The small intestine microbiota, nutritional modulation and relevance for health
Open accessAbstract
The intestinal microbiota plays a profound role in human health and extensive research has been dedicated to identify microbiota aberrations that are associated with disease. Most of this work has been targeting the large intestine and fecal microbiota, while the small intestine microbiota may also have a profound impact on various aspects of the host's physiology, including immune, metabolic and endocrine functions. This review highlights the recent advances made in the study of the human small intestine microbiota. In addition, it describes recent human and animal studies that underpin the importance of this part of the intestine for health of the host organism.
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Due to reliance on fecal microbiota assessments, comparatively little is known about the microbiota of the less accessible small intestine.
“due to our reliance of fecal microbiota assessments, comparatively little is known about the microbiota of the less accessible small intestine (El Aidy et al., 2015).”
From Gut reactions: Breaking down xenobiotic–microbiome interactions (2019) · cites this paper as El Aidy et al., 2015
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Cites
Diversity, stability and resilience of the human gut microbiota
Lozupone, C. A., Stombaugh, J. I., Gordon, J. I., Jansson, J. K., & Knight, R. (2012) · Nature · doi:10.1038/nature11550 · Cited by 5,533 · see citing works
Role of the microbiota in immunity and inflammation.
Belkaid, Y., & Hand, T. W. (2014) · Cell · doi:10.1016/j.cell.2014.03.011 · Cited by 5,385 · see citing works
Host-gut microbiota metabolic interactions
Nicholson, J. K., Holmes, E., Kinross, J., Burcelin, R., Gibson, G., Jia, W., & Pettersson, S. (2012) · Science · doi:10.1126/science.1223813 · Cited by 4,760 · see citing works
Functional interactions between the gut microbiota and host metabolism
Tremaroli, V., & Bäckhed, F. (2012) · Nature · doi:10.1038/nature11552 · Cited by 4,387 · see citing works
Gut microbiota in health and disease
Sekirov, I., Russell, S. L., Antunes, L. C. M., & Finlay, B. B. (2010) · Physiological Reviews · doi:10.1152/physrev.00045.2009 · Cited by 4,182 · see citing works
Induction of Colonic Regulatory T Cells by Indigenous <i>Clostridium</i> Species
Atarashi, K., Tanoue, T., Shima, T., Imaoka, A., Kuwahara, T., Momose, Y., Cheng, G., Yamasaki, S., Saito, T., Ohba, Y., et al. (2011) · Science · doi:10.1126/science.1198469 · Cited by 3,752 · see citing works
The gut microbiota--masters of host development and physiology
Sommer, F., & Bäckhed, F. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro2974 · Cited by 3,681 · see citing works
Hsiao, E. Y., McBride, S. W., Hsien, S., Sharon, G., Hyde, E. R., McCue, T., Codelli, J. A., Chow, J., Reisman, S. E., Petrosino, J. F., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.024 · Cited by 3,283 · see citing works
The Treatment-Naive Microbiome in New-Onset Crohn’s Disease
Gevers, D., Kugathasan, S., Denson, L. A., Vázquez-Baeza, Y., Van Treuren, W., Ren, B., Schwager, E., Knights, D., Song, S. J., Yassour, M., et al. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.02.005 · Cited by 3,220 · see citing works
Vrieze, A., Van Nood, E., Holleman, F., Salojärvi, J., Kootte, R. S., Bartelsman, J. F. W. M., Dallinga–Thie, G. M., Ackermans, M. T., Serlie, M. J., Oozeer, R., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.06.031 · Cited by 2,913 · see citing works
Genetics and pathogenesis of inflammatory bowel disease
Khor, B., Gardet, A., & Xavier, R. J. (2011) · Nature · doi:10.1038/nature10209 · Cited by 2,630 · see citing works
Microbiota-Generated Metabolites Promote Metabolic Benefits via Gut-Brain Neural Circuits
De Vadder, F., Kovatcheva-Datchary, P., Goncalves, D., Vinera, J., Zitoun, C., Duchampt, A., Bäckhed, F., & Mithieux, G. (2014) · Cell · doi:10.1016/j.cell.2013.12.016 · Cited by 2,200 · see citing works
Microbial Exposure During Early Life Has Persistent Effects on Natural Killer T Cell Function
Olszak, T., An, D., Zeissig, S., Vera, M. P., Richter, J., Franke, A., Glickman, J. N., Siebert, R., Baron, R. M., Kasper, D. L., et al. (2012) · Science · doi:10.1126/science.1219328 · Cited by 1,661 · see citing works
Gut immune maturation depends on colonization with a host-specific microbiota
Chung, H., Pamp, S. J., Hill, J. A., Surana, N. K., Edelman, S. M., Troy, E. B., Reading, N. C., Villablanca, E. J., Wang, S., Mora, J. R., et al. (2012) · Cell · doi:10.1016/j.cell.2012.04.037 · Cited by 1,241 · see citing works
Differential Adaptation of Human Gut Microbiota to Bariatric Surgery–Induced Weight Loss
Furet, J.-P., Kong, L.-C., Tap, J., Poitou, C., Basdevant, A., Bouillot, J.-L., Mariat, D., Corthier, G., Doré, J., Henegar, C., et al. (2010) · Diabetes · doi:10.2337/db10-0253 · Cited by 1,173 · see citing works
FXR is a molecular target for the effects of vertical sleeve gastrectomy
Ryan, K. K., Tremaroli, V., Clemmensen, C., Kovatcheva-Datchary, P., Myronovych, A., Karns, R., Wilson-Pérez, H. E., Sandoval, D. A., Kohli, R., Bäckhed, F., et al. (2014) · Nature · doi:10.1038/nature13135 · Cited by 931 · see citing works
