Electrophilic nitro-fatty acids: anti-inflammatory mediators in the vascular compartment
Open accessAbstract
Vascular inflammatory disorders are often associated with both decreased NO bioavailability and a lack of responsiveness to NO, a consequence of impaired NO biosynthesis, dysregulated l-arginine metabolism, endothelial nitric oxide synthase (eNOS) uncoupling and NO consumption induced by redox reactions of NO. The latter is mediated via oxidative inflammatory conditions altering NO-dependent endothelial function, including vascular tone and cell proliferation. The redox reactions of NO and byproducts such as nitrite can react to yield electrophilic nitro-fatty acid derivatives (NO(2)-FAs) and exemplify a biochemical convergence of reactions participating in NO and lipid signaling. NO(2)-FAs represent a novel therapeutic strategy to treat vascular disorders by improving endothelial dysfunction through enhancing NO signaling and blocking vascular smooth muscle proliferation, inflammation, and maladaptive remodeling.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Nitration of both fatty acids and guanine nucleotides has been shown to elicit responses that are protective against inflammatory tissue injury.
“nitration of both fatty acids and guanine nucleotides has been shown to elicit responses that are protective against inflammatory tissue injury[115, 116].”
From Current perspectives and challenges in understanding the role of nitrite as an integral player in nitric oxide biology and therapy (2011) · cites this paper as [116]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The L-Arginine-Nitric Oxide Pathway
Epstein, F. H., Moncada, S., & Higgs, A. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312303292706 · Cited by 6,678 · see citing works
Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly
Beckman, J. S., & Koppenol, W. H. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.5.c1424 · Cited by 5,513 · see citing works
Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress
Cai, H., & Harrison, D. G. (2000) · Circulation Research · doi:10.1161/01.res.87.10.840 · Cited by 3,839 · see citing works
15-Deoxy-Δ12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ
FORMAN, B. M., Tontonoz, P., Chen, J., Brun, R. P., Spiegelman, B. M., & Evans, R. M. (1995) · Cell · doi:10.1016/0092-8674(95)90193-0 · Cited by 2,858 · see citing works
Oxidized LDL Regulates Macrophage Gene Expression through Ligand Activation of PPARγ
Nagy, L., Tontonoz, P., Alvarez, J. G. A., Chen, H.-W., & Evans, R. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81574-3 · Cited by 1,861 · see citing works
Ignarro, L. J., Lippton, H., Edwards, J. C., Baricos, W. H., Hyman, A. L., Kadowitz, P. J., & Gruetter, C. A. (1981) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)32738-2 · Cited by 1,633 · cited 1× · see citing works
“Endothelial NO plays a critical role in the regulation of vascular homeostasis by inhibiting inflammatory cell function and smooth muscle proliferation [1,2].”
