The role of vagal neurocircuits in the regulation of nausea and vomiting

Babic, Tanja; Browning, Kirsteen N.

doi:10.1016/j.ejphar.2013.08.047

Cited by 216Nausea and vomiting managementVagus Nerve Stimulation ResearchGastrointestinal motility and disorders

The role of vagal neurocircuits in the regulation of nausea and vomiting

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Babic, Tanja, Browning, Kirsteen N.·2014·European Journal of Pharmacology

DOI 10.1016/j.ejphar.2013.08.047PMC PMC3893663

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Abstract

Nausea and vomiting are among the most frequently occurring symptoms observed by clinicians. While advances have been made in understanding both the physiological as well as the neurophysiological pathways involved in nausea and vomiting, the final common pathway(s) for emesis have yet to be defined. Regardless of the difficulties in elucidating the precise neurocircuitry involved in nausea and vomiting, it has been accepted for over a century that the locus for these neurocircuits encompasses several structures within the medullary reticular formation of the hindbrain and that the role of vagal neurocircuits in particular are of critical importance. The afferent vagus nerve is responsible for relaying a vast amount of sensory information from thoracic and abdominal organs to the central nervous system. Neurons within the nucleus of the tractus solitarius not only receive these peripheral sensory inputs but have direct or indirect connections with several other hindbrain, midbrain and forebrain structures responsible for the co-ordination of the multiple organ systems. The efferent vagus nerve relays the integrated and co-ordinated output response to several peripheral organs responsible for emesis. The important role of both sensory and motor vagus nerves, and the available nature of peripheral vagal afferent and efferent nerve terminals, provides extensive and readily accessible targets for the development of drugs to combat nausea and vomiting.

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The vagus nerve is responsible for the regulation of internal organ functions, such as digestion, heart rate, and respiratory rate, as well as vasomotor activity, and certain reflex actions, such as coughing, sneezing, swallowing, and vomiting.
“The vagus nerve is responsible for the regulation of internal organ functions, such as digestion, heart rate, and respiratory rate, as well as vasomotor activity, and certain reflex actions, such as coughing, sneezing, swallowing, and vomiting (17).”
From Vagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders (2018) · cites this paper as [17]

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Pickering AE Boscan P Paton JF 2003b Nociception attenuates parasympathetic but not sympathetic baroreflex via NK1 receptors in the rat nucleus tractus solitarii J Physiol 551 589 599 12813142 PMC2343224

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Authors: Babic, T., & Browning, K. N.
Affiliations: Pennsylvania State University (US)
Corresponding author: Browning, Kirsteen N.
ORCID: Babic, Tanja
Browning, Kirsteen N.
Venue: European Journal of Pharmacology
Publisher: Elsevier BV
Published: 2014-01
Volume: 722
Pages: 38-47
ISSN: 0014-2999 (ISSN-L)
DOI: 10.1016/j.ejphar.2013.08.047
PMC: PMC3893663
OpenAlex: W2082583113
Cited by: 216
References: 164
Citations by year: 2026: 16 · 2025: 15 · 2024: 14 · 2023: 26 · 2022: 24 · 2021: 28 · 2020: 22 · 2019: 23 · 2018: 13 · 2017: 11 · 2016: 11 · 2015: 6 · 2014: 6
FWCI: 1.36
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: European Journal of Pharmacology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases (DK- 55530, DK078364, R01DK055530, R01DK078364)
Topics: Health Sciences › Medicine › Surgery › Nausea and vomiting management
Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: nausea, vomiting, nucleus tractus solitarius, medullary reticular formation
MeSH terms: Animals, Humans, Nausea, Nerve Net, Vagus Nerve, Vomiting

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The role of vagal neurocircuits in the regulation of nausea and vomiting

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