Reduced scent marking and ultrasonic vocalizations in the BTBR T+tf/J mouse model of autism
Open accessAbstract
Qualitative impairments in communication, such as delayed language and poor interactive communication skills, are fundamental to the diagnosis of autism. Investigations into social communication in adult BTBR T+tf/J (BTBR) mice are needed to determine whether this inbred strain incorporates phenotypes relevant to the second diagnostic symptom of autism, communication deficits, along with its strong behavioral phenotypes relevant to the first and third diagnostic symptoms, impairments in social interactions and high levels of repetitive behavior. The aim of the present study was to simultaneously measure female urine-elicited scent marking and ultrasonic vocalizations in adult male BTBR mice, in comparison with a standard control strain with high sociability, C57BL/6J (B6), for the assessment of a potential communication deficit in BTBR. Adult male BTBR mice displayed lower scent marking and minimal ultrasonic vocalization responses to female urine obtained from both B6 and BTBR females. Lower scent marking and ultrasonic vocalizations in a social setting by BTBR, as compared with B6, are consistent with the well-replicated social deficits in this inbred mouse strain. Our findings support the interpretation that BTBR incorporate communication deficits, and suggest that scent marking and ultrasonic vocalizations offer promising measures of interest in social cues that may be widely applicable to investigations of mouse models of autism.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
BTBR T+tf/J mice display behavioral phenotypes relevant to all three diagnostic symptoms of autism.
“BTBR T+tf/J (BTBR) is a commercially available inbred strain of mouse that displays behavioral phenotypes relevant to all three diagnostic symptoms of autism (60–62, 64, 66, 68–70, 72, 74–78).”
From Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism (2012) · cites this paper as [70]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
Diagnostic and Statistical Manual of Mental Disorders.
Widiger, T. A. (2000) · Oxford University Press eBooks · doi:10.1037/10518-009 · Cited by 19,767 · see citing works
Autism From 2 to 9 Years of Age
Lord, C., Risi, S., DiLavore, P. S., Shulman, C., Thurm, A., & Pickles, A. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.6.694 · Cited by 973 · see citing works
Pheromones and Animal Behaviour: Communication by Smell and Taste
Wyatt, T. D. (2003) · doi:10.1017/cbo9780511615061 · Cited by 951 · see citing works
Autism and the pervasive developmental disorders
Volkmar, F. R., & Klin, A. (2012) · doi:10.1093/med/9780199696758.003.0214 · Cited by 931 · see citing works
Autism‐like behavioral phenotypes in BTBR T+tf/J mice
McFarlane, H. G., Kusek, G. K., Yang, M., Phoenix, J. L., Bolivar, V. J., & Crawley, J. N. (2008) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2007.00330.x · Cited by 812 · see citing works
Self-citationMouse behavioral tasks relevant to autism: Phenotypes of 10 inbred strains
MOY, S., NADLER, J., YOUNG, N., PEREZ, A., HOLLOWAY, L., BARBARO, R., BARBARO, J., WILSON, L., THREADGILL, D., & LAUDER, J. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.07.030 · Cited by 776 · see citing works
Autism and pervasive developmental disorders
Volkmar, F. R., Lord, C., Bailey, A., Schultz, R. T., & Klin, A. (2004) · Journal of Child Psychology and Psychiatry · doi:10.1046/j.0021-9630.2003.00317.x · Cited by 616 · see citing works
(2007) · PubMed · Cited by 597 · see citing works
Jamain, S., Radyushkin, K., Hammerschmidt, K., Granon, S., Boretius, S., Varoqueaux, F., Ramanantsoa, N., Gallego, J., Ronnenberg, A., Winter, D., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711555105 · Cited by 556 · see citing works
Unusual repertoire of vocalizations in the BTBR T+tf/J mouse model of autism
Scattoni, M. L., Gandhy, S. U., Ricceri, L., & Crawley, J. N. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003067 · Cited by 550 · see citing works
Self-citationMammalian social odours: attraction and individual recognition
Brennan, P., & Kendrick, K. M. (2006) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2006.1931 · Cited by 510 · see citing works
Desjardins, C., MARUNIAK, J. A., & Bronson, F. H. (1973) · Science · doi:10.1126/science.182.4115.939 · Cited by 449 · see citing works
Altered ultrasonic vocalization in mice with a disruption in the Foxp2 gene
Shu, W., Cho, J. Y., Jiang, Y., Zhang, M., Weisz, D. J., Elder, G. A., Schmeidler, J., Gasperi, R. D., Sosa, M. A. G., Rabidou, D., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503739102 · Cited by 415 · see citing works
Neuroligin‐3‐deficient mice: model of a monogenic heritable form of autism with an olfactory deficit
Radyushkin, K., Hammerschmidt, K., Boretius, S., Varoqueaux, F., El-Kordi, A., Ronnenberg, A., Winter, D., Frahm, J., Fischer, J., Brose, N., et al. (2009) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2009.00487.x · Cited by 359 · see citing works
Urine marking in populations of wild house mice Mus domesticus rutty. I. Communication between males
Hurst, J. L. (1990) · Animal Behaviour · doi:10.1016/s0003-3472(05)80916-9 · Cited by 335 · see citing works
