Prenatal stress disrupts social behavior, cortical neurobiology and commensal microbes in adult male offspring
Open accessAbstract
In utero and early neonatal exposure to maternal stress is linked with psychiatric disorders, and the underlying mechanisms are currently being elucidated. We used a prenatal stressor in pregnant mice to examine novel relationships between prenatal stress exposure, changes in the gut microbiome, and social behavior. Here, we show that males exposed to prenatal stress had a significant reduction in social behavior in adulthood, with increased corticosterone release following social interaction. Male offspring exposed to prenatal stress also had neuroinflammation, decreased oxytocin receptor, and decreased serotonin metabolism in their cortex in adulthood, which are linked to decreased social behavior. Finally, we found a significant difference in commensal microbes, including decreases in Bacteroides and Parabacteroides, in adult male offspring exposed to prenatal stress when compared to non-stressed controls. Our findings indicate that gestation is a critical window where maternal stress contributes to the development of aberrant social behaviors and alterations in cortical neurobiology, and that prenatal stress is sufficient to disrupt the male gut-brain axis into adulthood.
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The microbiota and HPA axis develop rapidly and profoundly in the first years of life.
“The microbiota and HPA axis develop rapidly and profoundly in the first years of life, and environmental stressors can affect both (146–148).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [146]
Environmental stressors can affect both the microbiota and the HPA axis.
“The microbiota and HPA axis develop rapidly and profoundly in the first years of life, and environmental stressors can affect both (146–148).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [146]
Male offspring presented with deficits in social cognition only, without disturbances in the other behavior or cognitive parameters measured.
“In contrast, male offspring presented with deficits in social cognition only, without disturbances in the other behavior or cognitive parameters measured (146).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [146]
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- Authors
- Gur, T. L., Palkar, A. V., Rajasekera, T., Allen, J., Niraula, A., Godbout, J., & Bailey, M. T.
- Affiliations
- The Ohio State University Wexner Medical Center (US)
- Nationwide Children's Hospital (US)
- Corresponding author
- Gur, Tamar L.
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2019-02
- Volume
- 359
- Pages
- 886-894
- ISSN
- 0166-4328 (ISSN-L)
- PMC
- PMC6542272
- OpenAlex
- W2810891667
- Cited by
- 127
- References
- 53
- Citations by year
- 2026: 12 · 2025: 18 · 2024: 19 · 2023: 23 · 2022: 15 · 2021: 21 · 2020: 15 · 2019: 4
- FWCI
- 5.76
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Ohio State University
- National Alliance for Research on Schizophrenia and Depression
- Brain and Behavior Research Foundation
- March of Dimes Prematurity Research Center Ohio Collaborative
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Keywords
- prenatal stress, maternal stress, social behavior, gut microbiota, gut-brain axis, corticosterone, neuroinflammation, oxytocin receptor, serotonin metabolism, Bacteroides, Parabacteroides, mental illness, mouse model
- MeSH terms
- Gastrointestinal Microbiome, Animals, Animals, Newborn, Calcium-Binding Proteins, Cerebral Cortex, Corticosterone, Female, Hydroxyindoleacetic Acid, Interpersonal Relations, Male, Microfilament Proteins, Pregnancy, Prenatal Exposure Delayed Effects, RNA, Ribosomal, 16S, Serotonin, Social Behavior Disorders, Stress, Psychological, Cytokines, Receptors, Oxytocin, Hindlimb Suspension, Recognition, Psychology, Mice
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