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Increased fidelity of protein synthesis extends lifespan
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Genetic manipulation of RPS23 to improve RNA-to-protein translation accuracy extends lifespan in Schizosaccharomyces pombe, Caenorhabditis elegans and Drosophila melanogaster.
“Genetic manipulation of the ribosomal protein RPS23 to improve the accuracy of RNA-to-protein translation extends lifespan in Schizosaccharomyces pombe , Caenorhabditis elegans and Drosophila melanogaster 80”
From Hallmarks of aging: An expanding universe (2023) · cites this paper as [80]
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mTOR is a key modulator of ageing and age-related disease
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“Interestingly, it was shown that one of the most well-studied anti-aging drugs, the mTOR inhibitor rapamycin (Johnson et al., 2013), reduces errors in translation in mammalian cells in vitro (Conn and Qian, 2013; Xie et al.”
BackgroundThe Biology of Proteostasis in Aging and Disease
Labbadia, J., & Morimoto, R. I. (2015) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060614-033955 · Cited by 1,472
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Campisi, J., Kapahi, P., Lithgow, G. J., Melov, S., Newman, J. C., & Verdin, E. (2019) · Nature · doi:10.1038/s41586-019-1365-2 · Cited by 1,389
Progressive disruption of cellular protein folding in models of polyglutamine diseases
Gidalevitz, T., Ben-Zvi, A., Ho, K. H., Brignull, H. R., & Morimoto, R. I. (2006) · Science · doi:10.1126/science.1124514 · Cited by 643
DNA damage and ageing: new-age ideas for an age-old problem
Garinis, G. A., van der Horst, G. T. J., Vijg, J., & H.J. Hoeijmakers, J. (2008) · Nature Cell Biology · doi:10.1038/ncb1108-1241 · Cited by 366
SIRT6 is responsible for more efficient DNA double-strand break repair in long-lived species
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Protein synthesis and quality control in aging
Anisimova, A. S., Alexandrov, A. I., Makarova, N. E., Gladyshev, V. N., & Dmitriev, S. E. (2018) · Aging · doi:10.18632/aging.101721 · Cited by 172
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Metadata
- Authors
- Martinez-Miguel, V. E., Lujan, C., Espie--Caullet, T., Martinez-Martinez, D., Moore, S., Backes, C., Gonzalez, S., Galimov, E. R., Brown, A. E. X., Halic, M., Tomita, K., Rallis, C., von der Haar, T., Cabreiro, F., & Bjedov, I.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2021-11
- Volume
- 33
- Issue
- 11
- Pages
- 2288-2300.e12
- ISSN
- 1550-4131
- PMC
- PMC8570412
- Cited by
- 137
- References
- 9
- Language
- en
- Licence
- Funders
- Royal Society (102531/Z/13/A, 102532/Z/12/Z, RSG∖R1∖180431)
- Cancer Research UK
- Imperial College London
- Medical Research Council (201487, MC-A654-5QC80)
- Biotechnology and Biological Sciences Research Council (BB/V006916/1)
- St. Jude Children's Research Hospital
- University of Essex
- Wellcome Trust
- American Lebanese Syrian Associated Charities
- University College London
- National Institutes of Health (1R01GM135599-01)
- European Research Council (842174)
- University of East London (RGS∖R1∖201348)
- University of Kent
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