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The central corticotropin releasing factor system during development and adulthood
Open accessAbstract
Corticotropin releasing factor (CRH) has been shown to contribute critically to molecular and neuroendocrine responses to stress during both adulthood and development. This peptide and its receptors are expressed in the hypothalamus, as well as in limbic brain areas including amygdala and hippocampus. This is consistent with roles for CRH in mediating the influence of stress on emotional behavior and cognitive function. The expression of CRH and of its receptors in hypothalamus, amygdala and hippocampus is age-dependent, and is modulated by stress throughout life (including the first postnatal weeks). Uniquely during development, the cardinal influence of maternal care on the central stress response governs the levels of central CRH expression, and may alter the 'set-point' of CRH-gene sensitivity to stress in a lasting manner.
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“The CEA is rich in stress hormones and their receptors,98, 99, 100, 101 and contributes to processing of stress signals.102, 103, 104”
From Preferential loss of dorsal-hippocampus synapses underlies memory impairments provoked by short, multimodal stress (2014) · cites this paper as [100]
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Metadata
- Authors
- Korosi, A., & Baram, T. Z.
- Affiliations
- University of California, Irvine (US)
- Corresponding author
- Baram, Tallie Z.
- ORCID
- Baram, Tallie Z.
- Venue
- European Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 2008-04
- Volume
- 583
- Issue
- 2-3
- Pages
- 204-214
- ISSN
- 0014-2999 (ISSN-L)
- PMC
- PMC2329668
- OpenAlex
- W2031394080
- Cited by
- 102
- References
- 172
- Citations by year
- 2026: 5 · 2025: 1 · 2024: 2 · 2022: 4 · 2021: 3 · 2020: 9 · 2019: 3 · 2018: 6 · 2017: 5 · 2016: 6 · 2015: 5 · 2014: 6 · 2013: 8 · 2012: 7
- FWCI
- 0.80
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- European Journal of Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Funders
- National Institutes of Health
- National Institute of Mental Health (MH73136, R01MH073136)
- National Institute of Neurological Disorders and Stroke (NS 28912, R01NS028912, R01NS039307)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Keywords
- corticotropin-releasing factor, CRH receptors, hypothalamus, amygdala, hippocampus, stress response, neuroendocrine stress response, developmental programming, maternal care, age-related gene expression, emotional behavior, cognitive function
- MeSH terms
- Adult, Age Factors, Animals, Brain, Corticotropin-Releasing Hormone, Humans, Rodentia, Stress, Physiological, Gene Expression, Receptors, Corticotropin-Releasing Hormone
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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