Differential effects of behavioral interventions with a graded physical activity component in patients suffering from Chronic Fatigue (Syndrome): an updated systematic review and meta-analysis.

Marques, M.M.; De Gucht, V.; Gouveia, M.J.; Leal, I.; Maes, S.

doi:10.1016/j.cpr.2015.05.009

Cited by 50Fibromyalgia and Chronic Fatigue Syndrome ResearchLong-Term Effects of COVID-19Musculoskeletal pain and rehabilitation

Differential effects of behavioral interventions with a graded physical activity component in patients suffering from Chronic Fatigue (Syndrome): an updated systematic review and meta-analysis.

Marques, M.M., De Gucht, V., Gouveia, M.J., Leal, I., Maes, S.·2015·Clinical Psychology Review

DOI 10.1016/j.cpr.2015.05.009

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Abstract

An updated systematic review and meta-analysis was conducted to (1) evaluate the effects of behavioral and psychological interventions containing a graded physical activity component upon fatigue severity, physical functioning, physical activity and psychological distress, and to (2) examine potential moderator effects of trial characteristics (type of control, setting, provider, length of treatment, psychological component, flexibility in physical activity, and minimal face to face patient-provider contact). Pertinent content of selected studies was extracted and rated on a scale of methodological quality. Sixteen randomized controlled trials (N=2004) were included in the meta-analyses. Significant small to medium effect sizes (Hedge's g=0.25 to g=0.66) were found for all outcomes at post-treatment (M=5.2months) and follow-up (M=11.7months), with the exception of physical activity at post-treatment (g=0.11). The largest effects were found for fatigue severity (g=0.61 to g=0.66). Subgroup analyses revealed that minimal contact interventions had additional beneficial effects upon fatigue (g=0.96) and depression (g=0.85). Interventions provided by psychologists-psychotherapists and interventions conducted in secondary-tertiary settings also resulted in more beneficial effects on fatigue. We found some indication of publication bias. The small number of studies and variability between them are limitations of this study. Future research should explore additional moderating effects in order to improve the effectiveness of interventions.

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The current treatments of choice for patients with chronic fatigue are moderately effective.
“The current treatments of choice for patients with chronic fatigue are moderately effective.”
From The relationship between improvement in insomnia severity and long-term outcomes in the treatment of chronic fatigue (2018) · cites this paper as Marques et al., 2015
GET has yielded effect sizes similar to that of CBT (g = 0.61).
“GET has yielded effect sizes similar to that of CBT (g = 0.61) (Marques et al., 2015).”
From The relationship between improvement in insomnia severity and long-term outcomes in the treatment of chronic fatigue (2018) · cites this paper as Marques et al., 2015

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Authors: Marques, M. M., De Gucht, V., Gouveia, M. J., Leal, I., & Maes, S.
Affiliations: Leiden University (NL)
ISPA - Instituto Universitário (PT)
Corresponding author: Marques, M.M.
ORCID: Marques, M.M.
Gouveia, M.J.
Leal, I.
Venue: Clinical Psychology Review
Publisher: Elsevier BV
Published: 2015-08
Volume: 40
Pages: 123-137
ISSN: 0272-7358 (ISSN-L)
DOI: 10.1016/j.cpr.2015.05.009
OpenAlex: W1608314085
Cited by: 50
References: 98
Citations by year: 2026: 1 · 2025: 2 · 2024: 2 · 2023: 7 · 2022: 5 · 2021: 6 · 2020: 3 · 2019: 4 · 2018: 10 · 2017: 4 · 2016: 4 · 2015: 2
FWCI: 0.92
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Clinical Psychology Review (publishedVersion)
PubMed (publishedVersion)
Leiden Repository (Leiden University) (submittedVersion)
UCL Discovery (University College London) (submittedVersion)
Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion)
Funders: Foundation for Science and Technology (SFRH/BD/47579/2008)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
Keywords: chronic fatigue syndrome, behavioral interventions, psychological intervention, fatigue severity, physical function, physical activity, psychological distress, depression, provider type, treatment setting, treatment moderators
MeSH terms: Exercise Therapy, Humans, Psychotherapy, Fatigue Syndrome, Chronic, Randomized Controlled Trials as Topic, Outcome Assessment, Health Care

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Differential effects of behavioral interventions with a graded physical activity component in patients suffering from Chronic Fatigue (Syndrome): an updated systematic review and meta-analysis.

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