Understanding the Dynamics of Physiological Changes, Protein Expression, and PFAS in Wildlife

Bangma, Jacqueline; Guillette, T.C.; Bommarito, Paige A.; Ng, Carla; Reiner, Jessica L.; Lindstrom, Andrew B.; Strynar, Mark J.

doi:10.1016/j.envint.2021.107037

Cited by 117Per- and polyfluoroalkyl substances researchToxic Organic Pollutants ImpactEnvironmental Toxicology and Ecotoxicology

Understanding the Dynamics of Physiological Changes, Protein Expression, and PFAS in Wildlife

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Bangma, Jacqueline, Guillette, T.C., Bommarito, Paige A., Ng, Carla, Reiner, Jessica L., Lindstrom, Andrew B., Strynar, Mark J.·2022·Environment International

DOI 10.1016/j.envint.2021.107037PMC PMC8802192

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Abstract

Per- and polyfluoroalkyl substances (PFAS) accumulation and elimination in both wildlife and humans is largely attributed to PFAS interactions with proteins, including but not limited to organic anion transporters (OATs), fatty acid binding proteins (FABPs), and serum proteins such as albumin. In wildlife, changes in the biotic and abiotic environment (e.g. salinity, temperature, reproductive stage, and health status) often lead to dynamic and responsive physiological changes that alter the prevalence and location of many proteins, including PFAS-related proteins. Therefore, we hypothesize that if key PFAS-related proteins are impacted as a result of environmentally induced as well as biologically programmed physiological changes (e.g. reproduction), then PFAS that associate with those proteins will also be impacted. Changes in tissue distribution across tissues of PFAS due to these dynamics may have implications for wildlife studies where these chemicals are measured in biological matrices (e.g., serum, feathers, eggs). For example, failure to account for factors contributing to PFAS variability in a tissue may result in exposure misclassification as measured concentrations may not reflect average exposure levels. The goal of this review is to share general information with the PFAS research community on what biotic and abiotic changes might be important to consider when designing and interpreting a biomonitoring or an ecotoxicity based wildlife study. This review will also draw on parallels from the epidemiological discipline to improve study design in wildlife research. Overall, understanding these connections between biotic and abiotic environments, dynamic protein levels, PFAS levels measured in wildlife, and epidemiology serves to strengthen study design and study interpretation and thus strengthen conclusions derived from wildlife studies for years to come.

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Distribution of PFAS throughout the body can also be impacted by abiotic factors, including salinity and temperature, which may alter the levels of proteins that bind PFAS.
“Distribution of PFAS throughout the body can also be impacted by abiotic factors, including salinity and temperature, which may alter the levels of proteins that bind PFAS (Bangma et al., 2022).”
From A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior (2022) · cites this paper as Bangma et al., 2022

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THE AUTHORS REPLY
Savitz, D. A., & Wellenius, G. A. (2018) · American Journal of Epidemiology · doi:10.1093/aje/kwy010 · Cited by 1 · see citing works

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[139]Sagiv SK,, Early-Pregnancy Plasma Concentrations of Perfluoroalkyl Substances and Birth Outcomes in Project Viva: Confounded by Pregnancy Hemodynamics? American Journal of Epidemiology, 2018. 187(4): p. 793– 802. 29155920 PMC5884712

