The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Transporters and receptors for short-chain fatty acids as the molecular link between colonic bacteria and the host
Abstract
The mutually beneficial relationship between colonic bacteria and the host has been recognized but the molecular aspects of the relationship remain poorly understood. Dietary fiber is critical to this relationship. The short-chain fatty acids acetate, propionate and butyrate, generated by bacterial fermentation of dietary fiber, serve as messengers between colonic bacteria and the host. The beneficial effects of these bacterial metabolites in colon include, but are not limited to, suppression of inflammation and prevention of cancer. Recent studies have identified the plasma membrane transporter SLC5A8 and the cell-surface receptors GPR109A and GPR43 as essential for the biologic effects of short-chain fatty acids in colon. These three proteins coded by the host genome provide the molecular link between colonic bacteria and the host.
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“Moreover, SCFA butyrate has anti-inflammatory properties thought to be owing to an epigenetic mechanism or to the activation of SCFA receptors leading to anti-inflammatory effects, anti-microbial effects, and to a decreased intestinal barrier leakiness (Forsythe and Kunze, 2013;Ganapathy et al., 2013;Maslowski and Mackay, 2011;Singh et al., 2014).”
From The Gut-Brain Axis in Parkinson’s Disease: Possibilities for Food-Based Therapies (2017) · cites this paper as Ganapathy et al., 2013
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Metadata
- Authors
- Ganapathy, V., Thangaraju, M., Prasad, P. D., Martin, P. M., & Singh, N.
- Affiliations
- Augusta University (US)
- Corresponding author
- Ganapathy, Vadivel
- Venue
- Current Opinion in Pharmacology
- Publisher
- Elsevier BV
- Published
- 2013-12
- Volume
- 13
- Issue
- 6
- Pages
- 869-874
- ISSN
- 1471-4892 (ISSN-L)
- OpenAlex
- W2081831171
- Cited by
- 290
- References
- 43
- Citations by year
- 2026: 14 · 2025: 15 · 2024: 30 · 2023: 28 · 2022: 26 · 2021: 43 · 2020: 27 · 2019: 20 · 2018: 20 · 2017: 26 · 2016: 19 · 2015: 10 · 2014: 10 · 2013: 1
- FWCI
- 1.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- short-chain fatty acids, colonic bacteria, gut microbiota, host-microbe communication, dietary fiber, SLC5A8, GPR109A, GPR43, butyrate, acetate, propionate, inflammation reduction, colorectal cancer prevention, bacterial fermentation
- MeSH terms
- Animals, Bacteria, Colon, Fatty Acids, Volatile, Humans, Receptors, Cell Surface, Membrane Transport Proteins
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