The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Impaired Synaptic Plasticity and Motor Learning in Mice with a Point Mutation Implicated in Human Speech Deficits
Open accessAbstract
The most well-described example of an inherited speech and language disorder is that observed in the multigenerational KE family, caused by a heterozygous missense mutation in the FOXP2 gene. Affected individuals are characterized by deficits in the learning and production of complex orofacial motor sequences underlying fluent speech and display impaired linguistic processing for both spoken and written language. The FOXP2 transcription factor is highly similar in many vertebrate species, with conserved expression in neural circuits related to sensorimotor integration and motor learning. In this study, we generated mice carrying an identical point mutation to that of the KE family, yielding the equivalent arginine-to-histidine substitution in the Foxp2 DNA-binding domain. Homozygous R552H mice show severe reductions in cerebellar growth and postnatal weight gain but are able to produce complex innate ultrasonic vocalizations. Heterozygous R552H mice are overtly normal in brain structure and development. Crucially, although their baseline motor abilities appear to be identical to wild-type littermates, R552H heterozygotes display significant deficits in species-typical motor-skill learning, accompanied by abnormal synaptic plasticity in striatal and cerebellar neural circuits.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Basal ganglia and cerebellar loops: motor and cognitive circuits
Middleton, F. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00040-5 · Cited by 1,940
Differential Corticostriatal Plasticity during Fast and Slow Motor Skill Learning in Mice
Costa, R. M., Cohen, D., & Nicolelis, M. A. L. (2004) · Current Biology · doi:10.1016/j.cub.2004.06.053 · Cited by 373
Self-citationNovel quantitative phenotypes of exercise training in mouse models
De Bono, J. P., Adlam, D., Paterson, D. J., & Channon, K. M. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00694.2005 · Cited by 197
Self-citationFunctional genetic analysis of mutations implicated in a human speech and language disorder
Vernes, S. C., Nicod, J., Elahi, F. M., Coventry, J. A., Kenny, N., Coupe, A.-M., Bird, L. E., Davies, K. E., & Fisher, S. E. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl392 · Cited by 167
Keays, D. A., Clark, T. G., Campbell, T. G., Broxholme, J., & Valdar, W. (2007) · Mammalian Genome · doi:10.1007/s00335-006-0065-z · Cited by 77
Self-citation
Cited by
A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice
Enard, W., Gehre, S., Hammerschmidt, K., Hölter, S. M., Blass, T., Somel, M., Brückner, M. K., Schreiweis, C., Winter, C., Sohr, R., et al. (2009) · Cell · doi:10.1016/j.cell.2009.03.041 · Cited by 605
Self-citationFitch, W. T. (2010) · doi:10.1017/cbo9780511817779 · Cited by 594
Foxp2 regulates gene networks implicated in neurite outgrowth in the developing brain
Vernes, S. C., Oliver, P. L., Spiteri, E., Lockstone, H. E., Puliyadi, R., Taylor, J. M., Ho, J., Mombereau, C., Brewer, A., Lowy, E., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002145 · Cited by 276
Social cognition and the evolution of language: constructing cognitive phylogenies
Fitch, W. T., Huber, L., & Bugnyar, T. (2010) · Neuron · doi:10.1016/j.neuron.2010.03.011 · Cited by 264
“In songbirds, FoxP2 is upregulated in nuclei involved in song learning (Haesler et al., 2004), and reduction of FoxP2 expression levels in song nuclei of zebra finches leads to less accurate, incomplete song learning (Haesler et al., 2007), providing direct evidence for the importance of FoxP2 in…”
Wöhr, M., Roullet, F. I., Hung, A. Y., Sheng, M., & Crawley, J. N. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020631 · Cited by 220
Human Models Are Needed for Studying Human Neurodevelopmental Disorders
Zhao, X., & Bhattacharyya, A. (2018) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2018.10.009 · Cited by 192
Schreiweis, C., Bornschein, U., Burguière, E., Kerimoglu, C., Schreiter, S., Dannemann, M., Goyal, S., Rea, E., French, C. A., Puliyadi, R., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1414542111 · Cited by 190
Self-citationReduced scent marking and ultrasonic vocalizations in the BTBR T+tf/J mouse model of autism
Wöhr, M., Roullet, F. I., & Crawley, J. N. (2011) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2010.00582.x · Cited by 169
Brain-specific Foxp1 deletion impairs neuronal development and causes autistic-like behaviour
Bacon, C., Schneider, M., Le Magueresse, C., Froehlich, H., Sticht, C., Gluch, C., Monyer, H., & Rappold, G. A. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.116 · Cited by 148
FOXP2 and the role of cortico-basal ganglia circuits in speech and language evolution
Enard, W. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.04.008 · Cited by 149
Kas, M. J., Glennon, J. C., Buitelaar, J., Ey, E., Biemans, B., Crawley, J., Ring, R. H., Lajonchere, C., Esclassan, F., Talpos, J., et al. (2014) · Psychopharmacology · doi:10.1007/s00213-013-3268-5 · Cited by 132
Mice do not require auditory input for the normal development of their ultrasonic vocalizations
Hammerschmidt, K., Reisinger, E., Westekemper, K., Ehrenreich, L., Strenzke, N., & Fischer, J. (2012) · BMC Neuroscience · doi:10.1186/1471-2202-13-40 · Cited by 123
Peter, B., Raskind, W. H., Matsushita, M., Lisowski, M., Vu, T., Berninger, V. W., Wijsman, E. M., & Brkanac, Z. (2011) · Journal of Neurodevelopmental Disorders · doi:10.1007/s11689-010-9065-0 · Cited by 117
FoxP influences the speed and accuracy of a perceptual decision in Drosophila
DasGupta, S., Ferreira, C. H., & Miesenböck, G. (2014) · Science · doi:10.1126/science.1252114 · Cited by 104
The evolution of FOXP2 in the light of admixture
Kuhlwilm, M. (2018) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2018.04.006 · Cited by 56
Evolution of language: Lessons from the genome
Fisher, S. E. (2017) · Psychonomic Bulletin & Review · doi:10.3758/s13423-016-1112-8 · Cited by 53
Self-citationCortical Foxp2 Supports Behavioral Flexibility and Developmental Dopamine D1 Receptor Expression
Co, M., Hickey, S. L., Kulkarni, A., Harper, M., & Konopka, G. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhz209 · Cited by 48
Characterization of Foxp2-expressing cells in the developing spinal cord
Morikawa, Y., Hisaoka, T., & Senba, E. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.05.022 · Cited by 33
Metadata
- Authors
- Groszer, M., Keays, D. A., Deacon, R. M. J., de Bono, J. P., Prasad-Mulcare, S., Gaub, S., Baum, M. G., French, C. A., Nicod, J., Coventry, J. A., Enard, W., Fray, M., Brown, S. D. M., Nolan, P. M., Pääbo, S., Channon, K. M., Costa, R. M., Eilers, J., Ehret, G., Rawlins, J. N. P., & Fisher, S. E.
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2008-03
- Volume
- 18
- Issue
- 5
- Pages
- 354-362
- ISSN
- 0960-9822 (ISSN-L)
- OpenAlex
- W1986382714
- Cited by
- 281
- References
- 5
- FWCI
- 11.07
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