Panksepp, J. B., Jochman, K. A., Kim, J. U., Koy, J. J., Wilson, E. D., Chen, Q., Wilson, C. R., & Lahvis, G. P. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000351 · Cited by 295 · see citing works
Groszer, M., Keays, D. A., Deacon, R. M. J., de Bono, J. P., Prasad-Mulcare, S., Gaub, S., Baum, M. G., French, C. A., Nicod, J., Coventry, J. A., et al. (2008) · Current Biology · doi:10.1016/j.cub.2008.01.060 · Cited by 281 · see citing works
Aggression, anxiety and vocalizations in animals: GABAA and 5-HT anxiolytics
Miczek, K. A., Weerts, E. M., Vivian, J. A., & Barros, H. M. T. (1995) · Psychopharmacology · doi:10.1007/bf02245590 · Cited by 277 · see citing works
Ultrasound and mating behaviour in rodents with some observations on other behavioural situations
Sales, G. (1972) · Journal of Zoology · doi:10.1111/j.1469-7998.1972.tb01345.x · Cited by 268 · see citing works
Assessing autism-like behavior in mice: Variations in social interactions among inbred strains
BOLIVAR, V, WALTERS, S., & PHOENIX, J. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.09.007 · Cited by 264 · see citing works
Mice: Individual Recognition by Olfactory Cues
Bowers, J. M., & ALEXANDER, B. K. (1967) · Science · doi:10.1126/science.158.3805.1208 · Cited by 257 · see citing works
Fujita, E., Tanabe, Y., Shiota, A., Ueda, M., Suwa, K., Momoi, M. Y., & Momoi, T. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712298105 · Cited by 233 · see citing works
Scent marking behavior as an odorant communication in mice
Arakawa, H., Blanchard, D. C., Arakawa, K., Dunlap, C., & Blanchard, R. J. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.05.012 · Cited by 229 · see citing works
Female mice respond to male ultrasonic ‘songs’ with approach behaviour
Hammerschmidt, K., Radyushkin, K., Ehrenreich, H., & Fischer, J. (2009) · Biology Letters · doi:10.1098/rsbl.2009.0317 · Cited by 226 · see citing works
Ultrasonic Communication in Rodents
SEWELL, G. D. (1970) · Nature · doi:10.1038/227410a0 · Cited by 222 · see citing works
Rat pup ultrasonic isolation calls: Possible mediation by the benzodiazepine receptor complex
Insel, T. R., Hill, J., & Mayor, R. B. (1986) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(86)90182-6 · Cited by 215 · see citing works
Social‐cognition and the broad autism phenotype: identifying genetically meaningful phenotypes
Losh, M. C., & Piven, J. (2006) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2006.01594.x · Cited by 209 · see citing works
Female behavior is affected by male ultrasonic vocalizations in house mice
Pomerantz, S. M., Núñez, A. A., & Bean, N. J. (1983) · Physiology & Behavior · doi:10.1016/0031-9384(83)90101-4 · Cited by 198 · see citing works
Development of a mouse test for repetitive, restricted behaviors: Relevance to autism
Moy, S. S., Nadler, J. J., Poe, M. D., Nonneman, R. J., Young, N. B., Koller, B. H., Crawley, J. N., Duncan, G. E., & Bodfish, J. W. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.10.029 · Cited by 195 · see citing works
Self-citationUltrasonic communication of adult myomorph rodents
Nyby, J., & Whitney, G. (1978) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(78)90003-9 · Cited by 173 · see citing works
Wang, H., Liang, S., Burgdorf, J. S., Wess, J., & Yeomans, J. S. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001893 · Cited by 172 · see citing works
Language and communication in autistic disorders
Uta Frith, A., & Happe, F. G. E. (1994) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1994.0133 · Cited by 156 · see citing works
Wöhr, M., & Schwarting, R. K. W. (2008) · Behavioral Neuroscience · doi:10.1037/0735-7044.122.2.310 · Cited by 156 · see citing works
Self-citationUltrasonic vocalizations during sex behavior of male house mice (Mus musculus): A description
Nyby, J. (1983) · Behavioral and Neural Biology · doi:10.1016/s0163-1047(83)90722-7 · Cited by 142 · see citing works
Hurst, J. L. (1990) · Animal Behaviour · doi:10.1016/s0003-3472(05)80918-2 · Cited by 136 · see citing works
Pheromonal regulation of male mouse ultrasonic courtship (Mus musculus)
Nyby, J., Wysocki, C. J., Whitney, G., & Dizinno, G. A. (1977) · Animal Behaviour · doi:10.1016/0003-3472(77)90009-4 · Cited by 135 · see citing works
Yang, M., Zhodzishsky, V., & Crawley, J. N. (2007) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2007.09.008 · Cited by 132 · see citing works
Self-citationDizinno, G., Whitney, G., & Nyby, J. (1978) · Behavioral Biology · doi:10.1016/s0091-6773(78)92094-1 · Cited by 131 · see citing works
Ultrasound recognition in house mice: Key-Stimulus configuration and recognition mechanism
Ehret, G., & Haack, B. (1982) · Journal of Comparative Physiology A · doi:10.1007/bf00619131 · Cited by 124 · see citing works
Yang, M. (2007) · Frontiers in Behavioral Neuroscience · doi:10.3389/neuro.08.001.2007 · Cited by 124 · see citing works
Postnatal lesion evidence against a primary role for the corpus callosum in mouse sociability
Yang, M., Clarke, A. M., & Crawley, J. N. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06714.x · Cited by 117 · see citing works
Self-citationElicitation of male mouse (Mus musculus) ultrasonic vocalizations: I. Urinary cues.