BackgroundRubbo, H., Radí, R., Trujillo, M., Telleri, R., Kalyanaraman, B., Barnes, S., KIRK, M. C., & Freeman, B. Α. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47160-8 · Cited by 1,350 · see citing works
Self-citationMinireview: Lipid Metabolism, Metabolic Diseases, and Peroxisome Proliferator-Activated Receptors
Lee, C., Olson, P., & Evans, R. M. (2003) · Endocrinology · doi:10.1210/en.2003-0288 · Cited by 891 · see citing works
Endothelial dysfunction and vascular disease
Vanhoutte, P. M., Shimokawa, H., Tang, E. H. C., & Félétou, M. (2009) · Acta Physiologica · doi:10.1111/j.1748-1716.2009.01964.x · Cited by 808 · see citing works
Endothelial Dysfunction in Pulmonary Hypertension
Budhiraja, R., Tuder, R. M., & Hassoun, P. M. (2004) · Circulation · doi:10.1161/01.cir.0000102381.57477.50 · Cited by 767 · see citing works
Differential Activation of Peroxisome Proliferator-activated Receptors by Eicosanoids
Yu, K., Bayona, W., Kallen, C. B., Harding, H. P., Ravera, C., McMahon, G., Brown, M. A., & Lazar, M. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.41.23975 · Cited by 709 · see citing works
Structural basis for the activation of PPARγ by oxidized fatty acids
Itoh, T., Fairall, L., Amin, K., Inaba, Y., Szántó, A., Bálint, B. L., Nagy, L., Yamamoto, K., & Schwabe, J. W. R. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1474 · Cited by 465 · see citing works
Nitrolinoleic acid. An endogenous peroxisome proliferator-activated receptor γ ligand
Schopfer, F. J., Lin, Y., Baker, P. R. S., Cui, T., Garcia-Barrio, M., Zhang, J., Chen, K., Chen, Y. E., & Freeman, B. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408384102 · Cited by 428 · see citing works
Self-citationAntioxidant and prooxidant mechanisms in the regulation of redox(y)-sensitive transcription factors
Haddad, J. J. (2002) · Cellular Signalling · doi:10.1016/s0898-6568(02)00053-0 · Cited by 427 · see citing works
Nitrated Fatty Acids: Endogenous Anti-inflammatory Signaling Mediators
Cui, T., Schopfer, F. J., Zhang, J., Chen, K., Ichikawa, T., Baker Paul, R. S., Batthyany, C., Chacko, B. K., Feng, X., Patel, R. P., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603357200 · Cited by 351 · see citing works
Self-citationO'Donnell, V. B., Eiserich, J. P., Chumley, P. H., Jablonsky, M. J., Krishna, N. R., Kirk, M., Barnes, S., Darley-Usmar, V. M., & Freeman, B. A. (1999) · Chemical Research in Toxicology · doi:10.1021/tx980207u · Cited by 289 · see citing works
Self-citationCalnek, D. S., Mazzella, L., Roser, S., Roman, J., & Hart, C. M. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000044461.01844.c9 · Cited by 286 · see citing works
Nitric Oxide Regulation of Tissue Free Radical Injury
Rubbo, H., Darley-Usmar, V. M., & Freeman, B. Α. (1996) · Chemical Research in Toxicology · doi:10.1021/tx960037q · Cited by 274 · see citing works
Self-citationNitro-fatty acid formation and signaling
Freeman, B. A., Baker, P. R. S., Schopfer, F. J., Woodcock, S. R., Napolitano, A., & d'Ischia, M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.r800004200 · Cited by 265 · see citing works
Self-citationExpression and function of soluble guanylate cyclase in pulmonary arterial hypertension
SCHERMULY, R. T., Stasch, J.-P., Pullamsetti, S. S., Middendorff, R., Müller, D., Schlüter, K., Dingendorf, A., Hackemack, S., Kołosionek, E., Kaulen, C., et al. (2008) · European Respiratory Journal · doi:10.1183/09031936.00114407 · Cited by 237 · see citing works
