A Sleep-Promoting Role for the Drosophila Serotonin Receptor 1A

Correlates of Sleep and Waking in Drosophila melanogaster

Shaw, P. J., Cirelli, C., Greenspan, R. J., & Tononi, G. (2000) · Science · doi:10.1126/science.287.5459.1834 · Cited by 1,295

Biogenic Amines and the States of Sleep: Pharmacological and neurophysiological studies suggest a relationship between brain serotonin and sleep.

Jouvet, M. (1969) · Science · doi:10.1126/science.163.3862.32 · Cited by 1,282

Rest in Drosophila is a sleep-like state

Hendricks, J. C., Finn, S. M., Panckeri, K. A., Chavkin, J., Williams, J. A., Sehgal, A., & Pack, A. I. (2000) · Neuron · doi:10.1016/s0896-6273(00)80877-6 · Cited by 1,050

Clues to the functions of mammalian sleep

Siegel, J. M. (2005) · Nature · doi:10.1038/nature04285 · Cited by 1,040

The BDGP Gene Disruption Project

Bellen, H. J., Levis, R. W., Liao, G., He, Y., Carlson, J. W., Tsang, G., Evans-Holm, M., Hiesinger, P. R., Schulze, K. L., Rubin, G. M., et al. (2004) · Genetics · doi:10.1534/genetics.104.026427 · Cited by 873

A complementary transposon tool kit for Drosophila melanogaster using P and piggyBac

Thibault, S. T., Singer, M. A., Miyazaki, W. Y., Milash, B., Dompe, N. A., Singh, C. M., Buchholz, R., Demsky, M., Fawcett, R., Francis-Lang, H. L., et al. (2004) · Nature Genetics · doi:10.1038/ng1314 · Cited by 826

Systematic generation of high-resolution deletion coverage of the Drosophila melanogaster genome

Parks, A. L., Cook, K. R., Belvin, M., Dompe, N. A., Fawcett, R., Huppert, K., Tan, L. R., Winter, C. G., Bogart, K. P., Deal, J. E., et al. (2004) · Nature Genetics · doi:10.1038/ng1312 · Cited by 755

A unique central tryptophan hydroxylase isoform

Walther, D. J., & Bader, M. (2003) · Biochemical Pharmacology · doi:10.1016/s0006-2952(03)00556-2 · Cited by 751

Tryptophan Hydroxylase-2 Controls Brain Serotonin Synthesis

Zhang, X., Beaulieu, J.-M., Sotnikova, T. D., Gainetdinov, R. R., & Caron, M. G. (2004) · Science · doi:10.1126/science.1097540 · Cited by 683

Dopamine Is a Regulator of Arousal in the Fruit Fly

Kume, K., Kume, S., Park, S. K., Hirsh, J., & Jackson, F. R. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2048-05.2005 · Cited by 597

Reduced sleep in Drosophila Shaker mutants

Cirelli, C., Bushey, D., Hill, S., Huber, R., Kreber, R., Ganetzky, B., & Tononi, G. (2005) · Nature · doi:10.1038/nature03486 · Cited by 474

Sleep in Drosophila is regulated by adult mushroom bodies

Joiner, W. J., Crocker, A., White, B. H., & Sehgal, A. (2006) · Nature · doi:10.1038/nature04811 · Cited by 454

Role of serotonin in memory impairment.

Buhot, M.-C., Martin, S., & Segu, L. (2000) · Annals of Medicine · doi:10.3109/07853890008998828 · Cited by 419

Sleep Homeostasis in Drosophila Melanogaster

Huber, R., Hill, S. L., Holladay, C., Biesiadecki, M., Tononi, G., & Cirelli, C. (2004) · Sleep · doi:10.1093/sleep/27.4.628 · Cited by 412

Molecular and pharmacological properties of insect biogenic amine receptors: Lessons from Drosophila melanogaster and Apis mellifera

Blenau, W., & Baumann, A. (2001) · Archives of Insect Biochemistry and Physiology · doi:10.1002/arch.1055 · Cited by 383

Dopaminergic Modulation of Arousal in Drosophila

Andretic, R., van Swinderen, B., & Greenspan, R. J. (2005) · Current Biology · doi:10.1016/j.cub.2005.05.025 · Cited by 358

Serotonin and the sleep/wake cycle: special emphasis on microdialysis studies

Portas, C. M., Bjorvatn, B., & Ursin, R. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00097-5 · Cited by 339

Insights from studying human sleep disorders

Mahowald, M. W., & Schenck, C. H. (2005) · Nature · doi:10.1038/nature04287 · Cited by 330

Antidepressants and their effect on sleep

Mayers, A. G., & Baldwin, D. S. (2005) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.726 · Cited by 323

Serotonin and sleep

Ursin, R. (2002) · Sleep Medicine Reviews · doi:10.1053/smrv.2001.0174 · Cited by 321

A family of Drosophila serotonin receptors with distinct intracellular signalling properties and expression patterns.

