Bernassola, F., Bove, P., Candi, E., Valentina, R., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06066-7 · Cited by 38
Molecular dynamics of inflammation resolution: therapeutic implications
Soliman, A. M., Soliman, M. M., Shah, S. S. H., Baig, H. A., Gouda, N. S., Alenezi, B. T., Alenezy, A. K., Hegazy, A. M. S., Jan, M., & Abdalla, E. H. E. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1600149 · Cited by 39
Erythrophagocytosis by Microglia/Macrophage in Intracerebral Hemorrhage: From Mechanisms to Translation
Liu, J., Zhu, Z., & Leung, G. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.818602 · Cited by 35
Specialized pro‐resolving mediators enhance the clearance of dead cells
Fredman, G., & Khan, S. (2023) · Immunological Reviews · doi:10.1111/imr.13278 · Cited by 35
The Role of Amino Acid Metabolism of Tumor Associated Macrophages in the Development of Colorectal Cancer
Jiang, M., Cui, H., Liu, Z., Zhou, X., Zhang, L., Cao, L., & Wang, M. (2022) · Cells · doi:10.3390/cells11244106 · Cited by 34
Photothermal Microneedle Hydrogel Patch for Refractory Soft Tissue Injuries through Thermosensitized Anti‐Inflammaging Modulation
Zhu, W., Liu, Q., Zhang, Z., Wang, Y., Mei, J., Xu, D., Zhou, J. Y., Su, Z., Zhang, X., Zhu, C., et al. (2024) · Small Structures · doi:10.1002/sstr.202400014 · Cited by 33
Immunometabolism in atherosclerosis: a new understanding of an old disease
Certo, M., Rahimzadeh, M., & Mauro, C. (2024) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2024.06.003 · Cited by 40
The Atherosclerotic Plaque Microenvironment as a Therapeutic Target
Pandit, R., & Yurdagul, A. (2025) · Current Atherosclerosis Reports · doi:10.1007/s11883-025-01294-y · Cited by 35
Self-citation
Integration of transcriptional and metabolic control in macrophage activation
Natoli, G., Pileri, F., Gualdrini, F., & Ghisletti, S. (2021) · EMBO Reports · doi:10.15252/embr.202153251 · Cited by 33
Mechanisms of continual efferocytosis by macrophages and its role in mitigating atherosclerosis
Kumar, D., Pandit, R., & Yurdagul, A. (2023) · Immunometabolism · doi:10.1097/in9.0000000000000017 · Cited by 37
Self-citation
Comparative brain metabolomics reveals shared and distinct metabolic alterations in Alzheimer's disease and progressive supranuclear palsy
Batra, R., Krumsiek, J., Wang, X., Allen, M., Blach, C., Kastenmüller, G., Arnold, M., Ertekin‐Taner, N., & Kaddurah‐Daouk, R. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14249 · Cited by 36
Self-citation
The efferocytosis dilemma: how neutrophil extracellular traps and PI3K/Rac1 complicate diabetic wound healing
Xie, Y., Yang, J., Zhu, H., Yang, R., & Fan, Y. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02092-4 · Cited by 37
Microneedles Loaded with Nitric-Oxide Driven Nanomotors Improve Force-Induced Efferocytosis Impairment and Sterile Inflammation by Revitalizing Macrophage Energy Metabolism
Tan, H., Wang, S., He, X., Yang, G., Zhu, Y., Yang, S., Yan, S., Gong, C., Bai, W., Hu, Y. Y., et al. (2025) · ACS Nano · doi:10.1021/acsnano.5c01877 · Cited by 33
Toward the Characterization of Human Pro-Resolving Macrophages?