Protein Damage by Reactive Electrophiles: Targets and Consequences
Liebler, D. C. (2007) · Chemical Research in Toxicology · doi:10.1021/tx700235t · Cited by 235 · see citing works
Dumitrascu, R., Weißmann, N., Ghofrani, H. A., Dony, E., Beuerlein, K., Schmidt, H. H. H. W., Stasch, J., Gnoth, M. J., Seeger, W., Grimminger, F., et al. (2006) · Circulation · doi:10.1161/circulationaha.105.581405 · Cited by 224 · see citing works
hPPARgamma Ligand binding domain in complex with 4-HDHA
Itoh, T., Fairall, L., & Schwabe, J. W. R. (2008) · Worldwide Protein Data Bank · doi:10.2210/pdb2vv1/pdb · Cited by 223 · see citing works
Nitro-fatty Acid Reaction with Glutathione and Cysteine
Baker, L. M. S., Baker, P. R. S., Golin-Bisello, F., Schopfer, F. J., Fink, M., Woodcock, S. R., Branchaud, B. P., Radi, R., & Freeman, B. A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704085200 · Cited by 200 · see citing works
Self-citationTransduction of Redox Signaling by Electrophile-Protein Reactions
Rudolph, T. K., & Freeman, B. Α. (2009) · Science Signaling · doi:10.1126/scisignal.290re7 · Cited by 200 · see citing works
Self-citationRosiglitazone Attenuates Chronic Hypoxia–Induced Pulmonary Hypertension in a Mouse Model
Nisbet, R. E., Bland, J. M., Kleinhenz, D. J., Mitchell, P. O., Walp, E. R., Sutliff, R. L., & Hart, C. M. (2009) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2008-0132oc · Cited by 188 · see citing works
Rudolph, V., Rudolph, T. K., Schopfer, F. J., Bonacci, G., Woodcock, S. R., Cole, M. P., Baker, P. R. S., Ramani, R., & Freeman, B. A. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvp275 · Cited by 188 · see citing works
Self-citationBeyond lipid-lowering: effects of statins on endothelial nitric oxide
Laufs, U. (2003) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-002-0556-0 · Cited by 185 · see citing works
Ryan, M. J., Didion, S. P., Mathur, S. N., Faraci, F. M., & Sigmund, C. D. (2004) · Hypertension · doi:10.1161/01.hyp.0000116303.71408.c2 · Cited by 184 · see citing works
Nitric Oxide Reaction with Lipid Peroxyl Radicals Spares α-Tocopherol during Lipid Peroxidation
Rubbo, H., Radí, R., Anselmi, D., KIRK, M. C., Barnes, S., Butler, J., Eiserich, J. P., & Freeman, B. Α. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.15.10812 · Cited by 182 · see citing works
Self-citationPolikandriotis, J. A., Mazzella, L., Rupnow, H. L., & Hart, C. M. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000177805.65864.d4 · Cited by 169 · see citing works
Molecular recognition of nitrated fatty acids by PPARγ
Li, Y., Zhang, J., Schopfer, F. J., Martynowski, D., Garcia-Barrio, M. T., Kovach, A., Suino-Powell, K., Baker, P. R. S., Freeman, B. A., Chen, Y. E., et al. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1447 · Cited by 168 · see citing works
Self-citationNrf2-dependent and -independent Responses to Nitro-fatty Acids in Human Endothelial Cells
Kansanen, E., Jyrkkänen, H.-K., Volger, O. L., Leinonen, H., Kivelä, A. M., Häkkinen, S.-K., Woodcock, S. R., Schopfer, F. J., Horrevoets, A. J., Ylä-Herttuala, S., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.064873 · Cited by 165 · see citing works
Self-citationCho, D., Choi, Y. J., Jo, S. A., & Jo, I. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m309451200 · Cited by 163 · see citing works
Villacorta, L., Zhang, J., Garcia-Barrio, M. T., Chen, X.-L., Freeman, B. A., Chen, Y. E., & Cui, T. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00261.2007 · Cited by 144 · see citing works
