Aging, immune senescence, and immunotherapy: a comprehensive review

Frailty in Older Adults: Evidence for a Phenotype

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Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

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Correspondence - Tranexamic acid for traumatic brain injury

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Pembrolizumab versus Chemotherapy for PD-L1-Positive Non-Small-Cell Lung Cancer

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Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer

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A global clinical measure of fitness and frailty in elderly people

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Nivolumab versus Docetaxel in Advanced Squamous-Cell Non–Small-Cell Lung Cancer

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PD-1 blockade induces responses by inhibiting adaptive immune resistance

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Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial

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Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma

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Nivolumab in Previously Untreated Melanoma without <i>BRAF</i> Mutation

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Overall Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma

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Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

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Nivolumab for Recurrent Squamous-Cell Carcinoma of the Head and Neck

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Durvalumab after chemoradiotherapy in stage III non–small-cell lung cancer

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Ipilimumab plus Dacarbazine for Previously Untreated Metastatic Melanoma

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Enhancement of Antitumor Immunity by CTLA-4 Blockade

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Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial

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Frailty in relation to the accumulation of deficits

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Atezolizumab versus docetaxel for patients with previously treated non-small-cell lung cancer (POPLAR): a multicentre, open-label, phase 2 randomised controlled trial

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Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial

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Intraepithelial CD8 + tumor-infiltrating lymphocytes and a high CD8 + /regulatory T cell ratio are associated with favorable prognosis in ovarian cancer

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Management of toxicities from immunotherapy: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

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Selective rejection of H–2-deficient lymphoma variants suggests alternative immune defence strategy

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PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity

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Atezolizumab as first-line treatment in cisplatin-ineligible patients with locally advanced and metastatic urothelial carcinoma: a single-arm, multicentre, phase 2 trial

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Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group

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Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trial

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Induction of Tumor Immunity by Removing CD25+CD4+ T Cells: A Common Basis Between Tumor Immunity and Autoimmunity

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Predicting the risk of chemotherapy toxicity in older patients: The Chemotherapy Risk Assessment Scale for High‐Age Patients (CRASH) score

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Antibody response to influenza vaccination in the elderly: A quantitative review

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Ageing and infection

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Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells

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Comparison of 2 frailty indexes for prediction of falls, disability, fractures, and death in older women

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Combined nivolumab and ipilimumab versus ipilimumab alone in patients with advanced melanoma: 2-year overall survival outcomes in a multicentre, randomised, controlled, phase 2 trial

Hodi, F. S., Chesney, J., Pavlick, A. C., Robert, C., Grossmann, K. F., McDermott, D. F., Linette, G. P., Meyer, N., Giguere, J. K., Agarwala, S. S., et al. (2016) · The Lancet Oncology · doi:10.1016/s1470-2045(16)30366-7 · Cited by 968 · see citing works

Nivolumab for classical Hodgkin's lymphoma after failure of both autologous stem-cell transplantation and brentuximab vedotin: a multicentre, multicohort, single-arm phase 2 trial

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Cross-sectional Comparison of the Prevalence of Age-Associated Comorbidities and Their Risk Factors Between HIV-Infected and Uninfected Individuals: The AGEhIV Cohort Study

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Neutrophil elastase–mediated degradation of IRS-1 accelerates lung tumor growth

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Aging, frailty and age-related diseases

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Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer

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Morbidity and Aging in HIV-Infected Persons: The Swiss HIV Cohort Study

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Innate Immune Recognition of Cancer

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Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response

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Prospects for the use of NK cells in immunotherapy of human cancer

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Ipilimumab 10 mg/kg versus ipilimumab 3 mg/kg in patients with unresectable or metastatic melanoma: a randomised, double-blind, multicentre, phase 3 trial

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Natural killer-like nonspecific tumor cell lysis mediated by specific ligand-activated Vα14 NKT cells

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Longitudinal Studies of Clonally Expanded CD8 T Cells Reveal a Repertoire Shrinkage Predicting Mortality and an Increased Number of Dysfunctional Cytomegalovirus-Specific T Cells in the Very Elderly

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Tumor infiltrating Foxp3+ regulatory T‐cells are associated with recurrence in pathologic stage I NSCLC patients

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Three Decades of Comprehensive Geriatric Assessment: Evidence Coming From Different Healthcare Settings and Specific Clinical Conditions

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B‐cell diversity decreases in old age and is correlated with poor health status

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Geriatric assessment predicts survival for older adults receiving induction chemotherapy for acute myelogenous leukemia

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Breast Cancer Cells Stimulate Neutrophils to Produce Oncostatin M: Potential Implications for Tumor Progression

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Neutrophils Promote Liver Metastasis via Mac-1–Mediated Interactions with Circulating Tumor Cells

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Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation

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Seropositivity to Cytomegalovirus, Inflammation, All-Cause and Cardiovascular Disease-Related Mortality in the United States

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Biology of Immune Responses to Vaccines in Elderly Persons

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NK cells and NKT cells collaborate in host protection from methylcholanthrene-induced fibrosarcoma