Saas, P., Chagué, C., Maraux, M., & Cherrier, T. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.593300 · Cited by 34
Efferocytosis: Unveiling its potential in autoimmune disease and treatment strategies
Xing, J., Wang, K., Xu, Y.-C., Pei, Z.-J., Yu, Q., Liu, X., Dong, Y.-L., Li, S., Chen, Y., Zhao, Y., et al. (2024) · Autoimmunity Reviews · doi:10.1016/j.autrev.2024.103578 · Cited by 31
Role of Apoptotic Cell Clearance in Pneumonia and Inflammatory Lung Disease
Zheng, D. J., Taka, M. A., & Heit, B. (2021) · Pathogens · doi:10.3390/pathogens10020134 · Cited by 32
Fate and long-lasting therapeutic effects of mesenchymal stromal/stem-like cells: mechanistic insights
Hoseinzadeh, A., Esmaeili, S., Sahebi, R., Melak, A. M., Mahmoudi, M., Hasannia, M., & Baharlou, R. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04158-z · Cited by 36
Sulforaphane promotes diabetic wound healing by regulating macrophage efferocytosis and polarization
Huang, Y., Wang, B., Ma, Z., Chen, T., Zou, H., Chen, Y., Dong, Z. F., Chen, J., Zhang, H., Ding, Y., et al. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114243 · Cited by 31
Age-Related Impairments in Immune Cell Efferocytosis and Autophagy Hinder Atherosclerosis Regression
Boucher, D. M., Robichaud, S., Lorant, V., Salazar‐León, J., Suliman, I., Rasheed, A., Susser, L. I., Emerton, C., Geoffrion, M., Jong, E. D., et al. (2025) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.124.321662 · Cited by 36
Pro-Resolving Ligands Orchestrate Phagocytosis
Decker, C., Sadhu, S., & Fredman, G. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.660865 · Cited by 34
Efferocytosis in liver disease
Shi, H., Moore, M. P., Wang, X., & Tabas, I. (2024) · JHEP Reports · doi:10.1016/j.jhepr.2023.100960 · Cited by 30
Self-citation
The diverse roles of macrophages in metabolic inflammation and its resolution
Ray, A. G., Odum, O., Wiseman, D., & Weinstock, A. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1147434 · Cited by 31
Multiomics reveal the central role of pentose phosphate pathway in resident thymic macrophages to cope with efferocytosis-associated stress
Tsai, T., Zhou, T.-A., Hsieh, Y., Wang, J.-C., Cheng, H.-K., Huang, C., Tsai, P.-Y., Fan, H.-H., Feng, H.-K., Huang, Y. Y., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111065 · Cited by 29
Arginase-1 inhibition reduces migration ability and metastatic colonization of colon cancer cells
Wang, X., Xiang, H., Toyoshima, Y., Shen, W., Shichi, S., Nakamoto, H., Kimura, S., Sugiyama, K., Homma, S., Miyagi, Y., et al. (2023) · Cancer & Metabolism · doi:10.1186/s40170-022-00301-z · Cited by 29
Self-citation
Impaired TIM4-mediated efferocytosis by liver macrophages contributes to fibrosis in metabolic dysfunction–associated steatohepatitis
Shi, H., Wang, X., Sloas, C., Gerlach, B., Yurdagul, A., Moore, M. P., Jung, E. J., Mirshahi, F., Ronzoni, L., Sanyal, A. J., et al. (2025) · Science Translational Medicine · doi:10.1126/scitranslmed.adv2106 · Cited by 30
Self-citation
Mechanism of Efferocytosis in Determining Ischaemic Stroke Resolution—Diving into Microglia/Macrophage Functions and Therapeutic Modality
Xie, X.-D., Dong, S., Liu, R., Shi, L., & Zhu, T. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04060-4 · Cited by 28
Hijacking homeostasis: Regulation of the tumor microenvironment by apoptosis
Gregory, C. D. (2023) · Immunological Reviews · doi:10.1111/imr.13259 · Cited by 29
RNA-binding proteins in vascular inflammation and atherosclerosis
Sachse, M., Tual-Chalot, S., Ciliberti, G., Amponsah-Offeh, M., Stamatelopoulos, K., Gatsiou, A., & Stellos, K. (2023) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2023.01.008 · Cited by 29
Cell type–specific efferocytosis determines functional plasticity of alveolar macrophages
Better, J., Estiri, M., Wetstein, M., Pervizaj-Oruqaj, L., Malainou, C., Ogungbemi-Alt, V. K., Ferrero, M. R., Langelage, M., Kuznetsova, I., Vazquez‐Armendariz, A. I., et al. (2025) · Science Immunology · doi:10.1126/sciimmunol.adl3852 · Cited by 32
Efferocytosis Mediated Modulation of Injury after Neonatal Brain Hypoxia-Ischemia
Mike, J. K., & Ferriero, D. M. (2021) · Cells · doi:10.3390/cells10051025 · Cited by 27
New Insights Into the Role of Mitochondria Quality Control in Ischemic Heart Disease
Xin, Y., Zhang, X., Li, J., Gao, H., Li, J., Li, J., Hu, W., & Li, H. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.774619 · Cited by 28
Secretome of Mesenchymal Stem Cells from Consecutive Hypoxic Cultures Promotes Resolution of Lung Inflammation by Reprogramming Anti-Inflammatory Macrophages
Xu, Z., Lin, L., Fan, Y., Huselstein, C., de Isla, N., He, X., Chen, Y., & Li, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084333 · Cited by 27
Tackling inflammation in atherosclerosis: Are we there yet and what lies beyond?
