A tale of two tails: activation of DNA damage checkpoint kinase Mec1/ATR by the 9-1-1 clamp and by Dpb11/TopBP1

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The Rad9–Hus1–Rad1 (9–1–1) clamp activates checkpoint signaling via TopBP1Preprint

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The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeastPreprint

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The structural determinants of checkpoint activation

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BRCT Domain-containing Protein TopBP1 Functions in DNA Replication and Damage Response

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A DNA Damage-Regulated BRCT-Containing Protein, TopBP1, Is Required for Cell Survival

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The novel DNA damage checkpoint protein Ddc1p is phosphorylated periodically during the cell cycle and in response to DNA damage in budding yeast

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The checkpoint clamp, Rad9-Rad1-Hus1 complex, preferentially stimulates the activity of apurinic/apyrimidinic endonuclease 1 and DNA polymerase   in long patch base excision repair

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Signaling Pathways that Regulate Cell DivisionPreprint

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Telomeres and Mitochondrial Metabolism: Implications for Cellular Senescence and Age-related Diseases

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A Role for the MRN Complex in ATR Activation via TOPBP1 Recruitment

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The most important thing is the tail: Multitudinous functionalities of intrinsically disordered protein termini

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Highly mutagenic and severely imbalanced dNTP pools can escape detection by the S-phase checkpoint

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ATAD5 regulates the lifespan of DNA replication factories by modulating PCNA level on the chromatin

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The Unstructured C-Terminal Tail of the 9-1-1 Clamp Subunit Ddc1 Activates Mec1/ATR via Two Distinct Mechanisms

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Ixr1 Is Required for the Expression of the Ribonucleotide Reductase Rnr1 and Maintenance of dNTP Pools

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Interactions of Human Mismatch Repair Proteins MutSα and MutLα with Proteins of the ATR-Chk1 Pathway

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DNA damage response and repair in colorectal cancer: Defects, regulation and therapeutic implications

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Pot1 and telomere maintenance

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Dynamics of Rad9 Chromatin Binding and Checkpoint Function Are Mediated by Its Dimerization and Are Cell Cycle–Regulated by CDK1 Activity

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Rad17 Plays a Central Role in Establishment of the Interaction between TopBP1 and the Rad9-Hus1-Rad1 Complex at Stalled Replication Forks

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Structural Basis of Mec1-Ddc2-RPA Assembly and Activation on Single-Stranded DNA at Sites of Damage

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Neurogenesis requires TopBP1 to prevent catastrophic replicative DNA damage in early progenitors

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Loading of Meiotic Cohesin by SCC-2 Is Required for Early Processing of DSBs and for the DNA Damage Checkpoint

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Conditional Inactivation of the DNA Damage Response Gene Hus1 in Mouse Testis Reveals Separable Roles for Components of the RAD9-RAD1-HUS1 Complex in Meiotic Chromosome Maintenance

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Protein intrinsic disorder and induced pluripotent stem cells.

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Saccharomyces cerevisiae as a model system to study the response to anticancer agents

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Elevated Levels of the Polo Kinase Cdc5 Override the Mec1/ATR Checkpoint in Budding Yeast by Acting at Different Steps of the Signaling Pathway

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Stalled replication forks: Making ends meet for recognition and stabilization

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Nuclear DNA Replication in Trypanosomatids: There Are No Easy Methods for Solving Difficult Problems

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Mind the gap: keeping UV lesions in check

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Human CTF18-RFC clamp-loader complexed with non-synthesising DNA polymerase ε efficiently loads the PCNA sliding clamp

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The Dimeric Architecture of Checkpoint Kinases Mec1ATR and Tel1ATM Reveal a Common Structural Organization

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Assembly of Slx4 signaling complexes behind DNA replication forks

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Roles of mutagenic translesion synthesis in mammalian genome stability, health and disease

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The Unstructured C-terminal Tail of Yeast Dpb11 (Human TopBP1) Protein Is Dispensable for DNA Replication and the S Phase Checkpoint but Required for the G2/M Checkpoint

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Dpb11/TopBP1 plays distinct roles in DNA replication, checkpoint response and homologous recombination

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Genome-Wide Screen Reveals Replication Pathway for Quasi-Palindrome Fragility Dependent on Homologous Recombination

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The DNA damage checkpoint pathway promotes extensive resection and nucleotide synthesis to facilitate homologous recombination repair and genome stability in fission yeast

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9-1-1: PCNA's specialized cousin

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Srs2 enables checkpoint recovery by promoting disassembly of DNA damage foci from chromatin

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Surprising complexity of the Asf1 histone chaperone-Rad53 kinase interaction

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S. cerevisiaeMre11 recruits conjugated SUMO moieties to facilitate the assembly and function of the Mre11-Rad50-Xrs2 complex

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Targeting the DNA damage response in cancer

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Site-Specific Phosphorylation of the DNA Damage Response Mediator Rad9 by Cyclin-Dependent Kinases Regulates Activation of Checkpoint Kinase 1

