Bioavailability and biological effects of bioactive compounds extracted with natural deep eutectic solvents and ionic liquids: advantages over conventional organic solvents

Natural deep eutectic solvents as new potential media for green technology

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Green and sustainable solvents in chemical processes

Clarke, C. J., Tu, W.-C., Levers, O., Bröhl, A., & Hallett, J. P. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00571 · Cited by 2,071

Anthocyanins: Natural Colorants with Health-Promoting Properties

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Natural deep eutectic solvents: Properties, applications, and perspectives

Liu, Y., Friesen, J. B., McAlpine, J. B., Lankin, D. C., Chen, S.-N., & Pauli, G. F. (2018) · Journal of Natural Products · doi:10.1021/acs.jnatprod.7b00945 · Cited by 1,304

The Role of Polyphenols in Human Health and Food Systems: A Mini-Review

Cory, H., Passarelli, S., Szeto, J., Tamez, M., & Mattei, J. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00087 · Cited by 1,297

Insights into the Nature of Eutectic and Deep Eutectic Mixtures

Martins, M. A. R., Pinho, S. P., & Coutinho, J. A. P. (2018) · Journal of Solution Chemistry · doi:10.1007/s10953-018-0793-1 · Cited by 1,235

A global perspective on carotenoids: Metabolism, biotechnology, and benefits for nutrition and health

Rodríguez-Concepción, M., Ávalos, J., Bonet, M. L., Boronat, A., Gómez‐Gómez, L., Hornero‐Méndez, D., Limón, M. C., Meléndez‐Martínez, A. J., Olmedilla‐Alonso, B., Palou, A., et al. (2018) · Progress in Lipid Research · doi:10.1016/j.plipres.2018.04.004 · Cited by 1,064

Ionic-Liquid-Mediated Extraction and Separation Processes for Bioactive Compounds: Past, Present, and Future Trends

Ventura, S. P. M., Silva, F. A. E., Quental, M. V., Mondal, D., Freire, M. G., & Coutinho, J. A. P. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00550 · Cited by 1,055

Application of Deep Eutectic Solvents (DES) for Phenolic Compounds Extraction: Overview, Challenges, and Opportunities

Ruesgas-Ramón, M., Figueroa-Espinoza, M. C., & Durand, E. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b01054 · Cited by 790

Anthocyanins as natural food colours—selected aspects

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Hurdles and pitfalls in measuring antioxidant efficacy: A critical evaluation of ABTS, DPPH, and ORAC assays

Schaich, K. M., Tian, X., & Xie, J. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.01.043 · Cited by 599

Assessing the toxicity and biodegradability of deep eutectic solvents

Wen, Q., Chen, J.-X., Tang, Y.-L., Wang, J., & Yang, Z. (2015) · Chemosphere · doi:10.1016/j.chemosphere.2015.02.061 · Cited by 480

Natural deep eutectic solvents as beneficial extractants for enhancement of plant extracts bioactivity

Radošević, K., Ćurko, N., Gaurina Srček, V., Cvjetko Bubalo, M., Tomašević, M., Kovačević Ganić, K., & Radojčić Redovniković, I. (2016) · LWT · doi:10.1016/j.lwt.2016.05.037 · Cited by 404

Impact of ionic liquids in environment and humans: An overview

Frade, R. F. M., & Afonso, C. A. M. (2010) · Human & Experimental Toxicology · doi:10.1177/0960327110371259 · Cited by 258

Novel lactic acid-based natural deep eutectic solvents: Efficiency in the ultrasound-assisted extraction of antioxidant polyphenols from common native Greek medicinal plants

Bakirtzi, C., Triantafyllidou, K., & Makris, D. P. (2016) · Journal of Applied Research on Medicinal and Aromatic Plants · doi:10.1016/j.jarmap.2016.03.003 · Cited by 245

Applications of Ionic Liquids in the Food and Bioproducts Industries

Hijo, A. A. C. T., Máximo, G. J., da Costa, M. C., Batista, E. A. C., & Meirelles, A. J. A. (2016) · ACS Sustainable Chemistry & Engineering · doi:10.1021/acssuschemeng.6b00560 · Cited by 241

Natural Deep Eutectic Solvents (NADES) as a Tool for Bioavailability Improvement: Pharmacokinetics of Rutin Dissolved in Proline/Glycine after Oral Administration in Rats: Possible Application in Nutraceuticals

Faggian, M., Sut, S., Perissutti, B., Baldan, V., Grabnar, I., & Dall’Acqua, S. (2016) · Molecules · doi:10.3390/molecules21111531 · Cited by 237

Tailoring and recycling of deep eutectic solvents as sustainable and efficient extraction media

