Student or educator? Sign up with your school email and get 6 months of Pro free.
Cited by 334

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Sequential Roles of Cdc42, Par-6, aPKC, and Lgl in the Establishment of Epithelial Polarity during Drosophila Embryogenesis

Open access
Hutterer, Andrea, Betschinger, Joerg, Petronczki, Mark, Knoblich, Juergen A·2004·Developmental Cell

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.devcel.2004.05.003

Cites

7 of 7 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 7 references

Research works printed but not linked: 54

  1. Bachmann, 2001, Drosophila Stardust is a partner of Crumbs in the control of epithelial cell polarity, Nature, 414, 638, 10.1038/414638a · DOI · Paper page
  2. Betschinger, 2003, The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl, Nature, 422, 326, 10.1038/nature01486 · DOI · Paper page
  3. Bhat, 1999, Discs Lost, a novel multi-PDZ domain protein, establishes and maintains epithelial polarity, Cell, 96, 833, 10.1016/S0092-8674(00)80593-0 · DOI · Paper page
  4. Bilder, 2000, Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors, Science, 289, 113, 10.1126/science.289.5476.113 · DOI · Paper page
  5. Brand, 1993, Targeted gene expression as a means of altering cell fates and generating dominant phenotypes, Development, 118, 401, 10.1242/dev.118.2.401 · DOI · Paper page
  6. Burbelo, 1995, A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases, J. Biol. Chem., 270, 29071, 10.1074/jbc.270.49.29071 · DOI · Paper page
  7. Butty, 2002, A positive feedback loop stabilizes the guanine-nucleotide exchange factor Cdc24 at sites of polarization, EMBO J., 21, 1565, 10.1093/emboj/21.7.1565 · DOI · Paper page
  8. Chant, 1999, Cell polarity in yeast, Annu. Rev. Cell Dev. Biol., 15, 365, 10.1146/annurev.cellbio.15.1.365 · DOI · Paper page
  9. Chou, 1992, Use of a yeast site-specific recombinase to produce female germline chimeras in Drosophila, Genetics, 131, 643, 10.1093/genetics/131.3.643 · DOI · Paper page
  10. Crawford, 1998, Cellularization in Drosophila melanogaster is disrupted by the inhibition of rho activity and the activation of Cdc42 function, Dev. Biol., 204, 151, 10.1006/dbio.1998.9061 · DOI
  11. Cuenca, 2003, Polarization of the C. elegans zygote proceeds via distinct establishment and maintenance phases, Development, 130, 1255, 10.1242/dev.00284 · DOI · Paper page
  12. Etemad-Moghadam, 1995, Asymmetrically distributed PAR-3 protein contributes to cell polarity and spindle alignment in early C. elegans embryos, Cell, 83, 743, 10.1016/0092-8674(95)90187-6 · DOI · Paper page
  13. Gao, 2002, Assembly of epithelial tight junctions is negatively regulated by Par6, Curr. Biol., 12, 221, 10.1016/S0960-9822(01)00663-7 · DOI · Paper page
  14. Garrard, 2003, Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6, EMBO J., 22, 1125, 10.1093/emboj/cdg110 · DOI · Paper page
  15. Genova, 2000, Functional analysis of Cdc42 in actin filament assembly, epithelial morphogenesis, and cell signaling during Drosophila development, Dev. Biol., 221, 181, 10.1006/dbio.2000.9671 · DOI
  16. Gotta, 2001, Distinct roles for Galpha and Gbetagamma in regulating spindle position and orientation in Caenorhabditis elegans embryos, Nat. Cell Biol., 3, 297, 10.1038/35060092 · DOI · Paper page
  17. Gotta, 2001, CDC-42 controls early cell polarity and spindle orientation in C. elegans, Curr. Biol., 11, 482, 10.1016/S0960-9822(01)00142-7 · DOI · Paper page
  18. Henrique, 2003, Cell polarity, Curr. Opin. Genet. Dev., 13, 341, 10.1016/S0959-437X(03)00077-7 · DOI
  19. Hong, 2001, Drosophila Stardust interacts with Crumbs to control polarity of epithelia but not neuroblasts, Nature, 414, 634, 10.1038/414634a · DOI · Paper page
