Hormone-dependent adolescent organization of socio-sexual behaviors in mammals
Open accessAbstract
The adolescent transition from childhood to adulthood requires both reproductive and behavioral maturation as individuals acquire the ability to procreate. Gonadal steroid hormones are key players in the maturation of behaviors required for reproductive success. Beyond activating behavior in adulthood, testicular and ovarian hormones organize the adolescent brain and program adult-typical and sex-typical expression of sociosexual behaviors. Testicular hormones organize sexual and agonistic behaviors, including social proficiency-the ability to adapt behavior as a function of social experience. Ovarian hormones organize behaviors related to energy balance and maternal care. These sex differences in the behaviors that are programmed by gonadal hormones during adolescence suggest that evolution has selected for hormone-dependent sex-specific organization of behaviors that optimize reproductive fitness.
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The same hormones that contribute to the development of the secondary sex characteristics also play a critical role in reorganizing neural circuitry.
“The same hormones that contribute to the developmental of the secondary sex characteristics also play a critical role in reorganizing neural circuitry (Schulz and Sisk, 2016, Sisk, 2016, Sisk and Zehr, 2005).”
From Becoming a sexual being: The “elephant in the room” of adolescent brain development (2017) · cites this paper as Sisk, 2016
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Cites
Sexual Behavior in the Human Male
Kinsey, A. C., Pomeroy, W. R., & Martin, C. E. (1948) · Physical Therapy · doi:10.1093/ptj/28.2.93 · Cited by 5,577 · see citing works
PHOENIX, C. H., GOY, R. W., GERALL, A. A., & YOUNG, W. C. (1959) · Endocrinology · doi:10.1210/endo-65-3-369 · Cited by 1,934 · see citing works
The neurobiology of social cognition
Adolphs, R. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00202-6 · Cited by 1,432 · see citing works
The neural basis of puberty and adolescence
Sisk, C. L., & Foster, D. L. (2004) · Nature Neuroscience · doi:10.1038/nn1326 · Cited by 1,085 · see citing works
Self-citationPubertal hormones organize the adolescent brain and behavior
Sisk, C. L., & Zehr, J. L. (2005) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2005.10.003 · Cited by 1,082 · see citing works
Self-citationBack to the future: The organizational-activational hypothesis adapted to puberty and adolescence
Schulz, K. M., Molenda-Figueira, H. A., & Sisk, C. L. (2009) · Hormones and Behavior · doi:10.1016/j.yhbeh.2009.03.010 · Cited by 587 · see citing works
Self-citationSexual Behavior in the Human Male
Burlingame, C. C. (1948) · American Journal of Psychiatry · doi:10.1176/ajp.104.12.811 · Cited by 453 · see citing works
Pubertal hormones modulate the addition of new cells to sexually dimorphic brain regions
Ahmed, E. I., Zehr, J. L., Schulz, K. M., Lorenz, B. H., DonCarlos, L. L., & Sisk, C. L. (2008) · Nature Neuroscience · doi:10.1038/nn.2178 · Cited by 396 · see citing works
Self-citationDifferentiation of coital behavior in mammals: A comparative analysis
Baum, M. J. (1979) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(79)90013-7 · Cited by 321 · see citing works
Hormonal influences on sexually differentiated behavior in nonhuman primates.
