Genetic variation in sodium-dependent ascorbic acid transporters and risk of gastric cancer in Poland
Open accessAbstract
Higher ascorbic acid consumption is associated with a reduced risk of gastric cancer in numerous epidemiologic studies. We investigated whether single nucleotide polymorphisms (SNPs) in SLC23A1 and SLC23A2--genes that encode key ascorbic acid transport proteins--affect gastric cancer risk in 279 incident cases and 414 age- and gender-matched controls drawn from a population-based case-control study in Poland. Compared to subjects who were homozygous for the common G allele of the SLC23A2 SNP rs12479919, carriers of the AA genotype had a 41% lower risk of gastric cancer [odds ratio (OR)=0.59, 95% confidence interval (CI): 0.36-0.95; P trend=0.06]. A haplotype that contained the common allele of the rs6139591, rs2681116 and rs14147458 SNPs in SLC23A2 was also significantly inversely associated with gastric malignancy. No other polymorphisms in either gene were related to risk, and there was no effect modification by ascorbic acid intake. These findings suggest that genetic variation in SLC23A2 impacts gastric cancer risk, although confirmation in other studies is required.
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- Authors
- Wright, M. E., Andreotti, G., Lissowska, J., Yeager, M., Zatonski, W., Chanock, S. J., Chow, W.-H., & Hou, L.
- Affiliations
- University of Illinois Chicago (US)
- National Institutes of Health (US)
- The Maria Sklodowska-Curie National Research Institute of Oncology (PL)
- United States Department of Health and Human Services (US)
- National Cancer Institute (US)
- Northwestern University (US)
- Corresponding author
- Wright, Margaret E.
- ORCID
- Venue
- European Journal of Cancer
- Publisher
- Elsevier BV
- Published
- 2009-07
- Volume
- 45
- Issue
- 10
- Pages
- 1824-1830
- ISSN
- 0959-8049 (ISSN-L)
- PMC
- PMC2747493
- OpenAlex
- W2104987433
- Cited by
- 62
- References
- 33
- Citations by year
- 2025: 2 · 2023: 2 · 2022: 1 · 2021: 4 · 2020: 5 · 2019: 3 · 2018: 5 · 2017: 5 · 2016: 5 · 2015: 1 · 2014: 9 · 2013: 7 · 2012: 5
- FWCI
- 2.52
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- European Journal of Cancer (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (n01cp005626-000)
- National Cancer Institute (N01 CP005626)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Keywords
- gastric cancer, SLC23A1, SLC23A2, single nucleotide polymorphisms, genetic susceptibility, vitamin C intake, haplotype association, Poland
- MeSH terms
- Adult, Aged, Ascorbic Acid, Diet, Female, Genotype, Humans, Male, Middle Aged, Stomach Neoplasms, Genetic Variation, Case-Control Studies, Age Distribution, Sex Distribution, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Symporters, Organic Anion Transporters, Sodium-Dependent, Young Adult, Sodium-Coupled Vitamin C Transporters
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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