Jeong, K. M., Lee, M. S., Nam, M. W., Zhao, J., Jin, Y., Lee, D.-K., Kwon, S. W., Jeong, J. H., & Lee, J. (2015) · Journal of Chromatography A · doi:10.1016/j.chroma.2015.10.083 · Cited by 219

Extraction of value-added components from food industry based and agro-forest biowastes by deep eutectic solvents

Jablonský, M., Škulcová, A., Romero, A. M., & Šíma, J. (2018) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2018.06.349 · Cited by 197

Ecotoxicity of Cholinium-Based Deep Eutectic Solvents

de Morais, P., Gonçalves, F. J. M., Coutinho, J. A. P., & Ventura, S. P. M. (2015) · ACS Sustainable Chemistry & Engineering · doi:10.1021/acssuschemeng.5b01124 · Cited by 182

Unraveling the cytotoxicity and metabolic pathways of binary natural deep eutectic solvent systems

Mbous, Y. P., Hayyan, M., Wong, W. F., Looi, C. Y., & Hashim, M. A. (2017) · Scientific Reports · doi:10.1038/srep41257 · Cited by 182

Deep eutectic solvent‐based extraction of polyphenolic antioxidants from onion ( Allium cepa L.) peel

Pal, C. B. T., & Jadeja, G. C. (2018) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.9395 · Cited by 167

Highly efficient extraction of anthocyanins from grape skin using deep eutectic solvents as green and tunable media

Jeong, K. M., Zhao, J., Jin, Y., Heo, S. R., Han, S. Y., Yoo, D. E., & Lee, J. (2015) · Archives of Pharmacal Research · doi:10.1007/s12272-015-0678-4 · Cited by 145

Natural Deep Eutectic Solvents (NADES) to Enhance Berberine Absorption: An In Vivo Pharmacokinetic Study

Sut, S., Faggian, M., Baldan, V., Poloniato, G., Castagliuolo, I., Grabnar, I., Perissutti, B., Brun, P., Maggi, F., Voinovich, D., et al. (2017) · Molecules · doi:10.3390/molecules22111921 · Cited by 120

Food additive safety

Pressman, P., Clemens, R., Hayes, W., & Reddy, C. S. (2017) · Toxicology Research and Application · doi:10.1177/2397847317723572 · Cited by 112

A novel switchable-hydrophilicity, natural deep eutectic solvent (NaDES)-based system for bio-safe biorefinery

Sed, G., Cicci, A., Jessop, P. G., & Bravi, M. (2018) · RSC Advances · doi:10.1039/c8ra08536f · Cited by 97

Unraveling the ecotoxicity of deep eutectic solvents using the mixture toxicity theory

Maçario, I. P. E., Jesus, F. T., Pereira, J. L., Ventura, S. P. M., Gonçalves, A. M. M., Coutinho, J. A. P., & Gonçalves, F. J. M. (2018) · Chemosphere · doi:10.1016/j.chemosphere.2018.08.153 · Cited by 94

Toxicity of Natural Deep Eutectic Solvent Betaine:Glycerol in Rats

Benlebna, M., Ruesgas-Ramón, M., Bonafos, B., Fouret, G., Casas, F., Coudray, C., Durand, E., Cruz Figueroa-Espinoza, M., & Feillet-Coudray, C. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b01746 · Cited by 90

One-step sample preparation for convenient examination of volatile monoterpenes and phenolic compounds in peppermint leaves using deep eutectic solvents

Jeong, K. M., Jin, Y., Yoo, D. E., Han, S. Y., Kim, E. M., & Lee, J. (2018) · Food Chemistry · doi:10.1016/j.foodchem.2018.01.079 · Cited by 88

Environmentally-Friendly Extraction of Flavonoids from Cyclocarya paliurus (Batal.) Iljinskaja Leaves with Deep Eutectic Solvents and Evaluation of Their Antioxidant Activities

Shang, X., Tan, J., Du, Y., Liu, X., & Zhang, Z. (2018) · Molecules · doi:10.3390/molecules23092110 · Cited by 77

Ionic Liquids in HPLC and CE: A Hope for Future

Ali, I., Suhail, M., Sanagi, M. M., & Aboul-Enein, H. Y. (2017) · Critical Reviews in Analytical Chemistry · doi:10.1080/10408347.2017.1294047 · Cited by 68

Thermal and light stabilities and antioxidant activity of carotenoids from tomatoes extracted using an ultrasound-assisted completely solvent-free method

Martins, P. L. G., & de Rosso, V. V. (2016) · Food Research International · doi:10.1016/j.foodres.2016.01.015 · Cited by 60

Optimization of Ionic Liquid-Assisted Extraction of Biflavonoids from Selaginella doederleinii and Evaluation of Its Antioxidant and Antitumor Activity

