Reduced long-range functional connectivity in young children with autism spectrum disorder
Open accessAbstract
Autism spectrum disorder (ASD) is often described as a disorder of aberrant neural connectivity. Although it is important to study the pathophysiology of ASD in the developing cortex, the functional connectivity in the brains of young children with ASD has not been well studied. In this study, brain activity was measured non-invasively during consciousness in 50 young human children with ASD and 50 age- and gender-matched typically developing human (TD) children. We employed a custom child-sized magnetoencephalography (MEG) system in which sensors were located as close to the brain as possible for optimal recording in young children. We focused on theta band oscillations because they are thought to be involved in long-range networks associated with higher cognitive processes. The ASD group showed significantly reduced connectivity between the left-anterior and the right-posterior areas, exhibiting a decrease in the coherence of theta band (6 Hz) oscillations compared with the TD group. This reduction in coherence was significantly correlated with clinical severity in right-handed children with ASD. This is the first study to demonstrate reduced long-range functional connectivity in conscious young children with ASD using a novel MEG approach.
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Many neuroimaging studies show reduced long-range connectivity in individuals with autism spectrum disorder.
“A consistent finding in neuroimaging work in ASD research is indeed changes in connectivity, with many studies showing reduced long range connectivity in individuals with ASD (Glazebrook and Wallace, 2015; Kikuchi et al., 2015).”
From Behavioral, Perceptual, and Neural Alterations in Sensory and Multisensory Function in Autism Spectrum Disorder (2015) · cites this paper as Kikuchi et al., 2015
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Research works printed but not linked: 1
- Belmonte, M.K., Allen, G., Beckel-Mitchener, A., Boulanger, L.M., Carper, R.A., Webb, S.J. (2004). Autism and abnormal development of brain connectivity. The Journal of Neuroscience, 24, 9228-31.
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- Authors
- Kikuchi, M., Yoshimura, Y., Hiraishi, H., Munesue, T., Hashimoto, T., Tsubokawa, T., Takahashi, T., Suzuki, M., Higashida, H., & Minabe, Y.
- Affiliations
- Kanazawa University (JP)
- ORCID
- Venue
- Social Cognitive and Affective Neuroscience
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-04-09
- Volume
- 10
- Issue
- 2
- Pages
- 248-254
- ISSN
- 1749-5016 (ISSN-L)
- 1749-5024
- PMC
- PMC4321624
- OpenAlex
- W2171834490
- Cited by
- 64
- References
- 48
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 7 · 2023: 5 · 2022: 6 · 2021: 2 · 2020: 5 · 2019: 4 · 2018: 6 · 2017: 7 · 2016: 8 · 2015: 7 · 2014: 1
- FWCI
- 4.28
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Social Cognitive and Affective Neuroscience (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology (24000012)
- SENSHIN Medical Research Foundation
- Japan Society for the Promotion of Science (26670537, 26293262, 25293248, 24390282, 24000012)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, long-range functional connectivity, theta oscillations, coherence, young children, magnetoencephalography, clinical severity, neuronal connectivity
- MeSH terms
- Autism Spectrum Disorder, Alpha Rhythm, Brain, Brain Mapping, Child, Child, Preschool, Cognition, Female, Humans, Functional Laterality, Male, Neural Pathways, Neuropsychological Tests, Theta Rhythm, Magnetoencephalography
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