Lymphoid tissue inducer–like cells are an innate source of IL-17 and IL-22
Takatori, H., Kanno, Y., Watford, W. T., Tato, C. M., Weiss, G. E., Ivanov, I. I., Littman, D. R., & O’Shea, J. J. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20072713 · Cited by 737 · see citing works
Zoetendal, E. G., Raes, J., van den Bogert, B., Arumugam, M., Booijink, C. C. G. M., Troost, F. J., Bork, P., Wels, M., de Vos, W. M., & Kleerebezem, M. (2012) · The ISME Journal · doi:10.1038/ismej.2011.212 · Cited by 722 · see citing works
Self-citationMulti-Faceted Functions of Secretory IgA at Mucosal Surfaces
Corthésy, B. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00185 · Cited by 678 · see citing works
Salonen, A., Lahti, L., Salojärvi, J., Holtrop, G., Korpela, K., Duncan, S. H., Date, P., Farquharson, F., Johnstone, A. M., Lobley, G. E., et al. (2014) · The ISME Journal · doi:10.1038/ismej.2014.63 · Cited by 626 · see citing works
Lee, Y. S., Kim, J.-W., Osborne, O., Oh, D. Y., Sasik, R., Schenk, S., Chen, A., Chung, H., Murphy, A., Watkins, S. M., et al. (2014) · Cell · doi:10.1016/j.cell.2014.05.012 · Cited by 598 · see citing works
Exploring host–microbiota interactions in animal models and humansPreprint
Kostic, A. D., Howitt, M. R., & Garrett, W. S. (2013) · Genes & Development · doi:10.1101/gad.212522.112 · Cited by 491 · see citing works
Rajilić‐Stojanović, M., Heilig, H. G. H. J., Molenaar, D., Kajander, K., Surakka, A., Smidt, H., & De Vos, W. M. (2009) · Environmental Microbiology · doi:10.1111/j.1462-2920.2009.01900.x · Cited by 484 · see citing works
Role of the intestinal microbiome in health and disease: from correlation to causation
de Vos, W. M., & de Vos, E. A. (2012) · Nutrition Reviews · doi:10.1111/j.1753-4887.2012.00505.x · Cited by 440 · see citing works
Modulation of the Intestinal Microbiota Alters Colitis-Associated Colorectal Cancer Susceptibility
Uronis, J. M., Mühlbauer, M., Herfarth, H. H., Rubinas, T. C., Jones, G. S., & Jobin, C. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006026 · Cited by 425 · see citing works
Immune Responses to the Microbiota at the Intestinal Mucosal Surface
Duerkop, B. A., Vaishnava, S., & Hooper, L. V. (2009) · Immunity · doi:10.1016/j.immuni.2009.08.009 · Cited by 424 · see citing works
Ermund, A., Schutte, A. H., Johansson, M., Gustafsson, J. K., & Hansson, G. C. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00046.2013 · Cited by 392 · see citing works
van Baarlen, P., Troost, F. J., van Hemert, S., van Kraaij, C., de Vos, W. M., de Groot, P. J., Hooiveld, G. J. E. J., Brummer, R. J., & Kleerebezem, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809919106 · Cited by 384 · see citing works
Self-citationGut microbiota, enteroendocrine functions and metabolism
Cani, P. D., Everard, A., & Duparc, T. (2013) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2013.09.008 · Cited by 378 · see citing works
Lécuyer, E., Rakotobé, S., Garnier‐Lengliné, H., Lebreton, C., Picard, M., Juste, C., Fritzen, R., Eberl, G., McCoy, K. D., Macpherson, A. J., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.03.009 · Cited by 364 · see citing works
van Baarlen, P., Troost, F. J., van Kraaij, C., Hooiveld, G. J. E. J., Boekschoten, M. V., Brummer, R. J., & Kleerebezem, M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000079107 · Cited by 336 · see citing works
Self-citationDendritic cells in intestinal homeostasis and disease
Rescigno, M., & Sabatino, A. D. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39134 · Cited by 327 · see citing works
High temporal and inter‐individual variation detected in the human ileal microbiota
Booijink, C. C. G. M., El‐Aidy, S., Rajilić‐Stojanović, M., Heilig, H. G. H. J., Troost, F. J., Smidt, H., Kleerebezem, M., De Vos, W. M., & Zoetendal, E. G. (2010) · Environmental Microbiology · doi:10.1111/j.1462-2920.2010.02294.x · Cited by 324 · see citing works
Self-citationPatterns of Early Gut Colonization Shape Future Immune Responses of the Host
Hansen, C. H. F., Nielsen, D. S., Kverka, M., Zakostelska, Z. J., Kostovcikova, K., Hudcovic, T., Tlaskalová‐Hogenová, H., & Hansen, A. K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034043 · Cited by 310 · see citing works
Leser, T. D., & Mølbak, L. (2009) · Environmental Microbiology · doi:10.1111/j.1462-2920.2009.01941.x · Cited by 304 · see citing works
Microbiota, Disease, and Back to Health: A Metastable Journey
Blumberg, R. S., & Powrie, F. M. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004184 · Cited by 279 · see citing works
Perspective: Alpha-Bugs, Their Microbial Partners, and the Link to Colon Cancer
Sears, C. L., & Pardoll, D. M. (2011) · The Journal of Infectious Diseases · doi:10.1093/jinfdis/jiq061 · Cited by 259 · see citing works
Aidy, S. E., van Baarlen, P., Derrien, M., Lindenbergh-Kortleve, D. J., Hooiveld, G. J. E. J., Levenez, F., Dore, J. M., Dekker, J. P., Samsom, J. N., Nieuwenhuis, E. E. S., et al. (2012) · Mucosal Immunology · doi:10.1038/mi.2012.32 · Cited by 247 · see citing works