Saudou, F., Boschert, U., Amlaiky, N., Plassat, J. L., & Hen, R. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05021.x · Cited by 265

Serotonin Modulates Circadian Entrainment in Drosophila

Yuan, Q., Lin, F., Zheng, X., & Sehgal, A. (2005) · Neuron · doi:10.1016/j.neuron.2005.05.027 · Cited by 261

Biogenic amine systems in the fruit flyDrosophila melanogaster

Monastirioti, M. (1999) · Microscopy Research and Technique · doi:10.1002/(sici)1097-0029(19990415)45:2<106::aid-jemt5>3.0.co;2-3 · Cited by 260

Daytime sleepiness and insomnia as correlates of depression.

D, M. F. M. (2004) · PubMed · Cited by 245

Role of Molecular Oscillations in Generating Behavioral Rhythms in Drosophila

Yang, Z., & Sehgal, A. (2001) · Neuron · doi:10.1016/s0896-6273(01)00218-5 · Cited by 240

Ectopic G-protein expression in dopamine and serotonin neurons blocks cocaine sensitization in Drosophila melanogaster

Li, H., Chaney, S., Forte, M., & Hirsh, J. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00340-7 · Cited by 239

Fly pushing : the theory and practice of Drosophila genetics

Greenspan, R. J. (1996) · Medical Entomology and Zoology · Cited by 234

Cloning and characterization of a Drosophila serotonin receptor that activates adenylate cyclase.

Witz, P., Amlaiky, N., Plassat, J. L., Maroteaux, L., Borrelli, E., & Hen, R. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.22.8940 · Cited by 233

A non-circadian role for cAMP signaling and CREB activity in Drosophila rest homeostasis

Hendricks, J. C., Williams, J. A., Panckeri, K., Kirk, D., Tello, M., Yin, J. C.-P., & Sehgal, A. (2001) · Nature Neuroscience · doi:10.1038/nn743 · Cited by 231

Sleep and Serotonin An Unfinished Story

Jouvet, M. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00009-3 · Cited by 225

Robust and tissue-specific expression of TPH2 versus TPH1 in rat raphe and pineal gland

Patel, P. D., Pontrello, C., & Burke, S. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.09.002 · Cited by 217

Fly pushing: The theory and practice of Drosophila genetics

Spradling, A. C. (1997) · Trends in Genetics · doi:10.1016/s0168-9525(97)89749-1 · Cited by 204

Serotonergic Regulation of the Orexin/Hypocretin Neurons through the 5-HT1AReceptor

Muraki, Y., Yamanaka, A., Tsujino, N., Kilduff, T. S., Goto, K., & Sakurai, T. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1027-04.2004 · Cited by 203

Drosophila as a new model organism for the neurobiology of aggression?

Baier, A., Wittek, B., & Brembs, B. (2002) · Journal of Experimental Biology · doi:10.1242/jeb.205.9.1233 · Cited by 187

Gender Dimorphism in the Role of cycle (BMAL1) in Rest, Rest Regulation, and Longevity in Drosophila melanogaster

Hendricks, J. C., Lu, S., Kume, K., Yin, J. C.-P., Yang, Z., & Sehgal, A. (2003) · Journal of Biological Rhythms · doi:10.1177/0748730402239673 · Cited by 183

Key Role of 5-HT1BReceptors in the Regulation of Paradoxical Sleep as Evidenced in 5-HT1BKnock-Out Mice

Boutrel, B., Franc, B., Hen, R., Hamon, M., & Adrien, J. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-08-03204.1999 · Cited by 177

Contribution of 5-HT2Receptor Subtypes to Sleep–Wakefulness and Respiratory Control, and Functional Adaptations in Knock-Out Mice Lacking 5-HT2AReceptors

Popa, D., Léna, C., Fabre, V., Prenat, C., Gingrich, J., Escourrou, P., Hamon, M., & Adrien, J. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1724-05.2005 · Cited by 170

Photic Signaling by Cryptochrome in the Drosophila Circadian System

Lin, F.-J., Song, W., Meyer-Bernstein, E., Naidoo, N., & Sehgal, A. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.21.7287-7294.2001 · Cited by 169

Drosophila 5-HT2 serotonin receptor: coexpression with fushi-tarazu during segmentation.