Bhattacharya, P., Kanagasooriyan, R., & Subramanian, M. (2022) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2022.102283 · Cited by 31
Self-citation
Immunosenescence and macrophages: From basics to therapeutics
Zhu, H., Shen, F., Liao, T., Qian, H., & Liu, Y. (2023) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2023.106479 · Cited by 30
Journey of monocytes and macrophages upon influenza A virus infection
Ruscitti, C., Radermecker, C., & Marichal, T. (2024) · Current Opinion in Virology · doi:10.1016/j.coviro.2024.101409 · Cited by 27
Microneedle delivery of CAR-M-like engineered macrophages alleviates intervertebral disc degeneration through enhanced efferocytosis capacity
Zhou, X., Zhu, D., Wu, D., Li, G., Liang, H., Zhang, W., Wu, Y., Xu, H., Zhang, Z., Tong, B., et al. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.102079 · Cited by 27
Immunometabolism of Tissue-Resident Macrophages – An Appraisal of the Current Knowledge and Cutting-Edge Methods and Technologies
Zago, G., Saavedra, P. H. V., Keshari, K. R., & Perry, J. S. A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.665782 · Cited by 26
Macrophage metabolic regulation in atherosclerotic plaque
Dolfi, B., Gallerand, A., Haschemi, A., Guinamard, R., & Ivanov, S. (2021) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2021.08.010 · Cited by 29
Efferocytosis: the resolution of inflammation in cardiovascular and cerebrovascular disease
Zhang, B., Zou, Y., Yuan, Z., Jiang, K., Zhang, Z., Chen, S., Zhou, X., Wu, Q., & Zhang, X. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1485222 · Cited by 30
Phytochemical-mediated efferocytosis and autophagy in inflammation control
Vafadar, A., Tajbakhsh, A., Hosseinpour-Soleimani, F., Savardshtaki, A., & Hashempur, M. H. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02254-2 · Cited by 27
Blocking the HGF-MET pathway induces resolution of neutrophilic inflammation by promoting neutrophil apoptosis and efferocytosis
Félix, F. B., Dias, J., Vago, J. P., Martins, D. G., Beltrami, V. A., Fernandes, D. D. O., dos Santos, A. C. P. M., Queiroz‐Junior, C. M., Sousa, L. P., Amaral, F. A., et al. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2022.106640 · Cited by 26
Cellular metabolism changes in atherosclerosis and the impact of comorbidities
Dai, Y., Junho, C. V. C., Schieren, L., Wollenhaupt, J., Sluimer, J. C., van der Vorst, E. P. C., & Noels, H. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1446964 · Cited by 27
Efferocytosis in dendritic cells: an overlooked immunoregulatory process
Ma, Y., Jiang, T., Zhu, X., Xu, Y., Wan, K., Zhang, T., & Xie, M. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1415573 · Cited by 24
Crosstalk between macrophages and immunometabolism and their potential roles in tissue repair and regeneration
Ma, H., Gao, L., Chang, R., Zhai, L., & Zhao, Y. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e38018 · Cited by 30
Arginase 1 Insufficiency Precipitates Amyloid-β Deposition and Hastens Behavioral Impairment in a Mouse Model of Amyloidosis
Ma, C., Hunt, J. B., Selenica, M.-L. B., Sanneh, A., Sandusky-Beltran, L. A., Watler, M., Daas, R., Kovalenko, A., Liang, H., Placides, D., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.582998 · Cited by 24
Extracellular vesicle YRNA in atherosclerosis