Self-citationHoltzclaw, W. D., Dinkova‐Kostova, A. T., & Talalay, P. (2004) · Advances in Enzyme Regulation · doi:10.1016/j.advenzreg.2003.11.013 · Cited by 144 · see citing works
α-Hydroxyaldehydes, products of lipid peroxidation
Loidl‐Stahlhofen, A., & Spitelier, G. (1994) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(94)90264-x · Cited by 136 · see citing works
Wright, M. M., Schopfer, F. J., Baker, P. R. S., Vidyasagar, V., Powell, P., Chumley, P., Iles, K. E., Freeman, B. Α., & Agarwal, A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506541103 · Cited by 119 · see citing works
Self-citationNitro-fatty Acid Metabolome: Saturation, Desaturation, β-Oxidation, and Protein Adduction
Rudolph, V., Schopfer, F. J., Khoo, N. K. H., Rudolph, T. K., Cole, M. P., Woodcock, S. R., Bonacci, G., Groeger, A. L., Golin-Bisello, F., Chen, C.-S., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802298200 · Cited by 115 · see citing works
Self-citationKleinhenz, J., Kleinhenz, D. J., You, S., Ritzenthaler, J. D., Hansen, J. M., Archer, D. R., Sutliff, R. L., & Hart, C. M. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00148.2009 · Cited by 91 · see citing works
CEASER, E. K., Moellering, D. R., Shiva, S., Ramachandran, A., Landar, A. L., Venkartraman, A., Crawford, J., Patel, R. P., Dickinson, D. A., Ulasova, E., et al. (2004) · Biochemical Society Transactions · doi:10.1042/bst0320151 · Cited by 87 · see citing works
15-Lipoxygenase Catalytically Consumes Nitric Oxide and Impairs Activation of Guanylate Cyclase
O’Donnell, V. B., Taylor, K. B., Parthasarathy, S., Kühn, H., Koesling, D., Friebe, A., Bloodsworth, A., Darley-Usmar, V. M., & Freeman, B. Α. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.29.20083 · Cited by 87 · see citing works
Self-citationKhoo, N. K. H., Rudolph, V., Cole, M. P., Golin-Bisello, F., Schopfer, F. J., Woodcock, S. R., Batthyany, C., & Freeman, B. A. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.10.046 · Cited by 79 · see citing works
Self-citationMacrophage activation induces formation of the anti-inflammatory lipid cholesteryl-nitrolinoleate
Ferreira, A. M., Ferrari, M. I., Trostchansky, A., Batthyany, C., Souza, J. M., Alvarez, M. N., López, G. V., Baker, P. R. S., Schopfer, F. J., O'Donnell, V., et al. (2009) · Biochemical Journal · doi:10.1042/bj20080701 · Cited by 78 · see citing works
Self-citationAnti‐atherogenic effect of statins: role of nitric oxide, peroxynitrite and haem oxygenase‐1
Heeba, G. H., Moselhy, M., Hassan, M., Khalifa, M. M., Gryglewski, R., & Maliñski, T. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00125.x · Cited by 73 · see citing works
Nitro-fatty acid inhibition of neointima formation after endoluminal vessel injury
Cole, M. P., Rudolph, T. K., Khoo, N. K. H., Motanya, U. N., Golin-Bisello, F., Wertz, J. W., Schopfer, F. J., Rudolph, V., Woodcock, S. R., Bolisetty, S., et al. (2009) · Circulation Research · doi:10.1161/circresaha.109.199075 · Cited by 69 · see citing works
Self-citationFirst Direct Evidence for Lipid/Protein Conjugation in Oxidized Human Low Density Lipoprotein
Bolgar, M. S., Yang, C.-Y., & Gaskell, S. J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.45.27999 · Cited by 66 · see citing works
Gallon, A. A., & Pryor, W. A. (1994) · Lipids · doi:10.1007/bf02536725 · Cited by 61 · see citing works
Matsuda, Y., Hoshikawa, Y., Ameshima, S., Suzuki, S., Okada, Y., Tabata, T., Sugawara, T., Matsumura, Y., & Kondo, T. (2005) · PubMed · Cited by 61 · see citing works