Self-citationShort-Chain Fatty Acid Receptor and Its Contribution to Glucagon-Like Peptide-1 Release
Kaji, I., Karaki, S.-I., & Kuwahara, A. (2014) · Digestion · doi:10.1159/000356211 · Cited by 177 · see citing works
Diversity of human small intestinal Streptococcus and Veillonella populations
van den Bogert, B., Erkuş, O., Boekhorst, J., de Goffau, M. C., Smid, E. J., Zoetendal, E. G., & Kleerebezem, M. (2013) · FEMS Microbiology Ecology · doi:10.1111/1574-6941.12127 · Cited by 172 · see citing works
Self-citationMicrobial Communities in the Human Small Intestine: Coupling Diversity to Metagenomics
Booijink, C. C., Zoetendal, E. G., Kleerebezem, M., & de Vos, W. M. (2007) · Future Microbiology · doi:10.2217/17460913.2.3.285 · Cited by 164 · see citing works
Self-citationAidy, S. E., Merrifield, C. A., Derrien, M., van Baarlen, P., Hooiveld, G. J. E. J., Levenez, F., Dore, J. M., Dekker, J. P., Holmes, E. C., Claus, S. P., et al. (2012) · Gut · doi:10.1136/gutjnl-2011-301955 · Cited by 134 · see citing works
Self-citationA novel ingestible electronic drug delivery and monitoring device
Schaar, P. J. V. D., Dijksman, J., Gast, H. S. B.-D., Shimizu, J., van Lelyveld, N., Zou, H., Iordanov, V. P., Wanke, C., & Siersema, P. D. (2013) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2013.03.170 · Cited by 119 · see citing works
Roux-en-Y gastric bypass surgery in rats alters gut microbiota profile along the intestine
Osto, M., Abegg, K., Bueter, M., le Roux, C. W., Cani, P. D., & Lutz, T. A. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.06.008 · Cited by 85 · see citing works
Aidy, S. E., Derrien, M., Aardema, R., Hooiveld, G. J. E. J., Richards, S. E., Dane, A. D., Dekker, J. P., Vreeken, R. J., Levenez, F., Dore, J. M., et al. (2013) · Beneficial Microbes · doi:10.3920/bm2013.0018 · Cited by 82 · see citing works
Self-citationvan den Bogert, B., Boekhorst, J., Herrmann, R., Smid, E. J., Zoetendal, E. G., & Kleerebezem, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083418 · Cited by 74 · see citing works
Self-citationIncreased Hepatic Insulin Clearance After Roux-en-Y Gastric Bypass
Bojsen-Møller, K. N., Dirksen, C., Jørgensen, N. B., Jacobsen, S. H., Hansen, D. L., Worm, D., Naver, L., Kristiansen, V. B., Holst, J. J., & Madsbad, S. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-1286 · Cited by 69 · see citing works
Brugman, S., Schneeberger, K., Witte, M., Klein, M. R., van den Bogert, B., Boekhorst, J., Timmerman, H. M., Boes, M. L., Kleerebezem, M., & Nieuwenhuis, E. E. S. (2014) · Gut Microbes · doi:10.4161/19490976.2014.972228 · Cited by 67 · see citing works
Self-citationAre stool samples suitable for studying the link between gut microbiota and obesity?
Raoult, D., & Henrissat, B. (2014) · European Journal of Epidemiology · doi:10.1007/s10654-014-9905-4 · Cited by 66 · see citing works
Ermann, J., Staton, T. L., Glickman, J. N., Malefyt, R. D. W., & Glimcher, L. H. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408540111 · Cited by 66 · see citing works
GI Microbiota and Regulation of the Immune System
Huffnagle, G. B., & Noverr, M. C. (2008) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-09550-9 · Cited by 56 · see citing works
Effects of Microbiota on GI Health: Gnotobiotic Research
Wagner, R. D. (2009) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-09550-9_4 · Cited by 48 · see citing works
Small intestine and microbiota
Cotter, P. D. (2010) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e328341dc67 · Cited by 46 · see citing works
FXR: the key to benefits in bariatric surgery?
Kuipers, F., & Groen, A. K. (2014) · Nature Medicine · doi:10.1038/nm.3525 · Cited by 33 · see citing works
Menckeberg, C. L., Hol, J., Simons-Oosterhuis, Y., Raatgeep, H. C., de Ruiter, L. F., Lindenbergh-Kortleve, D. J., Male, A. M. K.-V., Aidy, S. E., van Lierop, P. P. E., Kleerebezem, M., et al. (2014) · Gut · doi:10.1136/gutjnl-2013-306149 · Cited by 29 · see citing works
Self-citationMicrobial Learning Lessons: SFB Educate the Immune System
Lee, Y. K., & Mazmanian, S. K. (2014) · Immunity · doi:10.1016/j.immuni.2014.04.002 · Cited by 24 · see citing works
Functional Intestinal Metagenomics
van den Bogert, B., Leimena, M. M., de Vos, W. M., Zoetendal, E. G., & Kleerebezem, M. (2011) · doi:10.1002/9781118010549.ch18 · Cited by 13 · see citing works
Self-citationHandbook of Molecular Microbial Ecology
Zhang, W. (2012) · Food Microbiology · doi:10.1016/j.fm.2012.01.003 · Cited by 13 · see citing works
Draft Genome Sequence of Veillonella parvula HSIVP1, Isolated from the Human Small Intestine
van den Bogert, B., Boekhorst, J., Smid, E. J., Zoetendal, E. G., & Kleerebezem, M. (2013) · Genome Announcements · doi:10.1128/genomea.00977-13 · Cited by 12 · see citing works
Self-citation
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- Brugman S, Schneeberger K, Witte M, Klein MR, van den Bogert B, Boekhorst J, Timmerman HM, Boes M, Kleerebezem M, Nieuwenhuis EES: T lymphocytes control microbial composition by actively repressing overgrowth of pathogenic bacteria in the zebrafish gut. Gut Microbes 2014. (in press).