Li, D., Qian, Y., Tian, Y.-J., Yuan, S.-M., Wei, W., & Gang, W. (2017) · Molecules · doi:10.3390/molecules22040586 · Cited by 56

The antagonist and synergist potential of cholinium-based deep eutectic solvents

Maçario, I. P. E., Ventura, S. P. M., Pereira, J. L., Gonçalves, A. M. M., Coutinho, J. A. P., & Gonçalves, F. J. M. (2018) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2018.09.027 · Cited by 50

Preparation, formation mechanism, photocatalytic, cytotoxicity and antioxidant activity of sodium niobate nanocubes

Nawaz, M., Almofty, S. A., & Qureshi, F. (2018) · PLoS ONE · doi:10.1371/journal.pone.0204061 · Cited by 23

Genotoxicity, mutagenicity and cytotoxicity of carotenoids extracted from ionic liquid in multiples organs of Wistar rats

Martins, P. L. G., de Rosso, V. V., da Silva, V. H. P., de Moura, C. F. G., & Ribeiro, D. A. (2016) · Experimental and Toxicologic Pathology · doi:10.1016/j.etp.2016.09.003 · Cited by 20

Biophenols and antioxidant activity in wild and cultivated heather

Dróżdż, P., Sentkowska, A., & Pyrzyńska, K. (2016) · Natural Product Research · doi:10.1080/14786419.2016.1222389 · Cited by 12

Screening of ionic liquids for extraction of flavonoids from heather

Dróżdż, P., & Pyrzyńska, K. (2018) · Natural Product Research · doi:10.1080/14786419.2018.1437441 · Cited by 9

Overview of the “Ionic Liquids meet Biomolecules” session at the 19th international IUPAB and 11th EBSA congress

Benedetto, A., & Galla, H. (2017) · Biophysical Reviews · doi:10.1007/s12551-017-0309-z · Cited by 8

Review of Alternative Solvents for Green Extraction of Food and Natural Products: Panorama, Principles, Applications and Prospects

Chemat, F., Vian, M. A., Ravi, H. K., Khadhraoui, B., Hilali, S., Périno, S., & Fabiano‐Tixier, A. (2019) · Molecules · doi:10.3390/molecules24163007 · Cited by 698

Natural Deep Eutectic Solvents (NADES): Phytochemical Extraction Performance Enhancer for Pharmaceutical and Nutraceutical Product Development

Hikmawanti, N. P. E., Ramadon, D., Jantan, I., & Mun’im, A. (2021) · Plants · doi:10.3390/plants10102091 · Cited by 411

The perspectives of natural deep eutectic solvents in agri-food sector

Mišan, A., Nađpal, J., Stupar, A., Pojić, M., Mandić, A., Verpoorte, R., & Choi, Y. H. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2019.1650717 · Cited by 316

Choline chloride-based deep eutectic solvents as green extractants for the isolation of phenolic compounds from biomass

Alam, M. A., Muhammad, G., Khan, M. N., Mofijur, M., Lv, Y., Xiong, W., & Xu, J. (2021) · Journal of Cleaner Production · doi:10.1016/j.jclepro.2021.127445 · Cited by 269

Emerging frontiers of deep eutectic solvents in drug discovery and drug delivery systems

Zainal-Abidin, M. H., Hayyan, M., Ngoh, G. C., Wong, W. F., & Looi, C. Y. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.09.019 · Cited by 259

Deep Eutectic Solvents for the Extraction of Bioactive Compounds from Natural Sources and Agricultural By-Products

Socas‐Rodríguez, B., Torres-Cornejo, M. V., Álvarez‐Rivera, G., & Mendiola, J. A. (2021) · Applied Sciences · doi:10.3390/app11114897 · Cited by 227

Which is the best food emerging solvent: IL, DES or NADES?

Benvenutti, L., Zielinski, A. A. F., & Ferreira, S. R. S. (2019) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2019.06.003 · Cited by 377

Natural deep eutectic solvents for sustainable bioactive compound extraction: Fundamentals, emerging technologies, current scale-up challenges, and future industrial perspectives

Myo, H., Liana, D., & Phanumartwiwath, A. (2026) · Advances in Sample Preparation · doi:10.1016/j.sampre.2026.100248

Lecture 5. Natural Deep Eutectic Solvents in Extraction of Biologically Active Compounds

Kovaleva, E. G., Aboushanab, S. A., & Lwamba, C. (2023) · Electronic scientific archive of UrFU (Ural Federal University)

Green solvents from ionic liquids and deep eutectic solvents to natural deep eutectic solvents

Vanda, H., Dai, Y., Wilson, E. G., Verpoorte, R., & Choi, Y. H. (2018) · Comptes Rendus. Chimie · doi:10.1016/j.crci.2018.04.002 · Cited by 467