Nyby, J., Wysocki, C. J., Whitney, G., Dizinno, G. A., & Schneider, J. E. (1979) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0077623 · Cited by 110 · see citing works
Social status and ultrasonic vocalizations of male mice
Nyby, J., Dizinno, G. A., & Whitney, G. (1976) · Behavioral Biology · doi:10.1016/s0091-6773(76)92198-2 · Cited by 102 · see citing works
Female odors evoke ultrasounds from male mice
Whitney, G., Alpern, M., Dizinno, G. A., & Horowitz, G. P. (1974) · Animal Learning & Behavior · doi:10.3758/bf03199109 · Cited by 101 · see citing works
Wöhr, M., Dahlhoff, M., Wolf, E., Holsboer, F., Schwarting, R. K. W., & Wotjak, C. T. (2008) · Behavior Genetics · doi:10.1007/s10519-008-9221-4 · Cited by 99 · see citing works
Self-citationHurst, J. L. (1989) · Animal Behaviour · doi:10.1016/0003-3472(89)90057-2 · Cited by 93 · see citing works
Cirulli, F., Santucci, D., Giovanni Laviola, A., Alleva, E., & Levine, S. D. (1994) · Developmental Psychobiology · doi:10.1002/dev.420270505 · Cited by 90 · see citing works
Urinary marking in male house mice: Responses to novel environmental and social stimuli☆
MARUNIAK, J. A., Owen, K., Bronson, F. H., & Desjardins, C. D. (1974) · Physiology & Behavior · doi:10.1016/0031-9384(74)90151-6 · Cited by 89 · see citing works
Fish, E. W., Sekinda, M., Ferrari, P. F., Dirks, A., & Miczek, K. A. (2000) · Psychopharmacology · doi:10.1007/s002130000370 · Cited by 87 · see citing works
Arakawa, H., Arakawa, K., Blanchard, D. C., & Blanchard, R. J. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.02.009 · Cited by 80 · see citing works
Experience-based vocalization of male mice to female chemosignals
Maggio, J. C., Maggio, J. C., & Whitney, G. (1983) · Physiology & Behavior · doi:10.1016/0031-9384(83)90186-5 · Cited by 76 · see citing works
Nyby, J., Bigelow, J., Kerchner, M., & Barbehenn, F. W. (1983) · Behavioral and Neural Biology · doi:10.1016/s0163-1047(83)90354-0 · Cited by 74 · see citing works
Exaggerated responses to stress in the BTBR T+tf/J mouse: An unusual behavioral phenotype
Benno, R. H., Smirnova, Y., Vera, S., Liggett, A., & Schanz, N. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.09.041 · Cited by 68 · see citing works
Scent marking behavior in male C57BL/6J mice: Sexual and developmental determination
Arakawa, H., ARAKAWA, K., Blanchard, D. C., & Blanchard, R. J. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.05.007 · Cited by 65 · see citing works
Nastiti, K., Benton, D., & Pf, B. (1991) · PubMed · Cited by 62 · see citing works
Effects of medial preoptic lesions on male mouse ultrasonic vocalizations and copulatory behavior
Bean, N. J., Núñez, A. A., & Conner, R. L. (1981) · Brain Research Bulletin · doi:10.1016/s0361-9230(81)80033-0 · Cited by 60 · see citing works
An ephemeral sex pheromone in the urine of female house mice (Mus domesticus)
Sipos, M. L., Kerchner, M., & Nyby, J. (1992) · Behavioral and Neural Biology · doi:10.1016/0163-1047(92)90375-e · Cited by 59 · see citing works
The influence of psychotropic drugs on the ultrasonic calling of mouse pups
Benton, D., & Nastiti, K. (1988) · Psychopharmacology · doi:10.1007/bf00212775 · Cited by 56 · see citing works
Takahashi, A., Yap, J. J., Bohager, D. Z., Faccidomo, S., Clayton, T., Cook, J. M., & Miczek, K. A. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1437-8 · Cited by 56 · see citing works
Cues that Elicit Ultrasounds from Adult Male Mice
Whitney, G., & Nyby, J. (1979) · American Zoologist · doi:10.1093/icb/19.2.457 · Cited by 54 · see citing works
Ultrasonic vocalizations in mice and rats: social contexts and functions
Costantini, F., & D'Amato, F. R. (2006) · Europe PMC (PubMed Central) · Cited by 54 · see citing works
Urination as a Social Response in Mice
REYNOLDS, E. (1971) · Nature · doi:10.1038/234481a0 · Cited by 53 · see citing works
Sex Selectivity of Mouse Ultrasonic Songs
Guo, Z., & Holy, T. E. (2007) · Chemical Senses · doi:10.1093/chemse/bjm015 · Cited by 53 · see citing works
THE OLFACTORY RESPONSE OF MICE TO URINE AND EFFECTS OF GONADECTOMY
DAVIES, V. J., & Bellamy, D. (1972) · Journal of Endocrinology · doi:10.1677/joe.0.0550011 · Cited by 46 · see citing works
Courtship ultrasonic vocalizations and social status in mice
D'Amato, F. R. (1991) · Animal Behaviour · doi:10.1016/s0003-3472(05)80354-9 · Cited by 45 · see citing works
Effect of altricial pup ultrasonic vocalization on maternal behavior
Wöhr, M., Oddi, D., & D'Amato, F. R. (2010) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-374593-4.00016-4 · Cited by 26 · see citing works