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Microbiota in health and diseases
Hou, K., Wu, Z.-X., Chen, X.-Y., Wang, J.-Q., Zhang, D., Xiao, C., Zhu, D., Koya, J. B., Wei, L., Li, J., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00974-4 · Cited by 3,171 · see citing works
An insight into gut microbiota and its functionalities
Adak, A., & Khan, M. R. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2943-4 · Cited by 1,485 · see citing works
Fate, activity, and impact of ingested bacteria within the human gut microbiota
Derrien, M., & van Hylckama Vlieg, J. E. T. (2015) · Trends in Microbiology · doi:10.1016/j.tim.2015.03.002 · Cited by 605 · see citing works
Hua, S. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00524 · Cited by 565 · see citing works
van Kessel, S. P., Frye, A. K., El-Gendy, A. O., Castejon, M., Keshavarzian, A., van Dijk, G., & El Aidy, S. (2019) · Nature Communications · doi:10.1038/s41467-019-08294-y · Cited by 521 · see citing works
The role of the intestinal microbiota in type 1 diabetes mellitus
Knip, M., & Siljander, H. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.218 · Cited by 434 · see citing works
Chevalier, G., Siopi, E., Guenin‐Macé, L., Pascal, M., Laval, T., Rifflet, A., Boneca, I. G., Demangel, C., Colsch, B., Pruvost, A., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19931-2 · Cited by 324 · see citing works
Gut reactions: Breaking down xenobiotic–microbiome interactions
Clarke, G., Sandhu, K. V., Griffin, B. T., Dinan, T. G., Cryan, J. F., & Hyland, N. P. (2019) · Pharmacological Reviews · doi:10.1124/pr.118.015768 · Cited by 319 · see citing works
Saffouri, G. B., Shields‐Cutler, R. R., Chen, J., Yang, Y., Lekatz, H. R., Hale, V. L., Cho, J. M., Battaglioli, E. J., Bhattarai, Y., Thompson, K. J., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09964-7 · Cited by 309 · see citing works
The food-gut axis: lactic acid bacteria and their link to food, the gut microbiome and human health
De Filippis, F., Pasolli, E., & Ercolini, D. (2020) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuaa015 · Cited by 303 · see citing works
Microbes vs. chemistry in the origin of the anaerobic gut lumen
Friedman, E. S., Bittinger, K. L., Esipova, T. V., Hou, L., Chau, L., Jiang, J., Mesaros, C., Lund, P. J., Liang, X., FitzGerald, G. A., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1718635115 · Cited by 272 · see citing works
Gut-on-a-chip: Current progress and future opportunities
Ashammakhi, N. A., Nasiri, R., de Barros, N. R., Tebon, P. J., Thakor, J., Goudie, M. J., Shamloo, A., Martín, M. G., & Khademhosseini, A. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120196 · Cited by 244 · see citing works
Wernimont, S. M., Radosevich, J., Jackson, M. I., Ephraim, E., Badri, D. V., MacLeay, J. M., Jewell, D. E., & Suchodolski, J. S. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01266 · Cited by 220 · see citing works
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Nishiyama, K., Sugiyama, M., & Mukai, T. (2016) · Microorganisms · doi:10.3390/microorganisms4030034 · Cited by 170 · see citing works
Age and the aging process significantly alter the small bowel microbiome
Leite, G., Pimentel, M., Barlow, G. M., Chang, C. Y.-Y., Hosseini, A., Wang, J., Parodi, G., Sedighi, R., Rezaie, A. R., & Mathur, R. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109765 · Cited by 158 · see citing works
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Shamriz, O., Mizrahi, H., Werbner, M., Shoenfeld, Y., Avni, O., & Koren, O. (2016) · Autoimmunity Reviews · doi:10.1016/j.autrev.2016.07.012 · Cited by 151 · see citing works
Gut microbiota modulates drug pharmacokinetics
Zhang, J., Zhang, J., & Wang, R. (2018) · Drug Metabolism Reviews · doi:10.1080/03602532.2018.1497647 · Cited by 151 · see citing works
Li, G., Yang, M. J., Zhou, K., Zhang, L., Tian, L., Lv, S., Jin, Y. T., Qian, W., Xiong, H., Lin, R., et al. (2015) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.1412.12047 · Cited by 141 · see citing works
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Watanabe, K., & Petri, W. A. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.07.030 · Cited by 139 · see citing works
The Impact of the Gut Microbiota on Drug Metabolism and Clinical Outcome.
