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Selective Activation of Cannabinoid CB2 Receptors Suppresses Hyperalgesia Evoked by Intradermal Capsaicin

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Activation of Cannabinoid CB2Receptors Suppresses C-Fiber Responses and Windup in Spinal Wide Dynamic Range Neurons in the Absence and Presence of Inflammation

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Novel 4-Oxo-1,4-dihydroquinoline-3-carboxamide Derivatives as New CB2Cannabinoid Receptors Agonists: Synthesis, Pharmacological Properties and Molecular Modeling

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Pharmacologic Interaction between Cannabinoid and either Clonidine or Neostigmine in the Rat Formalin Test

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Chronic Cannabinoid Receptor 2 Activation Reverses Paclitaxel Neuropathy Without Tolerance or Cannabinoid Receptor 1–Dependent Withdrawal

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Cannabinoid CB2 Agonist AM1710 Differentially Suppresses Distinct Pathological Pain States and Attenuates Morphine Tolerance and Withdrawal

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CB1 Knockout Mice Unveil Sustained CB2-Mediated Antiallodynic Effects of the Mixed CB1/CB2 Agonist CP55,940 in a Mouse Model of Paclitaxel-Induced Neuropathic Pain

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Cannabinoid Agonists Inhibit Neuropathic Pain Induced by Brachial Plexus Avulsion in Mice by Affecting Glial Cells and MAP Kinases

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CB1 and CB2 receptor agonists promote analgesia through synergy in a murine model of tumor pain

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Targeting Peripherally Restricted Cannabinoid Receptor 1, Cannabinoid Receptor 2, and Endocannabinoid-Degrading Enzymes for the Treatment of Neuropathic Pain Including Neuropathic Orofacial Pain

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Endocannabinoid regulation of spinal nociceptive processing in a model of neuropathic pain

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Activation of cannabinoid CB2 receptors reduces hyperalgesia in an experimental autoimmune encephalomyelitis mouse model of multiple sclerosis

Fu, W., & Taylor, B. K. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.04.002 · Cited by 29 · see citing works

Intrathecal Actions of the Cannabis Constituents Δ(9)-Tetrahydrocannabinol and Cannabidiol in a Mouse Neuropathic Pain Model

Casey, S. L., Mitchell, V. A., Sokolaj, E. E., Winters, B. L., & Vaughan, C. W. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158649 · Cited by 26 · see citing works

Antinociceptive Effects of Cannabichromene (CBC) in Mice: Insights from von Frey, Tail-Flick, Formalin, and Acetone Tests

Raup‐Konsavage, W. M., Sepúlveda, D. E., Wang, J., Dokholyan, N. V., Vrana, K. E., & Graziane, N. (2023) · Biomedicines · doi:10.3390/biomedicines12010083 · Cited by 24 · see citing works

Antinociceptive effects induced through the stimulation of spinal cannabinoid type 2 receptors in chronically inflamed mice

Curto-Reyes, V., Boto, T., Hidalgo, A., Menéndez, L., & Baamonde, A. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.06.057 · Cited by 24 · see citing works

Cannabinoid CB2 receptor stimulation attenuates brain edema and neurological deficits in a germinal matrix hemorrhage rat model

Tao, Y., Tang, J., Chen, Q., Guo, J., Li, L., Yang, L. M., Feng, H., Zhu, G., & Chen, Z. (2015) · Brain Research · doi:10.1016/j.brainres.2015.01.025 · Cited by 21 · see citing works

Preparation and Characterization of Liposomal β-Caryophyllene (Rephyll) by Nanofiber Weaving Technology and Its Effects on Delayed Onset Muscle Soreness (DOMS) in Humans: A Randomized, Double-Blinded, Crossover-Designed, and Placebo-Controlled Study

Amalraj, A., Jacob, J., C., K. V. A., & Gopi, S. (2020) · ACS Omega · doi:10.1021/acsomega.0c03456 · Cited by 20 · see citing works

Do cannabinoids have a role in cancer pain management?

Farquhar-Smith, W. P. (2009) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0b013e3283260612 · Cited by 15 · see citing works

Cannabinoid Receptor 2 Modulates Maturation of Dendritic Cells and Their Capacity to Induce Hapten-Induced Contact Hypersensitivity

Gaffal, E., Kemter, A. M., Scheu, S., Dantas, R. L., Vogt, J., Baune, B. T., Tüting, T., Zimmer, A., & Alferink, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21020475 · Cited by 15 · see citing works

Cannabinoid CB2 receptor‐mediated analgesia: mechanism‐based insights and therapeutic potential

Guenther, K. G., & Hohmann, A. G. (2025) · British Journal of Pharmacology · doi:10.1111/bph.70116 · Cited by 12 · see citing works

Pharmacological potential of JWH133, a cannabinoid type 2 receptor agonist in neurodegenerative, neurodevelopmental and neuropsychiatric diseases