Wallen, K. (2005) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2005.02.001 · Cited by 305 · see citing works
A sexually dimorphic hypothalamic circuit controls maternal care and oxytocin secretion
Scott, N., Prigge, M., Yizhar, O., & Kimchi, T. (2015) · Nature · doi:10.1038/nature15378 · Cited by 261 · see citing works
Juraska, J. M., Sisk, C. L., & DonCarlos, L. L. (2013) · Hormones and Behavior · doi:10.1016/j.yhbeh.2013.05.010 · Cited by 192 · see citing works
Self-citationSchulz, K. M., Richardson, H. N., Zehr, J. L., Osetek, A. J., Menard, T. A., & Sisk, C. L. (2004) · Hormones and Behavior · doi:10.1016/j.yhbeh.2003.12.007 · Cited by 169 · see citing works
Self-citationSchulz, K. M., & Sisk, C. L. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2006.04.025 · Cited by 154 · see citing works
Self-citationDendritic pruning of the medial amygdala during pubertal development of the male Syrian hamster
Zehr, J. L., Todd, B. J., Schulz, K. M., McCarthy, M. M., & Sisk, C. L. (2006) · Journal of Neurobiology · doi:10.1002/neu.20251 · Cited by 145 · see citing works
Self-citationPellis, S. M. (2002) · Archives of Sexual Behavior · doi:10.1023/a:1014070916047 · Cited by 124 · see citing works
Masculinization and Defeminization in Altricial and Precocial Mammals
Wallen, K., & Baum, M. J. (2002) · Elsevier eBooks · doi:10.1016/b978-012532104-4/50071-8 · Cited by 123 · see citing works
Vasopressin in the septal area of the golden hamster controls scent marking and grooming
Irvin, R. W., Szot, P., Dorsa, D. M., Potegal, M., & Ferris, C. F. (1990) · Physiology & Behavior · doi:10.1016/0031-9384(90)90213-n · Cited by 105 · see citing works
Testosterone Programs Adult Social Behavior before and during, But Not after, Adolescence
Schulz, K. M., Zehr, J. L., Salas-Ramirez, K. Y., & Sisk, C. L. (2009) · Endocrinology · doi:10.1210/en.2008-1708 · Cited by 105 · see citing works
Self-citationGonadal hormones during puberty organize environment-related social interaction in the male rat
Primus, R. J., & Kellogg, C. K. (1990) · Hormones and Behavior · doi:10.1016/0018-506x(90)90012-m · Cited by 103 · see citing works
Sexual Behavior Differentiation
Ward, I. L., & Ward, O. B. (1985) · Handbook of behavioral neurobiology · doi:10.1007/978-1-4684-4832-0_4 · Cited by 64 · see citing works
Schulz, K. M., Menard, T. A., Smith, D. A., Albers, H. E., & Sisk, C. L. (2006) · Hormones and Behavior · doi:10.1016/j.yhbeh.2006.06.006 · Cited by 57 · see citing works
Self-citationIntegration of Chemosensory and Hormonal Input in the Male Syrian Hamster Brain
Wood, R. I. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb10594.x · Cited by 54 · see citing works
Lorme, K. C. D., Schulz, K. M., Salas-Ramirez, K. Y., & Sisk, C. L. (2012) · Brain Research · doi:10.1016/j.brainres.2012.04.035 · Cited by 52 · see citing works
Self-citationMohr, M. A., & Sisk, C. L. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219443110 · Cited by 51 · see citing works
Self-citationDwyer, A. A., Quinton, R., Pitteloud, N., & Morin, D. (2014) · Sexual Medicine · doi:10.1002/sm2.50 · Cited by 46 · see citing works
Johnson, R. T., Breedlove, S. M., & Jordan, C. L. (2012) · The Journal of Comparative Neurology · doi:10.1002/cne.23286 · Cited by 41 · see citing works
Peripubertal castration of male rats, adult open field ambulation and partner preference behavior
Brand, T., & Slob, A. K. (1988) · Behavioural Brain Research · doi:10.1016/0166-4328(88)90141-6 · Cited by 40 · see citing works
Field, E. F., Whishaw, I. Q., Forgie, M. L., & Pellis, S. M. (2004) · Behavioral Neuroscience · doi:10.1037/0735-7044.118.6.1293 · Cited by 40 · see citing works
Synaptic Reorganisation of the Medial Amygdala During Puberty
Cooke, B. M. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.02075.x · Cited by 35 · see citing works
Organization of Territorial Marking Behavior by Testosterone During Puberty in Male Tree Shrews
Eichmann, F., & von Holst, D. (1998) · Physiology & Behavior · doi:10.1016/s0031-9384(98)00230-3 · Cited by 35 · see citing works