Enright, E. F., Gahan, C. G. M., Joyce, S. A., & Griffin, B. T. (2016) · PubMed Central · Cited by 139 · see citing works
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Li, Y., Hu, X., Yang, S., Zhou, J., Zhang, T., Qi, L., Sun, X., Fan, M., Xu, S., Cha, M., et al. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01705 · Cited by 137 · see citing works
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Altomare, A., Rosa, C. D., Imperia, E., Emerenziani, S., Cicala, M., & Guarino, M. P. L. (2021) · Nutrients · doi:10.3390/nu13051506 · Cited by 132 · see citing works
Safarchi, A., Al-Qadami, G. H., Tran, C. D., & Conlon, M. A. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1559521 · Cited by 133 · see citing works
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Kigerl, K. A., Mostacada, K., & Popovich, P. G. (2017) · Neurotherapeutics · doi:10.1007/s13311-017-0583-2 · Cited by 124 · see citing works
Current Advances in Chitosan Nanoparticles Based Oral Drug Delivery for Colorectal Cancer Treatment
Choukaife, H., Seyam, S., Alallam, B., Doolaanea, A. A., & Alfatama, M. (2022) · International Journal of Nanomedicine · doi:10.2147/ijn.s375229 · Cited by 122 · see citing works
Xylitol’s Health Benefits beyond Dental Health: A Comprehensive Review
Salli, K. M., Lehtinen, M. J., Tiihonen, K., & Ouwehand, A. C. (2019) · Nutrients · doi:10.3390/nu11081813 · Cited by 119 · see citing works
Mazzola, G., Murphy, K., Ross, R. P., Gioia, D. D., Biavati, B., Corvaglia, L., Faldella, G., & Stanton, C. (2016) · PLoS ONE · doi:10.1371/journal.pone.0157527 · Cited by 116 · see citing works
Oriá, R. B., Murray‐Kolb, L. E., Scharf, R. J., Pendergast, L. L., Lang, D., Kolling, G. L., & Guerrant, R. L. (2016) · Nutrition Reviews · doi:10.1093/nutrit/nuw008 · Cited by 110 · see citing works
Bogatyrev, S. R., Rolando, J. C., & Ismagilov, R. F. (2020) · Microbiome · doi:10.1186/s40168-020-0785-4 · Cited by 109 · see citing works
Zhang, W. Y., Ma, C., Xie, P., Zhu, Q., Wang, X., Yin, Y., & Kong, X. (2019) · Journal of Applied Microbiology · doi:10.1111/jam.14304 · Cited by 110 · see citing works
Tuikhar, N., Keisam, S., Labala, R. K., Imrat, Ramakrishnan, P., Arunkumar, M. C., Ahmed, G., Biagi, E., & Jeyaram, K. (2019) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2019.02.001 · Cited by 103 · see citing works
Seekatz, A. M., Schnizlein, M. K., Koenigsknecht, M. J., Baker, J. R., Hasler, W. L., Bleske, B. E., Young, V. B., & Sun, D. (2019) · mSphere · doi:10.1128/msphere.00126-19 · Cited by 98 · see citing works
Intestinal pH: a major driver of human gut microbiota composition and metabolism
Brinck, J. E., Sinha, A. K., Laursen, M. F., Dragsted, L. O., Raes, J., Vazquez-Uribe, R., Walter, J., Roager, H. M., & Licht, T. R. (2025) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-025-01092-6 · Cited by 100 · see citing works
Small Intestinal Bacterial Overgrowth in Children: A State-Of-The-Art Review
Rodriguez, D. A., Ryan, P. M., Monjaráz, E. M. T., Ramírez-Mayans, J. A., & Quigley, E. M. M. (2019) · Frontiers in Pediatrics · doi:10.3389/fped.2019.00363 · Cited by 93 · see citing works
Jejunum: The understudied meeting place of dietary lipids and the microbiota
Lema, I., Araújo, J. R., Rolhion, N., & Demignot, S. (2020) · Biochimie · doi:10.1016/j.biochi.2020.09.007 · Cited by 86 · see citing works
Zhang, L., Bahl, M. I., Roager, H. M., Fonvig, C. E., Hellgren, L. I., Frandsen, H. L., Pedersen, O. B., Holm, J., Hansen, T. F., & Licht, T. R. (2016) · The ISME Journal · doi:10.1038/ismej.2016.151 · Cited by 82 · see citing works
Dlugosz, A., Winckler, B., Lundin, E., Zakikhany, K., Sandström, G., Ye, W., Engstrand, L. G., & Lindberg, G. (2015) · Scientific Reports · doi:10.1038/srep08508 · Cited by 82 · see citing works
Enterotoxigenic E. coli virulence gene regulation in human infections
Crofts, A. A., Giovanetti, S. M., Rubin, E. J., Poly, F., Gutiérrez, R. L., Talaat, K. R., Porter, C. K., Riddle, M. S., DeNearing, B., Brubaker, J., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1808982115 · Cited by 80 · see citing works
Gut-brain axis serotonergic responses to acute stress exposure are microbiome-dependent
Lyte, J. M., Gheorghe, C. E., Goodson, M. S., Kelley‐Loughnane, N., Dinan, T. G., Cryan, J. F., & Clarke, G. (2020) · Neurogastroenterology & Motility · doi:10.1111/nmo.13881 · Cited by 77 · see citing works
Ingestible Osmotic Pill for In Vivo Sampling of Gut Microbiomes
Nejad, H. R., Oliveira, B. C. M., Sadeqi, A., Dehkharghani, A. S., Kondova, I. I., Langermans, J. A. M., Guasto, J., Tzipori, S. R., Widmer, G., & Sonkusale, S. (2019) · Advanced Intelligent Systems · doi:10.1002/aisy.201900053 · Cited by 77 · see citing works
