Investigating the mechanism(s) underlying switching between states in bipolar disorder

Young, Jared W.; Dulcis, Davide

doi:10.1016/j.ejphar.2015.03.019

Cited by 68Bipolar Disorder and TreatmentTreatment of Major DepressionNeuroscience and Neuropharmacology Research

Investigating the mechanism(s) underlying switching between states in bipolar disorder

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Young, Jared W., Dulcis, Davide·2015·European Journal of Pharmacology

DOI 10.1016/j.ejphar.2015.03.019PMC PMC4437855

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Abstract

Bipolar disorder (BD) is a unique disorder that transcends domains of function since the same patient can exhibit depression or mania, states with polar opposite mood symptoms. During depression, people feel helplessness, reduced energy, and risk aversion, while with mania behaviors include grandiosity, increased energy, less sleep, and risk preference. The neural mechanism(s) underlying each state are gaining clarity, with catecholaminergic disruption seen during mania, and cholinergic dysfunction during depression. The fact that the same patient cycles/switches between these states is the defining characteristic of BD however. Of greater importance therefore, is the mechanism(s) underlying cycling from one state - and its associated neural changes - to another, considered the 'holy grail' of BD research. Herein, we review studies investigating triggers that induce switching to these states. By identifying such triggers, researchers can study neural mechanisms underlying each state and importantly how such mechanistic changes can occur in the same subject. Current animal models of this switch are also discussed, from submissive- and dominant-behaviors to kindling effects. Focus however, is placed on how seasonal changes can induce manic and depressive states in BD sufferers. Importantly, changing photoperiod lengths can induce local switches in neurotransmitter expression in normal animals, from increased catecholaminergic expression during periods of high activity, to increased somatostatin and corticotrophin releasing factor during periods of low activity. Identifying susceptibilities to this switch would enable the development of targeted animal models. From animal models, targeted treatments could be developed and tested that would minimize the likelihood of switching.

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Seasonal mood symptoms may be related to the amount, duration and intensity of light varying across the seasons.
“symptoms may be related to the amount, duration and intensity of light varying across the seasons (that is, short versus long days)194”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [194]

