Ventral CA1 neurons store social memory
Open accessAbstract
The medial temporal lobe, including the hippocampus, has been implicated in social memory. However, it remains unknown which parts of these brain regions and their circuits hold social memory. Here, we show that ventral hippocampal CA1 (vCA1) neurons of a mouse and their projections to nucleus accumbens (NAc) shell play a necessary and sufficient role in social memory. Both the proportion of activated vCA1 cells and the strength and stability of the responding cells are greater in response to a familiar mouse than to a previously unencountered mouse. Optogenetic reactivation of vCA1 neurons that respond to the familiar mouse enabled memory retrieval and the association of these neurons with unconditioned stimuli. Thus, vCA1 neurons and their NAc shell projections are a component of the storage site of social memory.
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Inhibition of ventral CA1 and its projections to the nucleus accumbens and medial prefrontal cortex impair social memory.
“Although dorsal CA1 activity does not appear to be critical for social memory, inhibition of ventral CA1 [81] and its projections to both the NAc and mPFC impair social memory [81,83].”
From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [81]
Activating the social engram while administering a foot shock incepted a false memory that made the mice fearful of that conspecific.
“by activating this engram while administering a foot shock, they incepted a false memory that made the mice fearful of that conspecific.”
From Translational opportunities for circuit-based social neuroscience: advancing 21st century psychiatry (2021) · cites this paper as [5]
In rodents, false social memories can be "incepted."
“false social memories can be “incepted” [5]”
From Translational opportunities for circuit-based social neuroscience: advancing 21st century psychiatry (2021) · cites this paper as [5]
A social engram, or collection of cells encoding a memory trace for an individual conspecific, exists in ventral CA1 of hippocampus.
“Okuyama et al. [5] identified a social engram, or collection of cells encoding a memory trace for an individual conspecific, in ventral CA1 of hippocampus”
From Translational opportunities for circuit-based social neuroscience: advancing 21st century psychiatry (2021) · cites this paper as [5]
The medial and basolateral amygdala both project to the hippocampus, which expresses oxytocin receptors and is necessary for social recognition and memory formation.
“The medial and basolateral amygdala both project to the hippocampus, which expresses oxytocin receptors and is necessary for social recognition and memory formation [5,11].”
From Translational opportunities for circuit-based social neuroscience: advancing 21st century psychiatry (2021) · cites this paper as [5]
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Self-citation
- Authors
- Okuyama, T., Kitamura, T., Roy, D. S., Itohara, S., & Tonegawa, S.
- Affiliations
- Massachusetts Institute of Technology (US)
- RIKEN–MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.
- RIKEN Center for Brain Science (JP)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Tonegawa, Susumu
- Venue
- Science
- Published
- 2016-09-30
- Volume
- 353
- Issue
- 6307
- Pages
- 1536-1541
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC5493325
- OpenAlex
- W2525578234
- Cited by
- 657
- References
- 36
- Citations by year
- 2026: 54 · 2025: 88 · 2024: 78 · 2023: 73 · 2022: 77 · 2021: 75 · 2020: 60 · 2019: 55 · 2018: 59 · 2017: 34 · 2016: 3
- FWCI
- 32.03
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc)
- Funders
- RIKEN Brain Science Institute
- Howard Hughes Medical Institute
- JPB Foundation
- Japan Society for the Promotion of Science
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- social memory, ventral hippocampus, CA1 neurons, nucleus accumbens shell, memory storage, memory retrieval, medial temporal lobe
- MeSH terms
- Animals, Cerebral Ventricles, Female, Male, Mice, Inbred C57BL, Mice, Transgenic, Nucleus Accumbens, Mental Recall, Social Behavior, Pyramidal Cells, Mice, CA1 Region, Hippocampal, Optogenetics
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