Cited by 53Functional Brain Connectivity StudiesNeural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on Behavior

Ventral striatum functional connectivity during rewards and losses and symptomatology in depressed patients

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Quevedo, Karina, Ng, Rowena, Scott, Hannah, Kodavaganti, Srivastava, Smyda, Garry, Diwadkar, Vaibhav, Phillips, Mary·2017·Biological Psychology

Abstract

Background The ventral striatum (VS) and striatal network supports goal motivated behavior. Identifying how depressed patients differ in their striatal network during the processing of emotionally salient events is a step towards uncovering biomarkers for diagnosis and treatment.Methods 38 depressed and 30 healthy adults completed a task that examined brain activation to the anticipation and receipt of monetary rewards and losses. Data were collected using a 3T Siemens Trio scanner. Functional connectivity differences were examined with seeds in the Left or Right VS. FC estimates were regressed on specific symptoms.Results Depressed patients displayed higher functional connectivity between the VS and midline cortical areas during loss versus reward trials. Anhedonia and depressed mood were associated to fairly similar striatal circuits but suicidality was associated to a unique VS-midline structures coupling, while depression severity was linked to higher VS to caudate and precuneus connectivity during loss versus reward trials.Conclusions Depression is characterized by excessive VS coupling to cognitive control and associative networks during losses versus rewards. High VS to midline cortical structures coupling may index suicidality.

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Crossref · 10.1016/j.biopsycho.2016.11.004

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  • During reward processing, in loss vs reward conditions, higher coupling between the VS and prefrontal areas including the ACC, and connectivity of the VS with the left caudate and mid-cingulate, was observed, mainly driven by higher connectivity during loss/disappointment vs relief/win.

    “During reward processing, more specifically loss vs reward conditions, higher coupling between the VS and prefrontal areas, including the ACC, as well as connectivity of the VS and the left caudate and mid-cingulate was shown, which was mainly driven by higher connectivity during loss/disappointment vs relief/win (Quevedo et al., 2017).”

    From Circuit Mechanisms of Reward, Anhedonia, and Depression (2019) · cites this paper as Quevedo et al., 2017

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  1. First MB Spitzer RL Gibbon M Williams JBW 1995 Structured Clinical Interview for DSM-IV Axis I Disorders-Patient Edition (SCID-I/P, Version 2.0) New York Biometrics Research Department, New York State Psychiatric Institute

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Authors
Quevedo, K., Ng, R., Scott, H., Kodavaganti, S., Smyda, G., Diwadkar, V., & Phillips, M.
Affiliations
  • University of Minnesota (US)
  • University of Pittsburgh (US)
  • Wayne State University (US)
Corresponding author
Quevedo, Karina
Venue
Biological Psychology
Publisher
Elsevier BV
Published
2017-02
Volume
123
Pages
62-73
ISSN
0301-0511 (ISSN-L)
OpenAlex
W2552254046
Cited by
53
References
106
Citations by year
2026: 2 · 2025: 4 · 2024: 6 · 2023: 6 · 2022: 8 · 2021: 7 · 2020: 4 · 2019: 2 · 2018: 10 · 2017: 4
FWCI
3.39
Type
journal article
Language
en
Open access
Locations
  • Biological Psychology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (5r01mh076971-05)
  • National Institute of Mental Health (R01-MH076971, R01MH111177, K01MH092601, R01MH059299)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
ventral striatum, functional connectivity, depression, reward processing, loss processing, anhedonia, suicidality, caudate nucleus, precuneus, cognitive control, depression severity, biomarkers
MeSH terms
Adult, Cerebral Cortex, Depression, Female, Humans, Magnetic Resonance Imaging, Male, Reward, Executive Function, Suicidal Ideation, Anhedonia, Connectome, Ventral Striatum

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