Self-citationElicitation of male mouse ultrasounds: Bladder urine and aged urine from females
Nyby, J., & Zakeski, D. M. (1980) · Physiology & Behavior · doi:10.1016/0031-9384(80)90405-9 · Cited by 26 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Roberts Wolf JO Sherman PW Scent Marking. 255-266 Rodent societies. An Ecological and Evolutionary Perspective 2007 The University of Chicago Press Chicago
Cited by
Sorted by citations
Behavioural phenotyping assays for mouse models of autism
Silverman, J. L., Yang, M., Lord, C., & Crawley, J. N. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2851 · Cited by 1,462 · see citing works
Self-citationMalkova, N. V., Yu, C. Z., Hsiao, E. Y., Moore, M. J., & Patterson, P. H. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.01.011 · Cited by 662 · see citing works
In utero exposure to valproic acid and autism — A current review of clinical and animal studies
Roullet, F., Lai, J., & Foster, J. A. (2013) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2013.01.004 · Cited by 425 · see citing works
Self-citationYang, M., Bozdagi, O., Scattoni, M. L., Wöhr, M., Roullet, F. I., Katz, A. M., Abrams, D. N., Kalikhman, D., Simon, H., Woldeyohannes, L., et al. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.6107-11.2012 · Cited by 369 · see citing works
Self-citationScattoni, M. L., Ricceri, L., & Crawley, J. N. (2010) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2010.00623.x · Cited by 336 · see citing works
Self-citationNeuroprotective Actions of Dietary Choline
Blusztajn, J., Slack, B., & Mellott, T. (2017) · Nutrients · doi:10.3390/nu9080815 · Cited by 254 · see citing works
Silverman, J. L., Smith, D. G., Rizzo, S. J. S., Karras, M. N., Turner, S. M., Tolu, S. S., Bryce, D. K., Smith, D. L., Fonseca, K., Ring, R. H., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003501 · Cited by 251 · see citing works
Self-citationHan, S., Tai, C., Jones, C. J., Scheuer, T., & Catterall, W. A. (2014) · Neuron · doi:10.1016/j.neuron.2014.01.016 · Cited by 231 · see citing works
Translational animal models of autism and neurodevelopmental disorders
Crawley, J. N. (2012) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2012.14.3/jcrawley · Cited by 227 · see citing works
Self-citationWöhr, M., Roullet, F. I., Hung, A. Y., Sheng, M., & Crawley, J. N. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020631 · Cited by 220 · see citing works
Self-citationThe oxytocin system in drug discovery for autism: Animal models and novel therapeutic strategies
Modi, M. E., & Young, L. J. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.12.010 · Cited by 218 · see citing works
Structured evaluation of rodent behavioral tests used in drug discovery research
Hånell, A., & Marklund, N. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00252 · Cited by 188 · see citing works
Wöhr, M., & Scattoni, M. L. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.05.047 · Cited by 178 · see citing works
Self-citationBehavioral phenotypes of genetic mouse models of autism
Kazdoba, T. M., Leach, P. T., & Crawley, J. N. (2015) · Genes Brain & Behavior · doi:10.1111/gbb.12256 · Cited by 179 · see citing works
Self-citationTranslational Mouse Models of Autism: Advancing Toward Pharmacological Therapeutics
Kazdoba, T. M., Leach, P. T., Yang, M., Silverman, J. L., Solomon, M., & Crawley, J. N. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2015_5003 · Cited by 172 · see citing works
Self-citationMotor and cognitive stereotypies in the BTBR T+tf/J mouse model of autism
Pearson, B. L., Pobbe, R. L. H., Defensor, E. B., Oasay, L., Bolivar, V. J., Blanchard, D. C., & Blanchard, R. J. (2011) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2010.00659.x · Cited by 171 · see citing works
Aberrant immune responses in a mouse with behavioral disorders
Heo, Y., Zhang, Y., Gao, D., Miller, V. M., & Lawrence, D. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020912 · Cited by 168 · see citing works
Female Presence and Estrous State Influence Mouse Ultrasonic Courtship Vocalizations
Hanson, J. L., & Hurley, L. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040782 · Cited by 160 · see citing works
The BTBR T+tf/J mouse model for autism spectrum disorders–in search of biomarkers
Meyza, K. Z., Defensor, E. B., Jensen, A. L., Corley, M. J., Pearson, B. L., Pobbe, R. L. H., Bolivar, V. J., Blanchard, D. C., & Blanchard, R. J. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.07.021 · Cited by 147 · see citing works