Chen, W., Li, L., Wang, J., Li, Q., Zhang, R., Wang, S., Wu, Y., & Xing, D. (2021) · Clinica Chimica Acta · doi:10.1016/j.cca.2021.02.003 · Cited by 24
Resolution of chronic inflammation and cancer
Tezcan, G., Yakar, N., Hastürk, H., Dyke, T. E. V., & Kantarcı, A. (2024) · Periodontology 2000 · doi:10.1111/prd.12603 · Cited by 25
Methylglyoxal deteriorates macrophage efferocytosis in diabetic wounds through ROS-induced ubiquitination degradation of KLF4
Zhu, H., Wang, W., Zhu, J., Chen, X., Wang, J., Wang, J., Liu, D., Yang, P., & Liu, Y. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.02.030 · Cited by 23
Metabolic Modulation of Macrophage Function Post Myocardial Infarction
Zhao, M., Wang, D. D.-H., Liu, X., & Tian, R. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00674 · Cited by 23
Ongoing Exposure to Peritoneal Dialysis Fluid Alters Resident Peritoneal Macrophage Phenotype and Activation Propensity
Sutherland, T. E., Shaw, T. N., Lennon, R., Herrick, S. E., & Rückerl, D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.715209 · Cited by 22
Regulation of intrinsic and extrinsic metabolic pathways in tumour‐associated macrophages
Davuluri, G. V. N., & Chan, C. (2022) · FEBS Journal · doi:10.1111/febs.16465 · Cited by 25
Mitochondrial respiration in microglia is essential for response to demyelinating injury but not proliferation
Stoolman, J. S., Grant, R. A., Poor, T. A., Weinberg, S. E., D’Alessandro, K. B., Tan, J., Hu, J. Y.-S., Zerrer, M. E., Wood, W. A., Harding, M. C., et al. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01080-1 · Cited by 24
Cellular mechanisms underlying the impairment of macrophage efferocytosis
Ma, Y., Kemp, S. S., Yang, X., Wu, M. H., & Yuan, S. Y. (2023) · Immunology Letters · doi:10.1016/j.imlet.2023.02.001 · Cited by 22
Immunometabolism in atherosclerotic disorders
Fleetwood, A. J., Noonan, J. E., Gruta, N. L. L., Kallies, A., & Murphy, A. J. (2024) · Nature Cardiovascular Research · doi:10.1038/s44161-024-00473-5 · Cited by 28
Liquid chromatography-tandem mass spectrometry based quantification of arginine metabolites including polyamines in different sample matrices
Langner, M., Mateska, I., Bechmann, N., Wielockx, B., Chavakis, T., Alexaki, V. I., & Peitzsch, M. (2022) · Journal of Chromatography A · doi:10.1016/j.chroma.2022.463021 · Cited by 22
Immune Cell Activation in Obesity and Cardiovascular Disease
Garcia, J. N., Wanjalla, C. N., Mashayekhi, M., & Hasty, A. H. (2022) · Current Hypertension Reports · doi:10.1007/s11906-022-01222-4 · Cited by 25
Resolution of inflammation, an active process to restore the immune microenvironment balance: A novel drug target for treating arterial hypertension
Zhang, J., Liu, S., Ding, W. B., Wan, J., Qin, J., & Wang, M. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102352 · Cited by 23
Apoptotic cell-derived metabolites in efferocytosis-mediated resolution of inflammation
Mao, Y. (2021) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2021.10.002 · Cited by 21
Before the “cytokine storm”: Boosting efferocytosis as an effective strategy against SARS-CoV-2 infection and associated complications
Dutta, S., Mukherjee, A., & Nongthomba, U. (2022) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2022.01.002 · Cited by 21
Efferocyte‐Derived MCTRs Metabolically Prime Macrophages for Continual Efferocytosis via Rac1‐Mediated Activation of Glycolysis
