The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury
Open accessAbstract
Continual efferocytic clearance of apoptotic cells (ACs) by macrophages prevents necrosis and promotes injury resolution. How continual efferocytosis is promoted is not clear. Here, we show that the process is optimized by linking the metabolism of engulfed cargo from initial efferocytic events to subsequent rounds. We found that continual efferocytosis is enhanced by the metabolism of AC-derived arginine and ornithine to putrescine by macrophage arginase 1 (Arg1) and ornithine decarboxylase (ODC). Putrescine augments HuR-mediated stabilization of the mRNA encoding the GTP-exchange factor Dbl, which activates actin-regulating Rac1 to facilitate subsequent rounds of AC internalization. Inhibition of any step along this pathway after first-AC uptake suppresses second-AC internalization, whereas putrescine addition rescues this defect. Mice lacking myeloid Arg1 or ODC have defects in efferocytosis in vivo and in atherosclerosis regression, while treatment with putrescine promotes atherosclerosis resolution. Thus, macrophage metabolism of AC-derived metabolites allows for optimal continual efferocytosis and resolution of injury.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Earlier studies identified a conserved metabolic circuit essential for the high efferocytic activity of reparative macrophages. This pathway involves the conversion of apoptotic cell-derived arginine and ornithine into putrescine via arginase 1 (Arg1) and ornithine decarboxylase (ODC).”
From Macrophage duality in liver diseases: heterogeneity, plasticity, and the quest for precision therapeutics (2026) · cites this paper as [51]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Thus, metabolic processing of one apoptotic cell augments the capacity to clear the next, providing a fundamental mechanism for injury resolution.”
From Macrophage duality in liver diseases: heterogeneity, plasticity, and the quest for precision therapeutics (2026) · cites this paper as [51]
The cited source says what the claim attributes to it.
In the citing paper
“Putrescine, in turn, fuels a self-reinforcing cycle that promotes continual efferocytosis—the sequential clearance of apoptotic corpses—by enhancing Rac1-dependent phagosome internalization (51).”
From Macrophage duality in liver diseases: heterogeneity, plasticity, and the quest for precision therapeutics (2026) · cites this paper as [51]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Fiji: an open-source platform for biological-image analysis
Schindelin, J., Arganda-Carreras, I., Frise, E., Kaynig, V., Longair, M., Pietzsch, T., Preibisch, S., Rueden, C., Saalfeld, S., Schmid, B., et al. (2012) · Nature Methods · doi:10.1038/nmeth.2019 · Cited by 66,890
Macrophages in Tissue Repair, Regeneration, and Fibrosis
Wynn, T. A., & Vannella, K. M. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.015 · Cited by 4,481
Alternative Activation of Macrophages: An Immunologic Functional Perspective
Martinez, F. O., Helming, L., & Gordon, S. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132532 · Cited by 2,745
Conditional gene targeting in macrophages and granulocytes using LysMcre mice
Clausen, B. E., Burkhardt, C., Reith, W., Renkawitz, R., & Förster, I. (1999) · Transgenic Research · doi:10.1023/a:1008942828960 · Cited by 2,098
Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities
Bäck, M., Yurdagul, A., Tabas, I., Öörni, K., & Kovanen, P. T. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0169-2 · Cited by 1,341
Self-citationMetabolism via Arginase or Nitric Oxide Synthase: Two Competing Arginine Pathways in Macrophages
Rath, M., ller, I. M. ⁄., Kropf, P., Closs, E. I., & Munder, M. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00532 · Cited by 1,332
Brennan, C. M., & Steitz*, J. A. (2001) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000854 · Cited by 1,095
Phagocytosis of apoptotic cells in homeostasis
Arandjelovic, S., & Ravichandran, K. S. (2015) · Nature Immunology · doi:10.1038/ni.3253 · Cited by 959
Arginase-1–Expressing Macrophages Suppress Th2 Cytokine–Driven Inflammation and Fibrosis
Pesce, J. T., Ramalingam, T. R., Mentink-Kane, M. M., Wilson, M. S., El Kasmi, K. C., Smith, A. M., Thompson, R. W., Cheever, A. W., Murray, P. J., & Wynn, T. A. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000371 · Cited by 816
A-González, N., Bensinger, S. J., Hong, C., Beceiro, S., Bradley, M. N., Zelcer, N., Deniz, J. M., Ramírez, C. M., Díaz, M., Gallardo, G., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.06.018 · Cited by 703
Macrophage Dysfunction Impairs Resolution of Inflammation in the Wounds of Diabetic Mice