Low stress reactivity and neuroendocrine factors in the BTBR T+tf/J mouse model of autism
Silverman, J. L., Yang, M., Turner, S. M., Katz, A. M., Bell, D. B., Koenig, J. I., & Crawley, J. N. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.09.059 · Cited by 146 · see citing works
Self-citationKane, M. J., Angoa‐Pérez, M., Briggs, D. I., Sykes, C. E., Francescutti, D. M., Rosenberg, D. R., & Kuhn, D. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048975 · Cited by 140 · see citing works
Oxytocin receptor knockout mice display deficits in the expression of autism-related behaviors
Pobbe, R. L. H., Pearson, B. L., Defensor, E. B., Bolivar, V. J., Young, W. S., Lee, H., Blanchard, D. C., & Blanchard, R. J. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.10.010 · Cited by 139 · see citing works
Defensor, E. B., Pearson, B. L., Pobbe, R. L. H., Bolivar, V. J., Blanchard, D. C., & Blanchard, R. J. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.10.033 · Cited by 136 · see citing works
Scattoni, M. L., Martire, A., Cartocci, G., Ferrante, A., & Ricceri, L. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.12.028 · Cited by 134 · see citing works
Ellegood, J., Babineau, B. A., Henkelman, R. M., Lerch, J. P., & Crawley, J. N. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2012.12.029 · Cited by 135 · see citing works
Self-citationBehavioral and Neuroanatomical Phenotypes in Mouse Models of Autism
Ellegood, J., & Crawley, J. N. (2015) · Neurotherapeutics · doi:10.1007/s13311-015-0360-z · Cited by 132 · see citing works
Self-citationMcTighe, S. M., Webb, S. J. N., Lin, Q., Hughes, Z. A., & Smith, D. G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062189 · Cited by 133 · see citing works
Dodero, L., Damiano, M., Galbusera, A., Bifone, A., Tsaftsaris, S. A., Scattoni, M. L., & Gozzi, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076655 · Cited by 116 · see citing works
Wöhr, M., Silverman, J. L., Scattoni, M. L., Turner, S. M., Harris, M., Saxena, R., & Crawley, J. N. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.07.024 · Cited by 124 · see citing works
Self-citationSemple, B. D., Zamani, A., Rayner, G., Shultz, S. R., & Jones, N. C. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.07.018 · Cited by 123 · see citing works
Brunner, D., Kabitzke, P., He, D., Cox, K., Thiede, L., Hanania, T., Sabath, E., Alexandrov, V., Saxe, M., Peles, E., et al. (2015) · PLOS ONE · doi:10.1371/journal.pone.0134572 · Cited by 111 · see citing works
Role of Microglia in Autism: Recent Advances
Takano, T. (2015) · Developmental Neuroscience · doi:10.1159/000398791 · Cited by 122 · see citing works
General and social anxiety in the BTBR T+ tf/J mouse strain
Pobbe, R. L. H., Defensor, E. B., Pearson, B. L., Bolivar, V. J., Blanchard, D. C., & Blanchard, R. J. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.08.039 · Cited by 115 · see citing works
AMPAKINE enhancement of social interaction in the BTBR mouse model of autism
Silverman, J. L., Oliver, C. F., Karras, M. N., Gastrell, P. T., & Crawley, J. N. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.07.013 · Cited by 112 · see citing works
Self-citationSocial peers rescue autism‐relevant sociability deficits in adolescent mice
Yang, M., Perry, K., Weber, M. D., Katz, A. M., & Crawley, J. N. (2011) · Autism Research · doi:10.1002/aur.163 · Cited by 106 · see citing works
Self-citationFluoxetine but not risperidone increases sociability in the BTBR mouse model of autism
Chadman, K. K. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.09.012 · Cited by 104 · see citing works
Roullet, F., Wöhr, M., & Crawley, J. N. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.06.004 · Cited by 97 · see citing works
Self-citationFound in translation: Understanding the biology and behavior of experimental traumatic brain injury
Bondi, C. O., Semple, B. D., Noble‐Haeusslein, L. J., Osier, N. D., Carlson, S. W., Dixon, C. E., Giza, C. C., & Kline, A. E. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.12.004 · Cited by 91 · see citing works
Neural Mechanisms Underlying Repetitive Behaviors in Rodent Models of Autism Spectrum Disorders
Gandhi, T., & Lee, C. C. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.592710 · Cited by 94 · see citing works
Segal‐Gavish, H., Karvat, G., Barak, N., Barzilay, R., Ganz, J., Edry, L., Aharony, I., Offen, D., & Kimchi, T. (2015) · Autism Research · doi:10.1002/aur.1530 · Cited by 93 · see citing works
