Cited by 968Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental DisordersFunctional Brain Connectivity Studies

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Why the frontal cortex in autism might be talking only to itself: local over-connectivity but long-distance disconnection

Courchesne, Eric, Pierce, Karen·2005·Current Opinion in Neurobiology

DOI 10.1016/j.conb.2005.03.001

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Abstract

Although it has long been thought that frontal lobe abnormality must play an important part in generating the severe impairment in higher-order social, emotional and cognitive functions in autism, only recently have studies identified developmentally early frontal lobe defects. At the microscopic level, neuroinflammatory reactions involving glial activation, migration defects and excess cerebral neurogenesis and/or defective apoptosis might generate frontal neural pathology early in development. It is hypothesized that these abnormal processes cause malformation and thus malfunction of frontal minicolumn microcircuitry. It is suggested that connectivity within frontal lobe is excessive, disorganized and inadequately selective, whereas connectivity between frontal cortex and other systems is poorly synchronized, weakly responsive and information impoverished. Increased local but reduced long-distance cortical-cortical reciprocal activity and coupling would impair the fundamental frontal function of integrating information from widespread and diverse systems and providing complex context-rich feedback, guidance and control to lower-level systems.

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Buxhoeveden, 2004, Decreased cell column spacing in autism [abstract], Soc Neurosci, 582.6
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Authors: Courchesne, E., & Pierce, K.
Affiliations: University of California San Diego (US)
Corresponding author: Courchesne, Eric
ORCID: Courchesne, Eric
Pierce, Karen
Venue: Current Opinion in Neurobiology
Publisher: Elsevier BV
Published: 2005-04
Volume: 15
Issue: 2
Pages: 225-230
ISSN: 0959-4388 (ISSN-L)
DOI: 10.1016/j.conb.2005.03.001
OpenAlex: W2131541104
Cited by: 968
References: 51
Citations by year: 2026: 30 · 2025: 32 · 2024: 23 · 2023: 52 · 2022: 31 · 2021: 37 · 2020: 40 · 2019: 44 · 2018: 52 · 2017: 50 · 2016: 73 · 2015: 81 · 2014: 71 · 2013: 68 · 2012: 59
FWCI: 3.06
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Current Opinion in Neurobiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Mental Health (K01-MH01814, 2R01 MH 36840, R01MH036840, K01MH001814)
National Institute of Neurological Disorders and Stroke (2-R01-NS-19855, R01NS019855)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords: autism spectrum disorder, frontal cortex, cortical connectivity, neuroinflammation, glial activation, neuronal migration defects, apoptosis, information integration
MeSH terms: Autistic Disorder, Frontal Lobe, Humans, Nerve Net

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Why the frontal cortex in autism might be talking only to itself: local over-connectivity but long-distance disconnection

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