Khanna, S., Biswas, S., Shang, Y., Collard, E., Azad, A., Kauh, C., Bhasker, V., Gordillo, G. M., Sen, C. K., & Roy, S. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009539 · Cited by 694
CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis
Kojima, Y., Volkmer, J.-P., McKenna, K., Civelek, M., Lusis, A. J., Miller, C. L., Direnzo, D., Nanda, V., Ye, J., Connolly, A. J., et al. (2016) · Nature · doi:10.1038/nature18935 · Cited by 683
Exploring RNA transcription and turnover in vivo by using click chemistry
Jao, C. Y., & Salic, A. N. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808480105 · Cited by 674
Macrophage subsets in atherosclerosis
Chinetti, G., Colin, S., & Staels, B. (2014) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2014.173 · Cited by 669
Monocyte-macrophages and T cells in atherosclerosis
Tabas, I., & Lichtman, A. H. (2017) · Immunity · doi:10.1016/j.immuni.2017.09.008 · Cited by 646
Self-citationRBPmap: a web server for mapping binding sites of RNA-binding proteins
Paz, I., Kosti, I., Ares, M., Cline, M., & Mandel‐Gutfreund, Y. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku406 · Cited by 581
Dalli, J., & Serhan, C. N. (2012) · Blood · doi:10.1182/blood-2012-04-423525 · Cited by 572
Zhang, S., Weinberg, S., DeBerge, M., Gainullina, A., Schipma, M., Kinchen, J. M., Ben-Sahra, I., Gius, D. R., Yvan-Charvet, L., Chandel, N. S., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2018.12.004 · Cited by 485
Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages
Kawane, K., Ohtani, M., Miwa, K., Kizawa, T., Kanbara, Y., Yoshioka, Y., Yoshikawa, H., & Nagata, S. (2006) · Nature · doi:10.1038/nature05245 · Cited by 467
Uptake of apoptotic cells drives the growth of a pathogenic trypanosome in macrophages
Freire-de-Lima, C. G., Nascimento, D. O., Soares, M. B. P., Bozza, P. T., Castro-Faria-Neto, H. C., Mello, F. G. D., DosReis, G. A., & Lopes, M. F. (2000) · Nature · doi:10.1038/35003208 · Cited by 455
An, J., Muoio, D. M., Shiota, M., Fujimoto, Y., Cline, G. W., Shulman, G. I., Koves, T. R., Stevens, R., Millington, D., & Newgard, C. B. (2004) · Nature Medicine · doi:10.1038/nm995 · Cited by 450
Self-citationVandivier, R. W., Henson, P. M., & Douglas, I. S. (2006) · CHEST Journal · doi:10.1378/chest.129.6.1673 · Cited by 450
Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation Resolution
Proto, J. D., Doran, A. C., Gusarova, G., Yurdagul, A., Sozen, E., Subramanian, M., Islam, M. N., Rymond, C. C., Du, J., Hook, J., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.07.015 · Cited by 441
Self-citationClearance of apoptotic cells by phagocytes
Erwig, L.-P., & Henson, P. M. (2008) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4402184 · Cited by 422
Fredman, G., Hellmann, J., Proto, J. D., Kuriakose, G., Colas, R. A., Dorweiler, B., Connolly, E. S., Solomon, R., Jones, D. M., Heyer, E. J., et al. (2016) · Nature Communications · doi:10.1038/ncomms12859 · Cited by 411
Self-citationLiving on the Edge: Efferocytosis at the Interface of Homeostasis and Pathology
Morioka, S., Maueröder, C., & Ravichandran, K. S. (2019) · Immunity · doi:10.1016/j.immuni.2019.04.018 · Cited by 391
Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation
Puleston, D. J., Buck, M. D., Geltink, R. I. K., Kyle, R. L., Caputa, G., O’Sullivan, D., Cameron, A. M., Castoldi, Â., Musa, Y., Kabat, A. M., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.05.003 · Cited by 385
Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release
Morioka, S., Perry, J. S. A., Raymond, M. H., Medina, C. B., Zhu, Y., Zhao, L., Serbulea, V., Önengüt-Gümüşcü, S., Leitinger, N., Kucenas, S., et al. (2018) · Nature · doi:10.1038/s41586-018-0735-5 · Cited by 379
Mitochondrial fission promotes the continued clearance of apoptotic cells by macrophages
Wang, Y., Subramanian, M., Yurdagul, A., Barbosa-Lorenzi, V. C., Cai, B., de Juan-Sanz, J., Ryan, T. A., Nomura, M., Maxfield, F. R., & Tabas, I. (2017) · Cell · doi:10.1016/j.cell.2017.08.041 · Cited by 364
Self-citationModulation of Macrophage Efferocytosis in Inflammation
Johnson, D. K., Frasch, S. C., Fernandez-Boyanapalli, R. F., Henson, P. M., & Bratton, D. L. (2011) · Frontiers in Immunology · doi:10.3389/fimmu.2011.00057 · Cited by 362
STAT6/Arg1 promotes microglia/macrophage efferocytosis and inflammation resolution in stroke mice
Cai, W., Dai, X., Chen, J., Zhao, J., Xu, M., Zhang, L., Yang, B., Zhang, W., Rocha, M., Nakao, T., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.131355 · Cited by 317 · cited 1×
“Further, an Arg1 pathway in brain microglia and macrophages was shown to play a role in clearing dead neurons and promoting inflammation resolution after stroke, though the mechanism linking Arg1 to efferocytosis in this setting remains to be elucidated (Cai et al., 2019).”