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Munkholm, K., Pedersen, B. K., Kessing, L. V., & Vinberg, M. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.05.011 · Cited by 48 · see citing works
Differential responses to distinct psychotropic agents of selectively bred dominant and submissive animals
Nesher, E., Gross, M., Lisson, S., Tikhonov, T., Yadid, G., & Pinhasov, A. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.08.040 · Cited by 47 · see citing works
Sensitization, Kindling, and Carbamazepine: An Update on their Implications for the Course of Affective Illness
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Circadian Phase Shifting, Alerting, and Antidepressant Effects of Bright Light Treatment
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Lifetime Characteristics of Evening-Preference and Irregular Bed-Rise Time Are Associated With Lifetime Seasonal Variation of Mood and Behavior: Comparison Between Individuals With Bipolar Disorder and Healthy Controls
Baek, J. H., Kim, J. S., Kim, M. J., Ryu, S., Lee, K., Ha, K., & Hong, K. S. (2014) · Behavioral Sleep Medicine · doi:10.1080/15402002.2014.974179 · Cited by 46 · see citing works
Interpersonal and Social Rhythm Group Therapy for Patients with Bipolar Disorder
Bouwkamp, C. G., de Kruiff, M. E., van Troost, T. M., Snippe, D., Blom, M. J., de Winter, R. F. P., & Judith Haffmans, P. M. (2013) · International Journal of Group Psychotherapy · doi:10.1521/ijgp.2013.63.1.97 · Cited by 46 · see citing works
Elucidating Poor Decision-Making in a Rat Gambling Task
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The Role of Catechol-O-Methyltransferase in Reward Processing and Addiction
Tunbridge, E. M., Huber, A., Farrell, S., Stumpenhorst, K., Harrison, P. J., & Walton, M. E. (2012) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152712800672409 · Cited by 46 · see citing works
Clonidine in the treatment of mania and mixed bipolar disorder
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Consideration of species differences in developing novel molecules as cognition enhancers
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Mania Following Sleep Deprivation
Wright, J. B. D. (1993) · The British Journal of Psychiatry · doi:10.1192/bjp.163.5.679 · Cited by 41 · see citing works
Earliest symptoms discriminating juvenile‐onset bipolar illness from ADHD
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Treating patients with bipolar disorder and substance dependence: Lessons learned
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Generation and Characterization of Humanized Mice Carrying COMT158 Met/Val Alleles
Risbrough, V. B., Ji, B., Hauger, R., & Zhou, X. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.29 · Cited by 41 · see citing works
Role of serotonin in seasonal affective disorder.
Gupta, A. K., Sharma, P. K., Garg, V. K., Singh, A. K., & Mondal, S. (2013) · PubMed · Cited by 41 · see citing works
Mood and metabolic consequences of sleep deprivation as a potential endophenotype’ in bipolar disorder
Aydin, A., Selvi, Y., Besiroglu, L., Boysan, M., Atli, A., Ozdemir, O., Kilic, S., & Balaharoglu, R. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.04.007 · Cited by 40 · see citing works
Seasonality of manic depressive illness in Canada
Whitney, D. K., Sharma, V., & Kueneman, K. (1999) · Journal of Affective Disorders · doi:10.1016/s0165-0327(98)00197-9 · Cited by 40 · see citing works
Carbamazepine and Carbamazepine-10,11− Epoxide Inhibit Amygdala-Kindled Seizures in the Rat but Do Not Block Their Development
Weiss, S. R. B., & Post, R. M. (1987) · Clinical Neuropharmacology · doi:10.1097/00002826-198706000-00008 · Cited by 40 · see citing works
Norepinephrine Transporter Gene Variation Modulates Acute Response to d-Amphetamine
Dlugos, A. M., Freitag, C. M., Hohoff, C., McDonald, J. M., Cook, E. H., Deckert, J., & de Wit, H. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.09.031 · Cited by 40 · see citing works
From antipsychotic to anti-schizophrenia drugs: role of animal models
Geyer, M. A., Olivier, B., Joëls, M., & Kahn, R. S. (2012) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2012.06.006 · Cited by 39 · see citing works
SK channel function regulates the dopamine phenotype of neurons in the substantia nigra pars compacta
Aumann, T. D., Gantois, I., Egan, K., Vais, A., Tomas, D., Drago, J., & Horne, M. K. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.07.005 · Cited by 38 · see citing works
An Evolutionary Analysis of Antigen Processing and Presentation across Different Timescales Reveals Pervasive Selection
Forni, D., Cagliani, R., Tresoldi, C., Pozzoli, U., GIOIA, L. D., Filippi, G., Riva, S., Menozzi, G., Colleoni, M., Biasin, M., et al. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004189 · Cited by 37 · see citing works
Rodent models for mania: practical approaches
Kara, N., & Einat, H. (2013) · Cell and Tissue Research · doi:10.1007/s00441-013-1594-x · Cited by 35 · see citing works
Acute and chronic antidepressant drug treatments induce opposite effects in the social behaviour of rats
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The effect of antidepressant drugs on dominance behavior in rats competing for food.
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Adolescent social instability stress increases aggression in a food competition task in adult male Long‐Evans rats
Cumming, M. J., Thompson, M. A., & McCormick, C. M. (2014) · Developmental Psychobiology · doi:10.1002/dev.21252 · Cited by 33 · see citing works
Alterations in dopamine clearance and catechol-O-methyltransferase activity by dopamine infusions in children
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Postnatal Development of a Segmental Switch Enables Corticospinal Tract Transmission to Spinal Forelimb Motor Circuits
Chakrabarty, S., & Martin, J. H. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5286-09.2010 · Cited by 31 · see citing works

