Cited by 293Gut microbiota and healthGastrointestinal motility and disordersDrug Transport and Resistance Mechanisms

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Transporters and receptors for short-chain fatty acids as the molecular link between colonic bacteria and the host

Ganapathy, Vadivel, Thangaraju, Muthusamy, Prasad, Puttur D, Martin, Pamela M, Singh, Nagendra·2013·Current Opinion in Pharmacology

DOI 10.1016/j.coph.2013.08.006

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Abstract

The mutually beneficial relationship between colonic bacteria and the host has been recognized but the molecular aspects of the relationship remain poorly understood. Dietary fiber is critical to this relationship. The short-chain fatty acids acetate, propionate and butyrate, generated by bacterial fermentation of dietary fiber, serve as messengers between colonic bacteria and the host. The beneficial effects of these bacterial metabolites in colon include, but are not limited to, suppression of inflammation and prevention of cancer. Recent studies have identified the plasma membrane transporter SLC5A8 and the cell-surface receptors GPR109A and GPR43 as essential for the biologic effects of short-chain fatty acids in colon. These three proteins coded by the host genome provide the molecular link between colonic bacteria and the host.

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Authors: Ganapathy, V., Thangaraju, M., Prasad, P. D., Martin, P. M., & Singh, N.
Affiliations: Augusta University (US)
Corresponding author: Ganapathy, Vadivel
ORCID: Ganapathy, Vadivel
Thangaraju, Muthusamy
Prasad, Puttur D
Martin, Pamela M
Singh, Nagendra
Venue: Current Opinion in Pharmacology
Publisher: Elsevier BV
Published: 2013-12
Volume: 13
Issue: 6
Pages: 869-874
ISSN: 1471-4892 (ISSN-L)
DOI: 10.1016/j.coph.2013.08.006
OpenAlex: W2081831171
Cited by: 290
References: 43
Citations by year: 2026: 14 · 2025: 15 · 2024: 30 · 2023: 28 · 2022: 26 · 2021: 43 · 2020: 27 · 2019: 20 · 2018: 20 · 2017: 26 · 2016: 19 · 2015: 10 · 2014: 10 · 2013: 1
FWCI: 1.26
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Current Opinion in Pharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Keywords: short-chain fatty acids, colonic bacteria, gut microbiota, host-microbe communication, dietary fiber, SLC5A8, GPR109A, GPR43, butyrate, acetate, propionate, inflammation reduction, colorectal cancer prevention, bacterial fermentation
MeSH terms: Animals, Bacteria, Colon, Fatty Acids, Volatile, Humans, Receptors, Cell Surface, Membrane Transport Proteins

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Transporters and receptors for short-chain fatty acids as the molecular link between colonic bacteria and the host

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