Koenis, D. S., Matteis, R. D., Rajeeve, V., Cutillas, P. R., & Dalli, J. (2023) · Advanced Science · doi:10.1002/advs.202304690 · Cited by 19
Macrophage mediators and mechanisms in cardiovascular disease
Schelemei, P., Wagner, E., Picard, F. S. R., & Winkels, H. (2024) · The FASEB Journal · doi:10.1096/fj.202302001r · Cited by 23
Analysis of mechanism, therapeutic strategies, and potential natural compounds against atherosclerosis by targeting iron overload-induced oxidative stress
Zhang, J., Nie, C., Zhang, Y., Yang, L., Du, X., Liu, L., Chen, Y., Yang, Q. S., Zhu, X., & Li, Q. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117112 · Cited by 22
Immunoregulatory Macrophages Modify Local Pulmonary Immunity and Ameliorate Hypoxic Pulmonary Hypertension
Fernandez‐Gonzalez, A., Mukhia, A., Nadkarni, J., Willis, G. R., Reis, M., Zhumka, K., Vitali, S. H., Liu, X., Galls, A., Mitsialis, S. A., et al. (2024) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.124.321264 · Cited by 21
Recent advances in dead cell clearance during acute lung injury and repair
Noone, P. M., & Reddy, S. P. (2021) · Faculty Reviews · doi:10.12703/r/10-33 · Cited by 21
Nanoparticle-based itaconate treatment recapitulates low-cholesterol/low-fat diet-induced atherosclerotic plaque resolution
Hong, N. E., Chaplin, A. M. L., Di, L., Ravodina, A. M., Bevan, G. H., Gao, H., Asase, C., Gangwar, R. S., Cameron, M. J., Mignery, M., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114911 · Cited by 20
Efferocytosis and Its Role in Rheumatic Diseases
Tang, X., Peng, Y., Jiang, Z., Yu, B., Peng, D., Xie, X., Li, F., & Ge, Y. L. (2025) · Arthritis & Rheumatology · doi:10.1002/art.43268 · Cited by 21
MCTR3 reprograms arthritic monocytes to upregulate Arginase-1 and exert pro-resolving and tissue-protective functions in experimental arthritis
Pistorius, K., Ly, L., Souza, P. R., Gómez, E. A., Koenis, D. S., Rodrı́guez, A. R., Foster, J., Sosabowski, J. K., Hopkinson, M., Rajeeve, V., et al. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.103974 · Cited by 20
2021 Jeffrey M. Hoeg Award Lecture: Defining the Role of Efferocytosis in Cardiovascular Disease: A Focus on the CD47 (Cluster of Differentiation 47) Axis
Jarr, K.-U., Kojima, Y., Weissman, I. L., & Leeper, N. J. (2022) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.122.317049 · Cited by 21
L-norvaline affects the proliferation of breast cancer cells based on the microbiome and metabolome analysis
Zhu, Q., Zai, H., Zhang, K., Zhang, X., Luo, N., Li, X., Hu, Y., & Wu, Y. (2022) · Journal of Applied Microbiology · doi:10.1111/jam.15620 · Cited by 20
Targeted Metabolomic Biomarkers for Stroke Subtyping
Lee, E., Kim, D. J., Kang, D.-W., Yang, W., Jeong, H., Kim, J., Ko, S., Lee, S., Yoon, B., Cho, J., et al. (2023) · Translational Stroke Research · doi:10.1007/s12975-023-01137-5 · Cited by 20
The resolution of phagosomes
Mylvaganam, S., & Freeman, S. A. (2023) · Immunological Reviews · doi:10.1111/imr.13260 · Cited by 23
Resolvin D2 limits atherosclerosis progression via myeloid cell‐GPR18
Lipscomb, M., Walis, S., Marinello, M., Mena, H. A., MacNamara, K. C., Spite, M. R., & Fredman, G. (2024) · The FASEB Journal · doi:10.1096/fj.202302336rr · Cited by 21
Efferocytosis: The Janus‐Faced Gatekeeper of Aging and Tumor Fate