Soldán, M., Argalášová, Ľ., Hadvinová, L., Galileo, B., & Babjaková, J. (2024) · Nutrients · doi:10.3390/nu16183134 · Cited by 82 · see citing works
Liu, Y., Zheng, Z., Yu, L., Wu, S., Sun, L., Wu, S., Xu, Q., Cai, S., Qin, N., & Bao, W. (2019) · Scientific Reports · doi:10.1038/s41598-019-40235-z · Cited by 72 · see citing works
Ding, Y., Jiang, X., Yao, X., Zhang, H., Song, Z., He, X., & Cao, R. (2021) · Animals · doi:10.3390/ani11113294 · Cited by 74 · see citing works
Microbial-Driven Butyrate Regulates Jejunal Homeostasis in Piglets During the Weaning Stage
Zhong, X. Z., Zhang, Z., Wang, S., Cao, L., Zhou, L., Sun, A., Zhong, Z. A., & Nabben, M. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.03335 · Cited by 74 · see citing works
The Impact of Epicatechin on Human Cognition: The Role of Cerebral Blood Flow
Haskell‐Ramsay, C. F., Schmitt, J. A. J., & Actis‐Goretta, L. (2018) · Nutrients · doi:10.3390/nu10080986 · Cited by 70 · see citing works
Gut Microbiota in NSAID Enteropathy: New Insights From Inside
Wang, X., Tang, Q., Hou, H., Zhang, W., Li, M., Chen, D., Gu, Y., Wang, B., Hou, J., Liu, Y., et al. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.679396 · Cited by 69 · see citing works
β2→1-Fructans Modulate the Immune System In Vivo in a Microbiota-Dependent and -Independent Fashion
Fransen, F., Sahasrabudhe, N. M., Elderman, M. E., Bosveld, M., Aidy, S. E., Hugenholtz, F., Borghuis, T., Kousemaker, B., Winkel, S. L., Jongh, C. E. V. D. G., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00154 · Cited by 68 · see citing works
The small intestine: dining table of host–microbiota meetings
Delbaere, K., Roegiers, I. H., Bron, A., Durif, C., de Wiele, T. V., Blanquet‐Diot, S., & Marinelli, L. (2023) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuad022 · Cited by 69 · see citing works
Organoid technologies for the study of intestinal microbiota–host interactions
Bozzetti, V., & Senger, S. (2022) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2022.02.001 · Cited by 65 · see citing works
Evaluating Human Intestinal Cell Lines for Studying Dietary Protein Absorption
Jochems, P. G. M., Garssen, J., Keulen, A. V., Masereeuw, R., & Jeurink, P. V. (2018) · Nutrients · doi:10.3390/nu10030322 · Cited by 64 · see citing works
An overview of the bacterial contribution to Crohn disease pathogenesis
Alhagamhmad, M. H., Day, A. S., Lemberg, D. A., & Leach, S. T. (2016) · Journal of Medical Microbiology · doi:10.1099/jmm.0.000331 · Cited by 62 · see citing works
Hu, P., Zhao, F., Zhu, W., & Wang, J. (2019) · Food & Function · doi:10.1039/c9fo00676a · Cited by 61 · see citing works
Huang, K., Yan, Y., Chen, D., Zhao, Y. N., Dong, W., Zeng, X., & Cao, Y. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c04253 · Cited by 60 · see citing works
Gut Microbiota and Clostridium difficile: What We Know and the New Frontiers
Piccioni, A., Rosa, F., Manca, F., Pignataro, G., Zanza, C., Savioli, G., Covino, M., Ojetti, V., Gasbarrini, A., Franceschi, F., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113323 · Cited by 62 · see citing works
Probiotics: a proactive approach to health. A symposium report
Thomas, L. V., Suzuki, K., & Zhao, J. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515004043 · Cited by 59 · see citing works
Hepatocellular Carcinoma: How the Gut Microbiota Contributes to Pathogenesis, Diagnosis, and Therapy
Luo, W., Guo, S., Zhou, Y., Zhao, J., Wang, M., Sang, L.-X., Chang, B., & Wang, B. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.873160 · Cited by 59 · see citing works
Development of a host‐microbiome model of the small intestine
Calatayud, M., Dezutter, O., Hernandez‐Sanabria, E., Hidalgo‐Martinez, S., Meysman, F. J. R., & de Wiele, T. V. (2018) · The FASEB Journal · doi:10.1096/fj.201801414r · Cited by 55 · see citing works
Recent Advances in Cell‐Based In Vitro Models to Recreate Human Intestinal Inflammation
Macedo, M. H., Neto, M. D., Pastrana, L. M., Gonçalves, C., & Xavier, M. (2023) · Advanced Science · doi:10.1002/advs.202301391 · Cited by 56 · see citing works
Slowing Down Ageing: The Role of Nutrients and Microbiota in Modulation of the Epigenome
Gadecka, A., & Bielak-Żmijewska, A. (2019) · Nutrients · doi:10.3390/nu11061251 · Cited by 55 · see citing works
Colom, J., Freitas, D., Simon, A., Brodkorb, A., Buckley, M. J. M., Deaton, J. G., & Winger, A. M. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.715863 · Cited by 50 · see citing works
van Trijp, M. P. H., Rösch, C., An, R., Keshtkar, S., Logtenberg, M. J., Hermes, G. D. A., Zoetendal, E. G., Schols, H. A., & Hooiveld, G. J. E. J. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202000455 · Cited by 48 · see citing works