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The Inositol Trisphosphate/Calcium Signaling Pathway in Health and Disease
Berridge, M. J. (2016) · Physiological Reviews · doi:10.1152/physrev.00006.2016 · Cited by 757 · see citing works
Rhythms of life: circadian disruption and brain disorders across the lifespan
Logan, R. W., & McClung, C. A. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0088-y · Cited by 713 · see citing works
Biological hypotheses and biomarkers of bipolar disorder
Sigitova, E., Fišar, Z., Hroudová, J., Cikánková, T., & Raboch, J. (2016) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12476 · Cited by 247 · see citing works
Environmental factors, life events, and trauma in the course of bipolar disorder
Aldinger, F., & Schulze, T. G. (2016) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12433 · Cited by 139 · see citing works
Animal models of bipolar mania: The past, present and future
Logan, R. W., & McClung, C. A. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2015.08.041 · Cited by 136 · see citing works
Animal models for bipolar disorder: from bedside to the cage
Beyer, D. K. E., & Freund, N. (2017) · International Journal of Bipolar Disorders · doi:10.1186/s40345-017-0104-6 · Cited by 110 · see citing works
Canalization and plasticity in psychopathology
Carhart-Harris, R. L., Chandaria, S., Erritzøe, D., Gazzaley, A. H., Girn, M., Kettner, H., Mediano, P. A. M., Nutt, D. J., Rosas, F. E., Roseman, L., et al. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109398 · Cited by 103 · see citing works
Seasonality in affective disorders
Wirz‐Justice, A. (2017) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2017.07.010 · Cited by 103 · see citing works
Mice with reduced DAT levels recreate seasonal-induced switching between states in bipolar disorder
Young, J. W., Cope, Z. A., Romoli, B., Schrurs, E., Joosen, A., van Enkhuizen, J., Sharp, R. F., & Dulcis, D. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0031-y · Cited by 81 · see citing works
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Circadian Mechanisms Underlying Reward-Related Neurophysiology and Synaptic Plasticity
Parekh, P. K., & McClung, C. A. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00187 · Cited by 75 · see citing works
Mixed States in Bipolar Disorder: Etiology, Pathogenesis and Treatment
Muneer, A. (2017) · Chonnam Medical Journal · doi:10.4068/cmj.2017.53.1.1 · Cited by 62 · see citing works
Mood‐related central and peripheral clocks
Ketchesin, K. D., Becker‐Krail, D. D., & McClung, C. A. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14253 · Cited by 60 · see citing works
Local neuropeptide signaling modulates serotonergic transmission to shape the temporal organization of C. elegans egg-laying behavior
Banerjee, N., Bhattacharya, R., Gorczyca, M. G., Collins, K. M., & Francis, M. M. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006697 · Cited by 46 · see citing works
A systematic review on sleep alterations anticipating the onset of bipolar disorder
Pancheri, C., Verdolini, N., Pacchiarotti, I., Samalin, L., Chiaie, R. D., Biondi, M., Carvalho, A. F., Valdes, M., Ritter, P. S., Vieta, E., et al. (2019) · European Psychiatry · doi:10.1016/j.eurpsy.2019.02.003 · Cited by 45 · see citing works
Association between solar insolation and a history of suicide attempts in bipolar I disorder
Bauer, M., Glenn, T., Alda, M., Andreassen, O. A., Angelopoulos, E. K., Ardau, R., Ayhan, Y., Baethge, C., Bauer, R., Baune, B. T., et al. (2019) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2019.03.001 · Cited by 46 · see citing works
Modeling bipolar disorder in mice by increasing acetylcholine or dopamine: chronic lithium treats most, but not all features
van Enkhuizen, J., Milienne-Petiot, M., Geyer, M. A., & Young, J. W. (2015) · Psychopharmacology · doi:10.1007/s00213-015-4000-4 · Cited by 44 · see citing works
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Involuntary admissions in Italy: the impact of seasonality
Aguglia, A., Moncalvo, M., Solia, F., & Maina, G. (2016) · International Journal of Psychiatry in Clinical Practice · doi:10.1080/13651501.2016.1214736 · Cited by 43 · see citing works
Preventive effects of blueberry extract on behavioral and biochemical dysfunctions in rats submitted to a model of manic behavior induced by ketamine
Debom, G. N., Gazal, M., Soares, M. S. P., do Couto, C. A. T., de Mattos, B. D. S., Lencina, C. L., Kaster, M. P., Ghisleni, G., Tavares, R. G., Braganhol, E., et al. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.10.008 · Cited by 43 · see citing works
