Interaction of Stress, Corticotropin-Releasing Factor, Arginine Vasopressin and Behaviour

Beurel, Eléonore; Nemeroff, Charles B.

doi:10.1007/7854_2014_306

Cited by 64Stress Responses and CortisolNeuropeptides and Animal PhysiologyNeuroendocrine regulation and behavior

Interaction of Stress, Corticotropin-Releasing Factor, Arginine Vasopressin and Behaviour

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Beurel, Eléonore, Nemeroff, Charles B.·2014·Current Topics in Behavioral Neurosciences

DOI 10.1007/7854_2014_306PMC PMC4171342

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Abstract

Stress mediates the activation of a variety of systems ranging from inflammatory to behavioral responses. In this review we focus on two neuropeptide systems, corticotropin-releasing factor (CRF) and arginine vasopressin (AVP), and their roles in regulating stress responses. Both peptides have been demonstrated to be involved in anxiogenic and depressive effects, actions mediated in part through their regulation of the hypothalamic-pituitary-adrenal axis and the release of adrenocorticotropic hormone. Because of the depressive effects of CRF and AVP, drugs modifying the stress-associated detrimental actions of CRF and AVP are under development, particularly drugs antagonizing CRF and AVP receptors for therapy in depression.

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Findings in mood disorders reveal alterations at the levels of intracellular signaling, gene expression, neurotrophic factors, neurogenesis, neuroinflammation, excitatory and inhibitory neurotransmission, and synaptic number and function in several brain regions implicated in depression.
“These findings reveal alterations at the levels of intracellular signaling, gene expression, neurotrophic factors, neurogenesis, neuroinflammation, excitatory and inhibitory neurotransmission, and synaptic number and function, and have been described in several brain regions implicated in depression 13-22 .”
From Neuroplasticity in cognitive and psychological mechanisms of depression: an integrative model (2020) · cites this paper as [13]
In section I, the paper describes reduced hippocampal neurogenesis and BDNF after chronic stress and altered immune function in mood disorders. Section II.1 reports changes in CRF-related gene expression in depressed patients in the hypothalamus and prefrontal cortex. These passages support parts of the claim, but they do not establish the full list of alterations—including excitatory and inhibitory neurotransmission and synaptic number and function—across several depression-related brain regions. Page numbers were not available in our copy. (LLM, conf=0.84)
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Stress, adaptation, and disease. Allostasis and allostatic load
McEWEN, B. S. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09546.x · Cited by 5,092 · see citing works
Physiology and neurobiology of stress and adaptation: central role of the brain
McEwen, B. S. (2007) · Physiological Reviews · doi:10.1152/physrev.00041.2006 · Cited by 4,981 · cited 1× · see citing works
“In the short term, the organism tends to adapt to the stress to maintain homeostasis, for example by eliminating the challenge or by avoidance (McEwen, 1998, 2007).”
Background
The Neuroendocrinology of Stress: A Never Ending Story
Lightman, S. L. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01711.x · Cited by 3,570 · see citing works
Association of psychosocial risk factors with risk of acute myocardial infarction in 11 119 cases and 13 648 controls from 52 countries (the INTERHEART study): case-control study
Rosengren, A., Hawken, S., Ôunpuu, S., Sliwa, K., Zubaid, M., Almahmeed, W. A., Blackett, K. N., Sitthi-amorn, C., Sato, H., & Yusuf, S. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17019-0 · Cited by 2,414 · see citing works
Neurocircuitry of stress: central control of the hypothalamo–pituitary–adrenocortical axis
Herman, J. P., & Cullinan, W. E. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10069-2 · Cited by 2,270 · see citing works
Pituitary-adrenal and autonomic responses to stress in women after sexual and physical abuse in childhood
Heim, C. (2000) · JAMA · doi:10.1001/jama.284.5.592 · Cited by 1,968 · see citing works
Organization of ovine corticotropin-releasing factor immunoreactive cells and fibers in the rat brain: an immunohistochemical study
Swanson, L. W., Sawchenko, P. E., Rivier, J., & Vale, W. W. (2008) · Neuroendocrinology · doi:10.1159/000123454 · Cited by 1,953 · see citing works
The link between childhood trauma and depression: insights from HPA axis studies in humans
Heim, C., Newport, D. J., Mletzko, T., Miller, A. H., & Nemeroff, C. B. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.03.008 · Cited by 1,704 · see citing works
Self-citation
Oxytocin, vasopressin, and the neurogenetics of sociality
Donaldson, Z. R., & Young, L. J. (2008) · Science · doi:10.1126/science.1158668 · Cited by 1,645 · see citing works
The interplay between the intestinal microbiota and the brain
Collins, S. M., Surette, M., & Bercik, P. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2876 · Cited by 1,611 · cited 1× · see citing works
“The composition of the microbiota of the gut is also affected by the HPA axis through the release of stress hormones and the sympatho-adrenal medullary system (Collins et al., 2012; Dinan and Cryan, 2012).”
Background
The neuro-symphony of stress
Joëls, M., & Baram, T. Z. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2632 · Cited by 1,521 · see citing works
Elevated Concentrations of CSF Corticotropin-Releasing Factor-Like Immunoreactivity in Depressed Patients
Nemeroff, C. B., Widerlöv, E., Bissette, G., Walléus, H., Karlsson, I., Eklund, K., Kilts, C. D., Loosen, P. T., & Vale, W. (1984) · Science · doi:10.1126/science.6334362 · Cited by 1,485 · see citing works
Self-citation
Depression and hypothalamic-pituitary-adrenal activation: a quantitative summary of four decades of research
Stetler, C., & Miller, G. E. (2011) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31820ad12b · Cited by 1,123 · see citing works
Corticotropin releasing activity of the new CRF is potentiated several times by vasopressin
Gillies, G. E., Linton, E. A., & Lowry, P. J. (1982) · Nature · doi:10.1038/299355a0 · Cited by 965 · see citing works
Balance of brain oxytocin and vasopressin: implications for anxiety, depression, and social behaviors
Neumann, I. D., & Landgraf, R. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.08.004 · Cited by 954 · see citing works
A role for central vasopressin in pair bonding in monogamous prairie voles
Winslow, J. T., Hastings, N., Carter, C. S., Harbaugh, C. R., & Insel, T. R. (1993) · Nature · doi:10.1038/365545a0 · Cited by 948 · cited 2× · see citing works
“AVP also regulates affiliative behaviors (Winslow et al., 1993), in particular paternal behaviors in voles, such as crouching over and contacting or grooming pups (Wang et al., 1994).”