Zhao, H., Bai, H., Deng, F., Zhong, R., Liu, L., Chen, L., & Zhang, H. (2022) · Antibiotics · doi:10.3390/antibiotics11020132 · Cited by 48 · see citing works
Han, K., Xie, F., Animasahun, O. H., Nenwani, M., Kitamoto, S., Kim, Y., Phoo, M. T., Xu, J., Wuchu, F., Omoloja, K., et al. (2024) · Nature Materials · doi:10.1038/s41563-024-01909-w · Cited by 48 · see citing works
Regulatory effects of marine polysaccharides on gut microbiota dysbiosis: A review
Ou, J., Wang, Z., Liu, X., Song, B., Chen, J., Li, R., Jia, X., Huang, R., Xiang, W., & Zhong, S. (2022) · Food Chemistry X · doi:10.1016/j.fochx.2022.100444 · Cited by 46 · see citing works
Ruigrok, R. A. A. A., Collij, V., Sureda, P. F., Klaassen, M. A. Y., Bolte, L. A., Jansen, B. H., Voskuil, M. D., Fu, J., Wijmenga, C., Zhernakova, A., et al. (2021) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjab020 · Cited by 42 · see citing works
Gallo, V., Arienzo, A., Tomassetti, F., & Antonini, G. (2024) · Foods · doi:10.3390/foods13060907 · Cited by 46 · see citing works
Hiel, S., Neyrinck, A. M., Rodriguez, J., Pachikian, B. D., Bouzin, C., Thissen, J., Cani, P. D., Bindels, L. B., & Delzenne, N. M. (2018) · Nutrients · doi:10.3390/nu10050532 · Cited by 41 · see citing works
The Microbiome-Host Interaction as a Potential Driver of Anastomotic Leak
Gershuni, V. M., & Friedman, E. S. (2019) · Current Gastroenterology Reports · doi:10.1007/s11894-019-0668-7 · Cited by 40 · see citing works
Cieplak, T., Wiese, M., Nielsen, S., de Wiele, T. V., van den Berg, F. W. J., & Nielsen, D. S. (2018) · FEMS Microbiology Letters · doi:10.1093/femsle/fny231 · Cited by 40 · see citing works
Effects of prebiotics on affect and cognition in human intervention studies
Desmedt, O., Broers, V., Zamariola, G., Pachikian, B. D., Delzenne, N. M., & Luminet, O. (2018) · Nutrition Reviews · doi:10.1093/nutrit/nuy052 · Cited by 40 · see citing works
Gao, Y., & Tian, T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411811 · Cited by 38 · see citing works
Han, Y., Tang, C., Zhao, Q., Fan, S., Yang, P., & Zhang, J. (2022) · Microorganisms · doi:10.3390/microorganisms10102001 · Cited by 36 · see citing works
Marlicz, W. M., Yung, D. E., Skonieczna‐Żydecka, K., Łoniewski, I., van Hemert, S., Łoniewska, B., & Koulaouzidis, A. (2017) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2017.1343664 · Cited by 37 · see citing works
Stolaki, M., Minekus, M., Venema, K., Lahti, L., Smid, E. J., Kleerebezem, M., & Zoetendal, E. G. (2019) · FEMS Microbiology Ecology · doi:10.1093/femsec/fiz096 · Cited by 35 · see citing works
Self-citationZaccaria, E., Klaassen, T., Alleleyn, A. M. E., Boekhorst, J., Smokvina, T., Kleerebezem, M., & Troost, F. J. (2023) · Microbiome · doi:10.1186/s40168-023-01491-4 · Cited by 34 · see citing works
Self-citationAn Insight on Novel Approaches & Perspectives for Gastro-Retentive Drug Delivery Systems
Dhiman, S., Philip, N., Singh, T. G., Babbar, R., Garg, N., Diwan, V., & Singh, P. (2022) · Current Drug Delivery · doi:10.2174/1567201819666220819200236 · Cited by 34 · see citing works
Baglatzi, L., Gavrili, S., Stamouli, K., Zachaki, S., Favre, L., Pecquet, S., Benyacoub, J., & Costalos, C. (2016) · Clinical Medicine Insights Pediatrics · doi:10.4137/cmped.s33096 · Cited by 33 · see citing works
Zhu, C., Song, W., Tao, Z., Liu, H., Zhang, S., Xu, W., & Li, H. (2020) · Poultry Science · doi:10.1016/j.psj.2019.12.030 · Cited by 32 · see citing works
Best Practices for Microbiome Study Design in Companion Animal Research
Jarett, J. K., Kingsbury, D. D., Dahlhausen, K. E., & Ganz, H. H. (2021) · Frontiers in Veterinary Science · doi:10.3389/fvets.2021.644836 · Cited by 34 · see citing works
Xu, M., Zhong, F., & Zhu, J. (2016) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2016.12.008 · Cited by 32 · see citing works
Impact of intestinal dysbiosis on breast cancer metastasis and progression
Zhang, J., Xie, Q., Huo, X., Liu, Z., Da, M., Yuan, M., Zhao, Y. D., & Shen, G. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1037831 · Cited by 31 · see citing works
Aziz‐Aliabadi, F., Noruzi, H., & Hassanabadi, A. (2023) · Veterinary Medicine and Science · doi:10.1002/vms3.1133 · Cited by 31 · see citing works
Xie, Q., Pan, M., Huang, R., Ximei, T., Tao, X., Shah, N. P., Wei, H., & Wan, C. (2016) · Journal of Dairy Science · doi:10.3168/jds.2016-11141 · Cited by 30 · see citing works
Karl, J. P., Armstrong, N. J., McClung, H. L., Player, R. A., Rood, J. C., Racicot, K., Soares, J. W., & Montain, S. J. (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.108217 · Cited by 30 · see citing works