  20. Hung, 1999, PAR-6 is a conserved PDZ domain-containing protein that colocalizes with PAR-3 in Caenorhabditis elegans embryos, Development, 126, 127, 10.1242/dev.126.1.127 · DOI · Paper page
  21. Hurd, 2003, Direct interaction of two polarity complexes implicated in epithelial tight junction assembly, Nat. Cell Biol., 5, 137, 10.1038/ncb923 · DOI · Paper page
  22. Johansson, 2000, The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1, J. Cell Sci., 113, 3267, 10.1242/jcs.113.18.3267 · DOI · Paper page
  23. Kalmes, 1996, A serine-kinase associated with the p127-l(2)gl tumour suppressor of Drosophila may regulate the binding of p127 to nonmuscle myosin II heavy chain and the attachment of p127 to the plasma membrane, J. Cell Sci., 109, 1359, 10.1242/jcs.109.6.1359 · DOI
  24. Kay, 2001, CDC-42 regulates PAR protein localization and function to control cellular and embryonic polarity in C. elegans, Curr. Biol., 11, 474, 10.1016/S0960-9822(01)00141-5 · DOI
  25. Knust, 2002, Composition and formation of intercellular junctions in epithelial cells, Science, 298, 1955, 10.1126/science.1072161 · DOI · Paper page
  26. Kraut, 1996, Role of inscuteable in orienting asymmetric cell divisions in Drosophila, Nature, 383, 50, 10.1038/383050a0 · DOI · Paper page
  27. Kuchinke, 1998, Control of spindle orientation in Drosophila by the Par-3-related PDZ domain protein Bazooka, Curr. Biol., 8, 1357, 10.1016/S0960-9822(98)00016-5 · DOI · Paper page
  28. Lecuit, 2000, Polarized insertion of new membrane from a cytoplasmic reservoir during cleavage of the Drosophila embryo, J. Cell Biol., 150, 849, 10.1083/jcb.150.4.849 · DOI · Paper page
  29. Li, 2003, Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42, Cell, 114, 215, 10.1016/S0092-8674(03)00559-2 · DOI · Paper page
  30. Luo, 1994, Distinct morphogenetic functions of similar small GTPases, Genes Dev., 8, 1787, 10.1101/gad.8.15.1787 · DOI · Paper page
  31. Muller, 2000, Genetic control of epithelial cell polarity, Dev. Dyn., 218, 52, 10.1002/(SICI)1097-0177(200005)218:1<52::AID-DVDY5>3.0.CO;2-L · doi:10.1002/(sici)1097-0177(200005)218:1<52::aid-dvdy5>3.0.co;2-l
  32. Musch, 2002, Mammalian homolog of Drosophila tumor suppressor lethal (2) giant larvae interacts with basolateral exocytic machinery in Madin-Darby canine kidney cells, Mol. Biol. Cell, 13, 158, 10.1091/mbc.01-10-0496 · DOI · Paper page
  33. Nam, 2003, Interaction of Par-6 and Crumbs complexes is essential for photoreceptor morphogenesis in Drosophila, Development, 130, 4363, 10.1242/dev.00648 · DOI
  34. Ohno, 2001, Intercellular junctions and cellular polarity, Curr. Opin. Cell Biol., 13, 641, 10.1016/S0955-0674(00)00264-7 · DOI · Paper page
  35. Ohshiro, 2000, Role of cortical tumour-suppressor proteins in asymmetric division of Drosophila neuroblast, Nature, 408, 593, 10.1038/35046087 · DOI · Paper page
  36. Pagliarini, 2003, A genetic screen in Drosophila for metastatic behavior, Science, 302, 1227, 10.1126/science.1088474 · DOI · Paper page
  37. Peng, 2000, The tumour-suppressor genes lgl and dlg regulate basal protein targeting in Drosophila neuroblasts, Nature, 408, 596, 10.1038/35046094 · DOI · Paper page
  38. Petronczki, 2001, DmPAR-6 directs epithelial polarity and asymmetric cell division of neuroblasts in Drosophila, Nat. Cell Biol., 3, 43, 10.1038/35050550 · DOI · Paper page
  39. Pielage, 2003, The Drosophila cell survival gene discs lost encodes a cytoplasmic codanin-1-like protein, not a homolog of tight junction PDZ protein Patj, Dev. Cell, 5, 841, 10.1016/S1534-5807(03)00358-7 · DOI