BackgroundArginase-1 and Ym1 are markers for murine, but not human, alternatively activated myeloid cells
Raes, G., Van den Bergh, R., De Baetselier, P., & Ghassabeh, G. H. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.11.6561 · Cited by 302
Mechanisms and Consequences of Defective Efferocytosis in Atherosclerosis
Yurdagul, A., Doran, A. C., Cai, B., Fredman, G., & Tabas, I. A. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2017.00086 · Cited by 300
Self-citationMerTK receptor cleavage promotes plaque necrosis and defective resolution in atherosclerosis
Cai, B., Thorp, E. B., Doran, A. C., Sansbury, B. E., Daemen, M. J. A. P., Dorweiler, B., Spite, M., Fredman, G., & Tabas, I. (2017) · Journal of Clinical Investigation · doi:10.1172/jci90520 · Cited by 262
Self-citationMetabolic regulation of macrophage phenotype and function
Saha, S., Shalova, I. N., & Biswas, S. K. (2017) · Immunological Reviews · doi:10.1111/imr.12603 · Cited by 260
Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein
Park, D., Han, C. Z., Elliott, M. R., Kinchen, J. M., Trampont, P. C., Das, S., Collins, S., Lysiak, J. J., Hoehn, K. L., & Ravichandran, K. S. (2011) · Nature · doi:10.1038/nature10340 · Cited by 250
Macrophage Apoptosis and Efferocytosis in the Pathogenesis of Atherosclerosis
Linton, M. F., Babaev, V. R., Huang, J., Linton, E. F., Tao, H., & Yancey, P. G. (2016) · Circulation Journal · doi:10.1253/circj.cj-16-0924 · Cited by 235
Mechanisms and consequences of efferocytosis in advanced atherosclerosis
Thorp, E., & Tabas, I. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0209115 · Cited by 231
Self-citationIL-10–producing macrophages preferentially clear early apoptotic cells
Xu, W., Roos, A., Schlagwein, N., Woltman, A. M., Daha, M. R., & van Kooten, C. (2006) · Blood · doi:10.1182/blood-2005-10-4144 · Cited by 225
Hardbower, D. M., Asim, M., Luis, P. B., Singh, K., Barry, D. P., Yang, C., Steeves, M. A., Cleveland, J. L., Schneider, C. G., Piazuelo, M. B., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1614958114 · Cited by 222
Self-citationABCA1 and ABCG1 Protect Against Oxidative Stress–Induced Macrophage Apoptosis During Efferocytosis
Yvan-Charvet, L., Pagler, T. A., Seimon, T. A., Thorp, E., Welch, C. L., Witztum, J. L., Tabas, I., & Tall, A. R. (2010) · Circulation Research · doi:10.1161/circresaha.110.217281 · Cited by 217
Self-citationImmunity to Helminths: Resistance, Regulation, and Susceptibility to Gastrointestinal Nematodes
Grencis, R. K. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120218 · Cited by 211
LAAT-1 Is the Lysosomal Lysine/Arginine Transporter That Maintains Amino Acid Homeostasis
Liu, B., Du, H., Rutkowski, R., Gartner, A., & Wang, X. (2012) · Science · doi:10.1126/science.1220281 · Cited by 195
Self-citation“Of Mice and Men”: Arginine Metabolism in Macrophages
Thomas, A. C., & Mattila, J. T. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00479 · Cited by 186
Boosting Inflammation Resolution in Atherosclerosis
Fredman, G., & Tabas, I. A. (2017) · American Journal Of Pathology · doi:10.1016/j.ajpath.2017.01.018 · Cited by 179
Self-citationThe hypusine-containing translation factor eIF5A
Dever, T. E., Gutierrez, E., & Shin, B. (2014) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2014.939608 · Cited by 178
Cai, B., Kasikara, C., Doran, A. C., Ramakrishnan, R., Birge, R. B., & Tabas, I. (2018) · Science Signaling · doi:10.1126/scisignal.aar3721 · Cited by 175
Self-citationRequirement for Rho GTPases and PI 3-kinases during apoptotic cell phagocytosis by macrophages