Background
Stressor specificity of central neuroendocrine responses: implications for stress-related disorders
Pacák, K., & Palkovits, M. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.4.0436 · Cited by 926 · see citing works
Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1
Timpl, P., Spanagel, R., Sillaber, I., Kresse, A., Reul, J. M. H. M., Stalla, G. K., Blanquet, V., Steckler, T., Holsboer, F., & Wurst, W. (1998) · Nature Genetics · doi:10.1038/520 · Cited by 919 · see citing works
Corticotropin Releasing Factor Receptor 1–Deficient Mice Display Decreased Anxiety, Impaired Stress Response, and Aberrant Neuroendocrine Development
Smith, G. W., Aubry, J.-M., Dellu, F., Contarino, A., Bilezikjian, L. M., Gold, L. H., Chen, R., Marchuk, Y., Hauser, C., Bentley, C. A., et al. (1998) · Neuron · doi:10.1016/s0896-6273(00)80491-2 · Cited by 892 · see citing works
Hypothalamic Control of Adrenocorticotropin Secretion: Advances since the Discovery of 41-Residue Corticotropin-Releasing Factor
Antoni, F. A. (1986) · Endocrine Reviews · doi:10.1210/edrv-7-4-351 · Cited by 888 · see citing works
Vasopressin and Oxytocin Excite Distinct Neuronal Populations in the Central Amygdala
Huber, D., Veinante, P., & Stoop, R. (2005) · Science · doi:10.1126/science.1105636 · Cited by 804 · see citing works
Corticotropin releasing factor produces behavioural activation in rats
Sutton, R., Koob, G., le Moal, M., Rivier, J., & Vale, W. (1982) · Nature · doi:10.1038/297331a0 · Cited by 744 · see citing works
Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated
Zobel, A. W., Nickel, T., Künzel, H. E., Ackl, N., Sonntag, A., Ising, M., & Holsboer, F. (2000) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(00)00016-9 · Cited by 705 · see citing works
Increased Numbers of Corticotropin-Releasing Hormone Expressing Neurons in the Hypothalamic Paraventricular Nucleus of Depressed Patients
Raadsheer, F. C., Hoogendijk, W. J. G., Stam, F. C., Tilders, F. J. H., & Swaab, D. F. (2008) · Neuroendocrinology · doi:10.1159/000126778 · Cited by 667 · see citing works
Cortisol and post-traumatic stress disorder in adults: Systematic review and meta-analysis
Meewisse, M.-L., Reitsma, J. B., De Vries, G.-J., Gersons, B. P. R., & Olff, M. (2007) · British Journal of Psychiatry · doi:10.1192/bjp.bp.106.024877 · Cited by 661 · see citing works
Maternal care and hippocampal plasticity: evidence for experience-dependent structural plasticity, altered synaptic functioning, and differential responsiveness to glucocorticoids and stress
Champagne, D. L., Bagot, R. C., van Hasselt, F., Ramakers, G., Meaney, M. J., de Kloet, E. R., Joels, M., & Krugers, H. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0526-08.2008 · Cited by 661 · see citing works
Vasopressinergic control of pituitary adrenocorticotropin secretion comes of age
Antoni, F. A. (1993) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1993.1004 · Cited by 636 · see citing works
INFECTION OF CHIMPANZEES BY HUMAN T-LYMPHOTROPIC RETROVIRUSES IN BRAIN AND OTHER TISSUES FROM AIDS PATIENTS
Gajdusek, D. C., Gibbs, C., Rodgers‐Johnson, P., Amyx, H. L., Asher, D. M., Epstein, L. G., Sarin, P. S., Gallo, R. C., Maluish, A. E., Arthur, L. O., et al. (1985) · The Lancet · doi:10.1016/s0140-6736(85)91011-6 · Cited by 599 · see citing works
Regulation of the stress response by the gut microbiota: implications for psychoneuroendocrinology
Dinan, T. G., & Cryan, J. F. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.03.007 · Cited by 577 · see citing works
Regulation of pituitary ACTH secretion during chronic stress
Aguilera, G. (1994) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1994.1013 · Cited by 557 · cited 1× · see citing works
“ACTH in turn promotes the synthesis and secretion of glucocorticoids from the adrenal cortex (Aguilera, 1994; Antoni, 1986a).”