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Decline in CD28+ T cells in centenarians and in long-term T cell cultures: a possible cause for both in vivo and in vitro immunosenescence

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Changes in CD8 and CD4 lymphocyte subsets, T cell proliferation responses and non-survival in the very old: the Swedish longitudinal OCTO-immune study

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NK cells and NKT cells collaborate in host protection from methylcholanthrene-induced fibrosarcoma

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Frailty Screening in the Community Using the FRAIL Scale

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Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence

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Invariant NKT cells reduce the immunosuppressive activity of influenza A virus–induced myeloid-derived suppressor cells in mice and humans

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Aging and cytomegalovirus infection differentially and jointly affect distinct circulating T cell subsets in humans

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Specific localisation of human cytomegalovirus nucleic acids and proteins in human colorectal cancer

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Naive T Cell Maintenance and Function in Human Aging

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Aging Down-Regulates the Transcription Factor E2A, Activation-Induced Cytidine Deaminase, and Ig Class Switch in Human B Cells

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Signal transduction and functional changes in neutrophils with aging

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The aging innate immune system

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Neutrophils efficiently cross-prime naive T cells in vivo

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Cohort Study of Cytomegalovirus Infection as a Risk Factor for Carotid Intimal-Medial Thickening, a Measure of Subclinical Atherosclerosis

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Depletion of human regulatory T cells specifically enhances antigen-specific immune responses to cancer vaccines

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Expanding Therapeutic Options for Older Adults: Case‐Based Updates in Breast and Lung Cancer

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Bioinformatics Identification and Validation of Aging‑Related Molecular Subtype and Prognostic Signature in Sarcoma

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Clinical and molecular impacts of tumor mutational burden in histological and cytological specimens from cancer patients

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A Real-Time Plasma Concentration Prediction Model for Voriconazole in Elderly Patients via Machine Learning Combined with Population PharmacokineticsPreprint

Chen, Y., Liu, R., Ma, P., Shang, S., Yu, M., Xie, L., Zhao, L., & Huang, Y. (2024) · doi:10.22541/au.171782996.66229530/v1 · Cited by 2 · see citing works

Antimicrobial Effect of 1,25 Dihydroxy Vitamin Don Escherichia coli and its Association with Serum 25 Hydroxy Vitamin D Level: An Experimental Study on the Elderly Women

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The essential elements of adaptive immunity and their relevance to cancer immunology

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Immunotherapy: should we worry about immunosenescence?

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Clostridium (Now Clostridioides) difficile-Associated Disease

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Gastrointestinal Infections

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Prognostic impact of infection on mortality in geriatric patients admitted to the cardiac intensive care unit

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Clostridium (Now Clostridioides) difficile-Associated Disease

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Etiology and Outcomes in Elderly Patients Admitted For Acute Infections

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Single-cell sequencing characterizes intratumoral profile of immune cells in old micePreprint

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The complexity of cancer immunotherapy illustrated through skin tumors

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Gastrointestinal Infections

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The effects of selenium administration on mean platelet volume, neutrophil-to-lymphocyte ratio, and red cell distribution width in critically ill older adults: A double-blinded randomized clinical trial

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Vieillissement et cancers

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Machine learning based obesity and aging related signature for predicting the prognosis and immunotherapy benefit in stomach adenocarcinoma

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Additional file 2 of The predictive value of tumor mutation burden for immune checkpoint inhibitors therapy in non-small cell lung cancer is affected by patients’ age

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Additional file 1 of The predictive value of tumor mutation burden for immune checkpoint inhibitors therapy in non-small cell lung cancer is affected by patients’ age

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IL-6 and Immunosenescence in the Current Research on Immunotherapy for Elderly Lung Cancer Patients

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Efficacy and safety of immunotherapy in elderly patients with advanced non-small cell lung cancer: a real-world study stratified by age

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Tumor immunosenescence drives breast cancer progression and therapeutic resistance: mechanisms and emerging interventions

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Renal Cell Carcinoma in the Geriatric Population: Toward a Frailty-Adapted Therapeutic Paradigm

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Hybrid PLGA nanoparticles outperform SLNs in intracellular delivery of an anti-inflammatory lipid mediator to skeletal muscle cells

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Whole-body CD8 PET imaging captures changes in systemic lymphocyte distribution associated with cancer immunotherapy-related toxicityPreprint

Peeters, E., van Genugten, E. A. J., Stormezand, G. N., Schmiedehausen, K., Margolin, K. A., Postow, M. A., Heskamp, S., Herpen, C. M. L., Westdorp, H., & Aarntzen, E. H. J. G. (2026) · Research Square · doi:10.21203/rs.3.rs-10831511/v1

Clinical features and outcomes of atezolizumab-associated encephalitis

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Aging, cancer, and antitumor immunity

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Clinical benefit of immune checkpoint inhibitors in elderly cancer patients: Current evidence from immunosenescence pathophysiology to clinical trial results

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Immune Checkpoint Inhibitors in Geriatric Oncology

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Immunosenescence: unraveling the impact on cancer immunotherapy in the aging population

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Immunotherapy in older adults with gynecologic cancers: rethinking age as a limiting factor

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