Cited by 80Immunotherapy and Immune ResponsesImmune Response and InflammationImmune responses and vaccinations

Reduced numbers of plasmacytoid dendritic cells in aged blood donors

Pérez-Cabezas, Begoña, Naranjo-Gómez, Mar, Fernández, Marco A., Grífols, Juan R., Pujol-Borrell, Ricardo, Borràs, Francesc E.·2007·Experimental Gerontology

Abstract

Dendritic cells (DC) play essential functions in both innate and adaptive immune responses. Peripheral blood DCs are divided into two major subsets, named conventional DC (cDC) and plasmacytoid DC (pDC), which play specific functions in the immune response. The absolute numbers of DCs (and their subsets) in peripheral blood may suffer variations due to physiological or pathological reasons, and therefore the enumeration of DC subsets in blood samples may be of clinical interest. However, to date this enumeration has produced controversial rather than consistent results. Here, using a two-tube platform approach, peripheral blood DCs have been enumerated in samples from healthy blood donors aged 18-65 years old. The results obtained showed a significant age-related decrease in pDC numbers, whilst cDC numbers remained unaltered. The different protocols used to define and enumerate DC subsets from blood samples may account for the controversial results reported before, thus emphasizing the importance of a general consensus to enumerate DCs. Reduced pDC numbers may be related to the higher susceptibility to infection and deficient response to vaccination often observed in aged individuals.

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Crossref · 10.1016/j.exger.2007.05.010

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Authors
Pérez-Cabezas, B., Naranjo-Gómez, M., Fernández, M. A., Grífols, J. R., Pujol-Borrell, R., & Borràs, F. E.
Affiliations
  • Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol (ES)
  • Universitat Autònoma de Barcelona (ES)
Corresponding author
Borràs, Francesc E.
Venue
Experimental Gerontology
Publisher
Elsevier BV
Published
2007-10
Volume
42
Issue
10
Pages
1033-1038
ISSN
0531-5565 (ISSN-L)
OpenAlex
W2003131595
Cited by
80
References
19
Citations by year
2026: 1 · 2025: 3 · 2024: 1 · 2023: 3 · 2022: 7 · 2021: 9 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 8 · 2016: 6 · 2015: 3 · 2014: 5 · 2013: 10 · 2012: 3
FWCI
1.49
Type
journal article
Language
en
Open access
closed
Locations
  • Experimental Gerontology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Keywords
plasmacytoid dendritic cells, myeloid dendritic cells, aging, blood donors, age-related decline, immunosenescence, vaccine response, infection susceptibility
MeSH terms
Adolescent, Adult, Aged, Aging, Blood Donors, Cell Count, Dendritic Cells, Female, Humans, Male, Middle Aged, Immunophenotyping

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