Reduced numbers of plasmacytoid dendritic cells in aged blood donors
Abstract
Dendritic cells (DC) play essential functions in both innate and adaptive immune responses. Peripheral blood DCs are divided into two major subsets, named conventional DC (cDC) and plasmacytoid DC (pDC), which play specific functions in the immune response. The absolute numbers of DCs (and their subsets) in peripheral blood may suffer variations due to physiological or pathological reasons, and therefore the enumeration of DC subsets in blood samples may be of clinical interest. However, to date this enumeration has produced controversial rather than consistent results. Here, using a two-tube platform approach, peripheral blood DCs have been enumerated in samples from healthy blood donors aged 18-65 years old. The results obtained showed a significant age-related decrease in pDC numbers, whilst cDC numbers remained unaltered. The different protocols used to define and enumerate DC subsets from blood samples may account for the controversial results reported before, thus emphasizing the importance of a general consensus to enumerate DCs. Reduced pDC numbers may be related to the higher susceptibility to infection and deficient response to vaccination often observed in aged individuals.
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Elderly people have a diminished capacity to produce type I interferons.
“have diminished capacity to produce type I IFNs119-121.”
From SARS-CoV-2, COVID-19 and the aging immune system (2021) · cites this paper as [120]
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- Authors
- Pérez-Cabezas, B., Naranjo-Gómez, M., Fernández, M. A., Grífols, J. R., Pujol-Borrell, R., & Borràs, F. E.
- Affiliations
- Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol (ES)
- Universitat Autònoma de Barcelona (ES)
- Corresponding author
- Borràs, Francesc E.
- Venue
- Experimental Gerontology
- Publisher
- Elsevier BV
- Published
- 2007-10
- Volume
- 42
- Issue
- 10
- Pages
- 1033-1038
- ISSN
- 0531-5565 (ISSN-L)
- OpenAlex
- W2003131595
- Cited by
- 80
- References
- 19
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 3 · 2022: 7 · 2021: 9 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 8 · 2016: 6 · 2015: 3 · 2014: 5 · 2013: 10 · 2012: 3
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Gerontology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- plasmacytoid dendritic cells, myeloid dendritic cells, aging, blood donors, age-related decline, immunosenescence, vaccine response, infection susceptibility
- MeSH terms
- Adolescent, Adult, Aged, Aging, Blood Donors, Cell Count, Dendritic Cells, Female, Humans, Male, Middle Aged, Immunophenotyping
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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