Background
Reduced Corticotropin Releasing Factor Binding Sites in the Frontal Cortex of Suicide Victims
Nemeroff, C. B. (1988) · Archives of General Psychiatry · doi:10.1001/archpsyc.1988.01800300075009 · Cited by 555 · see citing works
Self-citation
Intraventricular corticotropin-releasing factor enhances behavioral effects of novelty
Britton, D. R., Koob, G. F., Rivier, J., & Vale, M. L. (1982) · Life Sciences · doi:10.1016/0024-3205(82)90416-7 · Cited by 534 · see citing works
Stressor categorization: acute physical and psychological stressors elicit distinctive recruitment patterns in the amygdala and in medullary noradrenergic cell groups
Dayas, C. V., Buller, K. M., Crane, J. W., Xu, Y., & Day, T. A. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01733.x · Cited by 514 · see citing works
Vasopressin: Behavioral roles of an “original” neuropeptide
Caldwell, H. K., Lee, H.-J., Macbeth, A. H., & Young, W. S. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.10.007 · Cited by 504 · see citing works
The neuroendocrine basis of social recognition
Ferguson, J. N., Young, L. J., & Insel, T. R. (2002) · Frontiers in Neuroendocrinology · doi:10.1006/frne.2002.0229 · Cited by 494 · see citing works
Anxiolytic- and antidepressant-like effects of the non-peptide vasopressin V <sub>1b</sub> receptor antagonist, SSR149415, suggest an innovative approach for the treatment of stress-related disorders
Griebel, G., Simiand, J., Serradeil-Le Gal, C., Wagnon, J., Pascal, M., Scatton, B., Maffrand, J.-P., & Soubrié, P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.092012099 · Cited by 471 · see citing works
Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress
Müller, M. B., Zimmermann, S., Sillaber, I., Hagemeyer, T. P., Deussing, J. M., Timpl, P., Kormann, M., Droste, S. K., Kühn, R., Reul, J. M. H. M., et al. (2003) · Nature Neuroscience · doi:10.1038/nn1123 · Cited by 446 · see citing works
Vasopressin V1a and V1b Receptors: From Molecules to Physiological Systems
Koshimizu, T., Nakamura, K., Egashira, N., Hiroyama, M., Nonoguchi, H., & Tanoue, A. (2012) · Physiological Reviews · doi:10.1152/physrev.00035.2011 · Cited by 413 · see citing works
Dysregulation in the Suicide Brain: mRNA Expression of Corticotropin-Releasing Hormone Receptors and GABA<sub>A</sub>Receptor Subunits in Frontal Cortical Brain Region
Merali, Z., Du, L., Hrdina, P., Palkovits, M., Faludi, G., Poulter, M. O., & Anisman, H. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.4734-03.2004 · Cited by 400 · see citing works
Role of septal vasopressin innervation in paternal behavior in prairie voles (Microtus ochrogaster).
Wang, Z., Ferris, C. F., & De Vries, G. J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.1.400 · Cited by 381 · see citing works
Central CRH system in depression and anxiety — Evidence from clinical studies with CRH1 receptor antagonists
Holsboer, F., & Ising, M. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.12.032 · Cited by 380 · see citing works
Vasopressinergic regulation of the hypothalamic–pituitary–adrenal axis: implications for stress adaptation
Aguilera, G., & Rabadan-Diehl, C. (2000) · Regulatory Peptides · doi:10.1016/s0167-0115(00)00196-8 · Cited by 375 · see citing works
International Union of Pharmacology. XXXVI. Current Status of the Nomenclature for Receptors for Corticotropin-Releasing Factor and Their Ligands
Hauger, R. L., Grigoriadis, D. E., Dallman, M. F., Plotsky, P. M., Vale, W., & Dautzenberg, F. M. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.1.3 · Cited by 365 · see citing works
Mismatch or cumulative stress: Toward an integrated hypothesis of programming effects
Nederhof, E., & Schmidt, M. V. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.12.008 · Cited by 363 · see citing works
Central Nervous System Effects of the Neurohypophyseal Hormones and Related Peptides
de Wied, D., Diamant, M., & Fodor, M. (1993) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1993.1009 · Cited by 327 · see citing works
Corticotropin-releasing hormone receptor subtypes and emotion
Steckler, T., & Holsboer, F. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00170-5 · Cited by 323 · see citing works
Vasopressin-dependent neural circuits underlying pair bond formation in the monogamous prairie vole
Lim, M. M., & Young, L. J. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2003.12.008 · Cited by 322 · see citing works
Sex-specific influences of vasopressin on human social communication
Thompson, R. R., George, K., Walton, J. C., Orr, S. P., & Benson, J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600406103 · Cited by 312 · see citing works
Facilitation of Affiliation and Pair-Bond Formation by Vasopressin Receptor Gene Transfer into the Ventral Forebrain of a Monogamous Vole
Pitkow, L. J., Sharer, C. A., Ren, X., Insel, T. R., Terwilliger, E. F., & Young, L. J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07392.2001 · Cited by 295 · see citing works
Vasopressin cells in the medial amygdala of the rat project to the lateral septum and ventral hippocampus
Caffé, A. R., van Leeuwen, F. W., & Luiten, P. G. M. (1987) · Journal of Comparative Neurology · doi:10.1002/cne.902610206 · Cited by 286 · see citing works
Association of fluoxetine treatment with reductions in CSF concentrations of corticotropin-releasing hormone and arginine vasopressin in patients with major depression
(1993) · American Journal of Psychiatry · doi:10.1176/ajp.150.4.656 · Cited by 278 · see citing works
The animal and human neuroendocrinology of social cognition, motivation and behavior
McCall, C., & Singer, T. (2012) · Nature Neuroscience · doi:10.1038/nn.3084 · Cited by 273 · see citing works
Effects of early life stress on adult male aggression and hypothalamic vasopressin and serotonin.