Caruso, A., Ricceri, L., & Scattoni, M. L. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.06.011 · Cited by 85 · see citing works
Roy, S., Watkins, N. W., & Heck, D. H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044816 · Cited by 87 · see citing works
Grimsley, J. M. S., Sheth, S. P., Vallabh, N., Grimsley, C. A., Bhattal, J., Latsko, M. S., Jasnow, A. M., & Wenstrup, J. J. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00038 · Cited by 88 · see citing works
Ultrasonic vocalizations in mice: relevance for ethologic and neurodevelopmental disorders studies
Premoli, M., Memo, M., & Bonini, S. A. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.300340 · Cited by 82 · see citing works
Premoli, M., Pietropaolo, S., Wöhr, M., Simola, N., & Bonini, S. A. (2023) · European Journal of Neuroscience · doi:10.1111/ejn.15957 · Cited by 78 · see citing works
Self-citationInflammatory profiles in the BTBR mouse: how relevant are they to autism spectrum disorders?
Careaga, M., Schwartzer, J., & Ashwood, P. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.06.006 · Cited by 77 · see citing works
Modeling autism-relevant behavioral phenotypes in rats and mice: Do ‘autistic’ rodents exist?
Servadio, M., Vanderschuren, L. J. M. J., & Trezza, V. (2015) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000163 · Cited by 76 · see citing works
Dysfunctional dopaminergic neurotransmission in asocial BTBR mice
Squillace, M., Dodero, L., Federici, M., Migliarini, S., Errico, F., Napolitano, F., Krashia, P., Maio, A. D., Galbusera, A., Bifone, A., et al. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.69 · Cited by 73 · see citing works
Dougnon, G., & Matsui, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147550 · Cited by 71 · see citing works
Langley, E. A., Krykbaeva, M., Blusztajn, J. K., & Mellott, T. J. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.09.043 · Cited by 70 · see citing works
Rapamycin improves sociability in the BTBR T+Itpr3/J mouse model of autism spectrum disorders
Burket, J. A., Benson, A. D., Tang, A., & Deutsch, S. I. (2013) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2013.11.005 · Cited by 67 · see citing works
Daimon, C. M., Jasien, J., Wood, W. H., Zhang, Y., Becker, K. G., Silverman, J. L., Crawley, J. N., Martin, B., & Maudsley, S. R. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00324 · Cited by 67 · see citing works
Self-citationMouse Models of Autism: Testing Hypotheses About Molecular Mechanisms
Roullet, F., & Crawley, J. N. (2011) · Current topics in behavioral neurosciences · doi:10.1007/7854_2010_113 · Cited by 65 · see citing works
Self-citationThe Roles of Oxytocin and CD38 in Social or Parental Behaviors
Lopatina, O. L., Ивановна, И. А., Salmina, A. B., & Higashida, H. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2012.00182 · Cited by 64 · see citing works
Seese, R. R., Maske, A. R., LYNCH, G. S., & Gall, C. M. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.13 · Cited by 62 · see citing works
Blanchard, D. C., Summers, C. H., & Blanchard, R. J. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.06.008 · Cited by 60 · see citing works
Ultrasonic vocalizations of adult male Foxp2‐mutant mice: behavioral contexts of arousal and emotion
Gaub, S., Fisher, S. E., & Ehret, G. (2015) · Genes Brain & Behavior · doi:10.1111/gbb.12274 · Cited by 61 · see citing works
Needham, B. D., Tang, W., & Wu, W. (2018) · Developmental Neurobiology · doi:10.1002/dneu.22581 · Cited by 59 · see citing works
Lehmann, M. L., Geddes, C. E., Lee, J. L., & Herkenham, M. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069822 · Cited by 56 · see citing works
Keesom, S. M., Finton, C. J., Sell, G. L., & Hurley, L. M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0169705 · Cited by 55 · see citing works
Burket, J. A., Benson, A. D., Tang, A., & Deutsch, S. I. (2013) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2013.05.003 · Cited by 56 · see citing works
Hodges, S. L., Nolan, S. O., Reynolds, C. D., & Lugo, J. N. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.05.052 · Cited by 55 · see citing works
Aerodynamics and motor control of ultrasonic vocalizations for social communication in mice and rats
Håkansson, J., Jiang, W., Xue, Q., Zheng, X., Ding, M. L., Agarwal, A., & Elemans, C. P. H. (2022) · BMC Biology · doi:10.1186/s12915-021-01185-z · Cited by 55 · see citing works
BTBR T+tf/J mice: Autism-relevant behaviors and reduced fractone-associated heparan sulfate