Hashiesh, H. M., Jha, N. K., Sharma, C., Gupta, P. K., Jha, S. K., Patil, C. R., Goyal, S. N., & Ojha, S. K. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174398 · Cited by 13 · see citing works

The cannabinoid receptor-2 is involved in allergic inflammation

Mimura, T., Ueda, Y., Watanabe, Y., & Sugiura, T. (2012) · Life Sciences · doi:10.1016/j.lfs.2012.04.005 · Cited by 12 · see citing works

Targeting the Cannabinoid System to Produce Analgesia

Sagar, D. R., Jhaveri, M. D., & Chapman, V. (2009) · Current topics in behavioral neurosciences · doi:10.1007/978-3-540-88955-7_11 · Cited by 10 · see citing works

Cannabinoid receptor agonists from Conus venoms alleviate pain-related behavior in rats

Jergová, S., Perez, C., Imperial, J. S., Gajavelli, S., Jain, A., Abin, A., Olivera, B. M., & Sagen, J. (2021) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2021.173182 · Cited by 9 · see citing works

Identification and biochemical analyses of selective CB2 agonists

Scott, C. E., Tang, Y., Alt, A. J., Burford, N. T., Gerritz, S. W., Ogawa, L. M., Zhang, L., & Kendall, D. A. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.03.054 · Cited by 9 · see citing works

Understanding the endocannabinoid system as a modulator of the trigeminal pain response to concussion

Elliott, M. B., Ward, S. J., Abood, M. E., Tuma, R. F., & Jallo, J. (2017) · Concussion · doi:10.2217/cnc-2017-0010 · Cited by 8 · see citing works

Novel targets in pain research: The case for CB2 receptors as a biorational pain target

Brownjohn, P. W., & Ashton, J. C. (2009) · Current Anaesthesia and Critical Care · doi:10.1016/j.cacc.2009.07.014 · Cited by 7 · see citing works

Aspirin-triggered lipoxin A4 reduces neuropathic pain and anxiety-like behaviours in male diabetic rats: antinociceptive enhancement by cannabinoid receptor agonists

Ferreira, M. V., Jesus, C. H. A., da Costa, J. P. B., Oliveira, G., Liebl, B., Verri, W. A., Jr., Zanoveli, J. M., & da Cunha, J. M. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177254 · Cited by 6 · see citing works

Improvement in the Cognitive Function in Chronic Pain: Therapeutic Potential of the Endocannabinoid System

Karimi‐Haghighi, S., & Shaygan, M. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04814-8 · Cited by 5 · see citing works

The potential neuroprotective effects of cannabinoids against paclitaxel-induced peripheral neuropathy: in vitro study on neurite outgrowth

Creangă-Murariu, I., Filipiuc, L.-E., Gogu, M.-R., Ciorpac, M., Cumpăt, C. M., Tamba, B.-I., & Alexa‐Stratulat, T. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1395951 · Cited by 5 · see citing works

Spinal dorsal horn neurons involved in the alleviating effects of cannabinoid receptor agonists on neuropathic allodynia-like behaviors in rats

Sueto, D., Eriko, I., Onishi, A., & Tsuda, M. (2025) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2025.02.008 · Cited by 4 · see citing works

Il sistema endocannabinoide: attuali conoscenze e potenziali applicazioni in odontostomatologia

Pavanini, S., Lauriola, S., Mottola, A., & Cocchi, R. (2010) · Italian Oral Surgery · doi:10.1016/j.ios.2010.11.004 · Cited by 4 · see citing works

Recent data on cannabinoids and their pharmacological implications in neuropathic pain.

Coman, O. A., Păunescu, H., Coman, L., Bădărău, A., & Fulga, I. (2008) · PubMed Central · Cited by 3 · see citing works

Spinal Cord is the Primary Site of Action of the Cannabinoid CB2 Receptor Agonist JWH133 that Suppresses Neuropathic Pain: Possible Involvement of Microglia

Shimoyama, H., Tsuda, M., Masuda, T., Yoshinaga, R., Tsukamoto, K., Tozaki‐Saitoh, H., & Inoue, K. (2014) · The Open Pain Journal · doi:10.2174/1876386301407010001 · Cited by 3 · see citing works

Perspectives on Stem Cell Therapy in Diabetic Neuropathic Pain

Montagnoli, T. L., Santos, A. D., Sudo, S. Z., Gubert, F., Vasques, J. F., Méndez‐Otero, R., de Sá, M. P. L., & Zapata‐Sudo, G. (2024) · Neurology International · doi:10.3390/neurolint16050070 · Cited by 2 · see citing works

Evaluation of deuterated [ 18 F]JHU94620 for imaging cannabinoid type 2 receptors in rodent and monkey brain

Maqbool, M., Gündel, D., Liow, J. S., Hong, J. S., Parcon, P. A., Cureton, R., Pamie-George, M. T., Jenson, A. E., Wu, S., Henter, I. D., et al. (2025) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x251371377 · Cited by 1 · see citing works