The Mechanobiology of Pulmonary Vascular Remodeling in the Congenital Absence of eNOS
Kobs, R. W., & Chesler, N. C. (2006) · Biomechanics and Modeling in Mechanobiology · doi:10.1007/s10237-006-0018-1 · Cited by 55 · see citing works
Differential Potencies of Naturally Occurring Regioisomers of Nitrolinoleic Acid in PPARγ Activation
Alexander, R. L., Wright, M. W., Gorczynski, M. J., Smitherman, P. K., Akiyama, T. E., Wood, H. B., Berger, J. P., King, S. B., & Morrow, C. S. (2008) · Biochemistry · doi:10.1021/bi8016747 · Cited by 19 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [50]Freeman BA Baker PR Schopfer FJ Woodcock SR Napolitano A d’Ischia M Nitro-fatty acid formation and signaling J Biol Chem 2008 283 15515 15519 18285326 PMC2414282
Cited by
Sorted by citations
Yu, F., Li, P., Wang, B., & Han, K. (2013) · Journal of the American Chemical Society · doi:10.1021/ja401360a · Cited by 618 · see citing works
Free radical biology and medicine
(2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00484-2 · Cited by 549 · see citing works
Heme oxygenase–1, oxidation, inflammation, and atherosclerosis
Araujo, J. A., Zhang, M., & Yin, F. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00119 · Cited by 443 · see citing works
Maia, L. B., & Moura, J. J. G. (2014) · Chemical Reviews · doi:10.1021/cr400518y · Cited by 401 · see citing works
Protein palmitoylation and subcellular trafficking
Aicart-Ramos, C., Valero, R. A., & Rodríguez‐Crespo, I. (2011) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2011.07.009 · Cited by 373 · see citing works
Macrophages and Their Role in Atherosclerosis: Pathophysiology and Transcriptome Analysis
Bobryshev, Y. V., Ivanova, E. A., Chistiakov, D. A., Nikiforov, N. G., & Orekhov, A. N. (2016) · BioMed Research International · doi:10.1155/2016/9582430 · Cited by 354 · see citing works
Formation and signaling actions of electrophilic lipids
Schopfer, F. J., Cipollina, C., & Freeman, B. A. (2011) · Chemical Reviews · doi:10.1021/cr200131e · Cited by 299 · see citing works
Self-citationBiomarkers of lipid peroxidation in clinical material
Niki, E. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.03.020 · Cited by 297 · see citing works
Ghouleh, I. A., Khoo, N. K. H., Knaus, U. G., Griendling, K. K., Touyz, R. M., Thannickal, V. J., Barchowsky, A., Nauseef, W. M., Kelley, E. E., Bauer, P. M., et al. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.06.011 · Cited by 249 · see citing works
Self-citationChistiakov, D. A., Bobryshev, Y. V., Nikiforov, N. G., Elizova, N. V., Sobenin, I. A., & Orekhov, A. N. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.03.055 · Cited by 174 · see citing works
RetractedLipoxidation adducts with peptides and proteins: Deleterious modifications or signaling mechanisms?
Domingues, R. M., Domingues, P. M., Melo, T., Pérez‐Sala, D., Reis, A., & Spickett, C. M. (2013) · Journal of Proteomics · doi:10.1016/j.jprot.2013.06.004 · Cited by 165 · see citing works
Phenotypic modulation of macrophages in response to plaque lipids
Adamson, S., & Leitinger, N. (2011) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32834a97e4 · Cited by 154 · see citing works
Carbon monoxide: Mechanisms of action and potential clinical implications
Rochette, L., Cottin, Y., Zeller, M., & Vergely, C. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.09.007 · Cited by 145 · see citing works
Do antioxidants impair signaling by reactive oxygen species and lipid oxidation products?