Blanchard, D. C., Defensor, E. B., Meyza, K. Z., Pobbe, R. L. H., Pearson, B. L., Bolivar, V. J., & Blanchard, R. J. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.06.008 · Cited by 54 · see citing works
The role of the dopamine D1 receptor in social cognition: studies using a novel genetic rat model
Homberg, J. R., Olivier, J. D. A., Broeke, M. V., Youn, J., Ellenbroek, A. K., Karel, P., Shan, L., van Boxtel, R., Ooms, S. J., Balemans, M., et al. (2016) · Disease Models & Mechanisms · doi:10.1242/dmm.024752 · Cited by 52 · see citing works
NMDA receptor activation regulates sociability by its effect on mTOR signaling activity
Burket, J. A., Benson, A. D., Tang, A., & Deutsch, S. I. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.02.009 · Cited by 50 · see citing works
Chao, O. Y.-H., Yunger, R., & Yang, Y. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.03.014 · Cited by 51 · see citing works
Therapeutic Effect of a Synthetic RORα/γ Agonist in an Animal Model of Autism
Wang, Y., Billon, C., Walker, J. K., & Burris, T. P. (2015) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5b00159 · Cited by 48 · see citing works
Characterization of ultrasonic vocalizations of Fragile X mice
Belagodu, A. P., Johnson, A. M., & Galvez, R. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.04.016 · Cited by 46 · see citing works
Perinatal Influences of Valproate on Brain and Behaviour: An Animal Model for Autism
Ranger, P., & Ellenbroek, B. A. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2015_404 · Cited by 42 · see citing works
Modeling dopamine dysfunction in autism spectrum disorder: from invertebrates to vertebrates
DiCarlo, G. E., & Wallace, M. T. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.12.017 · Cited by 39 · see citing works
Wöhr, M. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00073 · Cited by 43 · see citing works
Self-citationAffective communication in rodents
Wöhr, M., van Gaalen, M. M., & Schwarting, R. K. W. (2015) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000172 · Cited by 42 · see citing works
Self-citationNeuronal correlates of asocial behavior in a BTBR T+Itpr3tf/J mouse model of autism
Meyza, K. Z., Nikolaev, T., Kondrakiewicz, K., Blanchard, D. C., Blanchard, R. J., & Knapska, E. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00199 · Cited by 42 · see citing works
Influence of stimulant-induced hyperactivity on social approach in the BTBR mouse model of autism
Silverman, J. L., Babineau, B. A., Oliver, C. F., Karras, M. N., & Crawley, J. N. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.07.042 · Cited by 42 · see citing works
Self-citationPobbe, R. L. H., Pearson, B. L., Blanchard, D. C., & Blanchard, R. J. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2012.02.024 · Cited by 40 · see citing works
The effects of aging on the BTBR mouse model of autism spectrum disorder
Jasien, J., Daimon, C. M., Wang, R., Shapiro, B. K., Martin, B., & Maudsley, S. R. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00225 · Cited by 41 · see citing works
Sociosexual and Communication Deficits after Traumatic Injury to the Developing Murine Brain
Semple, B. D., Noble‐Haeusslein, L. J., Kwon, Y. J., Sam, P. N., Gibson, A. M., Grissom, S., Brown, S., Adahman, Z., Hollingsworth, C. A., Kwakye, A., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103386 · Cited by 39 · see citing works
Clinical and Neurobiological Relevance of Current Animal Models of Autism Spectrum Disorders
Kim, K. C., Gonzales, E. L., Lázaro, M. T., Choi, C. S., Bahn, G. H., Yoo, H. J., & Shin, C. Y. (2016) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2016.061 · Cited by 40 · see citing works
Toddes, C., Lefevre, E. M., Brandner, D. D., Zugschwert, L., & Rothwell, P. E. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.2440-20.2021 · Cited by 34 · see citing works
Schwartzer, J. J., Koenig, C. M., & Berman, R. F. (2012) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2012.08.007 · Cited by 39 · see citing works
Physiological and Behavioral Responses to Vocalization Playback in Mice
Niemczura, A. C., Grimsley, J. M. S., Kim, C., Alkhawaga, A., Poth, A., Carvalho, A., & Wenstrup, J. J. (2020) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.00155 · Cited by 35 · see citing works
Ahadullah, Yau, S., Lu, H., Lee, T. M. C., Guo, H., & Chan, C. C. H. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.06.043 · Cited by 33 · see citing works