Veenema, A. H., Blume, A., Niederle, D., Buwalda, B., & Neumann, I. D. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05045.x · Cited by 271 · see citing works
Neuropeptide Concentrations in the Cerebrospinal Fluid of Depressed Patients Treated with Electroconvulsive Therapy
Nemeroff, C. B., Bissette, G., Akil, H., & Fink, M. (1991) · The British Journal of Psychiatry · doi:10.1192/bjp.158.1.59 · Cited by 253 · see citing works
Self-citation
Gene expression analysis in the human hypothalamus in depression by laser microdissection and real-time PCR: the presence of multiple receptor imbalances
Wang, S.-S., Kamphuis, W., Huitinga, I., Zhou, J.-N., & Swaab, D. F. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.38 · Cited by 250 · see citing works
Animal models for depression and the mismatch hypothesis of disease
Schmidt, M. V. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.07.001 · Cited by 204 · see citing works
The Functional Neuroanatomy of Corticotropin‐Releasing Factor
Sawchenko, P. E., Imaki, T., Potter, E., Kovács, K. J., Imaki, J., & Vale, W. W. (2007) · Novartis Foundation symposium · doi:10.1002/9780470514368.ch2 · Cited by 195 · see citing works
Vasopressin and the Output of the Hypothalamic Biological Clock
Kalsbeek, A., Fliers, E., Hofman, M. A., Swaab, D. F., & Buijs, R. M. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.01956.x · Cited by 192 · see citing works
Effects of transgenic overproduction of CRH on anxiety‐like behaviour
van Gaalen, M. M., Stenzel‐Poore, M. P., Holsboer, F., & Steckler, T. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02040.x · Cited by 189 · see citing works
Hippocampal corticotropin releasing hormone: pre- and postsynaptic location and release by stress
Chen, Y., Brunson, K. L., Adelmann, G., Bender, R. A., Frotscher, M., & Baram, T. Z. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.03.036 · Cited by 179 · see citing works
Circadian Rhythm of Salivary Cortisol in Holocaust Survivors With and Without PTSD
Yehuda, R., Golier, J. A., & Kaufman, S. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.5.998 · Cited by 177 · see citing works
Corticotropin-Releasing Hormone
Taylor, A. L., & Fishman, L. M. (1988) · New England Journal of Medicine · doi:10.1056/nejm198807283190405 · Cited by 175 · see citing works
Sculpting the hippocampus from within: stress, spines, and CRH
Maras, P. M., & Baram, T. Z. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.01.005 · Cited by 174 · see citing works
Emergence of an Isolated Arginine Vasopressin (AVP) Response to Stress after Repeated Restraint: A Study of Both AVP and Corticotropin-Releasing Hormone Messenger Ribonucleic Acid (RNA) and Heteronuclear RNA1
Ma, X., Levy, A., & Lightman, S. L. (1997) · Endocrinology · doi:10.1210/endo.138.10.5446 · Cited by 171 · see citing works
Reduction of Hypothalamic Vasopressinergic Hyperdrive Contributes to Clinically Relevant Behavioral and Neuroendocrine Effects of Chronic Paroxetine Treatment in a Psychopathological Rat Model
Keck, M. E., Welt, T., Müller, M. B., Uhr, M., Ohl, F., Wigger, A., Toschi, N., Holsboer, F., & Landgraf, R. (2002) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300040 · Cited by 168 · see citing works
Chapter 16 Neurohypophyseal hormone receptor systems in brain and periphery
Jard, S., Barberis, C., Audigier, S., & Tribollet, E. (1987) · Progress in brain research · doi:10.1016/s0079-6123(08)60206-x · Cited by 164 · see citing works
Increased corticotropin-releasing hormone immunoreactivity in monoamine-containing pontine nuclei of depressed suicide men
Austin, M. C., Janosky, J. E., & Murphy, H. A. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001250 · Cited by 162 · see citing works
The vasopressin system — From antidiuresis to psychopathology
Frank, E., & Landgraf, R. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.11.063 · Cited by 159 · see citing works
Novelty-seeking behavior predicts vulnerability in a rodent model of depression
Stedenfeld, K. A., Clinton, S. M., Kerman, I. A., Akil, H., Watson, S. J., & Sved, A. F. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.02.001 · Cited by 153 · see citing works
Clinical and Neurobiological Effects of Tianeptine and Paroxetine in Major Depression
Nickel, T., Sonntag, A., Schill, J., Zobel, A. W., Ackl, N., Brunnauer, A., Murck, H., Ising, M., Yassouridis, A., Steiger, A., et al. (2003) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-200304000-00008 · Cited by 152 · see citing works
CSF corticotropin-releasing hormone and somatostatin in major depression: response to antidepressant treatment and relapse
Banki, C. M., Karmacsi, L., Bissette, G., & Nemeroff, C. B. (1992) · European Neuropsychopharmacology · doi:10.1016/0924-977x(92)90019-5 · Cited by 149 · see citing works
Self-citation
High-Affinity CRF1 Receptor Antagonist NBI-34041: Preclinical and Clinical Data Suggest Safety and Efficacy in Attenuating Elevated Stress Response
Ising, M., Zimmermann, U. S., Kunzel, H. E., Uhr, M., Foster, A. C., Learned, S. M., Holsboer, F., & Grigoriadis, D. E. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301328 · Cited by 143 · see citing works
The Central Vasopressinergic System: Examining the Opportunities for Psychiatric Drug Development
Ring, R. H. (2005) · Current Pharmaceutical Design · doi:10.2174/1381612053382241 · Cited by 141 · see citing works
Early Life Stress Enhances the Vulnerability to Chronic Psychosocial Stress and Experimental Colitis in Adult Mice
Veenema, A. H., Reber, S. O., Selch, S., Obermeier, F., & Neumann, I. D. (2008) · Endocrinology · doi:10.1210/en.2007-1469 · Cited by 138 · see citing works
Novel and Transient Populations of Corticotropin-Releasing Hormone-Expressing Neurons in Developing Hippocampus Suggest Unique Functional Roles: A Quantitative Spatiotemporal Analysis
Chen, Y., Bender, R. A., Frotscher, M., & Baram, T. Z. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07171.2001 · Cited by 137 · see citing works
Vasopressin receptor V1a regulates circadian rhythms of locomotor activity and expression of clock-controlled genes in the suprachiasmatic nuclei
Li, J., Burton, K. J., Zhang, C., Hu, S.-B., & Zhou, Q. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90463.2008 · Cited by 135 · see citing works
Treatment of depression with the CRH-1-receptor antagonist R121919: endocrine changes and side effects
Kunzel, H. E., Zobel, A. W., Nickel, T., Ackl, N., Uhr, M., Sonntag, A., Ising, M., & Holsboer, F. (2003) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(03)00070-0 · Cited by 134 · see citing works
Vasopressin released within the central amygdala promotes maternal aggression
Bosch, O. J., & Neumann, I. D. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07115.x · Cited by 134 · see citing works
Vasopressin Modulates Medial Prefrontal Cortex–Amygdala Circuitry during Emotion Processing in Humans
Zink, C. F., Stein, J. L., Kempf, L., Hakimi, S., & Meyer‐Lindenberg, A. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4899-09.2010 · Cited by 131 · see citing works
Intranasal Arginine Vasopressin Enhances the Encoding of Happy and Angry Faces in Humans
Guastella, A. J., Kenyon, A. R., Alvares, G. A., Carson, D. S., & Hickie, I. B. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.03.014 · Cited by 130 · see citing works
The involvement of the vasopressin system in stress-related disorders
Landgraf, R. (2006) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152706776359664 · Cited by 127 · cited 2× · see citing works
“These approaches include central or peripheral administration of V1 receptor antagonists, siRNA, knockout mice, and adenoviral overexpression of V1 receptors (Landgraf 2006; Mak et al. 2012; Pitkow et al. 2001; Ring 2005; Ryckmans 2010; Simon et al. 2008).”