Niki, E. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.09.025 · Cited by 138 · see citing works
Villacorta, L., Chang, L., Salvatore, S. R., Ichikawa, T., Zhang, J., Petrovic-Djergovic, D., Jia, L., Carlsen, H., Schopfer, F. J., Freeman, B. A., et al. (2013) · Cardiovascular Research · doi:10.1093/cvr/cvt002 · Cited by 116 · see citing works
Self-citationDietary nitrate supplementation improves revascularization in chronic ischemia
Hendgen-Cotta, U. B., Luedike, P., Totzeck, M., Kropp, M., Schicho, A., Stock, P., Rammos, C., Niessen, M., Heiss, C., Lundberg, J. O., et al. (2012) · Circulation · doi:10.1161/circulationaha.112.112912 · Cited by 110 · see citing works
Characterization and quantification of endogenous fatty acid nitroalkene metabolites in human urine
Salvatore, S. R., Vitturi, D. A., Baker, P. R. S., Bonacci, G., Koenitzer, J. R., Woodcock, S. R., Freeman, B. A., & Schopfer, F. J. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m037804 · Cited by 82 · see citing works
Self-citationRole of bioactive lipid mediators in obese adipose tissue inflammation and endocrine dysfunction
Lopategi, A., López‐Vicario, C., Alcaraz‐Quiles, J., García‐Alonso, V., Rius, B., Titos, E., & Clària, J. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.09.033 · Cited by 79 · see citing works
Ieda, N., Nakagawa, H., Tao, P., Yang, D., Suzuki, T., & Miyata, N. (2012) · Journal of the American Chemical Society · doi:10.1021/ja206744z · Cited by 68 · see citing works
Awwad, K., Steinbrink, S. D., Frömel, T., Lill, N., Isaak, J., Häfner, A., Roos, J., Hofmann, B., Heide, H., Geißlinger, G., et al. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5473 · Cited by 60 · see citing works
Self-citationVitturi, D. A., & Patel, R. P. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.05.037 · Cited by 59 · see citing works
Nitro-fatty acids in cardiovascular regulation and diseases characteristics and molecular mechanisms
Villacorta, L. (2015) · Frontiers in bioscience · doi:10.2741/4425 · Cited by 50 · see citing works
Influence of nutrition in PCB-induced vascular inflammation
Petriello, M. C., Newsome, B. J., & Hennig, B. (2013) · Environmental Science and Pollution Research · doi:10.1007/s11356-013-1549-5 · Cited by 48 · see citing works
Post-Translational Modification of Proteins Mediated by Nitro-Fatty Acids in Plants: Nitroalkylation
Aranda‐Caño, L., Sánchez-Calvo, B., Begara-Morales, J. C., Chaki, M., Mata-Pérez, C., Padilla, M. N., Valderrama, R., & Barroso, J. B. (2019) · Plants · doi:10.3390/plants8040082 · Cited by 42 · see citing works
Combined losartan and nitro-oleic acid remarkably improves diabetic nephropathy in mice
Liu, Y., Jia, Z., Liu, S., Downton, M., Liu, G., Du, Y., & Yang, T. (2013) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00157.2013 · Cited by 40 · see citing works
Das, U. N. (2013) · Clinical Lipidology · doi:10.2217/clp.13.32 · Cited by 35 · see citing works
Das, U. N. (2013) · Clinical Lipidology · doi:10.2217/clp.13.31 · Cited by 33 · see citing works
Ambrožová, G., Fidlerova, T., Vereščáková, H., Koudelka, A., Rudolph, T. K., Woodcock, S. R., Freeman, B. Α., Kubala, L., & Pekarová, M. (2016) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2016.07.010 · Cited by 32 · see citing works
Self-citationMacrophages and Their Contribution to the Development of Atherosclerosis
Bobryshev, Y. V., Nikiforov, N. G., Elizova, N. V., & Orekhov, A. N. (2017) · Results and problems in cell differentiation · doi:10.1007/978-3-319-54090-0_11 · Cited by 31 · see citing works
Nitrated fatty acids in cardiovascular diseases
