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Modeling metabolism of the human gut microbiome
Open accessAbstract
The human gut microbiome plays an important part in human health. The complexity of the microbiome makes it difficult to determine the detailed metabolic functions and cross-talk occurs between the individual species. In silico systems biology studies of the microbiome can help to identify metabolite exchanges among gut microbes. Constraint-based reconstruction and analysis methods use biochemically accurate genome-scale metabolic networks of microorganisms to simulate metabolism between species in a given microbiome and help generate novel hypotheses on microbial interactions. Here, we review metabolic modeling studies that have investigated metabolic functions of the gut microbiome.
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“Metabolic models of the microbiome, often utilizing our growing capacity to produce, process and handle big data, have yielded invaluable understanding in microbe-microbe interactions and microbe-environment interactions (Magnusdottir and Thiele, 2018;Sung et al., 2016).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Magnusdottir and Thiele, 2018
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Metadata
- Authors
- Magnúsdóttir, S., & Thiele, I.
- Affiliations
- University of Luxembourg (LU)
- Corresponding author
- Thiele, Ines
- Venue
- Current Opinion in Biotechnology
- Publisher
- Elsevier BV
- Published
- 2018-06
- Volume
- 51
- Pages
- 90-96
- ISSN
- 0958-1669 (ISSN-L)
- OpenAlex
- W2775633464
- Cited by
- 127
- References
- 83
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 10 · 2023: 14 · 2022: 16 · 2021: 27 · 2020: 17 · 2019: 26 · 2018: 8
- FWCI
- 1.31
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Current Opinion in Biotechnology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Open Repository and Bibliography (University of Luxembourg) (submittedVersion)
- Funders
- Luxembourg National Research Fund (FNR) ATTRACT programme grant (FNR/A12/01)
- Aides à la Formation-Recherche (FNR/6951193)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
- Keywords
- gut microbiota, microbial metabolism, constraint-based metabolic modeling, genome-scale metabolic networks, metabolite exchange, microbial interactions, human health
- MeSH terms
- Gastrointestinal Microbiome, Computer Simulation, Humans, Models, Biological, Systems Biology, Metabolic Networks and Pathways, Host-Pathogen Interactions, Microbial Interactions, Microbiota
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