Circulating, Interferon‐Producing Plasmacytoid Dendritic Cells Decline During Human Ageing
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Increased frequency and severity of infections in the elderly have been taken as indicative of declining immune function. Dendritic cells (DCs), the most important antigen‐presenting cells, play a central role in initiating and modulating immune responses. One type, DC2, arises from precursor plasmacytoid DCs (pDCs), a rare population of circulating blood cells, whose hallmark function is rapid and copious production of interferon‐α (IFN‐α) upon microbial challenge. We found significant decreases of the circulating pDCs during ageing in healthy adult humans, as defined both by flow cytometry and IFN‐α generation. Mean pDC/mm 3 in peripheral blood declined from 7.8 for the youngest age group (18–39 years) to 4.2 for the oldest (60–91 years; P = 0.017). IFN‐α generation declined similarly, from 3537 to 1201 IU/ml, respectively (P = 0.006). There was also a slight decline over the age range in the amount of IFN generated per pDC (slope = −0.0087; P = 0.046). CD4+ T cells decreased by approximately 20% over the same age range (P = 0.001), while there was no change in the total lymphocyte or monocyte counts.
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Elderly people have a diminished capacity to produce type I interferons.
“have diminished capacity to produce type I IFNs119-121.”
From SARS-CoV-2, COVID-19 and the aging immune system (2021) · cites this paper as [119]
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- Authors
- Shodell, M., & Siegal, F. P.
- Affiliations
- Long Island University (US)
- Saint Vincent's Catholic Medical Center (US)
- Corresponding author
- Siegal, F. P.
- Venue
- Scandinavian Journal of Immunology
- Publisher
- Wiley
- Published
- 2002-10-31
- Volume
- 56
- Issue
- 5
- Pages
- 518-521
- ISSN
- 0300-9475 (ISSN-L)
- 1365-3083
- OpenAlex
- W2012807110
- Cited by
- 189
- References
- 30
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 9 · 2023: 4 · 2022: 4 · 2021: 10 · 2020: 10 · 2019: 7 · 2018: 5 · 2017: 12 · 2016: 6 · 2015: 7 · 2014: 11 · 2013: 16 · 2012: 10
- FWCI
- 1.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Scandinavian Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Keywords
- plasmacytoid dendritic cells, aging, interferon-alpha, DC2, immunosenescence, CD4+ T cells, circulating immune cells, older adults, infection susceptibility
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Aging, Dendritic Cells, Female, Humans, Leukocytes, Mononuclear, Male, Middle Aged, Interferon-alpha, Lymphocyte Count, CD4 Lymphocyte Count
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