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An in-depth examination of Per- and Polyfluoroalkyl (PFAS) effects on transporters, with emphasis on the ABC superfamily: A critical review
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Red Blood Cell Folate Modifies the Association between Serum Per- and Polyfluoroalkyl Substances and Antibody Concentrations in U.S. Adolescents
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Four Decades of Spatiotemporal Variability of Per- and Polyfluoroalkyl Substances (PFASs) in the Baltic Sea
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Sublethal Toxicity of 17 Per- and Polyfluoroalkyl Substances with Diverse Structures to Ceriodaphnia dubia, Hyalella azteca, and Chironomus dilutus
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Per- and Polyfluoroalkyl Substances (PFASs) and Their Potential Effects on Female Reproductive Diseases
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Perfluoroalkyl substances in the meat of Polish farm animals and game – Occurrence, profiles and dietary intake
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Sulfonamide Per- and Polyfluoroalkyl Substances Can Impact Microorganisms Used in Aromatic Hydrocarbon and Trichloroethene Bioremediation
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Effect of lifestyle-based lipid lowering interventions on the relationship between circulating levels of per-and polyfluoroalkyl substances and serum cholesterol
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Partitioning of PFAS to serum, tissues, eggs, and hatchlings of an Australian freshwater turtle
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Photodynamic Priming Overcomes Per‐ and Polyfluoroalkyl Substance ( PFAS )‐Induced Platinum Resistance in Ovarian Cancer†
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Acute Exposure of Zebrafish (Danio rerio) to the Next-Generation Perfluoroalkyl Substance, Perfluoroethylcyclohexanesulfonate, Shows Similar Effects as Legacy Substances
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Perturbation of IP3R-dependent endoplasmic reticulum calcium homeostasis by PPARδ-activated metabolic stress leads to mouse spermatocyte apoptosis: A direct mechanism for perfluorooctane sulfonic acid-induced spermatogenic disorders
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The perils of poly- and perfluorinated chemicals on the reproductive health of humans, livestock, and wildlife
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Perfluoroalkyl and Polyfluoroalkyl Substances (PFAS) and Vitamin Metabolism: A Nutritional Perspective on an Emerging Environmental Health Issue
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What do emerging PFAS tell us that the classic ones did not? Insights from in vitro assays
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Can blood proteome diversity among fish species help explain perfluoroalkyl acid trophodynamics in aquatic food webs?
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Legacy and novel perfluoroalkyl substances in raw and cooked squids: Perspective from health risks and nutrient benefits
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Species-Specific Profiles of Per- and Polyfluoroalkyl Substances (PFAS) in Small Coastal Sharks Along the South Atlantic Bight of the United States
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Occurrence and pattern of legacy and emerging per- and Poly-FluoroAlkyl substances (PFAS) in eggs of loggerhead turtle Caretta caretta from western Mediterranean
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Role of niche and micro-habitat preferences in per- and polyfluoroalkyl substances occurrence in the gills of tropical lake fish species
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Phytoremediation Potential of Azolla filiculoides: Uptake and Toxicity of Seven Per- and Polyfluoroalkyl Substances (PFAS) at Environmentally Relevant Water Concentrations
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A comprehensive review on the distribution of per- and poly-fluoroalkyl substances in the environment across Sub-Saharan Africa revealed significant variation in their concentrations
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Assessment of per- and poly-fluoroalkyl substances and physiological biomarkers in aquarium-based bottlenose dolphins and killer whales
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Biological pathways of per- and polyfluoroalkyl substances (PFAS): A critical review of cellular and molecular toxicity mechanisms
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Trophic transfer of per- and polyfluoroalkyl substances in aquatic ecosystems
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The effects of estuarine outflows on coastal marine ecosystems in New South Wales, Australia
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Concentration Dependency of PFOS Bioaccumulation by Freshwater Benthic Algae
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High-Resolution Mass Spectrometry Non-Targeted Detection of Per- and Polyfluoroalkyl Substances in Roe Deer (Capreolus capreolus)
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Characterisation of the prdx4 gene in Squalius cephalus and its role in freshwater environments with varying impact of perfluoroalkyl substances (PFAS)
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Predictors of Serum Per- and Polyfluoroalkyl Substances Concentrations among U.S. Couples Attending a Fertility Clinic
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Occurrence and Maternal Transfer of Per- and Polyfluoroalkyl Substances (PFAS) in Pregnant Sharks from Florida Coastal Waters
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Destruction of perfluorooctane sulfonic acid (PFOS) in gas sparging incorporated UV-indole reductive treatment system – Benefits and challenges
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A machine learning multimodal profiling of Per- and Polyfluoroalkyls (PFAS) distribution across animal species organs via clustering and dimensionality reduction techniques
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Impacts of sex and gestation on bioaccumulation and transfer of per-and polyfluoroalkyl substances in loaches
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A decade of data and hundreds of analytes: Legacy and emerging chemicals in North American herring gull plasma
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Occurrence of PFAS in Lyon soils: contribution and impact of industrial activities
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Prenatal Exposure to Per- and Polyfluoroalkyl Substances and Maternal Thyroid Function during Pregnancy in a Cohort with High Familial Likelihood of Autism Spectrum Disorder
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PFAS contamination in Florida estuarine fishes: Levels, patterns, and estimated human and ecological health risks
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Comparative study on gene expression profiles in the liver of male neonatal mice prenatally exposed to PFOA and its alternative HFPO-DA
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Identifying proteomic prognostic markers for Alzheimer's disease with survival machine learning: The Framingham Heart Study
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Characterizing Important Dietary Exposure Sources of Perfluoroalkyl Acids in Inuit Youth and Adults in Nunavik Using a Feature Selection Tool
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Towards process-based modelling and parameterisation of bioaccumulation in humans across PFAS congeners
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Predicting Salt Effects on the Binding of PFAS to Protein
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Prenatal exposure to per- and polyfluoroalkyl substances and childhood executive function and behavioral difficulties at age 7: evidence from the Shanghai birth cohort study
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Mixture toxicity of perfluoroalkyl substances on the aquatic invertebrate Gammarus roeselii
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Mussels as integrative sentinels of emerging contaminants in aquatic ecosystems
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Development of a QSAR model for predicting PPARα activation by PFAS based on human in vitro data of a comprehensive panel of legacy and novel PFAS
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Impact of per- and polyfluoroalkyl substances (PFAS) in wild plants, soil and water in two Austrian national parks
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Assessment of perfluoroalkyl substances concentration levels in wild bat guano samples
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From pollutant-protein engagement to programmable bioremediation: chemoproteomics as a design framework for emerging contaminant degradation
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PFAS in pelagic Sargassum: A growing concern for the mexican caribbean coastline
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Evaluation of the impact of L-Tryptophan on the toxicology of Perfluorooctanoic acid in Daphnia magna: Characterization and perspectives
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Interaction of Perfluorooctanoate and Perfluorohexanoate with Moringa oleifera Seed Protein
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Species- and sex-specific bioaccumulation, tissue-specific distribution, and maternal transfer of per- and polyfluoroalkyl substances in tiger frogs (Hoplobatrachus chinensis) and forest frogs (Rana chensinensis)
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PFAS dynamics in the American black bear (Ursus americanus): Physiological stages (hyperphagia, hibernation, and post-hibernation), and temporal trends from 1989 to 2015
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Prenatal exposure to endocrine-disrupting chemicals and childhood atopic dermatitis: epidemiological evidence
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A molecular and cellular understanding of PFDA-exposure-associated outcomes on biological assemblies
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An Ecosystem-Scale Model of PFAS Dynamics in Stream-to-Riparian Food Webs
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Self-citation