Colas, J. F., Launay, J. M., Kellermann, O., Rosay, P., & Maroteaux, L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5441 · Cited by 168

Involvement of 5-HT1A Receptors in Homeostatic and Stress-Induced Adaptive Regulations of Paradoxical Sleep: Studies in 5-HT1A Knock-Out Mice

Boutrel, B., Monaca, C., Hen, R., Hamon, M., & Adrien, J. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-11-04686.2002 · Cited by 166

Pharmacogenetic rescue in time and space of the rutabaga memory impairment by using Gene-Switch

Mao, Z., Roman, G., Zong, L., & Davis, R. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306128101 · Cited by 157

Genetic Evidence for a Role of CREB in Sustained Cortical Arousal

Graves, L. A., Hellman, K. M., Veasey, S. C., Blendy, J. A., Pack, A. I., & Abel, T. G. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00882.2002 · Cited by 124

Receptor Mechanisms in the treatment of Schizophrenia

Reynolds, G. P. (2004) · Journal of Psychopharmacology · doi:10.1177/026988110401800303 · Cited by 118

Temporal and Spatial Development of Serotonin and Dopamine Neurons in the Drosophila CNS

Lundell, M. J., & Hirsh, J. (1994) · Developmental Biology · doi:10.1006/dbio.1994.1261 · Cited by 109

Sleep and Sleep Homeostasis in Mice Lacking the 5-HT2c Receptor

Frank, M. G. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(02)00353-6 · Cited by 106

5-HT1A/1B Receptor-Mediated Effects of the Selective Serotonin Reuptake Inhibitor, Citalopram, on Sleep: Studies in 5-HT1A and 5-HT1B Knockout Mice

Monaca, C. C., Boutrel, B., Hen, R., Hamon, M., & Adrien, J. (2002) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300109 · Cited by 90

Serotonin synthesis by two distinct enzymes inDrosophila melanogaster

Coleman, C. M., & Neckameyer, W. S. (2005) · Archives of Insect Biochemistry and Physiology · doi:10.1002/arch.20050 · Cited by 84

Reversibility of Para-chlorophenylalanine-induced insomnia by intrahypothalamic microinjection of l-5-hydroxytryptophan

Denoyer, M., Sallanon, M. M., Kitahama, K., Aubert, C., & Jouvet, M. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90234-0 · Cited by 79

Drosophila melanogaster: An Insect Model for Fundamental Studies of Sleep

Ho, K. S., & Sehgal, A. (2005) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(05)93041-3 · Cited by 78

Sleep and Serotonin: An Unfinished Story

Jouvet, M. (1999) · Neuropsychopharmacology · doi:10.1038/sj.npp.1395333 · Cited by 76

Synchronized Neural Activity in the Drosophila Memory Centers and Its Modulation by amnesiac

Rosay, P., Armstrong, J. D., Wang, Z., & Kaiser, K. (2001) · Neuron · doi:10.1016/s0896-6273(01)00323-3 · Cited by 70

Truncation of the A1 Adenosine Receptor Reveals Distinct Roles of the Membrane-proximal Carboxyl Terminus in Receptor Folding and G Protein Coupling

Pankevych, H., Korkhov, V. M., Freissmuth, M., & Nanoff, C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212918200 · Cited by 65

Treatment issues related to sleep and depression.

Thase, M. E. (2000) · PubMed · Cited by 58

Acute and long-term effects of the 5-HT2 receptor antagonist ritanserin on EEG power spectra, motor activity, and sleep: changes at the light–dark phase shift

Kántor, S., Jakus, R., Bódizs, R., Halász, P., & Bagdy, G. (2002) · Brain Research · doi:10.1016/s0006-8993(02)02698-7 · Cited by 55

Expression, stability, and membrane integration of truncation mutants of bovine rhodopsin

Heymann, J. A. W., & Subramaniam, S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.4966 · Cited by 39

Pharmacological and molecular targets in the search for novel antipsychotics

Scatton, B., & Sanger, D. J. (2000) · Behavioural Pharmacology · doi:10.1097/00008877-200006000-00008 · Cited by 39

Cell-Specific Manipulation of Second Messengers

Kerr, M., Davies, S. A., & Dow, J. A. T. (2004) · Current Biology · doi:10.1016/j.cub.2004.08.020 · Cited by 36

Mushroom Bodies, Ca2+ Oscillations, and the Memory Gene amnesiac

Davis, R. L. (2001) · Neuron · doi:10.1016/s0896-6273(01)00329-4 · Cited by 32

Control of sleep and wakefulness

Brown, R. E., Basheer, R., McKenna, J. T., Strecker, R. E., & McCarley, R. W. (2012) · Physiological Reviews · doi:10.1152/physrev.00032.2011 · Cited by 1,477

Circadian Rhythms and Sleep in Drosophila melanogaster

Dubowy, C., & Sehgal, A. (2017) · Genetics · doi:10.1534/genetics.115.185157 · Cited by 420

The genetic and molecular regulation of sleep: from fruit flies to humans

Cirelli, C. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2683 · Cited by 386

Chemoconnectomics: Mapping Chemical Transmission in Drosophila

Deng, B., Li, Q., Liu, X., Cao, Y., Li, B., Qian, Y., Xu, R., Mao, R., Zhou, E., Zhang, W., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.01.045 · Cited by 340

Unraveling the evolutionary determinants of sleep

Joiner, W. J. (2016) · Current Biology · doi:10.1016/j.cub.2016.08.068 · Cited by 232