Mollenhauer, M., Mehrkens, D., & Rudolph, V. (2018) · Nitric Oxide · doi:10.1016/j.niox.2018.03.016 · Cited by 29 · see citing works
Protection of nitro-fatty acid against kidney diseases
Wang, W., Li, C., & Yang, T. (2015) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00321.2015 · Cited by 27 · see citing works
New Insights into the Anti‐Inflammatory and Antioxidant Properties of Nitrated Phospholipids
Melo, T., Marques, S. S., Ferreira, I., Cruz, M. T., Domingues, P. M., Segundo, M. A., & Domingues, M. R. M. (2018) · Lipids · doi:10.1002/lipd.12007 · Cited by 27 · see citing works
Dapueto, R., Rodriguez‐Duarte, J., Galliussi, G., Kamaid, A., Bresque, M., Batthyány, C., López, G. V., & Escande, C. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101833 · Cited by 25 · see citing works
Lu, H., Sun, J., Liang, W., Zhang, J., Rom, O., Garcia-Barrio, M. T., Li, S., Villacorta, L., Schopfer, F. J., Freeman, B. Α., et al. (2019) · Physiological Genomics · doi:10.1152/physiolgenomics.00127.2018 · Cited by 23 · see citing works
Self-citationInflammatory signaling and metabolic regulation by nitro-fatty acids
Rom, O., Khoo, N. K. H., Chen, Y. E., & Villacorta, L. (2018) · Nitric Oxide · doi:10.1016/j.niox.2018.03.017 · Cited by 20 · see citing works
Self-citationNitro-fatty acids suppress ischemic ventricular arrhythmias by preserving calcium homeostasis
Mollenhauer, M., Mehrkens, D., Klinke, A., Lange, M., Remane, L., Friedrichs, K. P., Braumann, S., Geißen, S., Simsekyilmaz, S., Nettersheim, F. S., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-71870-6 · Cited by 20 · see citing works
Self-citationFranz, J., Bereau, T., Pannwitt, S., Veerappan, A., Lehr, A., Nubbemeyer, U., Dietz, U., Bonn, M., Weidner, T., & Schneider, D. (2017) · Chemistry - A European Journal · doi:10.1002/chem.201702041 · Cited by 20 · see citing works
Profiling and relative quantification of multiply nitrated and oxidized fatty acids
Milic, I., Griesser, E., Vemula, V., Ieda, N., Nakagawa, H., Miyata, N., Galano, J., Oger, C., Durand, T., & Fedorova, M. (2015) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-015-8766-3 · Cited by 18 · see citing works
Rodriguez‐Duarte, J., Galliussi, G., Dapueto, R., Rossello, J., Malacrida, L. S., Kamaid, A., Schopfer, F. J., Escande, C., López, G. V., & Batthyány, C. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14561 · Cited by 16 · see citing works
Zheng, R., Heck, D. E., Black, A. T., Gow, A., Laskin, D., & Laskin, J. (2013) · Free Radical Biology & Medicine · doi:10.1016/j.freeradbiomed.2013.10.011 · Cited by 15 · see citing works
Fatty acid nitroalkenes – Multi-target agents for the treatment of sickle cell disease
Chowdhury, F. A., Colussi, N., Sharma, M., Wood, K. C., Xu, J. Z., Freeman, B. Α., Schopfer, F. J., & Straub, A. C. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102941 · Cited by 12 · see citing works
Self-citationRac1 modification by an electrophilic 15-deoxy Δ12,14-prostaglandin J2 analog
Wall, S. B., Oh, J. Y., Mitchell, L., Laube, A. H., Campbell, S. L., Renfrow, M. B., & Landar, A. L. (2015) · Redox Biology · doi:10.1016/j.redox.2015.01.016 · Cited by 13 · see citing works
Braumann, S., Schumacher, W., Im, N. G., Nettersheim, F. S., Mehrkens, D., Bokredenghel, S., Hof, A., Nies, R. J., Adler, C., Winkels, H., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22169052 · Cited by 12 · see citing works
Self-citation(Poly)phenols and nitrolipids: Relevant participants in nitric oxide metabolism
Fraga, C. G., Trostchansky, A., Rocha, B. S., Laranjinha, J. A. N., Rubbo, H., & Galleano, M. (2022) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2022.101158 · Cited by 11 · see citing works