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DDR Inc., one business, two associates

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DNA Double Strand Break and Response Fluorescent Assays: Choices and Interpretation

Atkinson, J., Bezak, E., Le, H. V., & Kempson, I. M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25042227 · Cited by 24 · see citing works

Disease severity in a mouse model of ataxia telangiectasia is modulated by the DNA damage checkpoint gene Hus1

Balmus, G., Zhu, M., Mukherjee, S., Lyndaker, A. M., Hume, K. R., Lee, J., Riccio, M. L., Reeves, A. P., Sutter, N. B., Noden, D. M., et al. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds173 · Cited by 22 · see citing works

Slx4 scaffolding in homologous recombination and checkpoint control: lessons from yeast

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Three Distinct Modes of Mec1/ATR and Tel1/ATM Activation Illustrate Differential Checkpoint Targeting during Budding Yeast Early Meiosis

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DNA Damage Tolerance Mechanisms Revealed from the Analysis of Immunoglobulin V Gene Diversification in Avian DT40 Cells

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SUMO ‐targeted ubiquitin ligase RNF 4 plays a critical role in preventing chromosome loss

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Critical Function of γH2A in S-Phase

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PP2ACdc55is required for multiple events during meiosis I

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Clamping down on mammalian meiosis

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Abasic sites linked to dUTP incorporation in DNA are a major cause of spontaneous mutations in absence of base excision repair and Rad17–Mec3–Ddc1 (9–1–1) DNA damage checkpoint clamp in Saccharomyces cerevisiae

Collura, A., van der Kemp, P. A., & Boiteux, S. (2012) · DNA repair · doi:10.1016/j.dnarep.2011.12.004 · Cited by 14 · see citing works

A Survey of Essential Genome Stability Genes Reveals That Replication Stress Mitigation Is Critical for Peri-Implantation Embryogenesis

Kafer, G. R., & Cesare, A. J. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00416 · Cited by 12 · see citing works

Metabolic remodeling maintains a reducing environment for rapid activation of the yeast DNA replication checkpoint

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A Critical Role for Dna2 at Unwound Telomeres

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Mutations in the Non-Catalytic Subunit Dpb2 of DNA Polymerase Epsilon Affect the Nrm1 Branch of the DNA Replication Checkpoint

Dmowski, M., Rudzka, J., Campbell, J. L., Jonczyk, P., & Fijałkowska, I. J. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006572 · Cited by 11 · see citing works

OsRAD17 Is Required for Meiotic Double-Strand Break Repair and Plays a Redundant Role With OsZIP4 in Synaptonemal Complex Assembly

Hu, Q., Zhang, C., Xue, Z.-H., Ma, L., Liu, W., Shen, Y., Ma, B.-J., & Cheng, Z.-K. (2018) · Frontiers in Plant Science · doi:10.3389/fpls.2018.01236 · Cited by 9 · see citing works

Proteomic analysis of the S. cerevisiae response to the anticancer ruthenium complex KP1019

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ZmRAD17 Is Required for Accurate Double-Strand Break Repair During Maize Male Meiosis

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The Oxidative Stress Responsive Transcription Factor Pap1 Confers DNA Damage Resistance on Checkpoint-Deficient Fission Yeast Cells

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MRN- and 9-1-1-Independent Activation of the ATR-Chk1 Pathway during the Induction of the Virulence Program in the Phytopathogen Ustilago maydis

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A TRilogy of ATR’s Non-Canonical Roles Throughout the Cell Cycle and Its Relation to Cancer

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Mec1 Modulates Interhomolog Crossover and Interplays with Tel1 at Post Double-Strand Break Stages

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Novel Checkpoint Pathway Organization Promotes Genome Stability in Stationary-Phase Yeast Cells

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Deciphering the role of post-translational modifications in fanconi anemia proteins and their influence on tumorigenesis

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Interaction of Ddc1 and RPA with single-stranded/double-stranded DNA junctions in yeast whole cell extracts: Proteolytic degradation of the large subunit of replication protein A in ddc1Δ strains

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Cellular responses to compound stress induced by atmospheric-pressure plasma in fission yeast

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Extending the Interaction Repertoire of FHA and BRCT Domains

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Alternative Splicing of OsRAD1 Defines C-Terminal Domain Essential for Protein Function in Meiosis

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Recombinant expression and characterization of yeast Mrc1, a DNA replication checkpoint mediator

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Eukaryote DNA Replication and Recombination: an Intimate Association

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LIF Insensitivity and Expression of Proteins Activated by DNA Damage Response in Teratoma-Isolated Cells Derived from Mouse Embryonic Stem Cells

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Identification and characterization of novel factors that influence minisatellite stability in stationary phase yeast cells

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Assembly of Slx4 Checkpoint Signaling Complexes Behind Stressed DNA Replication Forks

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Mitotic Genome Variations in Yeast and Other Fungi

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ATR inhibitors: from targeting the DNA damage response to exploiting synthetic lethality-A paradigm shift in Cancer therapy.

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