  40. Plant, 2003, A polarity complex of mPar-6 and atypical PKC binds, phosphorylates and regulates mammalian Lgl, Nat. Cell Biol., 5, 301, 10.1038/ncb948 · DOI · Paper page
  41. Qiu, 2000, A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCzeta signaling and cell transformation, Curr. Biol., 10, 697, 10.1016/S0960-9822(00)00535-2 · DOI · Paper page
  42. Rolls, 2003, Drosophila aPKC regulates cell polarity and cell proliferation in neuroblasts and epithelia, J. Cell Biol., 163, 1089, 10.1083/jcb.200306079 · DOI · Paper page
  43. Schaefer, 2000, A protein complex containing Inscuteable and the Galpha-binding protein Pins orients asymmetric cell divisions in Drosophila, Curr. Biol., 10, 353, 10.1016/S0960-9822(00)00401-2 · DOI · Paper page
  44. Schaefer, 2001, Heterotrimeric G proteins direct two modes of asymmetric cell division in the Drosophila nervous system, Cell, 107, 183, 10.1016/S0092-8674(01)00521-9 · DOI · Paper page
  45. Schober, 1999, Bazooka recruits Inscuteable to orient asymmetric cell divisions in Drosophila neuroblasts, Nature, 402, 548, 10.1038/990135 · DOI · Paper page
  46. Strand, 1994, The Drosophila lethal(2)giant larvae tumor suppressor protein is a component of the cytoskeleton, J. Cell Biol., 127, 1345, 10.1083/jcb.127.5.1345 · DOI
  47. Tanentzapf, 2003, Interactions between the crumbs, lethal giant larvae and bazooka pathways in epithelial polarization, Nat. Cell Biol., 5, 46, 10.1038/ncb896 · DOI · Paper page
  48. Tepass, 1990, crumbs encodes an EGF-like protein expressed on apical membranes of Drosophila epithelial cells and required for organization of epithelia, Cell, 61, 787, 10.1016/0092-8674(90)90189-L · DOI · Paper page
  49. Tepass, 2001, Epithelial cell polarity and cell junctions in Drosophila, Annu. Rev. Genet., 35, 747, 10.1146/annurev.genet.35.102401.091415 · DOI · Paper page
  50. Wieschaus, 1984, Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster. III. Zygotic loci on the X chromosome and fourth chromosome, Rouxs Arch. Dev. Biol., 193, 296, 10.1007/BF00848158 · DOI · Paper page
  51. Wodarz, 1999, Bazooka provides an apical cue for Inscuteable localization in Drosophila neuroblasts, Nature, 402, 544, 10.1038/990128 · DOI · Paper page
  52. Wodarz, 2000, Drosophila atypical protein kinase C associates with Bazooka and controls polarity of epithelia and neuroblasts, J. Cell Biol., 150, 1361, 10.1083/jcb.150.6.1361 · DOI · Paper page
  53. Yamanaka, 2003, Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity, Curr. Biol., 13, 734, 10.1016/S0960-9822(03)00244-6 · DOI · Paper page
  54. Yu, 2000, Analysis of partner of inscuteable, a novel player of Drosophila asymmetric divisions, reveals two distinct steps in inscuteable apical localization, Cell, 100, 399, 10.1016/S0092-8674(00)80676-5 · DOI · Paper page

Cited by

See all 334

Metadata

Authors
Hutterer, A., Betschinger, J., Petronczki, M., & Knoblich, J. A.
Venue
Developmental Cell
Publisher
Elsevier BV
Published
2004-06
Volume
6
Issue
6
Pages
845-854
ISSN
1534-5807 (ISSN-L)
OpenAlex
W2059400753
Cited by
334
References
7
FWCI
6.56
Type
journal article
Language
en
Open access
bronze
Funders
Boehringer Ingelheim

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Sequential Roles of Cdc42, Par-6, aPKC, and Lgl in the Establishment of Epithelial Polarity during Drosophila Embryogenesis. https://app.cochat.ai/papers/10.1016/j.devcel.2004.05.003
The paper
Hutterer, A., Betschinger, J., Petronczki, M., & Knoblich, J. A. (2004). Sequential Roles of Cdc42, Par-6, aPKC, and Lgl in the Establishment of Epithelial Polarity during Drosophila Embryogenesis. Developmental Cell. https://doi.org/10.1016/j.devcel.2004.05.003

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.