Seasonal effects on bipolar disorder: A closer look
Rosenthal, S. J., Josephs, T., Kovtun, O., & McCarty, R. C. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.05.017 · Cited by 39 · see citing works
Bipolar disorders: is there an influence of seasonality or photoperiod?
Aguglia, A., Borsotti, A., & Maina, G. (2017) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2016-2144 · Cited by 38 · see citing works
The influence of sunlight exposure on hospitalization in emergency psychiatry
Aguglia, A., Borsotti, A., Cuniberti, F., Serafini, G., Amore, M., & Maina, G. (2017) · Chronobiology International · doi:10.1080/07420528.2017.1374286 · Cited by 38 · see citing works
Maximum Temperature and Solar Radiation as Predictors of Bipolar Patient Admission in an Emergency Psychiatric Ward
Aguglia, A., Serafini, G., Escelsior, A., Canepa, G., Amore, M., & Maina, G. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16071140 · Cited by 34 · see citing works
Validity and Usage of the Seasonal Pattern Assessment Questionnaire (SPAQ) in a French Population of Patients with Depression, Bipolar Disorders and Controls
Reynaud, È., Berna, F. S., Haffen, É., Weiner, L., Maruani, J., Lejoyeux, M., Schroder, C. M., Bourgin, P., & Geoffroy, P. A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10091897 · Cited by 34 · see citing works
Investigating the underlying mechanisms of aberrant behaviors in bipolar disorder from patients to models
van Enkhuizen, J., Geyer, M. A., Minassian, A., Perry, W., Henry, B. L., & Young, J. W. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.08.008 · Cited by 31 · see citing works
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Sensitivity to Climate and Weather Changes in Euthymic Bipolar Subjects: Association With Suicide Attempts
Nicola, M. D., Mazza, M., Panaccione, I., Moccia, L., Giuseppin, G., Marano, G., Grandinetti, P., Camardese, G., Berardis, D. D., Pompili, M., et al. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00095 · Cited by 31 · see citing works
Circuits Regulating Pleasure and Happiness in Bipolar Disorder
LOONEN, A. J. M. (2017) · Frontiers in Neural Circuits · doi:10.3389/fncir.2017.00035 · Cited by 29 · see citing works
Evidence of altered membrane phospholipid metabolism in the anterior cingulate cortex and striatum of patients with bipolar disorder I: A multi-voxel 1H MRS study
Cao, B., Stanley, J. A., Selvaraj, S., Mwangi, B., Passos, I. C., Zunta‐Soares, G. B., & Soares, J. C. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.06.006 · Cited by 26 · see citing works
Biomarkers of bipolar disorder based on metabolomics: A systematic review
Chen, J., Amdanee, N., Zuo, X., Wang, Y., Gong, M., Yang, Y., Li, H., Zhang, X., & Zhang, C. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.01.033 · Cited by 25 · see citing works
Dopamine transporter knockdown mice in the behavioral pattern monitor: A robust, reproducible model for mania-relevant behaviors
Kwiatkowski, M. A., Hellemann, G., Sugar, C. A., Cope, Z. A., Minassian, A., Perry, W., Geyer, M. A., & Young, J. W. (2017) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.12.007 · Cited by 22 · see citing works
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Enlightened: addressing circadian and seasonal changes in photoperiod in animal models of bipolar disorder
McCarty, R. C., Josephs, T., Kovtun, O., & Rosenthal, S. J. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01494-5 · Cited by 18 · see citing works
Hypomanic/manic switch after transcranial magnetic stimulation in mood disorders: A systematic review and meta-analysis
Miuli, A., Sepede, G., Stigliano, G., Mosca, A., Carlo, F. D. D., d'Andrea, G., Lalli, A., Spano, M., Pettorruso, M., Martinotti, G., et al. (2021) · World Journal of Psychiatry · doi:10.5498/wjp.v11.i8.477 · Cited by 19 · see citing works
Lithium and valproate prevent methylphenidate-induced mania-like behaviors in the hole board test
Souza, L. D. S., Silva, E. F., Santos, W. B., Asth, L., Soares, B. L., Soares-Rachetti, V. D. P., de Medeiros, Í. U., & Gavioli, E. C. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.06.044 · Cited by 19 · see citing works
Dosage-related nature of escitalopram treatment-emergent mania/hypomania: a case series
Yamaguchi, Y., Kimoto, S., Nagahama, T., & Kishimoto, T. (2018) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s168078 · Cited by 19 · see citing works
