Cited by 97Cannabis and Cannabinoid ResearchPain Mechanisms and TreatmentsInflammatory mediators and NSAID effects

Activation of CB1 and CB2 receptors attenuates the induction and maintenance of inflammatory pain in the rat

Elmes, Steven J.R., Winyard, Lisa A., Medhurst, Stephen J., Clayton, Nick M., Wilson, Alex W., Kendall, David A., Chapman, Victoria·2005·Pain

Abstract

The aim of the present study was to investigate the effects of cannabinoid agonists on established inflammatory hyperalgesia. We have compared the effects of pre-administration versus post-administration of a potent non-selective cannabinoid agonist HU210 and a selective CB2 receptor agonist JWH-133 on hindpaw weight bearing and paw oedema in the carrageenan model of inflammatory hyperalgesia. For comparative purposes we also determined the effects of the mu-opioid receptor agonist morphine and the COX2 inhibitor rofecoxib in this model. At 3 h following intraplantar injection of carrageenan (2%, 100 microl) there was a significant (P < 0.001) reduction in weight bearing on the ipsilateral hindpaw, compared to vehicle treated rats and a concomitant increase in ipsilateral hindpaw volume (P < 0.001), compared to vehicle treated rats. Systemic administration of HU210 (10 microg/kg) and JWH-133 (10 mg/kg) at 3 h following injection of carrageenan, significantly attenuated decreases in ipsilateral hindpaw weight bearing (P < 0.05 for both) and paw volume (P < 0.001 for both). Pre-administration of HU210 and JWH-133 had similar effects on weight bearing in this model. Pre-administered HU210 also significantly decreased carrageenan-induced changes in paw volume (P < 0.001), this was not the case for JWH-133. Effects of post-administered HU210 and JWH-133 on ipsilateral hindpaw weight bearing and paw volume were comparable to the effect of systemic post-administration of morphine and rofecoxib (3 mg/kg for both). In summary, both HU210 and JWH-133 attenuated established inflammatory hypersensitivity and swelling, suggesting that cannabinoid-based drugs have clinical potential for the treatment of established inflammatory pain responses.

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Crossref · 10.1016/j.pain.2005.09.005

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Authors
Elmes, S. J. R., Winyard, L. A., Medhurst, S. J., Clayton, N. M., Wilson, A. W., Kendall, D. A., & Chapman, V.
Affiliations
  • University of Nottingham (GB)
  • GlaxoSmithKline (United Kingdom) (GB)
Corresponding author
Chapman, Victoria
Venue
Pain
Published
2005-12
Volume
118
Issue
3
Pages
327-335
ISSN
0304-3959 (ISSN-L)
OpenAlex
W2080086221
Cited by
97
References
33
Citations by year
2025: 2 · 2024: 3 · 2023: 5 · 2022: 1 · 2021: 6 · 2020: 6 · 2019: 2 · 2018: 5 · 2017: 3 · 2016: 4 · 2015: 1 · 2014: 3 · 2013: 4 · 2012: 4
FWCI
7.02
Type
journal article
Language
en
Open access
closed
Locations
  • Pain (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • GlaxoSmithKline
  • University of Nottingham
Topics
  • Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
Keywords
cannabinoid receptors, CB1 receptor, CB2 receptor, HU-210, JWH-133, inflammatory hyperalgesia, inflammatory pain, carrageenan-induced paw edema, mu-opioid receptor, morphine, rofecoxib, COX-2 inhibition, cannabinoid receptor agonists
MeSH terms
Analgesics, Animals, Cannabinoids, Carrageenan, Drug Combinations, Hyperalgesia, Inflammation, Male, Dronabinol, Weight-Bearing, Treatment Outcome, Receptor, Cannabinoid, CB1, Receptor, Cannabinoid, CB2, Rats

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