Background
CRF-induced excessive grooming behavior in rats and mice
Dunn, A. J., Berridge, C. W., Lai, Y. I., & Yachabach, T. L. (1987) · Peptides · doi:10.1016/0196-9781(87)90069-6 · Cited by 121 · see citing works
Genes learn from stress: How infantile trauma programs us for depression
Murgatroyd, C., Wu, Y., Bockmühl, Y., & Spengler, D. (2010) · Epigenetics · doi:10.4161/epi.5.3.11375 · Cited by 114 · see citing works
Evidence that the lateral septum is involved in the antidepressant-like effects of the vasopressin V1b receptor antagonist, SSR149415
Stemmelin, J., Lukovic, L., Salome, N., & Griebel, G. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300562 · Cited by 112 · see citing works
Anatomy of melancholia: focus on hypothalamic–pituitary–adrenal axis overactivity and the role of vasopressin
Dinan, T. G., & Scott, L. V. (2005) · Journal of Anatomy · doi:10.1111/j.1469-7580.2005.00443.x · Cited by 110 · see citing works
High susceptibility to chronic social stress is associated with a depression-like phenotype
Schmidt, M. V., Scharf, S. H., Sterlemann, V., Ganea, K., Liebl, C., Holsboer, F., & Müller, M. B. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.10.002 · Cited by 103 · see citing works
The central corticotropin releasing factor system during development and adulthood
Korosi, A., & Baram, T. Z. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.11.066 · Cited by 102 · see citing works
Modulation of anxiety behavior in the elevated plus maze using peptidic oxytocin and vasopressin receptor ligands in the rat
Mak, P., Broussard, C., Vacy, K., & Broadbear, J. H. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881111416687 · Cited by 95 · see citing works
Effects of chronic social defeat on behavioral and neural correlates of sociality: Vasopressin, oxytocin and the vasopressinergic V1b receptor
Litvin, Y., Murakami, G., & Pfaff, D. W. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.03.007 · Cited by 90 · see citing works
Corticotropin-releasing hormone receptors in the medial prefrontal cortex regulate hypothalamic–pituitary–adrenal activity and anxiety-related behavior regardless of prior stress experience
Jaferi, A., & Bhatnagar, S. (2007) · Brain Research · doi:10.1016/j.brainres.2007.07.100 · Cited by 84 · see citing works
Comparison of the V1b antagonist, SSR149415, and the CRF1 antagonist, CP-154,526, in rodent models of anxiety and depression
Hodgson, R. A., Higgins, G. A., Guthrie, D. H., Lu, S. X., Pond, A. J., Mullins, D. E., Guzzi, M. F., Parker, E. M., & Varty, G. B. (2007) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.12.021 · Cited by 82 · see citing works
Long-term neuroendocrine effects of childhood maltreatment
Sjöberg, R. L. (2000) · JAMA · doi:10.1001/jama.284.18.2317 · Cited by 79 · see citing works
The pituitary mediates the anxiolytic-like effects of the vasopressin V1B receptor antagonist, SSR149415, in a social interaction test in rats
Shimazaki, T., Iijima, M., & Chaki, S. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.06.032 · Cited by 78 · see citing works
Neuromodulation of memory in the hippocampus by vasopressin
Alescio‐Lautier, B., Paban, V., & Soumireu-Mourat, B. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00542-2 · Cited by 76 · see citing works
The corticotropin-releasing factor receptor: a novel target for the treatment of depression and anxiety-related disorders
Grigoriadis, D. E. (2005) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.9.4.651 · Cited by 75 · see citing works
CRF and restraint-stress decrease exploratory behavior in hypophysectomized mice
Berridge, C. W., & Dunn, A. J. (1989) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(89)90551-0 · Cited by 73 · see citing works
Effect of desipramine on cerebrospinal fluid concentrations of corticotropin-releasing factor in human subjects
Veith, R. C., Lewis, N., Langohr, J. I., Murburg, M. M., Ashleigh, E. A., Castillo, S., Peskind, E. R., Pascualy, M., Bissette, G., Nemeroff, C. B., et al. (1993) · Psychiatry Research · doi:10.1016/0165-1781(93)90002-x · Cited by 71 · see citing works
Self-citation
Bacterial infection early in life protects against stressor-induced depressive-like symptoms in adult rats
Bilbo, S. D., Yirmiya, R., Amat, J., Paul, E. D., Watkins, L. R., & Maier, S. F. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.11.008 · Cited by 70 · see citing works
Vasopressin needs an audience: Neuropeptide elicited stress responses are contingent upon perceived social evaluative threats
Shalev, I., Israel, S., Uzefovsky, F., Gritsenko, I., Kaitz, M., & Ebstein, R. P. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.04.005 · Cited by 65 · see citing works
Suppression of Proinflammatory Cytokines Interleukin-1β and Tumor Necrosis Factor-α in Astrocytes by a V1Vasopressin Receptor Agonist: A cAMP Response Element-Binding Protein-Dependent Mechanism
Zhao, L., & Brinton, R. D. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4922-03.2004 · Cited by 62 · see citing works
Corticotropin-Releasing Hormone and Arginine Vasopressin in Depression
Bao, A., & Swaab, D. F. (2010) · Vitamins and hormones · doi:10.1016/s0083-6729(10)82018-7 · Cited by 60 · see citing works
Selectivity of d[Cha4]AVP and SSR149415 at human vasopressin and oxytocin receptors: evidence that SSR149415 is a mixed vasopressin V1b/oxytocin receptor antagonist
Griffante, C., Green, A., Curcuruto, O., Haslam, C. P., Dickinson, B. A., & Arban, R. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706383 · Cited by 60 · see citing works
Antidepressant-like effects of the vasopressin V1b receptor antagonist SSR149415 in the Flinders Sensitive Line rat
Overstreet, D. H., & Griebel, G. (2005) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2005.07.021 · Cited by 58 · see citing works
Neuronal Activity Is Required for the Circadian Rhythm of Vasopressin Gene Transcription in the Suprachiasmatic Nucleusin Vitro
Arima, H., House, S. B., Gainer, H., & Aguilera, G. (2002) · Endocrinology · doi:10.1210/en.2002-220393 · Cited by 58 · see citing works
Vasopressin Antagonists as Anxiolytics and Antidepressants: Recent Developments
Simon, N. G., Guillon, C., Fabio, K. M., Heindel, N. D., Lu, S., Miller, M., Ferris, C. F., Brownstein, M., Garippa, C., & KOPPEL, G. A. (2008) · Recent Patents on CNS Drug Discovery · doi:10.2174/157488908784534586 · Cited by 51 · see citing works
OXYTOCIN RECEPTORS IN RAT ADENOHYPOPHYSIS: EVIDENCE FROM RADIOLIGAND BINDING STUDIES.