Inhibition of the dopamine transporter as an animal model of bipolar disorder mania: Locomotor response, neuroimmunological profile and pharmacological modulation
Bastos, J. D. R., Perico, K. M., Vieira, É. L. M., Teixeira, A. L., Machado, F. S., de Miranda, A. S., & Moreira, F. A. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.04.004 · Cited by 17 · see citing works
Elevated Choline-Containing Compound Levels in Rapid Cycling Bipolar Disorder
Cao, B., Stanley, J. A., Passos, I. C., Mwangi, B., Selvaraj, S., Zunta‐Soares, G. B., & Soares, J. C. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.39 · Cited by 17 · see citing works
Converging evidence that short-active photoperiod increases acetylcholine signaling in the hippocampus
Cope, Z. A., Lavadia, M. L., Joosen, A., van de Cappelle, C. J. A., Lara, J. C., Huval, A., Kwiatkowski, M. K., Picciotto, M. R., Mineur, Y. S., Dulcis, D., et al. (2020) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-020-00824-2 · Cited by 15 · see citing works
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Melanopsin-mediated pupillary responses in bipolar disorder—a cross-sectional pupillometric investigation
Madsen, H. Ø., Ba‐Ali, S., Heegaard, S., Hageman, I., Knorr, U. B., Lund‐Andersen, H., Martiny, K., & Kessing, L. V. (2021) · International Journal of Bipolar Disorders · doi:10.1186/s40345-020-00211-3 · Cited by 14 · see citing works
Adjunctive treatment with psychostimulants and stimulant-like drugs for resistant bipolar depression: a systematic review and meta-analysis
Tsapakis, E.-M., Preti, A., Mintzas, M. D., & Fountoulakis, K. Ν. (2020) · CNS Spectrums · doi:10.1017/s109285292000156x · Cited by 14 · see citing works
Have antipsychotics a different speed of action in the acute treatment of mania? A single-blind comparative study
Buoli, M., Esposito, C. M., Godio, M., Caldiroli, A., Serati, M., & Altamura, A. C. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881117705098 · Cited by 12 · see citing works
Multiple-timescale dynamics, mixed mode oscillations and mixed affective states in a model of bipolar disorder
Pavlidis, E., Campillo, F., Goldbeter, A., & Desroches, M. (2022) · Cognitive Neurodynamics · doi:10.1007/s11571-022-09900-4 · Cited by 11 · see citing works
Neuroprotection elicited by resveratrol in a rat model of hypothyroidism: Possible involvement of cholinergic signaling and redox status
Cardoso, J. D. S., Baldissarelli, J., Reichert, K. P., Teixeira, F. C., Soares, M. S. P., Schetinger, M. R. C., Morsch, V. M., Filho, A. O. F. M., Duarte, H. R., Coriolano, F. H. R., et al. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111157 · Cited by 10 · see citing works
Role of gut microbiota in the GBR12909 model of mania-like behavior in mice
de Miranda, A. S., Vieira, É. L. M., Bastos, J. D. R., Ferreira, R. N., Nicoli, J. R., Teixeira, M. M., Vieira, L. Q., Moreira, F. A., & Teixeira, A. L. (2020) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2020.577292 · Cited by 10 · see citing works
Chronic nicotine, but not suramin or resveratrol, partially remediates the mania-like profile of dopamine transporter knockdown mice
Kwiatkowski, M. A., Roberts, B. Z., van Enkhuizen, J., Ji, B., Zhou, X., & Young, J. W. (2020) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2020.11.004 · Cited by 9 · see citing works
Self-citation
Treatment-induced mood switching in affective disorders
Tang, S. W., Tang, W. H., & Leonard, B. E. (2021) · Acta Neuropsychiatrica · doi:10.1017/neu.2021.47 · Cited by 9 · see citing works
Pupillary response to blue light as a biomarker of seasonal pattern in major depressive episode: a clinical study using pupillometry.
Maruani, J., Vissouze, L., Hebert, M., Rach, H., Zehani, F., Lejoyeux, M., Bourgin, P., & Geoffroy, P. A. (2025) · Psychiatry Research · doi:10.1016/j.psychres.2024.116333 · Cited by 7 · see citing works
Short-active photoperiod gestation induces psychiatry-relevant behavior in healthy mice but a resiliency to such effects are seen in mice with reduced dopamine transporter expression
Kwiatkowski, M. A., Cope, Z. A., Lavadia, M. L., van de Cappelle, C. J. A., Dulcis, D., & Young, J. W. (2020) · Scientific Reports · doi:10.1038/s41598-020-66873-2 · Cited by 7 · see citing works
Self-citation
Why is lithium effective in alleviating bipolar disorder?
Sato, K. (2021) · Medical Hypotheses · doi:10.1016/j.mehy.2021.110484 · Cited by 8 · see citing works
Therapeutic approaches employing natural compounds and derivatives for treating bipolar disorder: emphasis on experimental models of the manic phase