Cysteamine assay for the evaluation of bioactive electrophiles
Novák, D., Vrba, J., Zatloukalová, M., Roubalová, L., Stolarczyk, K., Dorčák, V., & Vacek, J. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.01.007 · Cited by 10 · see citing works
Shiva, S., Castro, L., & Brookes, P. S. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804273-1.00011-9 · Cited by 10 · see citing works
Wu, B., Chen, H., Liu, C. P., Hsu, L. Y., & Chen, I. J. (2011) · International Journal of Immunopathology and Pharmacology · doi:10.1177/039463201102400411 · Cited by 8 · see citing works
Arylnitroalkenes as scavengers of macrophage-generated oxidants
Celano, L., Carabio, C., Frache, R., Cataldo, N., Cerecetto, H., González, M., & Thomson, L. (2014) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2013.12.029 · Cited by 8 · see citing works
Nrf2 and the promotion of atherosclerosis:lessons to be learned
Araujo, J. A. (2012) · Clinical Lipidology · doi:10.2217/clp.12.5 · Cited by 8 · see citing works
Fatty acid nitroalkenes regulate intestinal lipid absorption
Schopfer, F. J., Teng, L., Sekandari, A., Ekhator, E. S., Kohan, A. B., Freeman, B. Α., & Fazzari, M. (2025) · Journal of Lipid Research · doi:10.1016/j.jlr.2025.100855 · Cited by 4 · see citing works
Self-citationEffects of fatty acid nitroalkanes on signal transduction pathways and airway macrophage activation
Wilkinson, M. L., & Gow, A. J. (2021) · Innate Immunity · doi:10.1177/17534259211015330 · Cited by 4 · see citing works
Ishima, Y., Narisoko, T., Kragh‐Hansen, U., Kotani, S., Nakajima, M., Otagiri, M., & Maruyama, T. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.08.043 · Cited by 4 · see citing works
TRPV1 in Cell Signaling: Molecular Mechanisms of Function and Modulation
Rosenbaum, T., & Jara-Oseguera, A. (2012) · Springer eBooks · doi:10.1007/978-94-007-5073-9_3 · Cited by 2 · see citing works
Antioxidant Therapy Against Persistent Organic Pollutants and Associated Diseases
Hennig, B., Petriello, M. C., Newsome, B. J., Perkins, J. T., & Liu, D. (2017) · Springer eBooks · doi:10.1007/978-3-319-67625-8_9 · Cited by 2 · see citing works
Chen, J.-H., & Hu, C. (2019) · Theoretical Chemistry Accounts · doi:10.1007/s00214-019-2455-9 · Cited by 1 · see citing works
- Authors
- Khoo, N. K., & Freeman, B. A.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Khoo, Nicholas KH
- ORCID
- Khoo, Nicholas KH
- Venue
- Current Opinion in Pharmacology
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 10
- Issue
- 2
- Pages
- 179-184
- ISSN
- 1471-4892 (ISSN-L)
- PMC
- PMC2843800
- OpenAlex
- W1984981225
- Cited by
- 56
- References
- 51
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 4 · 2016: 2 · 2015: 7 · 2014: 3 · 2013: 11 · 2012: 7
- FWCI
- 5.20
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (HL 64937, R01HL064937, R37HL058115, HL8115)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- nitric oxide, nitric oxide bioavailability, endothelial dysfunction, vascular inflammation, endothelial nitric oxide synthase uncoupling, arginine metabolism, nitrite, redox reactions, lipid signaling, vascular smooth muscle cell proliferation, vascular remodeling, anti-inflammatory mediators
- MeSH terms
- Animals, Cardiovascular Diseases, Endothelium, Vascular, Fatty Acids, Humans, Inflammation, Models, Biological, Nitric Oxide, Nitro Compounds, Peroxisome Proliferator-Activated Receptors, Cell Proliferation, NF-E2-Related Factor 2, Heme Oxygenase-1, Nitric Oxide Synthase Type III
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