Antoni, F. A. (1986) · Endocrinology · doi:10.1210/endo-119-5-2393 · Cited by 50 · see citing works
CORTICOTROPIN-RELEASING-FACTOR INDUCED PITUITARY-ADRENAL RESPONSE IN DEPRESSION
Holsboer, F., Gerken, A., Steiger, A., Benkert, O., Müller, O. A., & Stalla, G. K. (1984) · The Lancet · doi:10.1016/s0140-6736(84)90225-3 · Cited by 47 · see citing works
Alterations in the hypothalamic-pituitary-adrenal axis in a proposed animal model of depression with genetic muscarinic supersensitivity.
Owens, M. J., Overstreet, D. H., Knight, D. L., Rezvani, A. H., Ritchie, J., Bissette, G., Janowsky, D. S., & Nemeroff, C. B. (1991) · PubMed · Cited by 46 · see citing works
Self-citation
Both conditioned taste preference and aversion induced by corticotropin-releasing factor
Heinrichs, S. C., Britton, K. T., & Koob, G. F. (1991) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(91)90075-d · Cited by 46 · see citing works
Vasopressin Does Not Mediate Hypersensitivity of the Hypothalamic Pituitary Adrenal Axis during Chronic Stress
Chen, J., Young, S. F., Subburaju, S., Sheppard, J. R., Kiss, A., Atkinson, H. C., Wood, S. A., Lightman, S. L., Gal, C. S., & Aguilera, G. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1410.037 · Cited by 42 · see citing works
Oxytocin and the anterior pituitary gland.
Samson, W. K., & Schell, D. A. (1995) · PubMed · Cited by 40 · see citing works
Vasopressin Protects Hippocampal Neurones in Culture Against Nutrient Deprivation or Glutamate‐Induced Apoptosis
Chen, J., & Aguilera, G. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.02054.x · Cited by 37 · see citing works
An arginine vasopressin V1b antagonist, SSR149415 elicits antidepressant-like effects in an olfactory bulbectomy model
Iijima, M., & Chaki, S. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.12.008 · Cited by 33 · see citing works
The corticotropin-releasing factor 1 receptor antagonist, SSR125543, and the vasopressin 1b receptor antagonist, SSR149415, prevent stress-induced cognitive impairment in mice
Urani, A., Philbert, J., Cohen, C., & Griebel, G. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.02.019 · Cited by 29 · see citing works
Characterization of oxytocin receptors in rat adenohypophysis using a radioiodinated receptor antagonist peptide
Chadio, S. E., & Antoni, F. A. (1989) · Journal of Endocrinology · doi:10.1677/joe.0.1220465 · Cited by 22 · see citing works
Antiapoptotic effects of vasopressin in the neuronal cell line H32 involve protein kinase Cα and β
Chen, J., Liu, Y., Soh, J., & Aguilera, G. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06219.x · Cited by 20 · see citing works
Modulation of the vasopressin system for the treatment of CNS diseases.
Ryckmans, T. (2010) · PubMed · Cited by 14 · see citing works
Modulation of HPA Axis Function for Treatment of Mood Disorders
Brothers, S. P., Wahlestedt, C., & Nemeroff, C. B. (2012) · Royal Society of Chemistry eBooks · doi:10.1039/9781849734943-00276 · Cited by 4 · see citing works
Self-citation
Untitled work
Bayraktar (2000) · doi:10.1002/(sici)1096-9861(20000508)420:3
Cerebrospinal fluid concentrations of corticotropin-releasing hormone, vasopressin, and somatostatin in depressed patients and healthy controls: Response to amitriptyline treatment
Heuser, I., Bissette, G., Dettling, M., Schweiger, U., Gotthardt, U., Schmider, J., Lammers, C.-H., Nemeroff, C. B., & Holsboer, F. (1998) · Depression and Anxiety · doi:10.1002/(sici)1520-6394(1998)8:2
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Neuroplasticity in cognitive and psychological mechanisms of depression: an integrative model
Price, R. B., & Duman, R. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0615-x · Cited by 721 · see citing works
Stress and central autonomic network
Lamotte, G. J., Shouman, K., & Benarroch, E. E. (2021) · Autonomic Neuroscience · doi:10.1016/j.autneu.2021.102870 · Cited by 148 · see citing works
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Inda, C., Armando, N. G., Claro, P. A. D. S., & Silberstein, S. (2017) · Endocrine Connections · doi:10.1530/ec-17-0111 · Cited by 77 · see citing works
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Peeters, B., Meersseman, P., Perre, S. V., Wouters, P. J., Debaveye, Y. A., Langouche, L., & den Berghe, G. V. (2018) · Intensive Care Medicine · doi:10.1007/s00134-018-5427-y · Cited by 66 · see citing works
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Review of the direct and indirect effects of hyperglycemia on the HPA axis in T2DM and the co-occurrence of depression
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The parabrachial nucleus elicits a vigorous corticosterone feedback response to the pro-inflammatory cytokine IL-1β
Jagot, F., Gaston-Breton, R., Choi, A. J., Pascal, M., Bourhy, L., Dorado-Doncel, R., Conzelmann, K., Lledo, P., Lepousez, G., & Eberl, G. (2023) · Neuron · doi:10.1016/j.neuron.2023.05.009 · Cited by 57 · see citing works
Multi-systemic evaluation of biological and emotional responses to the Trier Social Stress Test: A meta-analysis and systematic review
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Iftikhar, K., Siddiq, A., Baig, S. G., & Zehra, S. (2019) · Neuropeptides · doi:10.1016/j.npep.2019.101993 · Cited by 48 · see citing works
Oxytocin and MDMA (‘Ecstasy’) enhance social reward in rats
Ramos, L., Hicks, C., Caminer, A., Goodwin, J., & McGregor, I. S. (2015) · Psychopharmacology · doi:10.1007/s00213-015-3899-9 · Cited by 40 · see citing works
Vasopressin neurons in the paraventricular hypothalamus promote wakefulness via lateral hypothalamic orexin neurons
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Behavioral Neurobiology of Stress-related Disorders
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Increased protein and mRNA expression of corticotropin-releasing factor (CRF), decreased CRF receptors and CRF binding protein in specific postmortem brain areas of teenage suicide subjects
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Maternal stress during pregnancy induces depressive-like behavior only in female offspring and correlates to their hippocampal Avp and Oxt receptor expression
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Self-citation
Activation of CRF/CRFR1 signaling in the basolateral nucleus of the amygdala contributes to chronic forced swim-induced depressive-like behaviors in rats
Chen, L., Song, L., Cai, J., Wei, T., Liu, L., Zhao, H., Liu, B.-H., Jing, H., Jin, Z., Liu, M., et al. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.10.027 · Cited by 26 · see citing works
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Early Life Stress Alters Adult Inflammatory Responses in a Mouse Model for Depression.