Recart, V. M., Spohr, L., Soares, M. S. P., Luduvico, K. P., Stefanello, F. M., & Spanevello, R. M. (2021) · Metabolic Brain Disease · doi:10.1007/s11011-021-00776-7 · Cited by 7 · see citing works
The Elusive “Switch Process” in Bipolar Disorder and Photoperiodism: A Hypothesis Centering on NADPH Oxidase-Generated Reactive Oxygen Species Within the Bed Nucleus of the Stria Terminalis
Raitiere, M. N. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.847584 · Cited by 6 · see citing works
Choroidal structural alterations and choroidal vascularity index in bipolar disorder patients
Torun, M., Dikmen, N. T., Saka, N. T., & Sönmez, M. (2023) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2023.103518 · Cited by 6 · see citing works
A case of methamphetamine use disorder presenting a condition of ultra-rapid cycler bipolar disorder
Ikawa, H., Kanata, S., Akahane, A., Tochigi, M., Hayashi, N., & Ikebuchi, E. (2019) · SAGE Open Medical Case Reports · doi:10.1177/2050313x19827739 · Cited by 5 · see citing works
NEK4 modulates circadian fluctuations of emotional behaviors and synaptogenesis in male mice
Yang, Z.-H., Cai, X., Zhang, C.-Y., Zhang, Q., Li, M., Ding, Z., Guo, Y.-Q., Ma, G.-L., Yang, C., Guo, L., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-53585-8 · Cited by 3 · see citing works
Lurasidone-Induced Manic Switch in an Adolescent with Bipolar I Disorder: a Case Report
Nair, S. S., Chua, C. J., & Teo, D. C. L. (2021) · East Asian Archives of Psychiatry · doi:10.12809/eaap2040 · Cited by 4 · see citing works
Long‐Term Efficacy and Resting‐State Functional Magnetic Resonance Imaging Changes of Deep Brain Stimulation in the Lateral Habenula Nucleus for Treatment‐Resistant Bipolar Disorder
Jiang, C. Q., Du, P., Guan, L., Hu, C., Wang, Z., Fan, T., Wang, J., & Cui, Z. (2025) · Brain and Behavior · doi:10.1002/brb3.70899 · Cited by 1 · see citing works
Psychobiological Model of Bipolar Disorder: Based on Imbalances of Glial-Neuronal Information Processing
Mitterauer, B. (2018) · Open Journal of Medical Psychology · doi:10.4236/ojmp.2018.74008 · Cited by 2 · see citing works
Greater Emotional Distress Due to Social Distancing and Greater Symptom Severity during the COVID-19 Pandemic in Individuals with Bipolar Disorder: A Multicenter Study in Austria, Germany, and Denmark
Schönthaler, E. M. D., Dalkner, N., Ratzenhofer, M., Fleischmann, E., Fellendorf, F. T., Bengesser, S., Birner, A., Maget, A., Lenger, M., Platzer, M., et al. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19137626 · Cited by 2 · see citing works
Electroconvulsive Therapy-Induced Mania in Bipolar Disorder: A Case Report
Eenoo, S. V., Bollen, O., & Janssens, S. (2024) · Cureus · doi:10.7759/cureus.75255 · Cited by 1 · see citing works
Lower morning levels of cortisol and neuropeptides in blood samples from patients with bipolar disorder
Yıldız, E., Elboğa, G., Uytun, M. Ç., Yılmaz, R., Selvı, Y., Ulusal, H., Çelik, E., Şahpolat, M., Yildiz, Z., Hurşıtoğlu, O., et al. (2022) · Journal of Affective Disorders Reports · doi:10.1016/j.jadr.2022.100406 · Cited by 1 · see citing works
Did we finally find a good animal model for bipolar disorder?
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Authors: Young, J. W., & Dulcis, D.
Affiliations: University of California San Diego (US)
Corresponding author: Young, Jared W.
Dulcis, Davide
ORCID: Young, Jared W.
Dulcis, Davide
Venue: European Journal of Pharmacology
Publisher: Elsevier BV
Published: 2015-07
Volume: 759
Pages: 151-162
ISSN: 0014-2999 (ISSN-L)
DOI: 10.1016/j.ejphar.2015.03.019
PMC: PMC4437855
OpenAlex: W1985521046
Cited by: 68
References: 238
Citations by year: 2026: 1 · 2025: 3 · 2024: 5 · 2023: 2 · 2022: 7 · 2021: 9 · 2020: 8 · 2019: 4 · 2018: 6 · 2017: 11 · 2016: 9 · 2015: 3
FWCI: 1.33
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: European Journal of Pharmacology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: NIH, United States (R01-MH042228, R01-MH071916)
Kavli (KIBM-2012-008)
Veteran׳s Administration VISN 22 Mental Illness Research, Education, and Clinical Center
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: bipolar disorder, state switching, mania, depression, seasonal variation, photoperiod, cholinergic dysfunction, kindling, neurotransmitter expression, somatostatin, corticotropin-releasing factor
MeSH terms: Animals, Behavior, Animal, Bipolar Disorder, Catecholamines, Choline, Disease Models, Animal, Humans, Seasons, Species Specificity, Photoperiod

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