Comparison of bacterial lipopolysaccharide-induced sickness behavior in rodents and humans: Relevance for symptoms of anxiety and depression
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Increasing evidence from animal and human studies suggests that inflammation may be involved in mood disorders. Sickness behavior and emotional changes induced by experimental inflammatory stimuli have been extensively studied in humans and rodents to better understand the mechanisms underlying inflammation-driven mood alterations. However, research in animals and humans have remained compartmentalized and a comprehensive comparison of inflammation-induced sickness and depressive-like behavior between rodents and humans is lacking. Thus, here, we highlight similarities and differences in the effects of bacterial lipopolysaccharide administration on the physiological (fever and cytokines), behavioral and emotional components of the sickness response in rodents and humans, and discuss the translational challenges involved. We also emphasize the differences between observable sickness behavior and subjective sickness reports, and advocate for the need to obtain both subjective reports and objective measurements of sickness behavior in humans. We aim to provide complementary insights for translational clinical and experimental research on inflammation-induced behavioral and emotional changes, and their relevance for mood disorders such as depression.
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Experimentally induced inflammation in healthy humans and rodents increases pain sensitivity, decreases mood, and changes motivational behaviors.
“Experimentally induced inflammation in healthy humans and rodents increases pain sensitivity, decreases mood and changes motivational behaviors, see, e.g., [20,21,22,23] for an overview.”
From Baseline Pro-Inflammatory Cytokine Levels Moderate Psychological Inflexibility in Behavioral Treatment for Chronic Pain (2022) · cites this paper as [23]
Section 4 reports increased negative mood after LPS administration in humans and says that animal and human studies both indicate altered incentive motivation. It treats mood in rodents as depressive-like behavior rather than a directly measured decrease in mood. The pain-sensitivity point appears only in titles in the References, not as a finding discussed in the paper’s text, so that part of the claim is not supported by this copy. (LLM, conf=0.85)
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- Authors
- Lasselin, J., Schedlowski, M., Karshikoff, B., Engler, H., Lekander, M., & Konsman, J. P.
- Affiliations
- Stockholm University (SE)
- Karolinska Institutet (SE)
- Essen University Hospital (DE)
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Lasselin, Julie
- ORCID
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2020-08
- Volume
- 115
- Pages
- 15-24
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W3025751058
- Cited by
- 165
- References
- 157
- Citations by year
- 2026: 18 · 2025: 21 · 2024: 35 · 2023: 31 · 2022: 31 · 2021: 25 · 2020: 4
- FWCI
- 1.48
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- Funders
- Hjärt-Lungfonden
- Vetenskapsrådet
- Stockholms Universitet
- Deutsche Forschungsgemeinschaft (316803389, SFB1280, TP A18)
- Hjärnfonden
- Astma- och Allergiförbundet
- Svenska Läkaresällskapet
- Centre National de la Recherche Scientifique
- Stockholm Stress Center
- Sweden-America Foundation
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- sickness behavior, bacterial lipopolysaccharide, inflammation, depression, anxiety, mood disorders, fever, cytokines, translational research, rodents
- MeSH terms
- Animals, Anxiety, Behavior, Animal, Depression, Humans, Inflammation, Lipopolysaccharides, Rodentia, Cytokines, Illness Behavior
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