Höhmann, C. F., Odebode, G., Naidu, L., & Koban, M. (2017) · PubMed · Cited by 19 · see citing works
Paraventricular hypothalamic vasopressin neurons induce self-grooming in mice
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Tectal corticotropin-releasing factor (CRF) neurons respond to fasting and a reactive stressor in the African Clawed Frog, Xenopus laevis
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Social behaviour is altered in the insulin-regulated aminopeptidase knockout mouse
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Stress Adaptation and the Hypothalamic‐Pituitary‐Adrenal Axis
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Limosilactobacillus reuteri administration alters the gut-brain-behavior axis in a sex-dependent manner in socially monogamous prairie voles
Donovan, M. L., Mackey, C. S., Lynch, M. D. J., Platt, G. N., Brown, A. N., Washburn, B. K., Trickey, D. J., Curtis, J. T., Liu, Y., Charles, T. C., et al. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1015666 · Cited by 9 · see citing works
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Dexmedetomidine Promotes NREM Sleep by Depressing Oxytocin Neurons in the Paraventricular Nucleus in Mice
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Probing for corticotropin-releasing hormone (CRH) in human blood for doping control purposes using immunoaffinity purification and LC-HRMS/MS
Knoop, A., Thomas, A., Bidlingmaier, M., Delahaut, P., Schänzer, W., & Thevis, M. (2017) · Analytical Methods · doi:10.1039/c7ay01349c · Cited by 7 · see citing works
Advanced intranasal peptide delivery systems for improved management of Alzheimer's disease
Majie, A., Karmakar, V., Ghosh, A., Chakraborty, S., Apurva, A., Layek, B., & Gorain, B. (2025) · Biomaterials Advances · doi:10.1016/j.bioadv.2025.214474 · Cited by 7 · see citing works
Maternal and umbilical cord copeptin levels in pregnancies complicated by fetal growth restriction
Bülbül, G. A., Kumru, S., Erol, O. Ö., İsenlik, B. S., Özdemir, Ö., Çağlar, M., Yılmaz, M., Kalaycı, M. Z., & Aydın, S. (2014) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2014.951622 · Cited by 6 · see citing works
Association of Copeptin With Sense of Coherence in Individuals With Varying Degrees of Glucose Intolerance
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Vasopressin in mechanisms of stress reactions and modulation of emotion
Belokoskova, S. G., & Tsikunov, S. G. (2018) · Reviews on Clinical Pharmacology and Drug Therapy · doi:10.17816/rcf1635-12 · Cited by 6 · see citing works
Sleep, Cognitive and Mood Symptoms in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Wallis, A., Jackson, M. L., Ball, M., Lewis, D. P., & Bruck, D. (2017) · Wiley eBooks · doi:10.1002/9781118993811.ch31 · Cited by 7 · see citing works
The clinical manifestation and treatment of Meniere's Disease from the viewpoint of the water homeostasis of the inner ear
Takeda, T., Takeda, S., & Kakigi, A. (2024) · Auris Nasus Larynx · doi:10.1016/j.anl.2024.08.002 · Cited by 7 · see citing works
Human–robot pair-bonding from a neuroendocrine perspective: Modeling the effect of oxytocin, arginine vasopressin, and dopamine on the social behavior of an autonomous robot
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Identification of moderate effect size genes in autism spectrum disorder through a novel gene pairing approach
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Xinghamide A, a New Cyclic Nonapeptide Found in Streptomyces xinghaiensis
Um, S., Lee, J., Kim, S. J., Cho, K. A., Kang, K. S., & Kim, S. H. (2023) · Marine Drugs · doi:10.3390/md21100509 · Cited by 4 · see citing works
Enhancing oxygenation of patients with coronavirus disease 2019: Effects on immunity and other health-related conditions
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Stress-Induced Immune Dysfunction: Implications for Intrapersonal and Interpersonal Processes
Sepehrinezhad, A., Momeni, J., Gorji, A., & Negah, S. S. (2020) · The Neuroscience Journal of Shefaye Khatam · doi:10.29252/shefa.8.2.93 · Cited by 3 · see citing works
Stress-induced urgent conditions in endocrinology
Vyunytska, L. V., Yuzvenko, Т. Y., Дашук, Т. І., Nіkonov, V. V., Vasyuk, V. L., & Korotchuk, N. V. (2024) · INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine) · doi:10.22141/2224-0721.20.1.2024.1360 · Cited by 3 · see citing works
Emotional Disorders in Development
Price, R. B., & Woody, M. L. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819641-0.00024-4 · Cited by 2 · see citing works
Role of interplay between endocannabinoids and neuropeptides in pathogenesis and therapy of depressive and anxiety disorders
Gołyszny, M. J., Dragon, J., & Obuchowicz, E. (2025) · Neuropeptides · doi:10.1016/j.npep.2025.102564 · Cited by 4 · see citing works
Sexual aggression and prenatal stress lead to poor maternal care and aggressive behaviour in male Wistar rat offspring
Mbiydzenyuy, N. E., Hemmings, S. M. J., Womersley, J. S., Shabangu, T. W., & Qulu, L. (2026) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2026.02.012 · Cited by 1 · see citing works
The Neurotrophic, Neuroprotective, Mitogenic, Antioxidant, and Antiapoptotic Properties of Vasopressin
Belokoskova, S. G., & Tsikunov, S. G. (2023) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-023-01461-1 · Cited by 1 · see citing works
[Diagnosis of a sudden loss of vision (without redness nor eye pain)].