Authors: Bangma, J., Guillette, T. C., Bommarito, P. A., Ng, C., Reiner, J. L., Lindstrom, A. B., & Strynar, M. J.
Affiliations: Oak Ridge Institute for Science and Education (US)
National Institute of Environmental Health Sciences (US)
University of Pittsburgh (US)
National Institute of Standards and Technology (US)
Environmental Protection Agency (US)
Corresponding author: Bangma, Jacqueline
ORCID: Bangma, Jacqueline
Guillette, T.C.
Bommarito, Paige A.
Ng, Carla
Reiner, Jessica L.
Lindstrom, Andrew B.
Strynar, Mark J.
Venue: Environment International
Publisher: Elsevier BV
Published: 2022-01
Volume: 159
Pages: 107037
ISSN: 0160-4120 (ISSN-L)
DOI: 10.1016/j.envint.2021.107037
PMC: PMC8802192
OpenAlex: W4200086124
Cited by: 117
References: 142
Citations by year: 2026: 28 · 2025: 33 · 2024: 28 · 2023: 23 · 2022: 5
FWCI: 1.04
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by/3.0/igo/ (vor)
Locations: Environment International (publishedVersion, cc-by)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Institutes of Health
National Institute of Environmental Health Sciences
Topics: Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Environmental Toxicology and Ecotoxicology
Keywords: per- and polyfluoroalkyl substances, PFAS, wildlife, protein expression, physiological changes, organic anion transporters, fatty acid binding protein, serum albumin, tissue distribution, exposure misclassification, biomonitoring, ecotoxicology, research design, reproductive stage, salinity, temperature
MeSH terms: Biological Monitoring, Animals, Animals, Wild, Fluorocarbons, Humans, Reproduction, Alkanesulfonic Acids

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Understanding the Dynamics of Physiological Changes, Protein Expression, and PFAS in Wildlife

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