Development of responses to vaginal secretion and other substances in golden hamsters
Johnston, R. E., & Coplin, B. (1979) · Behavioral and Neural Biology · doi:10.1016/s0163-1047(79)90242-5 · Cited by 35 · see citing works
Albers, H. E., & Cooper, T. T. (1995) · Peptides · doi:10.1016/0196-9781(94)00188-x · Cited by 33 · see citing works
Swithers, S. E., McCurley, M., Hamilton, E., & Doerflinger, A. (2008) · Hormones and Behavior · doi:10.1016/j.yhbeh.2008.05.009 · Cited by 30 · see citing works
Bell, M. R., Meerts, S. H., & Sisk, C. L. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.05.017 · Cited by 29 · see citing works
Self-citationShrenker, P., Maxson, S. C., & Ginsburg, B. E. (1985) · Physiology & Behavior · doi:10.1016/0031-9384(85)90408-1 · Cited by 29 · see citing works
Lorme, K. C. D., Bell, M. R., & Sisk, C. L. (2013) · Current Directions in Psychological Science · doi:10.1177/0963721413479607 · Cited by 26 · see citing works
Self-citationLorme, K. C. D., & Sisk, C. L. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.02.003 · Cited by 23 · see citing works
Self-citationLumia, A. R., Raskin, L. A., & Eckhert, S. J. (1977) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0077410 · Cited by 22 · see citing works
Davidson, J. K., Wolman, B. B., & Money, J. (1981) · Journal of Marriage and the Family · doi:10.2307/351359 · Cited by 21 · see citing works
Gonadectomy prior to puberty decreases normal parental behavior in adult mice
Kerčmar, J., Snoj, T., Tobet, S. A., & Majdič, G. (2014) · Hormones and Behavior · doi:10.1016/j.yhbeh.2014.09.007 · Cited by 20 · see citing works
Bell, M. R., Lorme, K. C. D., Figueira, R. J., Kashy, D. A., & Sisk, C. L. (2012) · European Journal of Neuroscience · doi:10.1111/ejn.12058 · Cited by 20 · see citing works
Self-citationCooke, B. M., Jordan, C. L., & Breedlove, S. M. (2007) · Hormones and Behavior · doi:10.1016/j.yhbeh.2007.04.008 · Cited by 15 · see citing works
Lorme, K. C. D., Bell, M. R., & Sisk, C. L. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.07.002 · Cited by 12 · see citing works
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Dahl, R. E., Allen, N. B., Wilbrecht, L., & Suleiman, A. B. (2018) · Nature · doi:10.1038/nature25770 · Cited by 1,196 · see citing works
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Koss, W. A., & Frick, K. M. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.23864 · Cited by 156 · see citing works
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Culbert, K. M., Sisk, C. L., & Klump, K. L. (2021) · Clinical Therapeutics · doi:10.1016/j.clinthera.2020.12.003 · Cited by 142 · see citing works
Self-citationHampson, E. (2020) · Hormones and Behavior · doi:10.1016/j.yhbeh.2019.104655 · Cited by 136 · see citing works
Becoming a sexual being: The “elephant in the room” of adolescent brain development
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- Authors
- Sisk, C. L.
- Affiliations
- Michigan State University (US)
- Corresponding author
- Sisk, Cheryl L
- ORCID
- Sisk, Cheryl L
- Venue
- Current Opinion in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2016-06
- Volume
- 38
- Pages
- 63-68
- ISSN
- 0959-4388 (ISSN-L)
- PMC
- PMC4921305
- OpenAlex
- W2294164911
- Cited by
- 63
- References
- 44
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 3 · 2023: 7 · 2022: 9 · 2021: 8 · 2020: 7 · 2019: 6 · 2018: 5 · 2017: 5 · 2016: 8
- FWCI
- 0.72
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Current Opinion in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (R01 MH090091, R01 MH068764)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- adolescent brain development, sex steroids, sociosexual behavior, sex differences in behavior, testicular hormones, ovarian hormones, agonistic behavior, maternal care, energy balance, reproductive fitness
- MeSH terms
- Animals, Humans, Mammals, Sexual Behavior, Sex Characteristics, Gonadal Steroid Hormones, Sexual Maturation
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