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Cited by 28Smoking Behavior and CessationSubstance Abuse Treatment and OutcomesPrenatal Substance Exposure Effects

Toward a comprehensive developmental model of smoking initiation and nicotine dependence

Open access
García-Rodríguez, Olaya, Blanco, Carlos, Wall, Melanie M., Wang, Shuai, Jin, Chelsea J., Kendler, Kenneth S.·2014·Drug and Alcohol Dependence
DOI 10.1016/j.drugalcdep.2014.09.002PMC PMC4253146
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Abstract

Background This study aims to identify predictors of smoking initiation and nicotine dependence (ND) to develop a comprehensive risk-factor model based on Kendler's development model for major depression. Methods Data were drawn from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC), Wave 2 (n=34,653). Risk factors were divided into five developmental tiers according to Kendler's model (childhood, early adolescence, late adolescence, adulthood, past-year). Hierarchical logistic regression models were built to predict the risk of smoking initiation and the risk of ND, given initiation. The continuation ratio (CR) was tested by ordinal logistic regression to examine whether the impact of the predictors was the same on smoking initiation or ND. Results The final models highlighted the importance of different tiers for each outcome. The CR identified substantial differences in the predictors of smoking initiation versus ND. Childhood tier appears to be more determinant for smoking initiation while the effect of more distal tiers (i.e. childhood and early adolescence) was tempered by more proximal ones (i.e. late adolescence, adulthood and past-year) in ND, with few sex differences. Conclusions The differential effect of some predictors on each outcome shows the complexity of pathways from smoking initiation to ND. While some risk factors may be shared, others impact only at one stage or have even an inverse effect. An adaptation of Kendler's developmental model for major depression showed high predictive power for smoking initiation and ND.

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  • Substance use and SUDs are multidetermined, with different risk factors playing varying roles at different life stages, from the prenatal period and childhood to early and late adulthood.

    “Substance use and SUDs are multidetermined, with the differ ent risk factors playing varying roles at different life stages, from the prenatal period and childhood to early and late adulthood 78,79,164 .”

    From Substance use disorders: a comprehensive update of classification, epidemiology, neurobiology, clinical aspects, treatment and prevention (2023) · cites this paper as [164]

    The Introduction and Discussion (page numbers unavailable) describe multiple risk factors whose associations differ across developmental periods and between smoking initiation and nicotine dependence. The study addresses smoking and nicotine dependence, not substance use and SUDs generally, and its developmental tiers begin in childhood rather than the prenatal period. (LLM, conf=0.87)

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  1. SAMHSA 2012 National Survey on Drug Use and Health, 2010 and 2011 Substance Abuse and Mental Health Services Administration Rockville, MD 27748105

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Authors
García-Rodríguez, O., Blanco, C., Wall, M. M., Wang, S., Jin, C. J., & Kendler, K. S.
Affiliations
  • New York State Psychiatric Institute (US)
  • Virginia Commonwealth University (US)
ORCID
Venue
Drug and Alcohol Dependence
Publisher
Elsevier BV
Published
2014-11
Volume
144
Pages
160-169
ISSN
0376-8716 (ISSN-L)
DOI
10.1016/j.drugalcdep.2014.09.002
PMC
PMC4253146
OpenAlex
W2025653876
Cited by
28
References
88
Citations by year
2025: 2 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 5 · 2020: 1 · 2019: 4 · 2018: 6 · 2017: 1 · 2016: 2 · 2015: 2
FWCI
1.11
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Drug and Alcohol Dependence (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Consultation of the Doctoral Thesis Database (TESEO) (Ministerio de Educación, Cultura y Deporte) (submittedVersion, cc-by-nc-nd)
Funders
  • National Institute on Drug Abuse (DA019606, DA023200, R01DA019606, K02DA023200)
  • National Cancer Institute (CA133050, R01CA133050)
Topics
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
Keywords
smoking initiation, nicotine dependence, developmental model, risk factors, adolescence, adulthood, sex differences, tobacco use
MeSH terms
Adolescent, Adult, Depressive Disorder, Major, Major Depressive Disorder, Female, Health Surveys, Humans, Male, Middle Aged, Risk Factors, Smoking, Tobacco Use Disorder, Logistic Models, Alcohol-Related Disorders, Young Adult

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