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Cited by 14Antifungal resistance and susceptibilityFungal Plant Pathogen ControlFungal Infections and Studies

Post-antifungal effects and time-kill studies of anidulafungin, caspofungin, and micafungin against Candida glabrata and Candida parapsilosis

Smith, Raymond P., Baltch, Aldona, Bopp, Lawrence H., Ritz, William J., Michelsen, Phyllis P.·2011·Diagnostic Microbiology and Infectious Disease
DOI 10.1016/j.diagmicrobio.2011.06.018
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Abstract

Candida glabrata (Cgl) and Candida parapsilosis (Cpa) can cause serious infections and can be resistant to some antifungal drugs. In treating infections caused by these organisms, killing rates and post-antifungal effects (PAFE) are important factors in both dose interval choice and outcome. Two strains each of Cgl and Cpa were studied. For PAFE studies, each organism was exposed to micafungin (MCF), anidulafungin (ANF), or caspofungin (CAS) for 1 h at concentrations ranging from 0.25 to 16×MIC. Cell suspensions were then washed 3 times and resuspended in fresh broth. Time 0 was immediately after resuspension of the yeast. Time-kill experiments were done using similar drug concentrations. Samples were removed at each time point (0-120 h) and viable counts determined. PAFE of ANF and CAS were generally very long, were markedly longer than those of MCF, and increased with increased drug concentration. For ANF and CAS, PAFE for Cgl were greater than those for Cpa only at 0.5 to 2 × MIC. Time-kill experiments showed that ANF, CAS, and MCF were fungicidal at 8 to 16 × MIC up to 120 h. CAS had the greatest activity against Cgl, while ANF and MCF were more active than CAS against Cpa. Because of the prolonged PAFE of these echinocandins, especially ANF and CAS, less frequent dosing during therapy of Cpa and Cgl infections could be considered. Further studies are needed to determine the clinical efficacy of longer dosing intervals.

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  • Time-kill experiments in vitro have shown that most C. glabrata cells die quickly when exposed to high doses of echinocandins, while a small and variable subpopulation dies more slowly, suggesting possible development of long-lived persister cells.

    “Time-kill experiments in vitro have shown that most C. glabrata cells die quickly when exposed to high doses of echinocandins, while a small and variable subpopulation dies more slowly (29, 30), suggesting the possible development of long-lived persister cells.”

    From Echinocandin tolerance and persistence <i>in vitro</i> are regulated by calcineurin signaling in <i>Candida glabrata</i> (2026) · cites this paper as [29]

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Authors
Smith, R. P., Baltch, A., Bopp, L. H., Ritz, W. J., & Michelsen, P. P.
Affiliations
  • Albany Stratton VA Medical Center Albany (US)
  • SUNY Cobleskill (US)
Corresponding author
Baltch, Aldona
Venue
Diagnostic Microbiology and Infectious Disease
Publisher
Elsevier BV
Published
2011-10
Volume
71
Issue
2
Pages
131-138
ISSN
0732-8893 (ISSN-L)
DOI
10.1016/j.diagmicrobio.2011.06.018
OpenAlex
W1986079333
Cited by
14
References
24
Citations by year
2025: 1 · 2022: 2 · 2020: 1 · 2019: 1 · 2018: 1 · 2016: 2 · 2015: 2 · 2013: 2 · 2012: 1
FWCI
0.86
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Diagnostic Microbiology and Infectious Disease (publishedVersion)
  • PubMed (publishedVersion)
Funders
Shandong Academy of Sciences
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
  • Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
Keywords
post-antifungal effect, time-kill kinetics, anidulafungin, caspofungin, micafungin, echinocandins, Candida glabrata, Candida parapsilosis, antifungal resistance, fungicidal activity, dosing interval, antifungal susceptibility
MeSH terms
Caspofungin, Micafungin, Anidulafungin, Antifungal Agents, Candida, Microbial Sensitivity Tests, Echinocandins, Lipopeptides

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