Knoll, A. T., Jiang, K., & Levitt, P. R. (2017) · Genes Brain & Behavior · doi:10.1111/gbb.12431 · Cited by 27 · see citing works
Ornoy, A., Echefu, B. E., & Becker, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251910469 · Cited by 33 · see citing works
Intact and impaired executive abilities in the BTBR mouse model of autism
Rutz, H. L. H., & Rothblat, L. A. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.05.048 · Cited by 32 · see citing works
Low home cage social behaviors in BTBR T+tf/J mice during juvenile development
Babineau, B. A., Yang, M., Berman, R. F., & Crawley, J. N. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.03.006 · Cited by 30 · see citing works
Self-citationShin, B., Cepeda, C., Estrada‐Sánchez, A. M., Levine, M. S., Hodaei, L., Dai, Y., Jung, J. W., Ganguly, A., Clark, P. M., & Devaskar, S. U. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.0503-18.2018 · Cited by 29 · see citing works
Novel inter-hemispheric white matter connectivity in the BTBR mouse model of autism
Miller, V. M., Gupta, D., Neu, N., Cotroneo, A., Boulay, C. B., & Seegal, R. F. (2013) · Brain Research · doi:10.1016/j.brainres.2013.04.001 · Cited by 28 · see citing works
Yang, M., Lewis, F., Foley, G., & Crawley, J. N. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.04.023 · Cited by 28 · see citing works
Self-citationGarcia‐Lazaro, J. A., Shepard, K. N., Miranda, J. A., Liu, R. C., & Lesica, N. A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0133251 · Cited by 28 · see citing works
Modeling Social Communication Deficits in Mouse Models of Autism
Michetti, C. (2012) · Autism - Open Access · doi:10.4172/2165-7890.s1-007 · Cited by 29 · see citing works
Social Reward and Empathy as Proximal Contributions to Altruism: The Camaraderie Effect
Lahvis, G. P. (2016) · Current topics in behavioral neurosciences · doi:10.1007/7854_2016_449 · Cited by 26 · see citing works
Animal Models of Autism Spectrum Disorders and Behavioral Techniques of their Examination
Hrabovska, S. V., & Salyha, Y. T. (2016) · Neurophysiology · doi:10.1007/s11062-017-9613-2 · Cited by 22 · see citing works
Grimsley, J. M. S., Gadziola, M. A., & Wenstrup, J. J. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2012.00089 · Cited by 23 · see citing works
Endo, N., Makinodan, M., Somayama, N., Komori, T., Kishimoto, T., & Nishi, M. (2019) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.18-0177 · Cited by 22 · see citing works
Rodent ultrasonic communication and its relevance for models of neuropsychiatric disorders
Wöhr, M., & Schwarting, R. K. W. (2010) · e-Neuroforum · doi:10.1007/s13295-010-0012-z · Cited by 21 · see citing works
Self-citationUltrasonic vocalizations during male–female interaction in the mouse model of Down syndrome Ts65Dn
Zampieri, B. L., Fernandez, F., Pearson-Smith, J. N., Stasko, M. R., & Costa, A. C. S. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.02.020 · Cited by 21 · see citing works
Amygdalar neurotransmission alterations in the BTBR mice model of idiopathic autism
Bové, M., Palmieri, M. A., Santoro, M., Agosti, L. P., Gaetani, S., Romano, A., Dimonte, S., Costantino, G., Sikora, V., Tucci, P., et al. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02905-z · Cited by 20 · see citing works
- Authors
- Wöhr, M., Roullet, F. I., & Crawley, J. N.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Wöhr, M.
- Venue
- Genes, Brain and Behavior
- Publisher
- Wiley
- Published
- 2010-03-22
- Volume
- 10
- Issue
- 1
- Pages
- 35-43
- ISSN
- 1601-183X (ISSN-L)
- 1601-1848
- PMC
- PMC2903641
- OpenAlex
- W2003863298
- Cited by
- 169
- References
- 69
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 8 · 2023: 6 · 2022: 11 · 2021: 7 · 2020: 11 · 2019: 4 · 2018: 9 · 2017: 6 · 2016: 11 · 2015: 20 · 2014: 16 · 2013: 13 · 2012: 22
- FWCI
- 10.47
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Genes Brain & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute for Health and Care Research
- National Institutes of Health
- National Institute of Mental Health (ZIAMH002179)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- BTBR T+tf/J mice, autism spectrum disorder, mouse models of autism, scent marking, ultrasonic vocalizations, social communication deficits, social interaction, C57BL/6J mice, social cues
- MeSH terms
- Animals, Animal Communication, Autistic Disorder, Behavior, Animal, Female, Male, Mice, Inbred C57BL, Mice, Neurologic Mutants, Motor Activity, Odorants, Ultrasonics, Urine, Vocalization, Animal, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review