Cited by 63Sexual Differentiation and DisordersNeuroendocrine regulation and behaviorHypothalamic control of reproductive hormones

Hormone-dependent adolescent organization of socio-sexual behaviors in mammals

Open access
Sisk, Cheryl L·2016·Current Opinion in Neurobiology

Abstract

The adolescent transition from childhood to adulthood requires both reproductive and behavioral maturation as individuals acquire the ability to procreate. Gonadal steroid hormones are key players in the maturation of behaviors required for reproductive success. Beyond activating behavior in adulthood, testicular and ovarian hormones organize the adolescent brain and program adult-typical and sex-typical expression of sociosexual behaviors. Testicular hormones organize sexual and agonistic behaviors, including social proficiency-the ability to adapt behavior as a function of social experience. Ovarian hormones organize behaviors related to energy balance and maternal care. These sex differences in the behaviors that are programmed by gonadal hormones during adolescence suggest that evolution has selected for hormone-dependent sex-specific organization of behaviors that optimize reproductive fitness.

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Crossref · 10.1016/j.conb.2016.02.004

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  • The same hormones that contribute to the development of the secondary sex characteristics also play a critical role in reorganizing neural circuitry.

    “The same hormones that contribute to the developmental of the secondary sex characteristics also play a critical role in reorganizing neural circuitry (Schulz and Sisk, 2016, Sisk, 2016, Sisk and Zehr, 2005).”

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Authors
Sisk, C. L.
Affiliations
Michigan State University (US)
Corresponding author
Sisk, Cheryl L
Venue
Current Opinion in Neurobiology
Publisher
Elsevier BV
Published
2016-06
Volume
38
Pages
63-68
ISSN
0959-4388 (ISSN-L)
OpenAlex
W2294164911
Cited by
63
References
44
Citations by year
2026: 4 · 2025: 1 · 2024: 3 · 2023: 7 · 2022: 9 · 2021: 8 · 2020: 7 · 2019: 6 · 2018: 5 · 2017: 5 · 2016: 8
FWCI
0.72
Type
journal article
Language
en
Open access
Locations
  • Current Opinion in Neurobiology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health (R01 MH090091, R01 MH068764)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
adolescent brain development, sex steroids, sociosexual behavior, sex differences in behavior, testicular hormones, ovarian hormones, agonistic behavior, maternal care, energy balance, reproductive fitness
MeSH terms
Animals, Humans, Mammals, Sexual Behavior, Sex Characteristics, Gonadal Steroid Hormones, Sexual Maturation

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