Cited by 246Gut microbiota and healthProbiotics and Fermented FoodsAnimal Nutrition and Physiology

The small intestine microbiota, nutritional modulation and relevance for health

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El Aidy, Sahar, van den Bogert, Bartholomeus, Kleerebezem, Michiel·2015·Current Opinion in Biotechnology

Abstract

The intestinal microbiota plays a profound role in human health and extensive research has been dedicated to identify microbiota aberrations that are associated with disease. Most of this work has been targeting the large intestine and fecal microbiota, while the small intestine microbiota may also have a profound impact on various aspects of the host's physiology, including immune, metabolic and endocrine functions. This review highlights the recent advances made in the study of the human small intestine microbiota. In addition, it describes recent human and animal studies that underpin the importance of this part of the intestine for health of the host organism.

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Crossref · 10.1016/j.copbio.2014.09.005

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  • Due to reliance on fecal microbiota assessments, comparatively little is known about the microbiota of the less accessible small intestine.

    “due to our reliance of fecal microbiota assessments, comparatively little is known about the microbiota of the less accessible small intestine (El Aidy et al., 2015).”

    From Gut reactions: Breaking down xenobiotic–microbiome interactions (2019) · cites this paper as El Aidy et al., 2015

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  1. Brugman S, Schneeberger K, Witte M, Klein MR, van den Bogert B, Boekhorst J, Timmerman HM, Boes M, Kleerebezem M, Nieuwenhuis EES: T lymphocytes control microbial composition by actively repressing overgrowth of pathogenic bacteria in the zebrafish gut. Gut Microbes 2014. (in press).

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Authors
El Aidy, S., van den Bogert, B., & Kleerebezem, M.
Affiliations
TiFN (NL)
Corresponding author
Kleerebezem, Michiel
Venue
Current Opinion in Biotechnology
Publisher
Elsevier BV
Published
2015-04
Volume
32
Pages
14-20
ISSN
0958-1669 (ISSN-L)
OpenAlex
W2027271580
Cited by
244
References
59
Citations by year
2026: 8 · 2025: 16 · 2024: 23 · 2023: 25 · 2022: 35 · 2021: 24 · 2020: 26 · 2019: 28 · 2018: 19 · 2017: 11 · 2016: 20 · 2015: 7 · 2014: 1
FWCI
1.20
Type
journal article
Language
en
Open access
Locations
  • Current Opinion in Biotechnology (publishedVersion, other-oa)
  • PubMed (publishedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, other-oa)
  • Socio-Environmental Systems Modeling (acceptedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
Keywords
small intestinal microbiota, gut microbiota, dietary modulation, host physiology, immune function, metabolic function, endocrine function, host-microbe interactions
MeSH terms
Amidohydrolases, Animals, Humans, Intestine, Small, Probiotics, Metabolic Syndrome, Microbiota

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