Hu, P., Mao, J., Zeng, Y., Sun, Z., Deng, H., Chen, C., Sun, W., & Tang, Z. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.922136 · Cited by 30 · see citing works
Exploiting the Metabolism of the Gut Microbiome as a Vehicle for Targeted Drug Delivery to the Colon
Bakshi, H. A., Quinn, G. A., Aljabali, A. A. A., Hakkim, F. L., Farzand, R., Nasef, M. M., Abuglela, N., Ansari, P., Mishra, V. K., Serrano‐Aroca, Á., et al. (2021) · Pharmaceuticals · doi:10.3390/ph14121211 · Cited by 29 · see citing works
Effects of Different Diets on Microbiota in The Small Intestine Mucus and Weight Regulation in Rats
Meng, Y., Li, X., Zhang, J., Wang, C., & Lu, F. (2019) · Scientific Reports · doi:10.1038/s41598-019-44994-7 · Cited by 30 · see citing works
Leite, G., Barlow, G. M., Parodi, G., Pimentel, M. L., Chang, C., Hosseini, A., Wang, J., Pimentel, M., & Mathur, R. (2022) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000001917 · Cited by 29 · see citing works
Visualization of Probiotic-Mediated Ca2+ Signaling in Intestinal Epithelial Cells In Vivo
Adachi, T., Kakuta, S., Aihara, Y., Kamiya, T., Watanabe, Y., Osakabe, N., Hazato, N., Miyawaki, A., Yoshikawa, S., Usami, T., et al. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00601 · Cited by 28 · see citing works
Guo, S., Liu, L., Lei, J., Qu, X., He, C., Tang, S., Xiao, B., Li, P., Gao, Q., Lan, F., et al. (2021) · animal · doi:10.1016/j.animal.2021.100399 · Cited by 27 · see citing works
Zhou, Y., Zhao, H., Wang, T., Zhao, X., Wang, J., & Wang, Q. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.819728 · Cited by 27 · see citing works
Small-intestinal or colonic microbiota as a potential amino acid source in animals
Bergen, W. G. (2014) · Amino Acids · doi:10.1007/s00726-014-1875-z · Cited by 28 · see citing works
Impact of Prebiotics on Enteric Diseases and Oxidative Stress
Gao, J., Azad, M. A. K., Han, H. L., Wan, D., & Li, T. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200211121916 · Cited by 26 · see citing works
Cui, J., Shi, C., Xia, P., Ning, K., Xiang, H., & Xie, Q. (2021) · Nutrients · doi:10.3390/nu13051543 · Cited by 25 · see citing works
Recent advances of intestinal microbiota transmission from mother to infant
Yang, L., Sakandar, H. A., Sun, Z., & Zhang, H. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104719 · Cited by 27 · see citing works
Deyaert, S., Moens, F., Pirovano, W., van den Bogert, B., Klaassens, E. S., Marzorati, M., de Wiele, T. V., Kleerebezem, M., & den Abbeele, P. V. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1054061 · Cited by 27 · see citing works
Self-citationLeite, G., Barlow, G. M., Rashid, M. A., Hosseini, A., Cohrs, D., Parodi, G., Morales, W., Weitsman, S. R., Rezaie, A. R., Pimentel, M., et al. (2024) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000002790 · Cited by 25 · see citing works
Shared Metabolic Profile of Caffeine in Parkinsonian Disorders
Takeshige‐Amano, H., Saiki, S., Fujimaki, M., Ueno, S., Li, Y., Hatano, T., Ishikawa, K., Oji, Y., Mori, A., Okuzumi, A., et al. (2020) · Movement Disorders · doi:10.1002/mds.28068 · Cited by 22 · see citing works
Does gut brain axis has an impact on Parkinson’s disease (PD)?
Elangovan, A., Dahiya, B., Kirola, L., Iyer, M., Jeeth, P., Maharaj, S., Kumari, N., Lakhanpal, V., Michel, T. M., Rao, K. R. S. S., et al. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102171 · Cited by 22 · see citing works
- Authors
- El Aidy, S., van den Bogert, B., & Kleerebezem, M.
- Affiliations
- TiFN (NL)
- Corresponding author
- Kleerebezem, Michiel
- ORCID
- Kleerebezem, Michiel
- Venue
- Current Opinion in Biotechnology
- Publisher
- Elsevier BV
- Published
- 2015-04
- Volume
- 32
- Pages
- 14-20
- ISSN
- 0958-1669 (ISSN-L)
- OpenAlex
- W2027271580
- Cited by
- 244
- References
- 59
- Citations by year
- 2026: 8 · 2025: 16 · 2024: 23 · 2023: 25 · 2022: 35 · 2021: 24 · 2020: 26 · 2019: 28 · 2018: 19 · 2017: 11 · 2016: 20 · 2015: 7 · 2014: 1
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Current Opinion in Biotechnology (publishedVersion, other-oa)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, other-oa)
- Socio-Environmental Systems Modeling (acceptedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Keywords
- small intestinal microbiota, gut microbiota, dietary modulation, host physiology, immune function, metabolic function, endocrine function, host-microbe interactions
- MeSH terms
- Amidohydrolases, Animals, Humans, Intestine, Small, Probiotics, Metabolic Syndrome, Microbiota
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