The Management of Neuropathic Pain

Toth, C., & Moulin, D. E. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139152211.019 · Cited by 1 · see citing works

Cannabinoid Receptor Mediated Analgesia: Novel Targets for Chronic Pain States

Chapman, V., Kendall, D. A., & Sagar, D. R. (2009) · Springer eBooks · doi:10.1007/978-1-4419-0226-9_15 · Cited by 1 · see citing works

Targeting the Endocannabinoid Metabolic Enzymes to Reduce Inflammatory Pain

Ghosh, S. (2014) · VCU Scholars Compass (Virginia Commonwealth University) · doi:10.25772/ngv2-th75 · Cited by 1 · see citing works

Prophylactic treatment with sulphonated immunoglobulin G attenuates development of mechanical allodynia-like response in mice with neuropathic pain

Yamamoto, W., Itano, Y., Kobayashi, T., Miura, D., & Kasahara, Y. (2015) · Journal of Veterinary Medical Science · doi:10.1292/jvms.15-0195

THEMED ISSUE: CANNABINOIDS RESEARCH PAPER Spinal and peripheral analgesic effects of the CB2 cannabinoid receptor agonist AM1241 in two models of bone cancer-induced pain

Llames, S. G., Hidalgo, A., Menéndez, L., & Baamonde, A. (2010)

Cannabinoids

Ware, M. A. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139152211.022

The cannabinoid system and its role in nociception

Beltramo, M. (2016) · Wiley eBooks · doi:10.1002/9781118455968.ch6

Basic Science of Spinal Receptors

Kroin, J. S., & Buvanendran, A. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-2217-8.00001-5

Protein Kinase A and Epac Mediate Chronic Pain after Injury

Fu, W. (2016) · UKnowledge (University of Kentucky) · doi:10.13023/etd.2016.524

Role of the Cannabinoid System in Modulating the Reinforcing and Relapse Related Properties of Nicotine in Rats

Gamaleddin, I. (2013) · TSpace (University of Toronto)

Multivalent Cathepsin Inhibitor, VBY-825, Attenuates Breast-Induced Bone Cancer Remodelling and Pain

Nikolich-Zugich, T. (2013) · UA Campus Repository (The University of Arizona)

Current World Literature

(2009) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0b013e3283277013

Cannabinoids delivery systems based on supramolecular inclusion complexes and polymeric nanocapsules for treatment of neuropathic pain

Astruc‐Diaz, F. (2012) · HAL · doi:10.70675/de9cec28z5760z44baz93c9zce536330b49f · Cited by 1 · see citing works

Le récepteur opioïde Mu et les interactions entre systèmes opioïde et cannabinoïde dans les effets nociceptifs et addictogènes de la morphine

Roeckel, L.-A. (2018) · doi:10.70675/f064a30ezd18fz44f5za9a5z7fd570a696b8

Cannabis

Koob, G. F., Arends, M. A., McCracken, M. L., & Moal, M. L. (2026) · Elsevier eBooks · doi:10.1016/b978-0-12-816791-5.00001-7

Novel Mechanisms and Therapeutics in the Treatment for Cancer-Induced Bone Pain

Lozano‐Ondoua, A. N. (2013) · UA Campus Repository (The University of Arizona)

Spinal Cord is the Primary Site of Action of the Cannabinoid CB2 Receptor Agonist JWH133 that Suppresses Neuropathic Pain: Possible Involvement of Microglia

Shimoyama, H., Tsuda, M., Masuda, T., Yoshinaga, R., Tsukamoto, K., Tozaki‐Saitoh, H., & Inoue, K. (2014) · The Open Pain Journal · doi:10.2174/1876386301407010001 · Cited by 3 · see citing works

Cannabinoid CB₂ receptor activation inhibits mechanically evoked responses of wide dynamic range dorsal horn neurons in naïve rats and in rat models of inflammatory and neuropathic pain

Elmes, S. J. R., Jhaveri, M. D., Smart, D., Kendall, D. A., & Chapman, V. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03690.x · Cited by 160 · see citing works

The cannabinoid CB2 receptor as a target for the treatment of neuropathic pain

Brownjohn, P. W. (2012) · Otago University Research Archive (University of Otago)

Central and peripheral sites of action for CB ₂ receptor mediated analgesic activity in chronic inflammatory and neuropathic pain models in rats

Hsieh, G. C., Pai, M., Chandran, P., Hooker, B. A., Zhu, C. Z., Salyers, A. K., Wensink, E. J., Zhan, C., Carroll, W. A., Dart, M. J., et al. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.01046.x · Cited by 139 · see citing works

CB2 receptor deletion on myeloid cells enhanced mechanical allodynia in a mouse model of neuropathic pain

Nent, E., Nozaki, C., Schmöle, A., Otte, D. M., & Zimmer, A. (2019) · Scientific Reports · doi:10.1038/s41598-019-43858-4 · Cited by 37 · see citing works