Leverrier, Y., & Ridley, A. J. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00047-1 · Cited by 164
Resolution of acute inflammation bridges the gap between innate and adaptive immunity
Newson, J., Stables, M. J., Karra, E., Vargas, F. A., Quezada, S. A., Motwani, M. P., Mack, M., Yona, S., Audzevich, T., & Gilroy, D. W. (2014) · Blood · doi:10.1182/blood-2014-03-562710 · Cited by 159
Identification and Validation of Novel Small Molecule Disruptors of HuR-mRNA Interaction
Wu, X., Lan, L., Wilson, D. M., Marquez, R. T., Tsao, W.-C., Gao, P., Roy, A., Turner, B. A., McDonald, P., Tunge, J. A., et al. (2015) · ACS Chemical Biology · doi:10.1021/cb500851u · Cited by 148
Nepal, S., Tiruppathì, C., Tsukasaki, Y., Farahany, J., Mittal, M., Rehman, J., Prockop, D. J., & Malik, A. B. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1821601116 · Cited by 136
Apoptotic Cells Induce a Phosphatidylserine-Dependent Homeostatic Response from Phagocytes
Kiss, R. S., Elliott, M. R., Ma, Z., Marcel, Y. L., & Ravichandran, K. S. (2006) · Current Biology · doi:10.1016/j.cub.2006.09.043 · Cited by 123
Feig, J. E., Vengrenyuk, Y., Reiser, V., Wu, C., Statnikov, A., Aliferis, C. F., Garabedian, M. J., Fisher, E. A., & Puig, O. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039790 · Cited by 118
Apoptotic cells trigger a membrane-initiated pathway to increase ABCA1
Fond, A. M., Lee, C. S., Schulman, I. G., Kiss, R. S., & Ravichandran, K. S. (2015) · Journal of Clinical Investigation · doi:10.1172/jci80300 · Cited by 114
Wu, J.-Y., Kao, H., Li, S., Stevens, R., Hillman, S. L., Millington, D. S., & Chen, Y.-T. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19574 · Cited by 104
Ramon, S., Dalli, J., Sanger, J. M., Winkler, J. W., Aursnes, M., Tungen, J. E., Hansen, T. V., & Serhan, C. N. (2016) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.12.012 · Cited by 101
Sun, L., Zhou, H., Zhu, Z., Qian, Y., Wang, L., Liang, Q., & Ye, R. D. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402164 · Cited by 90
The Requirement for Polyamines for Intestinal Epithelial Cell Migration Is Mediated through Rac1
Ray, R. M., McCormack, S. A., Covington, C., Viar, M. J., Zheng, Y., & Johnson, L. R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m208741200 · Cited by 86
The Rac-FRET Mouse Reveals Tight Spatiotemporal Control of Rac Activity in Primary Cells and Tissues
Johnsson, A., Dai, Y., Nobis, M., Baker, M. J., McGhee, E. J., Walker, S. A., Schwarz, J. P., Kadir, S. R., Morton, J. P., Myant, K., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.02.024 · Cited by 86
GEFs: Dual regulation of Rac1 signaling
Marei, H., & Malliri, A. (2016) · Small GTPases · doi:10.1080/21541248.2016.1202635 · Cited by 77
Myc‐nick promotes efferocytosis through M2 macrophage polarization during resolution of inflammation
Zhong, X., Lee, H., Kim, S. H., Park, S., Kim, W., Cha, Y., & Surh, Y. (2018) · The FASEB Journal · doi:10.1096/fj.201800223r · Cited by 62
Thomas, A. C., Sala‐Newby, G. B., Ismail, Y., Johnson, J. L., Pasterkamp, G., & Newby, A. C. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000256470.23842.94 · Cited by 61
Identification of Macrophage Arginase I as a New Candidate Gene of Atherosclerosis Resistance
Teupser, D., Burkhardt, R., Wilfert, W., Haffner, I., Nebendahl, K., & Thiery, J. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000195791.83380.4c · Cited by 61
Alhonen, L. I., Karppinen, A., Uusi‐Oukari, M., Vujcic, S., Korhonen, V., Halmekytö, M., Kramer, D. L., Hines, R., Jänne, J., & Porter, C. W. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.4.1964 · Cited by 55
LC3-associated phagocytosis in microbial pathogenesis
