The Roots of Autism and ADHD Twin Study in Sweden (RATSS)
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Neurodevelopmental disorders affect a substantial minority of the general population. Their origins are still largely unknown, but a complex interplay of genetic and environmental factors causing disturbances of the central nervous system's maturation and a variety of higher cognitive skills is presumed. Only limited research of rather small sample size and narrow scope has been conducted in neurodevelopmental disorders using a twin-differences design. The Roots of Autism and ADHD Twin Study in Sweden (RATSS) is an ongoing project targeting monozygotic twins discordant for categorical or dimensional autistic and inattentive/hyperactive-impulsive phenotypes as well as other neurodevelopmental disorders, and typically developing twin controls. Included pairs are 9 years of age or older, and comprehensively assessed for psychopathology, medical history, neuropsychology, and dysmorphology, as well as structural, functional, and molecular brain imaging. Specimens are collected for induced pluripotent (iPS) and neuroepithelial stem cells, genetic, gut bacteria, protein-/monoamine, and electron microscopy analyses. RATSS's objective is to generate a launch pad for novel surveys to understand the complexity of genotype-environment-phenotype interactions in autism spectrum disorder and attention-deficit hyperactivity disorder (ADHD). By October 2013, RATSS had collected data from 55 twin pairs, among them 10 monozygotic pairs discordant for autism spectrum disorder, seven for ADHD, and four for other neurodevelopmental disorders. This article describes the design, recruitment, data collection, measures, collected pairs’ characteristics, as well as ongoing and planned analyses in RATSS. Potential gains of the study comprise the identification of environmentally mediated biomarkers, the emergence of candidates for drug development, translational modeling, and new leads for prevention of incapacitating outcomes.
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The Roots of Autism and ADHD Twin Study Sweden (RATSS) is the largest collection of deeply clinically phenotyped autism twins.
“The Roots of Autism and ADHD Twin Study Sweden (RATSS) [272], a sub-study of the population-based Child and Adolescent Twin Study Sweden (CATSS) [273], is the largest collection of deeply clinically phenotyped autism twins.”
From The contribution of environmental exposure to the etiology of autism spectrum disorder (2019) · cites this paper as [272]
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Astenvald, R., Frick, M. A., Neufeld, J., Bölte, S., & Isaksson, J. (2022) · Child and Adolescent Psychiatry and Mental Health · doi:10.1186/s13034-022-00528-0 · Cited by 32 · see citing works
Self-citationEating Problems in Autistic Females and Males: A Co-twin Control Study
Lundin Remnélius, K., Neufeld, J., Isaksson, J., & Bölte, S. (2022) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-021-05198-z · Cited by 25 · see citing works
Self-citationEU-AIMS Longitudinal European Autism Project (LEAP): the autism twin cohort
the EU-AIMS LEAP group, Isaksson, J., Tammimies, K., Neufeld, J., Cauvet, É., Lundin, K., Buitelaar, J. K., Loth, E., Murphy, D. G. M., Spooren, W., et al. (2018) · Molecular Autism · doi:10.1186/s13229-018-0212-x · Cited by 17 · see citing works
Self-citation
- Authors
- Bölte, S., Willfors, C., Berggren, S., Norberg, J., Poltrago, L., Mevel, K., Coco, C., Fransson, P., Borg, J., Sitnikov, R., Toro, R., Tammimies, K., Anderlid, B.-M., Nordgren, A., Falk, A., Meyer, U., Kere, J., Landén, M., Dalman, C., Ronald, A., Anckarsäter, H., & Lichtenstein, P.
- Affiliations
- Region Stockholm (SE)
- Karolinska Institutet (SE)
- Centre National de la Recherche Scientifique (FR)
- Karolinska University Hospital (SE)
- Institut Pasteur (FR)
- ETH Zurich (CH)
- University of London (GB)
- University of Gothenburg (SE)
- Corresponding author
- Bölte, Sven
- ORCID
- Venue
- Twin Research and Human Genetics
- Publisher
- Cambridge University Press (CUP)
- Published
- 2014-04-15
- Volume
- 17
- Issue
- 3
- Pages
- 164-176
- ISSN
- 1832-4274 (ISSN-L)
- 1839-2628
- OpenAlex
- W2102707475
- Cited by
- 71
- References
- 85
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 4 · 2023: 9 · 2022: 5 · 2021: 9 · 2020: 6 · 2019: 9 · 2018: 7 · 2017: 7 · 2016: 4 · 2015: 2 · 2014: 1
- FWCI
- 2.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Twin Research and Human Genetics (publishedVersion)
- PubMed (publishedVersion)
- BIROn (Birkbeck, University of London) (acceptedVersion)
- HAL (submittedVersion, other-oa)
- BIROn (Birkbeck, University of London) (submittedVersion)
- eSpace (Curtin University) (submittedVersion)
- Figshare (submittedVersion, cc-by-nc-nd)
- Open Archive (Karolinska Institutet) (submittedVersion, cc-by-nc-nd)
- Repository for Publications and Research Data (ETH Zurich) (submittedVersion, other-oa)
- ETH Zürich Research Collection
- Funders
- European Federation of Pharmaceutical Industries and Associations (FP7/20072013)
- European Commission (2007–2013, FP7 2007-2013, 115300, FP7/2007)
- VINNOVA (259‐2012‐24, 115300)
- Svenska Forskningsrådet Formas (259-2012-24, 115300)
- Hjärnfonden (115300)
- Stockholms Läns Landsting
- Vetenskapsrådet (FP7/2007-2013, 115300, 259-2012-24)
- Magnus Bergvalls Stiftelse
- Stiftelsen Sunnerdahls Handikappfond
- Sällskapet Barnavård
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Keywords
- autism spectrum disorder, attention deficit hyperactivity disorder, monozygotic twins, discordant twins, neurodevelopmental disorders, gene-environment interaction, environmental risk factors, biomarkers, neuroimaging, gut microbiota, induced pluripotent stem cells, neuroepithelial stem cells, monoamines, dysmorphology
- MeSH terms
- Adolescent, Adult, Attention Deficit Disorder with Hyperactivity, Autistic Disorder, Child, Cognition, Diseases in Twins, Environment, Female, Humans, Male, Phenotype, Psychiatric Status Rating Scales, Sweden, Twins, Dizygotic, Twins, Monozygotic, Young Adult, Neuroimaging
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