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Traces of Experience in the Lateral Entorhinal Cortex
Open accessAbstract
A growing body of evidence suggests that memories are stored in the hippocampus by integrating spatial information from specialized cell types in the medial entorhinal cortex (MEC) with nonspatial information from cells in the lateral entorhinal cortex (LEC). LEC neurons show little spatial modulation when rats run in empty open-field environments but fire in the vicinity of discrete objects, suggesting that they provide information about the specific content of the spatial environment. It is unclear, however, whether firing at objects is elicited purely by stimulus properties, in a sensory-like manner, or whether any higher-order property, such as the history of experience, is also relevant. To address this question, we recorded from LEC neurons in an open field where objects were present on a subset of the trials. Whereas some neurons fired at the objects, other cells developed specific firing at places where objects had been located on previous trials, providing a readout of past experience in the environment. The latter cells generally did not respond to the object when it was present, suggesting that object cells and object-trace cells are independent cell classes. These findings identify LEC as a component of the hippocampal-cortical circuit for object-place memory.
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“Behavioral, imaging and electrophysiological recording data suggest that LEC preferentially processes object-associated information, e.g., the past and current locations of objects (Beer et al., 2013; Deshmukh and Knierim, 2011; Tsao et al., 2013; Van Cauter et al., 2013), and the context of the objects (Wilson et al., 2013b; Wilson et al., 2013c).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Tsao et al., 2013
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Metadata
- Authors
- Tsao, A., Moser, M.-B., & Moser, E. I.
- Affiliations
- Norwegian University of Science and Technology (NO)
- Corresponding author
- Tsao, Albert
- Moser, Edvard I.
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2013-03
- Volume
- 23
- Issue
- 5
- Pages
- 399-405
- ISSN
- 0960-9822 (ISSN-L)
- OpenAlex
- W2166846124
- Cited by
- 290
- References
- 46
- Citations by year
- 2026: 13 · 2025: 18 · 2024: 35 · 2023: 24 · 2022: 23 · 2021: 25 · 2020: 23 · 2019: 22 · 2018: 24 · 2017: 29 · 2016: 11 · 2015: 17 · 2014: 15 · 2013: 10
- FWCI
- 9.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Current Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Spatial Cognition and Navigation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- lateral entorhinal cortex, spatial memory, memory traces, hippocampus
- MeSH terms
- Animals, Male, Memory, Entorhinal Cortex, Rats, Long-Evans, Rats
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