Schille, S. A., Crauwels, P., Bohn, R., Bagola, K., Walther, P., & van Zandbergen, G. (2017) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2017.10.014 · Cited by 51
Impairment of macrophage function by inhibitors of ornithine decarboxylase activity
KIERSZENBAUM, F., Wirth, J. J., McCann, P. P., & Sjoerdsma, A. (1987) · Infection and Immunity · doi:10.1128/iai.55.10.2461-2464.1987 · Cited by 42
Willecke, F., Yuan, C., Oka, K., Chan, L., Hu, Y., Barnhart, S., Bornfeldt, K., Goldberg, I. J., & Fisher, E. A. A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0128996 · Cited by 40
Ren, B., Kampen, E. V., van Berkel, T. J. C., Cruickshank, S. M., & Eck, M. V. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.11.018 · Cited by 27
Ray, R. M., Bavaria, M. N., Bhattacharya, S., & Johnson, L. R. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00409.2010 · Cited by 12
Tarasenko, T. N., Rosas, O. R., Singh, L. N., Kristaponis, K., Vernon, H. J., & McGuire, P. J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0116594 · Cited by 11
Flagged first, then by citations
Cited by
Sorted by citations
Targeting inflammation in atherosclerosis — from experimental insights to the clinic
Soehnlein, O., & Libby, P. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00198-1 · Cited by 1,085
Amino Assets: How Amino Acids Support Immunity
Kelly, B. L., & Pearce, E. L. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.06.010 · Cited by 666
Macrophage-targeted nanomedicine for the diagnosis and treatment of atherosclerosis
Chen, W., Schilperoort, M., Cao, Y., Shi, J., Tabas, I. A., & Tao, W. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00629-x · Cited by 544
Self-citationDrugging the efferocytosis process: concepts and opportunities
Mehrotra, P., & Ravichandran, K. S. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00470-y · Cited by 459
Myeloid Cell-Derived Arginase in Cancer Immune Response
Grzywa, T. M., Sosnowska, A., Matryba, P., Rydzyńska, Z., Jasiński, M., Nowis, D., & Gołąb, J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00938 · Cited by 446
Metadata
- Authors
- Yurdagul, A., Subramanian, M., Wang, X., Crown, S. B., Ilkayeva, O. R., Darville, L., Kolluru, G. K., Rymond, C. C., Gerlach, B. D., Zheng, Z., Kuriakose, G., Kevil, C. G., Koomen, J. M., Cleveland, J. L., Muoio, D. M., & Tabas, I.
- Affiliations
- Columbia University Irving Medical Center (US)
- Institute of Genomics and Integrative Biology (IN)
- Columbia University (US)
- Duke University (US)
- Moffitt Cancer Center (US)
- Louisiana State University Health Sciences Center Shreveport (US)
- Corresponding author
- Yurdagul, Arif
- Tabas, Ira
- ORCID
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2020-03
- Volume
- 31
- Issue
- 3
- Pages
- 518-533.e10
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC7173557
- OpenAlex
- W3004079464
- Cited by
- 525
- References
- 70
- Citations by year
- 2026: 112 · 2025: 101 · 2024: 97 · 2023: 76 · 2022: 61 · 2021: 57 · 2020: 21
- FWCI
- 18.48
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Keywords
- efferocytosis, macrophage metabolism, arginine metabolism, ornithine, putrescine, arginase-1, ornithine decarboxylase, Rac1, actin cytoskeleton, atherosclerosis regression
- MeSH terms
- ELAV-Like Protein 1, Animals, Arginase, Arginine, Humans, Macrophages, Male, Mice, Inbred C57BL, Ornithine Decarboxylase, Phagocytosis, Putrescine, RNA, Messenger, Apoptosis, Gene Deletion, Jurkat Cells, Guanine Nucleotide Exchange Factors, rac1 GTP-Binding Protein, RNA Stability, Myeloid Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
