Cited by 169Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental DisordersNeuroendocrine regulation and behavior

Reduced scent marking and ultrasonic vocalizations in the BTBR T+tf/J mouse model of autism

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Wöhr, M., Roullet, F. I., Crawley, J. N.·2011·Genes, Brain and Behavior

Abstract

Qualitative impairments in communication, such as delayed language and poor interactive communication skills, are fundamental to the diagnosis of autism. Investigations into social communication in adult BTBR T+tf/J (BTBR) mice are needed to determine whether this inbred strain incorporates phenotypes relevant to the second diagnostic symptom of autism, communication deficits, along with its strong behavioral phenotypes relevant to the first and third diagnostic symptoms, impairments in social interactions and high levels of repetitive behavior. The aim of the present study was to simultaneously measure female urine-elicited scent marking and ultrasonic vocalizations in adult male BTBR mice, in comparison with a standard control strain with high sociability, C57BL/6J (B6), for the assessment of a potential communication deficit in BTBR. Adult male BTBR mice displayed lower scent marking and minimal ultrasonic vocalization responses to female urine obtained from both B6 and BTBR females. Lower scent marking and ultrasonic vocalizations in a social setting by BTBR, as compared with B6, are consistent with the well-replicated social deficits in this inbred mouse strain. Our findings support the interpretation that BTBR incorporate communication deficits, and suggest that scent marking and ultrasonic vocalizations offer promising measures of interest in social cues that may be widely applicable to investigations of mouse models of autism.

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  1. Roberts Wolf JO Sherman PW Scent Marking. 255-266 Rodent societies. An Ecological and Evolutionary Perspective 2007 The University of Chicago Press Chicago

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Authors
Wöhr, M., Roullet, F. I., & Crawley, J. N.
Affiliations
National Institutes of Health (US)
Corresponding author
Wöhr, M.
Venue
Genes, Brain and Behavior
Publisher
Wiley
Published
2010-03-22
Volume
10
Issue
1
Pages
35-43
ISSN
  • 1601-183X (ISSN-L)
  • 1601-1848
OpenAlex
W2003863298
Cited by
169
References
69
Citations by year
2026: 1 · 2025: 5 · 2024: 8 · 2023: 6 · 2022: 11 · 2021: 7 · 2020: 11 · 2019: 4 · 2018: 9 · 2017: 6 · 2016: 11 · 2015: 20 · 2014: 16 · 2013: 13 · 2012: 22
FWCI
10.47
Type
journal article
Language
en
Open access
Locations
  • Genes Brain & Behavior (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute for Health and Care Research
  • National Institutes of Health
  • National Institute of Mental Health (ZIAMH002179)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords
BTBR T+tf/J mice, autism spectrum disorder, mouse models of autism, scent marking, ultrasonic vocalizations, social communication deficits, social interaction, C57BL/6J mice, social cues
MeSH terms
Animals, Animal Communication, Autistic Disorder, Behavior, Animal, Female, Male, Mice, Inbred C57BL, Mice, Neurologic Mutants, Motor Activity, Odorants, Ultrasonics, Urine, Vocalization, Animal, Mice

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