Buisseret, D., & Cordonnier, M. (2014) · PubMed
Concomitant Behavioral, Electrochemical and Electrophysiological Study in Real Time on the Role of CRF and CRF Antagonist(S) in Anxiety and Depression: Possible Association CRF + 5-HT Receptor Antagonists?
Francesco, C. (2018) · International Journal of Brain Disorders and Treatment · doi:10.23937/2469-5866/1510022
The Effect of High-Fructose Corn syrup on Ethanol Taking, Seeking, and Palatability in Rats
Ayoub, S. M. (2018) · The Atrium (University of Guelph)
Syndrome of inappropriate antidiuresis as a maladaptive stress response shared by coronavirus disease 2019 and other cytokine storm disorders
Muccioli, L., Pensato, U., Guarino, M., Bisulli, F., & Fustini, M. F. (2022) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2022.05.031
Magnesium deficiency and stress
Kniazkova, I. I., Bogun, M. V., Golovachova, V. A., & Leshchyna, I. V. (2017) · Likarska sprava · doi:10.31640/ls-2017-8-16
Introduction
Rokach, A., & Clayton, S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-85853-3.00002-1
Role of Sleep in Neurogenesis
Ahamed, H. N., Irfan, N., Ansari, L. H. T., Ismail, Y., Uthumansha, U., Sridhar, S. B., Shareef, J., Thomas, S., & Janakiraman, A. K. (2024) · Springer eBooks · doi:10.1007/978-981-19-3949-5_37-1
Role of Sleep in Neurogenesis
Ahamed, H. N., Irfan, N., Ansari, L. H. T., Ismail, Y., Uthumansha, U., Sridhar, S. B., Shareef, J., Thomas, S., & Janakiraman, A. K. (2024) · Springer eBooks · doi:10.1007/978-981-99-7557-0_37
Additional file 1 of Paraventricular hypothalamic vasopressin neurons induce self-grooming in mice
Islam, M. T., Maejima, T., Matsui, A., & Mieda, M. (2022) · Figshare · doi:10.6084/m9.figshare.19844680
Intranasally administered neuropeptide S attenuated anxiogenic effect of acute stress with alterations in mRNA expression of nonapeptides in pubertal male rats: preliminary report
Gołyszny, M. J., & Zieliński, M. (2026) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-026-01962-9
The neurochemistry of conduct disorder, antisocial personality disorder, and psychopathy- current evidence and future directions
Tully, J., & Hind, E. (2026) · Aggression and Violent Behavior · doi:10.1016/j.avb.2026.102144

Vasopressin and the regulation of hypothalamic-pituitary-adrenal axis function: Implications for the pathophysiology of depression
Scott, L. V., & Dinan, T. G. (1998) · Life Sciences · doi:10.1016/s0024-3205(98)00027-7 · Cited by 281 · see citing works
The role of corticotropin-releasing factor and noradrenaline in stress-related responses, and the inter-relationships between the two systems
Dunn, A. J., & Swiergiel, A. H. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.11.069 · Cited by 94 · see citing works
The impact of neuropeptides in stress regulation, emotions and mood
Wiedemann, K. (2005) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-2005-920431
The role of corticotropin-releasing factor in depression and anxiety disorders
Arborelius, L., Owens, M., Plotsky, P., & Nemeroff, C. (1999) · Journal of Endocrinology · doi:10.1677/joe.0.1600001 · Cited by 1,378 · see citing works
Self-citation
Role of corticotropin-releasing factor family peptides and receptors in stress-related psychiatric disorders
Clark, M. S., & Kaiyala, K. J. (2003) · Seminars in Clinical Neuropsychiatry · doi:10.1053/scnp.2003.50011 · Cited by 17 · see citing works

Authors: Beurel, E., & Nemeroff, C. B.
Affiliations: University of Miami (US)
Corresponding author: Nemeroff, Charles B.
ORCID: Beurel, Eléonore
Nemeroff, Charles B.
Venue: Current Topics in Behavioral Neurosciences
Publisher: Springer Berlin Heidelberg
Published: 2014
Volume: 18
Pages: 67-80
ISSN: 1866-3370 (ISSN-L)
1866-3389
DOI: 10.1007/7854_2014_306
PMC: PMC4171342
OpenAlex: W146586184
Cited by: 64
References: 120
Citations by year: 2026: 4 · 2025: 2 · 2024: 10 · 2023: 6 · 2022: 5 · 2021: 3 · 2020: 4 · 2019: 7 · 2018: 7 · 2017: 8 · 2016: 2 · 2015: 3 · 2014: 3
FWCI: 6.73
Type: book chapter
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Current topics in behavioral neurosciences (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of Mental Health (K99MH090236, R00MH090236, R01MH094759)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords: stress, corticotropin-releasing factor, vasopressin, neuropeptides, hypothalamic-pituitary-adrenal axis, ACTH, anxiety, depression, CRF receptor antagonists, stress response

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Interaction of Stress, Corticotropin-Releasing Factor, Arginine Vasopressin and Behaviour

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