Liu, Z., Li, Y., Ren, Y., Chen, J., Weng, S., Zhou, Z., Luo, P., Cheng, Q., Xu, H., Ba, Y., et al. (2025) · Aging Cell · doi:10.1111/acel.14467 · Cited by 21
Programmed cell death and tissue regeneration: a link that should be resolved
Kopeina, G. S., Efimenko, A. Y., Va, T., & Zhivotovsky, B. (2025) · Physiological Reviews · doi:10.1152/physrev.00036.2024 · Cited by 20
Ischemic Conditioning Promotes Transneuronal Survival and Stroke Recovery via CD36-Mediated Efferocytosis
Ju, H., Kim, I., Pavlova, I., Mu, S., Park, K. W., Minkler, J., Madkoor, A., Wang, W., Wang, X., Wu, Z., et al. (2025) · Circulation Research · doi:10.1161/circresaha.124.325428 · Cited by 21
Self-citation
CKLF1 disrupts microglial efferocytosis following acute ischemic stroke by binding to phosphatidylserine
Fan, P., Lai, H.-Q., Wang, H., Hu, K., Ruan, Y., Ye, J.-R., Wang, S., Peng, Y., He, W., Li, G., et al. (2025) · Cell Death and Differentiation · doi:10.1038/s41418-025-01475-x · Cited by 18
Metabolic reprogramming in efferocytosis
Yan, Q., Li, K., Chen, L., Wang, A., Xi, Y., Xiao, H., & Yuan, L. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1677028 · Cited by 19
Cross-Talk Between Neutrophils and Macrophages Post-Myocardial Infarction: From Inflammatory Drivers to Therapeutic Targets
Ciortan, L., Macarie, R. D., Barbu, E., Naie, M. L., Mihaila, A. C., Serbanescu, M. A., & Butoi, E. D. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262110575 · Cited by 21

Authors: Yurdagul, A., Subramanian, M., Wang, X., Crown, S. B., Ilkayeva, O. R., Darville, L., Kolluru, G. K., Rymond, C. C., Gerlach, B. D., Zheng, Z., Kuriakose, G., Kevil, C. G., Koomen, J. M., Cleveland, J. L., Muoio, D. M., & Tabas, I.
Affiliations: Columbia University Irving Medical Center (US)
Institute of Genomics and Integrative Biology (IN)
Columbia University (US)
Duke University (US)
Moffitt Cancer Center (US)
Louisiana State University Health Sciences Center Shreveport (US)
Corresponding author: Yurdagul, Arif
Tabas, Ira
ORCID: Yurdagul, Arif
Subramanian, Manikandan
Wang, Xiaobo
Crown, Scott B.
Ilkayeva, Olga R.
Darville, Lancia
Kolluru, Gopi K.
Rymond, Christina C.
Gerlach, Brennan D.
Zheng, Ze
Kevil, Christopher G.
Koomen, John M.
Cleveland, John L.
Muoio, Deborah M.
Tabas, Ira
Venue: Cell Metabolism
Publisher: Elsevier BV
Published: 2020-03
Volume: 31
Issue: 3
Pages: 518-533.e10
ISSN: 1550-4131 (ISSN-L)
DOI: 10.1016/j.cmet.2020.01.001
PMC: PMC7173557
OpenAlex: W3004079464
Cited by: 525
References: 70
Citations by year: 2026: 112 · 2025: 101 · 2024: 97 · 2023: 76 · 2022: 61 · 2021: 57 · 2020: 21
FWCI: 18.48
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 367 d)
Locations: Cell Metabolism (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
Topics: Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Keywords: efferocytosis, macrophage metabolism, arginine metabolism, ornithine, putrescine, arginase-1, ornithine decarboxylase, Rac1, actin cytoskeleton, atherosclerosis regression
MeSH terms: ELAV-Like Protein 1, Animals, Arginase, Arginine, Humans, Macrophages, Male, Mice, Inbred C57BL, Ornithine Decarboxylase, Phagocytosis, Putrescine, RNA, Messenger, Apoptosis, Gene Deletion, Jurkat Cells, Guanine Nucleotide Exchange Factors, rac1 GTP-Binding Protein, RNA Stability, Myeloid Cells

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks